Yudong Zhang

Wei Ding, Yudong Zhang, Ruobing Xie et al.

As foundation models scale toward fusing more heterogeneous visual streams, understanding how diverse encoders interact under joint training becomes a prerequisite for principled design. Yet large vision-language models (LVLMs) currently lack the tools to do so, and parameter-efficient encoder configurations remain hard to identify before training. To re-examine encoder roles under joint training, on the 16-benchmark Cambrian-1 suite we retrain and evaluate all 31 non-empty subsets of five common vision encoders under a unified pipeline (~20k GPU-hours total), and report three findings. First, retraining each subset from scratch reveals encoder rankings that differ from those obtained by masking encoders on a fixed checkpoint, including which encoder ranks first overall. Second, we decompose each encoder's contribution into two axes, Capacity, the score an encoder reaches on its own, and Necessity, the drop when it is removed from the full pool. The two axes are not interchangeable. Pairing the two highest-Capacity encoders is suboptimal, while pairing a high-Capacity anchor with an adaptive complement matches the full five-encoder model. Adding further encoders beyond this pair yields only marginal gains. Third, at fixed parameter count, per-encoder pre-projector effective rank explains the residual score variation. The strongest pairs combine an anchor whose rank survives joint training with a complement whose rank expands under it, suggesting that higher-rank, less-collapsed projector inputs correspond to a more favorable optimization regime at the encoder-projector interface. Together, the Capacity-Necessity decomposition and the pre-projector rank analysis, along with comprehensive evaluation through retraining, expose a methodological gap in multi-encoder LVLM design, and offer concrete primitives for closing it.

Yudong Zhang, Ruobing Xie, Jiansheng Chen et al. · tsinghua

Large Vision-Language Models (LVLMs) have demonstrated their powerful multimodal capabilities. However, they also face serious safety problems, as adversaries can induce robustness issues in LVLMs through the use of well-designed adversarial examples. Therefore, LVLMs are in urgent need of detection tools for adversarial examples to prevent incorrect responses. In this work, we first discover that LVLMs exhibit regular attention patterns for clean images when presented with probe questions. We propose an unconventional method named PIP, which utilizes the attention patterns of one randomly selected irrelevant probe question (e.g., "Is there a clock?") to distinguish adversarial examples from clean examples. Regardless of the image to be tested and its corresponding question, PIP only needs to perform one additional inference of the image to be tested and the probe question, and then achieves successful detection of adversarial examples. Even under black-box attacks and open dataset scenarios, our PIP, coupled with a simple SVM, still achieves more than 98% recall and a precision of over 90%. Our PIP is the first attempt to detect adversarial attacks on LVLMs via simple irrelevant probe questions, shedding light on deeper understanding and introspection within LVLMs. The code is available at https://github.com/btzyd/pip.

Yulong Zou, Bo Liu, Cun-Jing Zheng et al.

Leveraging multimodal information from Magnetic Resonance Imaging (MRI) plays a vital role in lesion segmentation, especially for brain tumors. However, in clinical practice, multimodal MRI data are often incomplete, making it challenging to fully utilize the available information. Therefore, maximizing the utilization of this incomplete multimodal information presents a crucial research challenge. We present a novel meta-guided multi-modal learning (MGML) framework that comprises two components: meta-parameterized adaptive modality fusion and consistency regularization module. The meta-parameterized adaptive modality fusion (Meta-AMF) enables the model to effectively integrate information from multiple modalities under varying input conditions. By generating adaptive soft-label supervision signals based on the available modalities, Meta-AMF explicitly promotes more coherent multimodal fusion. In addition, the consistency regularization module enhances segmentation performance and implicitly reinforces the robustness and generalization of the overall framework. Notably, our approach does not alter the original model architecture and can be conveniently integrated into the training pipeline for end-to-end model optimization. We conducted extensive experiments on the public BraTS2020 and BraTS2023 datasets. Compared to multiple state-of-the-art methods from previous years, our method achieved superior performance. On BraTS2020, for the average Dice scores across fifteen missing modality combinations, building upon the baseline, our method obtained scores of 87.55, 79.36, and 62.67 for the whole tumor (WT), the tumor core (TC), and the enhancing tumor (ET), respectively. We have made our source code publicly available at https://github.com/worldlikerr/MGML.

Wenhao Tang, Junding Sun, Shuihua Wang et al.

In recent years, the rapid development of deep learning has led to a wide range of applications in the field of medical image classification. The variants of neural network models with ever-increasing performance share some commonalities: to try to mitigate overfitting, improve generalization, avoid gradient vanishing and exploding, etc. AlexNet first utilizes the dropout technique to mitigate overfitting and the ReLU activation function to avoid gradient vanishing. Therefore, we focus our discussion on AlexNet, which has contributed greatly to the development of CNNs in 2012. After reviewing over 40 papers, including journal papers and conference papers, we give a narrative on the technical details, advantages, and application areas of AlexNet.

Ziquan Zhu, Jing Tao, Shuihua Wang et al.

This paper proposes applying a novel deep-learning model, TBDLNet, to recognize CT images to classify multidrug-resistant and drug-sensitive tuberculosis automatically. The pre-trained ResNet50 is selected to extract features. Three randomized neural networks are used to alleviate the overfitting problem. The ensemble of three RNNs is applied to boost the robustness via majority voting. The proposed model is evaluated by five-fold cross-validation. Five indexes are selected in this paper, which are accuracy, sensitivity, precision, F1-score, and specificity. The TBDLNet achieves 0.9822 accuracy, 0.9815 specificity, 0.9823 precision, 0.9829 sensitivity, and 0.9826 F1-score, respectively. The TBDLNet is suitable for classifying multidrug-resistant tuberculosis and drug-sensitive tuberculosis. It can detect multidrug-resistant pulmonary tuberculosis as early as possible, which helps to adjust the treatment plan in time and improve the treatment effect.

Xinlei Yu, Chengming Xu, Guibin Zhang et al.

Despite the remarkable success of Vision-Language Models (VLMs), their performance on a range of complex visual tasks is often hindered by a "visual processing bottleneck": a propensity to lose grounding in visual evidence and exhibit a deficit in contextualized visual experience during prolonged generation. Drawing inspiration from human cognitive memory theory, which distinguishes short-term visually-dominant memory and long-term semantically-dominant memory, we propose VisMem, a cognitively-aligned framework that equips VLMs with dynamic latent vision memories, a short-term module for fine-grained perceptual retention and a long-term module for abstract semantic consolidation. These memories are seamlessly invoked during inference, allowing VLMs to maintain both perceptual fidelity and semantic consistency across thinking and generation. Extensive experiments across diverse visual benchmarks for understanding, reasoning, and generation reveal that VisMem delivers a significant average performance boost of 11.8% relative to the vanilla model and outperforms all counterparts, establishing a new paradigm for latent-space memory enhancement. The code will be available: https://github.com/YU-deep/VisMem.git.

Xiang Li, Long Lan, Husam Lahza et al.

In the face of rapid advances in medical imaging, cross-domain adaptive medical image detection is challenging due to the differences in lesion representations across various medical imaging technologies. To address this issue, we draw inspiration from large language models to propose EAFP-Med, an efficient adaptive feature processing module based on prompts for medical image detection. EAFP-Med can efficiently extract lesion features of different scales from a diverse range of medical images based on prompts while being flexible and not limited by specific imaging techniques. Furthermore, it serves as a feature preprocessing module that can be connected to any model front-end to enhance the lesion features in input images. Moreover, we propose a novel adaptive disease detection model named EAFP-Med ST, which utilizes the Swin Transformer V2 - Tiny (SwinV2-T) as its backbone and connects it to EAFP-Med. We have compared our method to nine state-of-the-art methods. Experimental results demonstrate that EAFP-Med ST achieves the best performance on all three datasets (chest X-ray images, cranial magnetic resonance imaging images, and skin images). EAFP-Med can efficiently extract lesion features from various medical images based on prompts, enhancing the model's performance. This holds significant potential for improving medical image analysis and diagnosis.

Mohsen Karami, Khadijeh, Jahanian et al.

In recent years, Reinforcement Learning (RL) has emerged as a powerful tool for solving a wide range of problems, including decision-making and genomics. The exponential growth of raw genomic data over the past two decades has exceeded the capacity of manual analysis, leading to a growing interest in automatic data analysis and processing. RL algorithms are capable of learning from experience with minimal human supervision, making them well-suited for genomic data analysis and interpretation. One of the key benefits of using RL is the reduced cost associated with collecting labeled training data, which is required for supervised learning. While there have been numerous studies examining the applications of Machine Learning (ML) in genomics, this survey focuses exclusively on the use of RL in various genomics research fields, including gene regulatory networks (GRNs), genome assembly, and sequence alignment. We present a comprehensive technical overview of existing studies on the application of RL in genomics, highlighting the strengths and limitations of these approaches. We then discuss potential research directions that are worthy of future exploration, including the development of more sophisticated reward functions as RL heavily depends on the accuracy of the reward function, the integration of RL with other machine learning techniques, and the application of RL to new and emerging areas in genomics research. Finally, we present our findings and conclude by summarizing the current state of the field and the future outlook for RL in genomics.

Lin Yang, Shuihua Wang, Yudong Zhang

Coronavirus disease 2019 (COVID-19) has spread all over the world for three years, but medical facilities in many areas still aren't adequate. There is a need for rapid COVID-19 diagnosis to identify high-risk patients and maximize the use of limited medical resources. Motivated by this fact, we proposed the deep learning framework MEDNC for automatic prediction and diagnosis of COVID-19 using computed tomography (CT) images. Our model was trained using two publicly available sets of COVID-19 data. And it was built with the inspiration of transfer learning. Results indicated that the MEDNC greatly enhanced the detection of COVID-19 infections, reaching an accuracy of 98.79% and 99.82% respectively. We tested MEDNC on a brain tumor and a blood cell dataset to show that our model applies to a wide range of problems. The outcomes demonstrated that our proposed models attained an accuracy of 99.39% and 99.28%, respectively. This COVID-19 recognition tool could help optimize healthcare resources and reduce clinicians' workload when screening for the virus.

Xing Xu, Xu Wang, Yudong Zhang et al.

Air-quality forecasting models are commonly evaluated on regional, preprocessed, and normalized datasets, where missing observations are removed or artificially completed. Such protocols simplify comparison but hide the conditions that dominate real monitoring networks: uneven global coverage, structured missingness, heterogeneous pollutant scales, and deployment cost. We introduce \textbf{AirQualityBench}, a global multi-pollutant benchmark designed to evaluate forecasting models under these realistic conditions. The benchmark contains hourly observations from 3,720 monitoring stations over 2021--2025, covers six major pollutants, and preserves provider-native observation masks. Rather than imputing a dense data tensor, AirQualityBench exposes missingness as part of the forecasting problem and reports errors on valid future observations after inverse transformation to physical concentration scales. Evaluating representative spatio-temporal models under this unified protocol shows that strong performance on sanitized datasets does not reliably transfer to global, fragmented monitoring streams. AirQualityBench therefore serves as a realistic testbed for scalable, mask-aware, and physically interpretable air-quality forecasting. All benchmark data, code, evaluation scripts, and baseline implementations are available at \href{https://github.com/Star-Learning/AirQualityBench}{GitHub}.

Yunkai Yang, Yudong Zhang, Kunquan Zhang et al.

With the rapid progress of controllable generation, training data synthesis has become a promising way to expand labeled datasets and alleviate manual annotation in remote sensing (RS). However, the complexity of semantic mask control and the uncertainty of sampling quality often limit the utility of synthetic data in downstream semantic segmentation tasks. To address these challenges, we propose a task-oriented data synthesis framework (TODSynth), including a Multimodal Diffusion Transformer (MM-DiT) with unified triple attention and a plug-and-play sampling strategy guided by task feedback. Built upon the powerful DiT-based generative foundation model, we systematically evaluate different control schemes, showing that a text-image-mask joint attention scheme combined with full fine-tuning of the image and mask branches significantly enhances the effectiveness of RS semantic segmentation data synthesis, particularly in few-shot and complex-scene scenarios. Furthermore, we propose a control-rectify flow matching (CRFM) method, which dynamically adjusts sampling directions guided by semantic loss during the early high-plasticity stage, mitigating the instability of generated images and bridging the gap between synthetic data and downstream segmentation tasks. Extensive experiments demonstrate that our approach consistently outperforms state-of-the-art controllable generation methods, producing more stable and task-oriented synthetic data for RS semantic segmentation.

Xiaotian Weng, Yi Chen, Zhichao Zheng et al.

Lightweight neural networks for single-image super-resolution (SISR) tasks have made substantial breakthroughs in recent years. Compared to low-frequency information, high-frequency detail is much more difficult to reconstruct. Most SISR models allocate equal computational resources for low-frequency and high-frequency information, which leads to redundant processing of simple low-frequency information and inadequate recovery of more challenging high-frequency information. We propose a novel High-Frequency Focused Network (HFFN) through High-Frequency Focused Blocks (HFFBs) that selectively enhance high-frequency information while minimizing redundant feature computation of low-frequency information. The HFFB effectively allocates more computational resources to the more challenging reconstruction of high-frequency information. Moreover, we propose a Local Feature Fusion Block (LFFB) effectively fuses features from multiple HFFBs in a local region, utilizing complementary information across layers to enhance feature representativeness and reduce artifacts in reconstructed images. We assess the efficacy of our proposed HFFN on five benchmark datasets and show that it significantly enhances the super-resolution performance of the network. Our experimental results demonstrate state-of-the-art performance in reconstructing high-frequency information while using a low number of parameters.

Xuan Yu, Xu Wang, Rui Zhu et al.

Generative Flow Networks (GFlowNets) have shown promising potential to generate high-scoring candidates with probability proportional to their rewards. As existing GFlowNets freely explore in state space, they encounter significant convergence challenges when scaling to large state spaces. Addressing this issue, this paper proposes to restrict the exploration of actor. A planner is introduced to partition the entire state space into overlapping partial state spaces. Given their limited size, these partial state spaces allow the actor to efficiently identify subregions with higher rewards. A heuristic strategy is introduced to switch partial regions thus preventing the actor from wasting time exploring fully explored or low-reward partial regions. By iteratively exploring these partial state spaces, the actor learns to converge towards the high-reward subregions within the entire state space. Experiments on several widely used datasets demonstrate that \modelname converges faster than existing works on large state spaces. Furthermore, \modelname not only generates candidates with higher rewards but also significantly improves their diversity.

Xuan Yu, Xu Wang, Rui Zhu et al.

As a probabilistic sampling framework, Generative Flow Networks (GFlowNets) show strong potential for constructing complex combinatorial objects through the sequential composition of elementary components. However, existing GFlowNets often suffer from excessive exploration over vast state spaces, leading to over-sampling of low-reward regions and convergence to suboptimal distributions. Effectively biasing GFlowNets toward high-reward solutions remains a non-trivial challenge. In this paper, we propose CMAB-GFN, which integrates a combinatorial multi-armed bandit (CMAB) framework with GFlowNet policies. The CMAB component prunes low-quality actions, yielding compact high-scoring subspaces for exploration. Restricting GFNs to these compact high-scoring subspaces accelerates the discovery of high-value candidates, while the exploration of different subspaces ensures that diversity is not sacrificed. Experimental results on multiple tasks demonstrate that CMAB-GFN generates higher-reward candidates than existing approaches.

Haodong Yuan, Yudong Zhang, Shengyin Fan et al.

The integration of a SLAM algorithm with place recognition technology empowers it with the ability to mitigate accumulated errors and to relocalize itself. However, existing methods for point cloud-based place recognition predominantly rely on the matching of descriptors, which are mostly lidar-centric. These methods suffer from two major drawbacks: first, they cannot perform place recognition when the distance between two point clouds is significant, and second, they can only calculate the rotation angle without considering the offset in the X and Y directions. To overcome these limitations, we propose a novel local descriptor that is constructed around the Main Object. By using a geometric method, we can accurately calculate the relative pose. We have provided a theoretical analysis to demonstrate that this method can overcome the aforementioned limitations. Furthermore, we conducted extensive experiments on KITTI Odometry and KITTI360, which indicate that our proposed method has significant advantages over state-of-the-art methods.

Zelin Tan, Zhouliang Yu, Bohan Lin et al.

We propose Process-Aware Policy Optimization (PAPO), a method that integrates process-level evaluation into Group Relative Policy Optimization (GRPO) through decoupled advantage normalization, to address two limitations of existing reward designs. Outcome reward models (ORM) evaluate only final-answer correctness, treating all correct responses identically regardless of reasoning quality, and gradually lose the advantage signal as groups become uniformly correct. Process reward models (PRM) offer richer supervision, but directly using PRM scores causes reward hacking, where models exploit verbosity to inflate scores while accuracy collapses. PAPO resolves both by composing the advantage from an outcome component Aout, derived from ORM and normalized over all responses, and a process component Aproc, derived from a rubric-based PRM and normalized exclusively among correct responses. This decoupled design ensures that Aout anchors training on correctness while Aproc differentiates reasoning quality without distorting the outcome signal. Experiments across multiple model scales and six benchmarks demonstrate that PAPO consistently outperforms ORM, reaching 51.3% vs.\ 46.3% on OlympiadBench while continuing to improve as ORM plateaus and declines.

Yudong Zhang, Ruobing Xie, Jiansheng Chen et al. · tsinghua

In typical multimodal tasks, such as Visual Question Answering (VQA), adversarial attacks targeting a specific image and question can lead large vision-language models (LVLMs) to provide incorrect answers. However, it is common for a single image to be associated with multiple questions, and LVLMs may still answer other questions correctly even for an adversarial image attacked by a specific question. To address this, we introduce the query-agnostic visual attack (QAVA), which aims to create robust adversarial examples that generate incorrect responses to unspecified and unknown questions. Compared to traditional adversarial attacks focused on specific images and questions, QAVA significantly enhances the effectiveness and efficiency of attacks on images when the question is unknown, achieving performance comparable to attacks on known target questions. Our research broadens the scope of visual adversarial attacks on LVLMs in practical settings, uncovering previously overlooked vulnerabilities, particularly in the context of visual adversarial threats. The code is available at https://github.com/btzyd/qava.

Qianqian Chen, Anglin Liu, Jingyang Zhang et al.

Accurate brain lesion segmentation in MRI is vital for effective clinical diagnosis and treatment planning. Due to high annotation costs and strict data privacy regulations, universal models require employing Continual Learning (CL) to adapt to evolving clinical tasks without losing previously acquired knowledge. However, existing CL paradigms often suffer from capacity limits or redundant parameter growth, and even advanced dynamic methods rely mostly on image-perception strategies that struggle to handle the substantial pathological and multimodal heterogeneity inherent in brain imaging. To address this issue, we propose Concept-Reasoning Expansion (CoRE) framework, which establishes a joint decision-making mechanism by integrating visual features with structured concepts. Through the alignment of image tokens with a hierarchical concept library, CoRE simulates clinical reasoning to guide both interpretable expert routing and demand-based model growth. This collaborative process ensures model evolution is grounded in clinical priors, preventing redundant parameter expansion while maximizing knowledge reuse. Extensive evaluations across 12 sequential brain lesion MRI tasks demonstrate that CoRE achieves state-of-the-art performance and provides a high knowledge starting point for efficient future adaptation. Its superior few-shot transferability and clinical interpretability further validate its effectiveness in managing non-stationary clinical data streams. Our code will be released soon.

Yudong Zhang, Ruobing Xie, Xingwu Sun et al. · tsinghua

Large vision-language models (LVLMs) have demonstrated exceptional performance on complex multimodal tasks. However, they continue to suffer from significant hallucination issues, including object, attribute, and relational hallucinations. To accurately detect these hallucinations, we investigated the variations in cross-modal attention patterns between hallucination and non-hallucination states. Leveraging these distinctions, we developed a lightweight detector capable of identifying hallucinations. Our proposed method, Detecting Hallucinations by Cross-modal Attention Patterns (DHCP), is straightforward and does not require additional LVLM training or extra LVLM inference steps. Experimental results show that DHCP achieves remarkable performance in hallucination detection. By offering novel insights into the identification and analysis of hallucinations in LVLMs, DHCP contributes to advancing the reliability and trustworthiness of these models. The code is available at https://github.com/btzyd/DHCP.

Wei Ding, Yilin Li, Yudong Zhang et al.

Large vision-language models (LVLMs) have achieved remarkable performance across diverse multimodal tasks, yet they continue to suffer from hallucinations, generating content that is inconsistent with the visual input. Prior work DHCP (Detecting Hallucinations by Cross-modal Attention Pattern) has explored hallucination detection from the perspective of cross-modal attention, but does not address hallucination mitigation. In this paper, we propose MHSA (Mitigating Hallucinations via Steered Attention), a lightweight framework that mitigates hallucinations by learning to correct cross-modal attention patterns in LVLMs. MHSA trains a simple three-layer MLP generator to produce corrected attention, guided by supervisory signals from the DHCP discriminator and the LVLM itself. During inference, MHSA mitigates both discriminative and generative hallucinations across various datasets and LVLMs by simply replacing the original cross-modal attention with the corrected one, without modifying any LVLM parameters. By extending cross-modal attention mechanisms from hallucination detection to hallucination mitigation, MHSA offers a novel perspective on hallucination research in LVLMs and helps enhance their reliability.

Yudong Zhang, Ruobing Xie, Yiqing Huang et al. · tsinghua

Recent advances in large vision-language models (LVLMs) have showcased their remarkable capabilities across a wide range of multimodal vision-language tasks. However, these models remain vulnerable to visual adversarial attacks, which can substantially compromise their performance. In this paper, we introduce F3, a novel adversarial purification framework that employs a counterintuitive ``fighting fire with fire'' strategy: intentionally introducing simple perturbations to adversarial examples to mitigate their harmful effects. Specifically, F3 leverages cross-modal attentions derived from randomly perturbed adversary examples as reference targets. By injecting noise into these adversarial examples, F3 effectively refines their attention, resulting in cleaner and more reliable model outputs. Remarkably, this seemingly paradoxical approach of employing noise to counteract adversarial attacks yields impressive purification results. Furthermore, F3 offers several distinct advantages: it is training-free and straightforward to implement, and exhibits significant computational efficiency improvements compared to existing purification methods. These attributes render F3 particularly suitable for large-scale industrial applications where both robust performance and operational efficiency are critical priorities. The code is available at https://github.com/btzyd/F3.

Libin Lan, Yanxin Li, Xiaojuan Liu et al.

Both CNN-based and Transformer-based methods have achieved remarkable success in medical image segmentation tasks. However, CNN-based methods struggle to effectively capture global contextual information due to the inherent limitations of convolution operations. Meanwhile, Transformer-based methods suffer from insufficient local feature modeling and face challenges related to the high computational complexity caused by the self-attention mechanism. To address these limitations, we propose a novel hybrid CNN-Transformer architecture, named MSLAU-Net, which integrates the strengths of both paradigms. The proposed MSLAU-Net incorporates two key ideas. First, it introduces Multi-Scale Linear Attention, designed to efficiently extract multi-scale features from medical images while modeling long-range dependencies with low computational complexity. Second, it adopts a top-down feature aggregation mechanism, which performs multi-level feature aggregation and restores spatial resolution using a lightweight structure. Extensive experiments conducted on benchmark datasets covering three imaging modalities demonstrate that the proposed MSLAU-Net outperforms other state-of-the-art methods on nearly all evaluation metrics, validating the superiority, effectiveness, and robustness of our approach. Our code is available at https://github.com/Monsoon49/MSLAU-Net.

Rui Zhu, Xuan Yu, Yudong Zhang et al.

Generative Flow Networks (GFlowNets) have emerged as a powerful tool for generating diverse and high-reward structured objects by learning to sample from a distribution proportional to a given reward function. Unlike conventional reinforcement learning (RL) approaches that prioritize optimization of a single trajectory, GFlowNets seek to balance diversity and reward by modeling the entire trajectory distribution. This capability makes them especially suitable for domains such as molecular design and combinatorial optimization. However, existing GFlowNets sampling strategies tend to overexplore and struggle to consistently generate high-reward samples, particularly in large search spaces with sparse high-reward regions. Therefore, improving the probability of generating high-reward samples without sacrificing diversity remains a key challenge under this premise. In this work, we integrate an enhanced Monte Carlo Tree Search (MCTS) into the GFlowNets sampling process, using MCTS-based policy evaluation to guide the generation toward high-reward trajectories and Polynomial Upper Confidence Trees (PUCT) to balance exploration and exploitation adaptively, and we introduce a controllable mechanism to regulate the degree of greediness. Our method enhances exploitation without sacrificing diversity by dynamically balancing exploration and reward-driven guidance. The experimental results show that our method can not only accelerate the speed of discovering high-reward regions but also continuously generate high-reward samples, while preserving the diversity of the generative distribution. All implementations are available at https://github.com/ZRNB/MG2FlowNet.

Libin Lan, Hongxing Li, Zunhui Xia et al.

Incomplete multi-modal medical image segmentation faces critical challenges from modality imbalance, including imbalanced modality missing rates and heterogeneous modality contributions. Due to their reliance on idealized assumptions of complete modality availability, existing methods fail to dynamically balance contributions and neglect the structural relationships between modalities, resulting in suboptimal performance in real-world clinical scenarios. To address these limitations, we propose a novel model, named Dynamic Modality-Aware Fusion Network (DMAF-Net). The DMAF-Net adopts three key ideas. First, it introduces a Dynamic Modality-Aware Fusion (DMAF) module to suppress missing-modality interference by combining transformer attention with adaptive masking and weight modality contributions dynamically through attention maps. Second, it designs a synergistic Relation Distillation and Prototype Distillation framework to enforce global-local feature alignment via covariance consistency and masked graph attention, while ensuring semantic consistency through cross-modal class-specific prototype alignment. Third, it presents a Dynamic Training Monitoring (DTM) strategy to stabilize optimization under imbalanced missing rates by tracking distillation gaps in real-time, and to balance convergence speeds across modalities by adaptively reweighting losses and scaling gradients. Extensive experiments on BraTS2020 and MyoPS2020 demonstrate that DMAF-Net outperforms existing methods for incomplete multi-modal medical image segmentation. Extensive experiments on BraTS2020 and MyoPS2020 demonstrate that DMAF-Net outperforms existing methods for incomplete multi-modal medical image segmentation. Our code is available at https://github.com/violet-42/DMAF-Net.

Cheng Wang, Siqi Chen, Donghua Mi et al.

Recent advances in medical imaging have established deep learning-based segmentation as the predominant approach, though it typically requires large amounts of manually annotated data. However, obtaining annotations for intracranial hemorrhage (ICH) remains particularly challenging due to the tedious and costly labeling process. Semi-supervised learning (SSL) has emerged as a promising solution to address the scarcity of labeled data, especially in volumetric medical image segmentation. Unlike conventional SSL methods that primarily focus on high-confidence pseudo-labels or consistency regularization, we propose SWDL-Net, a novel SSL framework that exploits the complementary advantages of Laplacian pyramid and deep convolutional upsampling. The Laplacian pyramid excels at edge sharpening, while deep convolutions enhance detail precision through flexible feature mapping. Our framework achieves superior segmentation of lesion details and boundaries through a difference learning mechanism that effectively integrates these complementary approaches. Extensive experiments on a 271-case ICH dataset and public benchmarks demonstrate that SWDL-Net outperforms current state-of-the-art methods in scenarios with only 2% labeled data. Additional evaluations on the publicly available Brain Hemorrhage Segmentation Dataset (BHSD) with 5% labeled data further confirm the superiority of our approach. Code and data have been released at https://github.com/SIAT-CT-LAB/SWDL.

Yudong Zhang, Ruobing Xie, Xingwu Sun et al. · tsinghua

The choice of a suitable visual language projector (VLP) is critical to the successful training of large visual language models (LVLMs). Mainstream VLPs can be broadly categorized into compressed and uncompressed projectors, and each offers distinct advantages in performance and computational efficiency. However, their security implications have not been thoroughly examined. Our comprehensive evaluation reveals significant differences in their security profiles: compressed projectors exhibit substantial vulnerabilities, allowing adversaries to successfully compromise LVLMs even with minimal knowledge of structure information. In stark contrast, uncompressed projectors demonstrate robust security properties and do not introduce additional vulnerabilities. These findings provide critical guidance for researchers in selecting optimal VLPs that enhance the security and reliability of visual language models. The code is available at https://github.com/btzyd/TCP.

Wan Li, Wei Li, Moheng Rong et al.

CT image-guided thermal ablation is widely used for lung cancer treatment; however, follow-up data indicate that physicians' subjective assessments of intraoperative images often overestimate the ablation effect, potentially leading to incomplete treatment. To address these challenges, we developed \textit{Respiratory Differencing}, a novel intraoperative CT image assistance system aimed at improving ablation evaluation. The system first segments tumor regions in preoperative CT images and then employs a multi-stage registration process to align these images with corresponding intraoperative or postoperative images, compensating for respiratory deformations and treatment-induced changes. This system provides two key outputs to help physicians evaluate intraoperative ablation. First, differential images are generated by subtracting the registered preoperative images from the intraoperative ones, allowing direct visualization and quantitative comparison of pre- and post-treatment differences. These differential images enable physicians to assess the relative positions of the tumor and ablation zones, even when the tumor is no longer visible in post-ablation images, thus improving the subjective evaluation of ablation effectiveness. Second, the system provides a quantitative metric that measures the discrepancies between the tumor area and the treatment zone, offering a numerical assessment of the overall efficacy of ablation.This pioneering system compensates for complex lung deformations and integrates pre- and intra-operative imaging data, enhancing quality control in cancer ablation treatments. A follow-up study involving 35 clinical cases demonstrated that our system significantly outperforms traditional subjective assessments in identifying under-ablation cases during or immediately after treatment, highlighting its potential to improve clinical decision-making and patient outcomes.

Libin Lan, Pengzhou Cai, Lu Jiang et al.

Accurate medical image segmentation is essential for clinical quantification, disease diagnosis, treatment planning and many other applications. Both convolution-based and transformer-based u-shaped architectures have made significant success in various medical image segmentation tasks. The former can efficiently learn local information of images while requiring much more image-specific inductive biases inherent to convolution operation. The latter can effectively capture long-range dependency at different feature scales using self-attention, whereas it typically encounters the challenges of quadratic compute and memory requirements with sequence length increasing. To address this problem, through integrating the merits of these two paradigms in a well-designed u-shaped architecture, we propose a hybrid yet effective CNN-Transformer network, named BRAU-Net++, for an accurate medical image segmentation task. Specifically, BRAU-Net++ uses bi-level routing attention as the core building block to design our u-shaped encoder-decoder structure, in which both encoder and decoder are hierarchically constructed, so as to learn global semantic information while reducing computational complexity. Furthermore, this network restructures skip connection by incorporating channel-spatial attention which adopts convolution operations, aiming to minimize local spatial information loss and amplify global dimension-interaction of multi-scale features. Extensive experiments on three public benchmark datasets demonstrate that our proposed approach surpasses other state-of-the-art methods including its baseline: BRAU-Net under almost all evaluation metrics. We achieve the average Dice-Similarity Coefficient (DSC) of 82.47, 90.10, and 92.94 on Synapse multi-organ segmentation, ISIC-2018 Challenge, and CVC-ClinicDB, as well as the mIoU of 84.01 and 88.17 on ISIC-2018 Challenge and CVC-ClinicDB, respectively.

Xinlei Yu, Chengming Xu, Zhangquan Chen et al.

The dominant paradigm of monolithic scaling in Vision-Language Models (VLMs) is failing for understanding and reasoning in documents, yielding diminishing returns as it struggles with the inherent need of this domain for document-based procedural reasoning, cognitive complexity, and factual accuracy. To this end, we introduce MACT, a Multi-Agent Collaboration framework with agent-wise adaptive Test-time scaling that pioneers a paradigm shift to procedural scaling, adapting dynamically to the functional entities of visual documents understanding and reasoning. MACT decomposes the visual document processing flow into four specialized agents, i.e., planning, execution, judgment, and answer, to resolve cognitive overload and introduce a critical self-correction loop for factual grounding. This collaborative architecture is amplified by an agent-wise adaptive test-time scaling strategy that intelligently allocates computational resources based on the complexity and redundancy of each functionality. Evaluated on multiple visual document understanding benchmarks, MACT achieves superior performance with a smaller parameter scale, adapting effectively to various document scenarios without compromising its general or mathematical reasoning capabilities. The three variants of MACT consistently attain top-three average performance rankings, with average performance enhancements of 9.9-11.5% over the base models. The source code will be released publicly.

Yudong Zhang, Ruobing Xie, Jiansheng Chen et al. · tsinghua

Contrastive learning is a prevalent technique in self-supervised vision representation learning, typically generating positive pairs by applying two data augmentations to the same image. Designing effective data augmentation strategies is crucial for the success of contrastive learning. Inspired by the story of the blind men and the elephant, we introduce JointCrop and JointBlur. These methods generate more challenging positive pairs by leveraging the joint distribution of the two augmentation parameters, thereby enabling contrastive learning to acquire more effective feature representations. To the best of our knowledge, this is the first effort to explicitly incorporate the joint distribution of two data augmentation parameters into contrastive learning. As a plug-and-play framework without additional computational overhead, JointCrop and JointBlur enhance the performance of SimCLR, BYOL, MoCo v1, MoCo v2, MoCo v3, SimSiam, and Dino baselines with notable improvements.

Siyue Li, Yongcheng Yao, Junru Zhong et al.

Manual segmentation is labor-intensive, and automatic segmentation remains challenging due to the inherent variability in meniscal morphology, partial volume effects, and low contrast between the meniscus and surrounding tissues. To address these challenges, we propose ERANet, an innovative semi-supervised framework for meniscus segmentation that effectively leverages both labeled and unlabeled images through advanced augmentation and learning strategies. ERANet integrates three key components: edge replacement augmentation (ERA), prototype consistency alignment (PCA), and a conditional self-training (CST) strategy within a mean teacher architecture. ERA introduces anatomically relevant perturbations by simulating meniscal variations, ensuring that augmentations align with the structural context. PCA enhances segmentation performance by aligning intra-class features and promoting compact, discriminative feature representations, particularly in scenarios with limited labeled data. CST improves segmentation robustness by iteratively refining pseudo-labels and mitigating the impact of label noise during training. Together, these innovations establish ERANet as a robust and scalable solution for meniscus segmentation, effectively addressing key barriers to practical implementation. We validated ERANet comprehensively on 3D Double Echo Steady State (DESS) and 3D Fast/Turbo Spin Echo (FSE/TSE) MRI sequences. The results demonstrate the superior performance of ERANet compared to state-of-the-art methods. The proposed framework achieves reliable and accurate segmentation of meniscus structures, even when trained on minimal labeled data. Extensive ablation studies further highlight the synergistic contributions of ERA, PCA, and CST, solidifying ERANet as a transformative solution for semi-supervised meniscus segmentation in medical imaging.

Jilan Cheng, Guoli Long, Zeyu Zhang et al.

Retinal diseases are a leading cause of vision impairment and blindness, with timely diagnosis being critical for effective treatment. Optical Coherence Tomography (OCT) has become a standard imaging modality for retinal disease diagnosis, but OCT images often suffer from issues such as speckle noise, complex lesion shapes, and varying lesion sizes, making interpretation challenging. In this paper, we propose a novel framework, WaveNet-SF, to enhance retinal disease detection by integrating the spatial-domain and frequency-domain learning. The framework utilizes wavelet transforms to decompose OCT images into low- and high-frequency components, enabling the model to extract both global structural features and fine-grained details. To improve lesion detection, we introduce a Multi-Scale Wavelet Spatial Attention (MSW-SA) module, which enhances the model's focus on regions of interest at multiple scales. Additionally, a High-Frequency Feature Compensation (HFFC) block is incorporated to recover edge information lost during wavelet decomposition, suppress noise, and preserve fine details crucial for lesion detection. Our approach achieves state-of-the-art (SOTA) classification accuracies of 97.82% and 99.58% on the OCT-C8 and OCT2017 datasets, respectively, surpassing existing methods. These results demonstrate the efficacy of WaveNet-SF in addressing the challenges of OCT image analysis and its potential as a powerful tool for retinal disease diagnosis.

Guoliang Zhao, Yuhan Fu, Shuaipeng Li et al. · tsinghua

Mixture-of-Experts (MoE) models have become the consensus approach for enabling parameter-efficient scaling and cost-effective deployment in large language models. However, existing scaling laws for dense models are inapplicable to MoE models, which stems from three critical challenges: the multiplicity of influencing factors, their intricate coupling relationships and the non-monotonic nature of their performance impacts. They collectively necessitate a fine-grained investigation into MoE-specific scaling laws. In this work, we perform a systematic decomposition of MoE settings, identifying five key factors that influence model performance from both size and structural perspectives (data size ($D$), total model size ($N$), activated model size ($N_a$), number of active experts ($G$) and the ratio of shared experts ($S$)). Specifically, we design $446$ controlled experiments to characterize their marginal effects, ultimately constructing a comprehensive and precise joint MoE scaling law that considers all essential factors. Furthermore, we derive the theoretically optimal and practically efficiency-aware optimal configurations for $G$, $S$ and $N_a/N$ with detailed analyses. Our results demonstrate that the optimal settings for $G$ and $S$ are independent of both the model architecture and data size. With the scaling of $N$, the optimal activation parameter ratio of $N_a/N$ becomes sparser. Our proposed MoE scaling law could function as an accurate and insightful guidance to facilitate future MoE model design and training.

Bo Liu, Yudong Zhang, Shuihua Wang et al.

Retinal vascular morphology is crucial for diagnosing diseases such as diabetes, glaucoma, and hypertension, making accurate segmentation of retinal vessels essential for early intervention. Traditional segmentation methods assume that training and testing data share similar distributions, which can lead to poor performance on unseen domains due to domain shifts caused by variations in imaging devices and patient demographics. This paper presents a novel approach, DGSSA, for retinal vessel image segmentation that enhances model generalization by combining structural and style augmentation strategies. We utilize a space colonization algorithm to generate diverse vascular-like structures that closely mimic actual retinal vessels, which are then used to generate pseudo-retinal images with an improved Pix2Pix model, allowing the segmentation model to learn a broader range of structure distributions. Additionally, we utilize PixMix to implement random photometric augmentations and introduce uncertainty perturbations, thereby enriching stylistic diversity and significantly enhancing the model's adaptability to varying imaging conditions. Our framework has been rigorously evaluated on four challenging datasets-DRIVE, CHASEDB, HRF, and STARE-demonstrating state-of-the-art performance that surpasses existing methods. This validates the effectiveness of our proposed approach, highlighting its potential for clinical application in automated retinal vessel analysis.

Zecheng Li, Zhihui Cao, Wenke Huang et al.

Graphical user interface (GUI) agents are rapidly progressing toward autonomous interaction and reliable task execution across diverse applications. However, two central challenges remain unresolved: automating the evaluation of agent trajectories and generating high-quality training data at scale to enable continual improvement. Existing approaches often depend on manual annotation or static rule-based verification, which restricts scalability and limits adaptability in dynamic environments. We present MagicGUI-RMS, a multi-agent reward model system that delivers adaptive trajectory evaluation, corrective feedback, and self-evolving learning capabilities. MagicGUI-RMS integrates a Domain-Specific Reward Model (DS-RM) with a General-Purpose Reward Model (GP-RM), enabling fine-grained action assessment and robust generalization across heterogeneous GUI tasks. To support reward learning at scale, we design a structured data construction pipeline that automatically produces balanced and diverse reward datasets, effectively reducing annotation costs while maintaining sample fidelity. During execution, the reward model system identifies erroneous actions, proposes refined alternatives, and continuously enhances agent behavior through an automated data-reflux mechanism. Extensive experiments demonstrate that MagicGUI-RMS yields substantial gains in task accuracy, behavioral robustness. These results establish MagicGUI-RMS as a principled and effective foundation for building self-improving GUI agents driven by reward-based adaptation.

Bohan Lin, Kuo Yang, Yingchuan Lai et al.

Multi-agent systems built on large language models (LLMs) promise enhanced problem-solving capabilities through collaborative division of labor. However, they frequently underperform single-agent baselines due to edge-level error cascades: minor inaccuracies at one message handoff propagate across the entire chain. We propose AgentAsk, a lightweight and plug-and-play clarification module that treats every inter-agent message as a potential failure point and inserts minimally necessary questions to arrest error propagation. AgentAsk follows a three-stage pipeline: (i) distilling edge-level judgments from curated failure traces into a compact policy, (ii) supervising the policy to determine when/what/whom/how to ask, and (iii) optimizing online with E-GRPO, a reinforcement learning objective that balances accuracy, latency, and cost. The module is architecture-agnostic and easy to integrate into existing orchestration. Across math, reasoning, and coding benchmarks, AgentAsk consistently improves accuracy and robustness over public multi-agent implementations while keeping overhead minimal, with latency and extra cost all less than 5%, approaching the performance of a strong evaluator. Beyond empirical improvements, we contribute a principled taxonomy of edge-level errors and a practical recipe for link-local intervention, offering a scalable pathway toward more reliable LLM-based multi-agent systems.

Libin Lan, Hongxing Li, Zunhui Xia et al.

Learning medical visual representations directly from paired images and reports through multimodal self-supervised learning has emerged as a novel and efficient approach to digital diagnosis in recent years. However, existing models suffer from several severe limitations. 1) neglecting the selection of negative samples, resulting in the scarcity of hard negatives and the inclusion of false negatives; 2) focusing on global feature extraction, but overlooking the fine-grained local details that are crucial for medical image recognition tasks; and 3) contrastive learning primarily targets high-level features but ignoring low-level details which are essential for accurate medical analysis. Motivated by these critical issues, this paper presents a Cross-Modal Cluster-Guided Negative Sampling (CM-CGNS) method with two-fold ideas. First, it extends the k-means clustering used for local text features in the single-modal domain to the multimodal domain through cross-modal attention. This improvement increases the number of negative samples and boosts the model representation capability. Second, it introduces a Cross-Modal Masked Image Reconstruction (CM-MIR) module that leverages local text-to-image features obtained via cross-modal attention to reconstruct masked local image regions. This module significantly strengthens the model's cross-modal information interaction capabilities and retains low-level image features essential for downstream tasks. By well handling the aforementioned limitations, the proposed CM-CGNS can learn effective and robust medical visual representations suitable for various recognition tasks. Extensive experimental results on classification, detection, and segmentation tasks across five downstream datasets show that our method outperforms state-of-the-art approaches on multiple metrics, verifying its superior performance.

Qiankun Zuo, Hao Tian, Chi-Man Pun et al.

Effective connectivity can describe the causal patterns among brain regions. These patterns have the potential to reveal the pathological mechanism and promote early diagnosis and effective drug development for cognitive disease. However, the current methods utilize software toolkits to extract empirical features from brain imaging to estimate effective connectivity. These methods heavily rely on manual parameter settings and may result in large errors during effective connectivity estimation. In this paper, a novel brain imaging-to-graph generation (BIGG) framework is proposed to map functional magnetic resonance imaging (fMRI) into effective connectivity for mild cognitive impairment (MCI) analysis. To be specific, the proposed BIGG framework is based on the diffusion denoising probabilistic models (DDPM), where each denoising step is modeled as a generative adversarial network (GAN) to progressively translate the noise and conditional fMRI to effective connectivity. The hierarchical transformers in the generator are designed to estimate the noise at multiple scales. Each scale concentrates on both spatial and temporal information between brain regions, enabling good quality in noise removal and better inference of causal relations. Meanwhile, the transformer-based discriminator constrains the generator to further capture global and local patterns for improving high-quality and diversity generation. By introducing the diffusive factor, the denoising inference with a large sampling step size is more efficient and can maintain high-quality results for effective connectivity generation. Evaluations of the ADNI dataset demonstrate the feasibility and efficacy of the proposed model. The proposed model not only achieves superior prediction performance compared with other competing methods but also predicts MCI-related causal connections that are consistent with clinical studies.

Huansheng Ning, Zhenyu Wang, Rongyang Li et al.

Disability is an important factor affecting todays society. At the same time, more and more sub-healthy people are sick due to reduced body functions and cognitive functions. Exercise rehabilitation is a kind of physical therapy, which can recover the motor ability, cognitive ability, and mental state of them through exercise. But the traditional exercise rehabilitation has some drawbacks so that people who need exercise rehabilitation cannot stick to it. Therefore, many researchers improved the drawbacks of traditional exercise rehabilitation by serious games for exercise rehabilitation. Although there were abundant achievements in the games, its relevant technologies and representative games are not be summarized systematically. To fill this gap, we introduced the significance of the convergence of exercise rehabilitation and serious games. Then, our paper sorted out the development of the games based on interaction mode between games and players. Besides, we analyzed the characteristics of different user groups and the specific functions of the games corresponding to them, and gave our classification based on this. Based on the classification, we reviewed related studies of the games in the past decade years and gave some suggestions on game design and development. Finally, we proposed serval research directions worth studying about the games technology development, functional design and social popularization.

Huiting He, Chengze Jiang, Yudong Zhang et al.

The time-varying quadratic miniaturization (TVQM) problem, as a hotspot currently, urgently demands a more reliable and faster--solving model. To this end, a novel adaptive coefficient constructs framework is presented and realized to improve the performance of the solution model, leading to the adaptive zeroing-type neural dynamics (AZTND) model. Then the AZTND model is applied to solve the TVQM problem. The adaptive coefficients can adjust the step size of the model online so that the solution model converges faster. At the same time, the integration term develops to enhance the robustness of the model in a perturbed environment. Experiments demonstrate that the proposed model shows faster convergence and more reliable robustness than existing approaches. Finally, the AZTND model is applied in a target tracking scheme, proving the practicality of our proposed model.

Chenghao Yang, Yudong Zhang, Smaranda Muresan

Social media has become a valuable resource for the study of suicidal ideation and the assessment of suicide risk. Among social media platforms, Reddit has emerged as the most promising one due to its anonymity and its focus on topic-based communities (subreddits) that can be indicative of someone's state of mind or interest regarding mental health disorders such as r/SuicideWatch, r/Anxiety, r/depression. A challenge for previous work on suicide risk assessment has been the small amount of labeled data. We propose an empirical investigation into several classes of weakly-supervised approaches, and show that using pseudo-labeling based on related issues around mental health (e.g., anxiety, depression) helps improve model performance for suicide risk assessment.

Yuanyuan Zheng, Rongyang Li, Sha Li et al.

Attention deficit and hyperactivity disorder (ADHD) have two main characteristics: inattention and impulsivity.It has many obstacles to the normal development of children and is very common among children.As an intervention, Serious games for ADHD(SGADs) have shown great potential and are very effective for these ADHD patients.Although many serious games have been developed for ADHD patients, but a review paper that summarizes and generalizes the topic of video games has not yet appeared.In this article, we first classified serious games about ADHD according to different platforms developed by video games, and then we conducted a systematic review of video games that can help children with ADHD diagnose and treat. Finally, we discussed and made suggestions based on the current development of SGADs.

Huimin Lu, Yujie Li, Yudong Zhang et al.

Underwater cameras are widely used to observe the sea floor. They are usually included in autonomous underwater vehicles, unmanned underwater vehicles, and in situ ocean sensor networks. Despite being an important sensor for monitoring underwater scenes, there exist many issues with recent underwater camera sensors. Because of lights transportation characteristics in water and the biological activity at the sea floor, the acquired underwater images often suffer from scatters and large amounts of noise. Over the last five years, many methods have been proposed to overcome traditional underwater imaging problems. This paper aims to review the state-of-the-art techniques in underwater image processing by highlighting the contributions and challenges presented in over 40 papers. We present an overview of various underwater image processing approaches, such as underwater image descattering, underwater image color restoration, and underwater image quality assessments. Finally, we summarize the future trends and challenges in designing and processing underwater imaging sensors.