Chao He

Zhaokun Zhou, Yuesheng Zhu, Chao He et al.

We consider two biologically plausible structures, the Spiking Neural Network (SNN) and the self-attention mechanism. The former offers an energy-efficient and event-driven paradigm for deep learning, while the latter has the ability to capture feature dependencies, enabling Transformer to achieve good performance. It is intuitively promising to explore the marriage between them. In this paper, we consider leveraging both self-attention capability and biological properties of SNNs, and propose a novel Spiking Self Attention (SSA) as well as a powerful framework, named Spiking Transformer (Spikformer). The SSA mechanism in Spikformer models the sparse visual feature by using spike-form Query, Key, and Value without softmax. Since its computation is sparse and avoids multiplication, SSA is efficient and has low computational energy consumption. It is shown that Spikformer with SSA can outperform the state-of-the-art SNNs-like frameworks in image classification on both neuromorphic and static datasets. Spikformer (66.3M parameters) with comparable size to SEW-ResNet-152 (60.2M,69.26%) can achieve 74.81% top1 accuracy on ImageNet using 4 time steps, which is the state-of-the-art in directly trained SNNs models.

Chao He, Hongxi Wei

Deep image hashing aims to map input images into simple binary hash codes via deep neural networks and thus enable effective large-scale image retrieval. Recently, hybrid networks that combine convolution and Transformer have achieved superior performance on various computer tasks and have attracted extensive attention from researchers. Nevertheless, the potential benefits of such hybrid networks in image retrieval still need to be verified. To this end, we propose a hybrid convolutional and self-attention deep hashing method known as HybridHash. Specifically, we propose a backbone network with stage-wise architecture in which the block aggregation function is introduced to achieve the effect of local self-attention and reduce the computational complexity. The interaction module has been elaborately designed to promote the communication of information between image blocks and to enhance the visual representations. We have conducted comprehensive experiments on three widely used datasets: CIFAR-10, NUS-WIDE and IMAGENET. The experimental results demonstrate that the method proposed in this paper has superior performance with respect to state-of-the-art deep hashing methods. Source code is available https://github.com/shuaichaochao/HybridHash.

Qiming He, Jing Li, Tian Guan et al.

Glomerular pathology is central to the diagnosis and prognosis of renal diseases, yet the heterogeneity of glomerular morphology and fine-grained lesion patterns remain challenging for current AI approaches. We present GloPath, an entity-centric foundation model trained on over one million glomeruli extracted from 14,049 renal biopsy specimens using multi-scale and multi-view self-supervised learning. GloPath addresses two major challenges in nephropathology: glomerular lesion assessment and clinicopathological insights discovery. For lesion assessment, GloPath was benchmarked across three independent cohorts on 52 tasks, including lesion recognition, grading, few-shot classification, and cross-modality diagnosis-outperforming state-of-the-art methods in 42 tasks (80.8%). In the large-scale real-world study, it achieved an ROC-AUC of 91.51% for lesion recognition, demonstrating strong robustness in routine clinical settings. For clinicopathological insights, GloPath systematically revealed statistically significant associations between glomerular morphological parameters and clinical indicators across 224 morphology-clinical variable pairs, demonstrating its capacity to connect tissue-level pathology with patient-level outcomes. Together, these results position GloPath as a scalable and interpretable platform for glomerular lesion assessment and clinicopathological discovery, representing a step toward clinically translatable AI in renal pathology.

HongYu Liu, Ruijie Wan, Yueju Han et al.

Audio classification plays an essential role in sentiment analysis and emotion recognition, especially for analyzing customer attitudes in marketing phone calls. Efficiently categorizing customer purchasing propensity from large volumes of audio data remains challenging. In this work, we propose a novel Multi-Segment Multi-Task Fusion Network (MSMT-FN) that is uniquely designed for addressing this business demand. Evaluations conducted on our proprietary MarketCalls dataset, as well as established benchmarks (CMU-MOSI, CMU-MOSEI, and MELD), show MSMT-FN consistently outperforms or matches state-of-the-art methods. Additionally, our newly curated MarketCalls dataset will be available upon request, and the code base is made accessible at GitHub Repository MSMT-FN, to facilitate further research and advancements in audio classification domain.

Chao He, Hongxi Wei

Deep image hashing aims to enable effective large-scale image retrieval by mapping the input images into simple binary hash codes through deep neural networks. More recently, Vision Mamba with linear time complexity has attracted extensive attention from researchers by achieving outstanding performance on various computer tasks. Nevertheless, the suitability of Mamba for large-scale image retrieval tasks still needs to be explored. Towards this end, we propose a visual state space hashing model, called MambaHash. Concretely, we propose a backbone network with stage-wise architecture, in which grouped Mamba operation is introduced to model local and global information by utilizing Mamba to perform multi-directional scanning along different groups of the channel. Subsequently, the proposed channel interaction attention module is used to enhance information communication across channels. Finally, we meticulously design an adaptive feature enhancement module to increase feature diversity and enhance the visual representation capability of the model. We have conducted comprehensive experiments on three widely used datasets: CIFAR-10, NUS-WIDE and IMAGENET. The experimental results demonstrate that compared with the state-of-the-art deep hashing methods, our proposed MambaHash has well efficiency and superior performance to effectively accomplish large-scale image retrieval tasks. Source code is available https://github.com/shuaichaochao/MambaHash.git

Jia Wang, Qian Xu, Xuanwen Ding et al.

In this paper, we introduce ProcureGym, an data-driven multi-agent simulation platform that models China's National Volume-Based drug Procurement (NVBP) as a Markov Game. Based on real-world data from 7 rounds of NVBP (covering 325 drugs and 2,267 firms), the platform establishes a high-fidelity simulation environment. Within this framework, we evaluate diverse agent models, including Reinforcement Learning (RL), Large Language Model (LLM), and Rule-based algorithms. Experimental results demonstrate that RL agents achieve superior winner alignment and profits. Further analyses show that maximum valid bidding price and procurement volume dominate strategic outcomes. ProcureGym thus serves as a rigorous instrument for assessing policy impacts and formulating future procurement strategies.

Jianqiang Ren, Chao He, Lin Liu et al.

There is a growing demand for customized and expressive 3D characters with the emergence of AI agents and Metaverse, but creating 3D characters using traditional computer graphics tools is a complex and time-consuming task. To address these challenges, we propose a user-friendly framework named Make-A-Character (Mach) to create lifelike 3D avatars from text descriptions. The framework leverages the power of large language and vision models for textual intention understanding and intermediate image generation, followed by a series of human-oriented visual perception and 3D generation modules. Our system offers an intuitive approach for users to craft controllable, realistic, fully-realized 3D characters that meet their expectations within 2 minutes, while also enabling easy integration with existing CG pipeline for dynamic expressiveness. For more information, please visit the project page at https://human3daigc.github.io/MACH/.

Xiaoyu Zheng, Jing Wen, Jiaxin Zhuang et al.

Polarization, as a new optical imaging tool, has been explored to assist in the diagnosis of pathology. Moreover, converting the polarimetric Mueller Matrix (MM) to standardized stained images becomes a promising approach to help pathologists interpret the results. However, existing methods for polarization-based virtual staining are still in the early stage, and the diffusion-based model, which has shown great potential in enhancing the fidelity of the generated images, has not been studied yet. In this paper, a Regulated Bridge Diffusion Model (RBDM) for polarization-based virtual staining is proposed. RBDM utilizes the bidirectional bridge diffusion process to learn the mapping from polarization images to other modalities such as H\&E and fluorescence. And to demonstrate the effectiveness of our model, we conduct the experiment on our manually collected dataset, which consists of 18,000 paired polarization, fluorescence and H\&E images, due to the unavailability of the public dataset. The experiment results show that our model greatly outperforms other benchmark methods. Our dataset and code will be released upon acceptance.

Chao He, Jianqiang Ren, Yuan Dong et al.

The 2D cartoon style is a prominent art form in digital character creation, particularly popular among younger audiences. While advancements in digital human technology have spurred extensive research into photorealistic digital humans and 3D characters, interactive 2D cartoon characters have received comparatively less attention. Unlike 3D counterparts, which require sophisticated construction and resource-intensive rendering, Live2D, a widely-used format for 2D cartoon characters, offers a more efficient alternative, which allows to animate 2D characters in a manner that simulates 3D movement without the necessity of building a complete 3D model. Furthermore, Live2D employs lightweight HTML5 (H5) rendering, improving both accessibility and efficiency. In this technical report, we introduce Textoon, an innovative method for generating diverse 2D cartoon characters in the Live2D format based on text descriptions. The Textoon leverages cutting-edge language and vision models to comprehend textual intentions and generate 2D appearance, capable of creating a wide variety of stunning and interactive 2D characters within one minute. The project homepage is https://human3daigc.github.io/Textoon_webpage/.

Jing-Xiao Liao, Chao He, Jipu Li et al.

Blind deconvolution (BD) has been demonstrated as an efficacious approach for extracting bearing fault-specific features from vibration signals under strong background noise. Despite BD's desirable feature in adaptability and mathematical interpretability, a significant challenge persists: How to effectively integrate BD with fault-diagnosing classifiers? This issue arises because the traditional BD method is solely designed for feature extraction with its own optimizer and objective function. When BD is combined with downstream deep learning classifiers, the different learning objectives will be in conflict. To address this problem, this paper introduces classifier-guided BD (ClassBD) for joint learning of BD-based feature extraction and deep learning-based fault classification. Firstly, we present a time and frequency neural BD that employs neural networks to implement conventional BD, thereby facilitating the seamless integration of BD and the deep learning classifier for co-optimization of model parameters. Subsequently, we develop a unified framework to use a deep learning classifier to guide the learning of BD filters. In addition, we devise a physics-informed loss function composed of kurtosis, $l_2/l_4$ norm, and a cross-entropy loss to jointly optimize the BD filters and deep learning classifier. Consequently, the fault labels provide useful information to direct BD to extract features that distinguish classes amidst strong noise. To the best of our knowledge, this is the first of its kind that BD is successfully applied to bearing fault diagnosis. Experimental results from three datasets demonstrate that ClassBD outperforms other state-of-the-art methods under noisy conditions.

Jingzhe Ding, Shengda Long, Changxin Pu et al.

Recent advances in coding agents suggest rapid progress toward autonomous software development, yet existing benchmarks fail to rigorously evaluate the long-horizon capabilities required to build complete software systems. Most prior evaluations focus on localized code generation, scaffolded completion, or short-term repair tasks, leaving open the question of whether agents can sustain coherent reasoning, planning, and execution over the extended horizons demanded by real-world repository construction. To address this gap, we present NL2Repo Bench, a benchmark explicitly designed to evaluate the long-horizon repository generation ability of coding agents. Given only a single natural-language requirements document and an empty workspace, agents must autonomously design the architecture, manage dependencies, implement multi-module logic, and produce a fully installable Python library. Our experiments across state-of-the-art open- and closed-source models reveal that long-horizon repository generation remains largely unsolved: even the strongest agents achieve below 40% average test pass rates and rarely complete an entire repository correctly. Detailed analysis uncovers fundamental long-horizon failure modes, including premature termination, loss of global coherence, fragile cross-file dependencies, and inadequate planning over hundreds of interaction steps. NL2Repo Bench establishes a rigorous, verifiable testbed for measuring sustained agentic competence and highlights long-horizon reasoning as a central bottleneck for the next generation of autonomous coding agents.

Yizhi Wang, Li Chen, Qiang Huang et al.

Cervical cancer remains a major malignancy, necessitating extensive and complex histopathological assessments and comprehensive support tools. Although deep learning shows promise, these models still lack accuracy and generalizability. General foundation models offer a broader reach but remain limited in capturing subspecialty-specific features and task adaptability. We introduce the Cervical Subspecialty Pathology (CerS-Path) diagnostic system, developed through two synergistic pretraining stages: self-supervised learning on approximately 190 million tissue patches from 140,000 slides to build a cervical-specific feature extractor, and multimodal enhancement with 2.5 million image-text pairs, followed by integration with multiple downstream diagnostic functions. Supporting eight diagnostic functions, including rare cancer classification and multimodal Q&A, CerS-Path surpasses prior foundation models in scope and clinical applicability. Comprehensive evaluations demonstrate a significant advance in cervical pathology, with prospective testing on 3,173 cases across five centers maintaining 99.38% screening sensitivity and excellent generalizability, highlighting its potential for subspecialty diagnostic translation and cervical cancer screening.

Chao He, Jianqiang Ren, Jianjing Xiang et al.

With the rapid advancement of large foundation models, AIGC, cloud rendering, and real-time motion capture technologies, digital humans are now capable of achieving synchronized facial expressions and body movements, engaging in intelligent dialogues driven by natural language, and enabling the fast creation of personalized avatars. While current mainstream approaches to digital humans primarily focus on 3D models and 2D video-based representations, interactive 2D cartoon-style digital humans have received relatively less attention. Compared to 3D digital humans that require complex modeling and high rendering costs, and 2D video-based solutions that lack flexibility and real-time interactivity, 2D cartoon-style Live2D models offer a more efficient and expressive alternative. By simulating 3D-like motion through layered segmentation without the need for traditional 3D modeling, Live2D enables dynamic and real-time manipulation. In this technical report, we present CartoonAlive, an innovative method for generating high-quality Live2D digital humans from a single input portrait image. CartoonAlive leverages the shape basis concept commonly used in 3D face modeling to construct facial blendshapes suitable for Live2D. It then infers the corresponding blendshape weights based on facial keypoints detected from the input image. This approach allows for the rapid generation of a highly expressive and visually accurate Live2D model that closely resembles the input portrait, within less than half a minute. Our work provides a practical and scalable solution for creating interactive 2D cartoon characters, opening new possibilities in digital content creation and virtual character animation. The project homepage is https://human3daigc.github.io/CartoonAlive_webpage/.

Yao Du, Jiaxin Zhuang, Xiaoyu Zheng et al.

Histopathology image analysis is fundamental to digital pathology, with hematoxylin and eosin (H&E) staining as the gold standard for diagnostic and prognostic assessments. While H&E imaging effectively highlights cellular and tissue structures, it lacks sensitivity to birefringence and tissue anisotropy, which are crucial for assessing collagen organization, fiber alignment, and microstructural alterations--key indicators of tumor progression, fibrosis, and other pathological conditions. To bridge this gap, we construct a polarization imaging system and curate a new dataset of over 13,000 paired Polar-H&E images. Visualizations of polarization properties reveal distinctive optical signatures in pathological tissues, underscoring its diagnostic value. Building on this dataset, we propose PolarHE, a dual-modality fusion framework that integrates H&E with polarization imaging, leveraging the latter ability to enhance tissue characterization. Our approach employs a feature decomposition strategy to disentangle common and modality specific features, ensuring effective multimodal representation learning. Through comprehensive validation, our approach significantly outperforms previous methods, achieving an accuracy of 86.70% on the Chaoyang dataset and 89.06% on the MHIST dataset. These results demonstrate that polarization imaging is a powerful and underutilized modality in computational pathology, enriching feature representation and improving diagnostic accuracy. PolarHE establishes a promising direction for multimodal learning, paving the way for more interpretable and generalizable pathology models.

Jiawen Li, Jiali Hu, Qiehe Sun et al. · tsinghua

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple instance learning (MIL) has been the primary method for adapting foundation models to WSIs. However, in this work we present a key experimental finding: a simple nonlinear mapping strategy combining mean pooling and a multilayer perceptron, called SiMLP, can effectively adapt patch-level foundation models to slide-level tasks without complex MIL-based learning. Through extensive experiments across diverse downstream tasks, we demonstrate the superior performance of SiMLP with state-of-the-art methods. For instance, on a large-scale pan-cancer classification task, SiMLP surpasses popular MIL-based methods by 3.52%. Furthermore, SiMLP shows strong learning ability in few-shot classification and remaining highly competitive with slide-level foundation models pretrained on tens of thousands of slides. Finally, SiMLP exhibits remarkable robustness and transferability in lung cancer subtyping. Overall, our findings challenge the conventional MIL-based fine-tuning paradigm, demonstrating that a task-agnostic representation strategy alone can effectively adapt foundation models to WSI analysis. These insights offer a unique and meaningful perspective for future research in digital pathology, paving the way for more efficient and broadly applicable methodologies.

Jiawen Li, Tian Guan, Qingxin Xia et al.

Foundation models have revolutionized the paradigm of digital pathology, as they leverage general-purpose features to emulate real-world pathological practices, enabling the quantitative analysis of critical histological patterns and the dissection of cancer-specific signals. However, these static general features constrain the flexibility and pathological relevance in the ever-evolving needs of clinical applications, hindering the broad use of the current models. Here we introduce PathFiT, a dynamic feature learning method that can be effortlessly plugged into various pathology foundation models to unlock their adaptability. Meanwhile, PathFiT performs seamless implementation across diverse pathology applications regardless of downstream specificity. To validate PathFiT, we construct a digital pathology benchmark with over 20 terabytes of Internet and real-world data comprising 28 H\&E-stained tasks and 7 specialized imaging tasks including Masson's Trichrome staining and immunofluorescence images. By applying PathFiT to the representative pathology foundation models, we demonstrate state-of-the-art performance on 34 out of 35 tasks, with significant improvements on 23 tasks and outperforming by 10.20% on specialized imaging tasks. The superior performance and versatility of PathFiT open up new avenues in computational pathology.

Chao He, Hongmei Shi, Ruixin Li et al.

The service conditions of wheelset bearings has a direct impact on the safe operation of railway heavy haul freight trains as the key components. However, speed fluctuation of the trains and few fault samples are the two main problems that restrict the accuracy of bearing fault diagnosis. Therefore, a cross-machine transfer diagnosis (pyDSN) network coupled with interpretable modulated differentiable short-time Fourier transform (STFT) and physics-informed balanced spectrum quality metric is proposed to learn domain-invariant and discriminative features under time-varying speeds. Firstly, due to insufficiency in extracting extract frequency components of time-varying speed signals using fixed windows, a modulated differentiable STFT (MDSTFT) that is interpretable with STFT-informed theoretical support, is proposed to extract the robust time-frequency spectrum (TFS). During training process, multiple windows with different lengths dynamically change. Also, in addition to the classification metric and domain discrepancy metric, we creatively introduce a third kind of metric, referred to as the physics-informed metric, to enhance transferable TFS. A physics-informed balanced spectrum quality (BSQ) regularization loss is devised to guide an optimization direction for MDSTFT and model. With it, not only can model acquire high-quality TFS, but also a physics-restricted domain adaptation network can be also acquired, making it learn real-world physics knowledge, ultimately diminish the domain discrepancy across different datasets. The experiment is conducted in the scenario of migrating from the laboratory datasets to the freight train dataset, indicating that the hybrid-driven pyDSN outperforms existing methods and has practical value.

Xiaopei Wan, Zhenhua Guo, Chao He et al.

Lacking enough high quality proposals for RoI box head has impeded two-stage and multi-stage object detectors for a long time, and many previous works try to solve it via improving RPN's performance or manually generating proposals from ground truth. However, these methods either need huge training and inference costs or bring little improvements. In this paper, we design a novel training method named APDI, which means augmenting proposals by the detector itself and can generate proposals with higher quality. Furthermore, APDI makes it possible to integrate IoU head into RoI box head. And it does not add any hyperparameter, which is beneficial for future research and downstream tasks. Extensive experiments on COCO dataset show that our method brings at least 2.7 AP improvements on Faster R-CNN with various backbones, and APDI can cooperate with advanced RPNs, such as GA-RPN and Cascade RPN, to obtain extra gains. Furthermore, it brings significant improvements on Cascade R-CNN.

Yuanxin Wu, Chao He, Gang Liu

Inertial navigation and attitude initialization in polar areas become a hot topic in recent years in the navigation community, as the widely-used navigation mechanization of the local level frame encounters the inherent singularity when the latitude approaches 90 degrees. Great endeavors have been devoted to devising novel navigation mechanizations such as the grid or transversal frames. This paper highlights the fact that the common Earth-frame mechanization is sufficiently good to well handle the singularity problem in polar areas. Simulation results are reported to demonstrate the singularity problem and the effectiveness of the Earth-frame mechanization.

Pengfei Liu, Ji Zhang, Cane Wing-Ki Leung et al.

Effective representation of a text is critical for various natural language processing tasks. For the particular task of Chinese sentiment analysis, it is important to understand and choose an effective representation of a text from different forms of Chinese representations such as word, character and pinyin. This paper presents a systematic study of the effect of these representations for Chinese sentiment analysis by proposing a multi-channel convolutional neural network (MCCNN), where each channel corresponds to a representation. Experimental results show that: (1) Word wins on the dataset of low OOV rate while character wins otherwise; (2) Using these representations in combination generally improves the performance; (3) The representations based on MCCNN outperform conventional ngram features using SVM; (4) The proposed MCCNN model achieves the competitive performance against the state-of-the-art model fastText for Chinese sentiment analysis.