Tanvir Hasan

Sahar Almahfouz Nasser, Juan Francisco Pesantez Borja, Jincheng Liu et al.

Despite significant progress in computational pathology, many AI models remain black-box and difficult to interpret, posing a major barrier to clinical adoption due to limited transparency and explainability. This has motivated continued interest in engineered image-based biomarkers, which offer greater interpretability but are often proposed based on anecdotal evidence or fragmented prior literature rather than systematic biological validation. We introduce SAGE (Structured Agentic system for hypothesis Generation and Evaluation), an agentic AI system designed to identify interpretable, engineered pathology biomarkers by grounding them in biological evidence. SAGE integrates literature-anchored reasoning with multimodal data analysis to correlate image-derived features with molecular biomarkers, such as gene expression, and clinically relevant outcomes. By coordinating specialized agents for biological contextualization and empirical hypothesis validation, SAGE prioritizes transparent, biologically supported biomarkers and advances the clinical translation of computational pathology.

Md Sajid Islam, Tanvir Hasan

Bluetooth-based mesh networks offer a promising infrastructure for offline communication in emergency and resource constrained scenarios. However, traditional routing strategies such as Ad hoc On-Demand Distance Vector (AODV) often degrade under congestion and dynamic topological changes. This study proposes a hybrid intelligent routing framework that augments AODV with supervised machine learning to improve next-hop selection under varied network constraints. The framework integrates four predictive models: a delivery success classifier, a TTL regressor, a delay regressor, and a forwarder suitability classifier, into a unified scoring mechanism that dynamically ranks neighbors during multi-hop message transmission. A simulation environment with stationary node deployments was developed, incorporating buffer constraints and device heterogeneity to evaluate three strategies: baseline AODV, a partial hybrid ML model (ABC), and the full hybrid ML model (ABCD). Across ten scenarios, the Hybrid ABCD model achieves approximately 99.97 percent packet delivery under these controlled conditions, significantly outperforming both the baseline and intermediate approaches. The results demonstrate that lightweight, explainable machine learning models can enhance routing reliability and adaptability in Bluetooth mesh networks, particularly in infrastructure-less environments where delivery success is prioritized over latency constraints.