Long Xu

Dawei Dai, Yuanhui Zhang, Long Xu et al.

The previous advancements in pathology image understanding primarily involved developing models tailored to specific tasks. Recent studies has demonstrated that the large vision-language model can enhance the performance of various downstream tasks in medical image understanding. In this study, we developed a domain-specific large language-vision assistant (PA-LLaVA) for pathology image understanding. Specifically, (1) we first construct a human pathology image-text dataset by cleaning the public medical image-text data for domain-specific alignment; (2) Using the proposed image-text data, we first train a pathology language-image pretraining (PLIP) model as the specialized visual encoder for pathology image, and then we developed scale-invariant connector to avoid the information loss caused by image scaling; (3) We adopt two-stage learning to train PA-LLaVA, first stage for domain alignment, and second stage for end to end visual question \& answering (VQA) task. In experiments, we evaluate our PA-LLaVA on both supervised and zero-shot VQA datasets, our model achieved the best overall performance among multimodal models of similar scale. The ablation experiments also confirmed the effectiveness of our design. We posit that our PA-LLaVA model and the datasets presented in this work can promote research in field of computational pathology. All codes are available at: https://github.com/ddw2AIGROUP2CQUPT/PA-LLaVA}{https://github.com/ddw2AIGROUP2CQUPT/PA-LLaVA

Mao Zheng, Zheng Li, Tao Chen et al.

Hy-MT2 is a family of fast-thinking multilingual translation models designed for complex real-world scenarios. It includes three model sizes: 1.8B, 7B, and 30B-A3B (MoE), all of which support translation among 33 languages and effectively follow translation instructions in multiple languages. For on-device deployment, with AngelSlim 1.25-bit extreme quantization, the 1.8B model requires only 440 MB of storage and improves inference speed by 1.5x. Multi-dimensional evaluations show that Hy-MT2 delivers outstanding performance across general, real-world business, domain-specific, and instruction-following translation tasks. The 7B and 30B models outperform open-source models such as DeepSeek-V4-Pro and Kimi K2.6 in fast-thinking mode, while the lightweight 1.8B model also surpasses mainstream commercial APIs from providers such as Microsoft and Doubao overall.

Tencent Hunyuan Team, Ao Liu, Botong Zhou et al. · tencent-ai

As Large Language Models (LLMs) rapidly advance, we introduce Hunyuan-TurboS, a novel large hybrid Transformer-Mamba Mixture of Experts (MoE) model. It synergistically combines Mamba's long-sequence processing efficiency with Transformer's superior contextual understanding. Hunyuan-TurboS features an adaptive long-short chain-of-thought (CoT) mechanism, dynamically switching between rapid responses for simple queries and deep "thinking" modes for complex problems, optimizing computational resources. Architecturally, this 56B activated (560B total) parameter model employs 128 layers (Mamba2, Attention, FFN) with an innovative AMF/MF block pattern. Faster Mamba2 ensures linear complexity, Grouped-Query Attention minimizes KV cache, and FFNs use an MoE structure. Pre-trained on 16T high-quality tokens, it supports a 256K context length and is the first industry-deployed large-scale Mamba model. Our comprehensive post-training strategy enhances capabilities via Supervised Fine-Tuning (3M instructions), a novel Adaptive Long-short CoT Fusion method, Multi-round Deliberation Learning for iterative improvement, and a two-stage Large-scale Reinforcement Learning process targeting STEM and general instruction-following. Evaluations show strong performance: overall top 7 rank on LMSYS Chatbot Arena with a score of 1356, outperforming leading models like Gemini-2.0-Flash-001 (1352) and o4-mini-2025-04-16 (1345). TurboS also achieves an average of 77.9% across 23 automated benchmarks. Hunyuan-TurboS balances high performance and efficiency, offering substantial capabilities at lower inference costs than many reasoning models, establishing a new paradigm for efficient large-scale pre-trained models.

Pingping Zhang, Jinlong Li, Kecheng Chen et al.

Existing codecs are designed to eliminate intrinsic redundancies to create a compact representation for compression. However, strong external priors from Multimodal Large Language Models (MLLMs) have not been explicitly explored in video compression. Herein, we introduce a unified paradigm for Cross-Modality Video Coding (CMVC), which is a pioneering approach to explore multimodality representation and video generative models in video coding. Specifically, on the encoder side, we disentangle a video into spatial content and motion components, which are subsequently transformed into distinct modalities to achieve very compact representation by leveraging MLLMs. During decoding, previously encoded components and video generation models are leveraged to create multiple encoding-decoding modes that optimize video reconstruction quality for specific decoding requirements, including Text-Text-to-Video (TT2V) mode to ensure high-quality semantic information and Image-Text-to-Video (IT2V) mode to achieve superb perceptual consistency. In addition, we propose an efficient frame interpolation model for IT2V mode via Low-Rank Adaption (LoRA) tuning to guarantee perceptual quality, which allows the generated motion cues to behave smoothly. Experiments on benchmarks indicate that TT2V achieves effective semantic reconstruction, while IT2V exhibits competitive perceptual consistency. These results highlight potential directions for future research in video coding.

Yufeng Zhong, Long Xu, Jiebo Luo et al.

3D dense captioning, as an emerging vision-language task, aims to identify and locate each object from a set of point clouds and generate a distinctive natural language sentence for describing each located object. However, the existing methods mainly focus on mining inter-object relationship, while ignoring contextual information, especially the non-object details and background environment within the point clouds, thus leading to low-quality descriptions, such as inaccurate relative position information. In this paper, we make the first attempt to utilize the point clouds clustering features as the contextual information to supply the non-object details and background environment of the point clouds and incorporate them into the 3D dense captioning task. We propose two separate modules, namely the Global Context Modeling (GCM) and Local Context Modeling (LCM), in a coarse-to-fine manner to perform the contextual modeling of the point clouds. Specifically, the GCM module captures the inter-object relationship among all objects with global contextual information to obtain more complete scene information of the whole point clouds. The LCM module exploits the influence of the neighboring objects of the target object and local contextual information to enrich the object representations. With such global and local contextual modeling strategies, our proposed model can effectively characterize the object representations and contextual information and thereby generate comprehensive and detailed descriptions of the located objects. Extensive experiments on the ScanRefer and Nr3D datasets demonstrate that our proposed method sets a new record on the 3D dense captioning task, and verify the effectiveness of our raised contextual modeling of point clouds.

Long Xu, Shanghong Li, Yongquan Chen et al.

Interactive segmentation algorithms based on click points have garnered significant attention from researchers in recent years. However, existing studies typically use sparse click maps as model inputs to segment specific target objects, which primarily affect local regions and have limited abilities to focus on the whole target object, leading to increased times of clicks. In addition, most existing algorithms can not balance well between high performance and efficiency. To address this issue, we propose a click attention algorithm that expands the influence range of positive clicks based on the similarity between positively-clicked regions and the whole input. We also propose a discriminative affinity loss to reduce the attention coupling between positive and negative click regions to avoid an accuracy decrease caused by mutual interference between positive and negative clicks. Extensive experiments demonstrate that our approach is superior to existing methods and achieves cutting-edge performance in fewer parameters. An interactive demo and all reproducible codes will be released at https://github.com/hahamyt/ClickAttention.

Long Xu, Peng Gao, Wen-Jia Tang et al.

Although deep learning-based visual tracking methods have made significant progress, they exhibit vulnerabilities when facing carefully designed adversarial attacks, which can lead to a sharp decline in tracking performance. To address this issue, this paper proposes for the first time a novel adversarial defense method based on denoise diffusion probabilistic models, termed DiffDf, aimed at effectively improving the robustness of existing visual tracking methods against adversarial attacks. DiffDf establishes a multi-scale defense mechanism by combining pixel-level reconstruction loss, semantic consistency loss, and structural similarity loss, effectively suppressing adversarial perturbations through a gradual denoising process. Extensive experimental results on several mainstream datasets show that the DiffDf method demonstrates excellent generalization performance for trackers with different architectures, significantly improving various evaluation metrics while achieving real-time inference speeds of over 30 FPS, showcasing outstanding defense performance and efficiency. Codes are available at https://github.com/pgao-lab/DiffDf.

Zhenyu Hou, Senming Tan, Zhihao Zhang et al.

Terrain analysis is critical for the practical ap- plication of ground mobile robots in real-world tasks, espe- cially in outdoor unstructured environments. In this paper, we propose a novel spatial-temporal traversability assessment method, which aims to enable autonomous robots to effectively navigate through complex terrains. Our approach utilizes sparse Gaussian processes (SGP) to extract geometric features (curvature, gradient, elevation, etc.) directly from point cloud scans. These features are then used to construct a high- resolution local traversability map. Then, we design a spatial- temporal Bayesian Gaussian kernel (BGK) inference method to dynamically evaluate traversability scores, integrating historical and real-time data while considering factors such as slope, flatness, gradient, and uncertainty metrics. GPU acceleration is applied in the feature extraction step, and the system achieves real-time performance. Extensive simulation experiments across diverse terrain scenarios demonstrate that our method outper- forms SOTA approaches in both accuracy and computational efficiency. Additionally, we develop an autonomous navigation framework integrated with the traversability map and validate it with a differential driven vehicle in complex outdoor envi- ronments. Our code will be open-source for further research and development by the community, https://github.com/ZJU-FAST-Lab/FSGP_BGK.

Long Xu, Yongquan Chen, Rui Huang et al.

Click-point-based interactive segmentation has received widespread attention due to its efficiency. However, it's hard for existing algorithms to obtain precise and robust responses after multiple clicks. In this case, the segmentation results tend to have little change or are even worse than before. To improve the robustness of the response, we propose a structured click intent model based on graph neural networks, which adaptively obtains graph nodes via the global similarity of user-clicked Transformer tokens. Then the graph nodes will be aggregated to obtain structured interaction features. Finally, the dual cross-attention will be used to inject structured interaction features into vision Transformer features, thereby enhancing the control of clicks over segmentation results. Extensive experiments demonstrated the proposed algorithm can serve as a general structure in improving Transformer-based interactive segmenta?tion performance. The code and data will be released at https://github.com/hahamyt/scc.

Wei-Long Tian, Peng Gao, Xiao Liu et al.

In recent years, visual tracking methods based on convolutional neural networks and Transformers have achieved remarkable performance and have been successfully applied in fields such as autonomous driving. However, the numerous security issues exposed by deep learning models have gradually affected the reliable application of visual tracking methods in real-world scenarios. Therefore, how to reveal the security vulnerabilities of existing visual trackers through effective adversarial attacks has become a critical problem that needs to be addressed. To this end, we propose an adaptive meta-gradient adversarial attack (AMGA) method for visual tracking. This method integrates multi-model ensembles and meta-learning strategies, combining momentum mechanisms and Gaussian smoothing, which can significantly enhance the transferability and attack effectiveness of adversarial examples. AMGA randomly selects models from a large model repository, constructs diverse tracking scenarios, and iteratively performs both white- and black-box adversarial attacks in each scenario, optimizing the gradient directions of each model. This paradigm minimizes the gap between white- and black-box adversarial attacks, thus achieving excellent attack performance in black-box scenarios. Extensive experimental results on large-scale datasets such as OTB2015, LaSOT, and GOT-10k demonstrate that AMGA significantly improves the attack performance, transferability, and deception of adversarial examples. Codes and data are available at https://github.com/pgao-lab/AMGA.

Long Xu, Choilam Wong, Yuhang Zhong et al.

We present a learning-enhanced motion planner for differential drive mobile manipulators to improve efficiency, success rate, and optimality. For task representation encoder, we propose a keypoint sequence extraction module that maps boundary states to 3D space via differentiable forward kinematics. Point clouds and keypoints are encoded separately and fused with attention, enabling effective integration of environment and boundary states information. We also propose a primitive-based truncated diffusion model that samples from a biased distribution. Compared with vanilla diffusion model, this framework improves the efficiency and diversity of the solution. Denoised paths are refined by trajectory optimization to ensure dynamic feasibility and task-specific optimality. In cluttered 3D simulations, our method achieves higher success rate, improved trajectory diversity, and competitive runtime compared to vanilla diffusion and classical baselines. The source code is released at https://github.com/nmoma/nmoma .

Long Xu, Shanghong Li, Yongquan Chen et al.

Interactive segmentation has gained significant attention for its application in human-computer interaction and data annotation. To address the target scale variation issue in interactive segmentation, a novel multi-scale token adaptation algorithm is proposed. By performing top-k operations across multi-scale tokens, the computational complexity is greatly simplified while ensuring performance. To enhance the robustness of multi-scale token selection, we also propose a token learning algorithm based on contrastive loss. This algorithm can effectively improve the performance of multi-scale token adaptation. Extensive benchmarking shows that the algorithm achieves state-of-the-art (SOTA) performance, compared to current methods. An interactive demo and all reproducible codes will be released at https://github.com/hahamyt/mst.

Long Xu, Junping Guo, Jianbo Zhao et al.

Molecular property prediction constitutes a cornerstone of drug discovery and materials science, necessitating models capable of disentangling complex structure-property relationships across diverse molecular modalities. Existing approaches frequently exhibit entangled representations--conflating structural, chemical, and functional factors--thereby limiting interpretability and transferability. Furthermore, conventional methods inadequately exploit complementary information from graphs, sequences, and geometries, often relying on naive concatenation that neglects inter-modal dependencies. In this work, we propose DMMRL, which employs variational autoencoders to disentangle molecular representations into shared (structure-relevant) and private (modality-specific) latent spaces, enhancing both interpretability and predictive performance. The proposed variational disentanglement mechanism effectively isolates the most informative features for property prediction, while orthogonality and alignment regularizations promote statistical independence and cross-modal consistency. Additionally, a gated attention fusion module adaptively integrates shared representations, capturing complex inter-modal relationships. Experimental validation across seven benchmark datasets demonstrates DMMRL's superior performance relative to state-of-the-art approaches. The code and data underlying this article are freely available at https://github.com/xulong0826/DMMRL.

Mingyu Dong, Chong Xia, Mingyuan Jia et al.

Humans exhibit an innate capacity to rapidly perceive and segment objects from video observations, and even mentally assemble them into structured 3D scenes. Replicating such capability, termed compositional 3D reconstruction, is pivotal for the advancement of Spatial Intelligence and Embodied AI. However, existing methods struggle to achieve practical deployment due to the insufficient integration of cross-modal information, leaving them dependent on manual object prompting, reliant on auxiliary visual inputs, and restricted to overly simplistic scenes by training biases. To address these limitations, we propose ReplicateAnyScene, a framework capable of fully automated and zero-shot transformation of casually captured videos into compositional 3D scenes. Specifically, our pipeline incorporates a five-stage cascade to extract and structurally align generic priors from vision foundation models across textual, visual, and spatial dimensions, grounding them into structured 3D representations and ensuring semantic coherence and physical plausibility of the constructed scenes. To facilitate a more comprehensive evaluation of this task, we further introduce the C3DR benchmark to assess reconstruction quality from diverse aspects. Extensive experiments demonstrate the superiority of our method over existing baselines in generating high-quality compositional 3D scenes.

Long Xu, Yongcai Chen, Fengshuo Liu et al.

Structure-Based Drug Design (SBDD) is a powerful strategy in computational drug discovery, utilizing three-dimensional protein structures to guide the design of molecules with improved binding affinity. However, capturing complex protein-ligand interactions across multiple scales remains challenging, as current methods often overlook the hierarchical organization and intrinsic asymmetry of these interactions. To address these limitations, we propose MSCoD, a novel Bayesian updating-based generative framework for structure-based drug design. In our MSCoD, Multi-Scale Information Bottleneck (MSIB) was developed, which enables semantic compression at multiple abstraction levels for efficient hierarchical feature extraction. Furthermore, a multi-head cooperative attention (MHCA) mechanism was developed, which employs asymmetric protein-to-ligand attention to capture diverse interaction types while addressing the dimensionality disparity between proteins and ligands. Empirical studies showed that MSCoD outperforms state-of-the-art methods on the benchmark dataset. Its real-world applicability is confirmed by case studies on difficult targets like KRAS G12D (7XKJ). Additionally, the MSIB and MHCA modules prove transferable, boosting the performance of GraphDTA on standard drug target affinity prediction benchmarks (Davis and Kiba). The code and data underlying this article are freely available at https://github.com/xulong0826/MSCoD.

Hongyu Li, Jia Li, Xin Ren et al.

Dust storms may remarkably degrade the imaging quality of Martian orbiters and delay the progress of mapping the global topography and geomorphology. To address this issue, this paper presents an approach that reuses the image dehazing knowledge obtained on Earth to resolve the dust-removal problem on Mars. In this approach, we collect remote-sensing images captured by Tianwen-1 and manually select hundreds of clean and dusty images. Inspired by the haze formation process on Earth, we formulate a similar visual degradation process on clean images and synthesize dusty images sharing a similar feature distribution with realistic dusty images. These realistic clean and synthetic dusty image pairs are used to train a deep model that inherently encodes dust irrelevant features and decodes them into dust-free images. Qualitative and quantitative results show that dust storms can be effectively eliminated by the proposed approach, leading to obviously improved topographical and geomorphological details of Mars.

Junqi Liu, Yun Zhang, Xiaoxia Huang et al.

Just Recognizable Difference (JRD) boosts coding efficiency for machine vision through visibility threshold modeling, but is currently limited to a single-task scenario. To address this issue, we propose a Multi-Task JRD (MT-JRD) dataset and an Attribute-assisted MT-JRD (AMT-JRD) model for Video Coding for Machines (VCM), enhancing both prediction accuracy and coding efficiency. First, we construct a dataset comprising 27,264 JRD annotations from machines, supporting three representative tasks including object detection, instance segmentation, and keypoint detection. Secondly, we propose the AMT-JRD prediction model, which integrates Generalized Feature Extraction Module (GFEM) and Specialized Feature Extraction Module (SFEM) to facilitate joint learning across multiple tasks. Thirdly, we innovatively incorporate object attribute information into object-wise JRD prediction through the Attribute Feature Fusion Module (AFFM), which introduces prior knowledge about object size and location. This design effectively compensates for the limitations of relying solely on image features and enhances the model's capacity to represent the perceptual mechanisms of machine vision. Finally, we apply the AMT-JRD model to VCM, where the accurately predicted JRDs are applied to reduce the coding bit rate while preserving accuracy across multiple machine vision tasks. Extensive experimental results demonstrate that AMT-JRD achieves precise and robust multi-task prediction with a mean absolute error of 3.781 and error variance of 5.332 across three tasks, outperforming the state-of-the-art single-task prediction model by 6.7% and 6.3%, respectively. Coding experiments further reveal that compared to the baseline VVC and JPEG, the AMT-JRD-based VCM improves an average of 3.861% and 7.886% Bjontegaard Delta-mean Average Precision (BD-mAP), respectively.

Xihua Sheng, Yingwen Zhang, Long Xu et al.

Multiview video is a key data source for volumetric video, enabling immersive 3D scene reconstruction but posing significant challenges in storage and transmission due to its massive data volume. Recently, deep learning-based end-to-end video coding has achieved great success, yet most focus on single-view or stereo videos, leaving general multiview scenarios underexplored. This paper proposes an end-to-end learned multiview video coding (LMVC) framework that ensures random access and backward compatibility while enhancing compression efficiency. Our key innovation lies in effectively leveraging independent-view motion and content information to enhance dependent-view compression. Specifically, to exploit the inter-view motion correlation, we propose a feature-based inter-view motion vector prediction method that conditions dependent-view motion encoding on decoded independent-view motion features, along with an inter-view motion entropy model that learns inter-view motion priors. To exploit the inter-view content correlation, we propose a disparity-free inter-view context prediction module that predicts inter-view contexts from decoded independent-view content features, combined with an inter-view contextual entropy model that captures inter-view context priors. Experimental results show that our proposed LMVC framework outperforms the reference software of the traditional MV-HEVC standard by a large margin, establishing a strong baseline for future research in this field.

Zheng Li, Yanming Guo, WenZhe Liu et al.

Cross-view geo-localization is a critical task for UAV navigation, event detection, and aerial surveying, as it enables matching between drone-captured and satellite imagery. Most existing approaches embed multi-modal data into a joint feature space to maximize the similarity of paired images. However, these methods typically assume perfect alignment of image pairs during training, which rarely holds true in real-world scenarios. In practice, factors such as urban canyon effects, electromagnetic interference, and adverse weather frequently induce GPS drift, resulting in systematic alignment shifts where only partial correspondences exist between pairs. Despite its prevalence, this source of noisy correspondence has received limited attention in current research. In this paper, we formally introduce and address the Noisy Correspondence on Cross-View Geo-Localization (NC-CVGL) problem, aiming to bridge the gap between idealized benchmarks and practical applications. To this end, we propose PAUL (Partition and Augmentation by Uncertainty Learning), a novel framework that partitions and augments training data based on estimated data uncertainty through uncertainty-aware co-augmentation and evidential co-training. Specifically, PAUL selectively augments regions with high correspondence confidence and utilizes uncertainty estimation to refine feature learning, effectively suppressing noise from misaligned pairs. Distinct from traditional filtering or label correction, PAUL leverages both data uncertainty and loss discrepancy for targeted partitioning and augmentation, thus providing robust supervision for noisy samples. Comprehensive experiments validate the effectiveness of individual components in PAUL,which consistently achieves superior performance over other competitive noisy-correspondence-driven methods in various noise ratios.

Dong Zhao, Jia Li, Hongyu Li et al.

Conventional CNNs-based dehazing models suffer from two essential issues: the dehazing framework (limited in interpretability) and the convolution layers (content-independent and ineffective to learn long-range dependency information). In this paper, firstly, we propose a new complementary feature enhanced framework, in which the complementary features are learned by several complementary subtasks and then together serve to boost the performance of the primary task. One of the prominent advantages of the new framework is that the purposively chosen complementary tasks can focus on learning weakly dependent complementary features, avoiding repetitive and ineffective learning of the networks. We design a new dehazing network based on such a framework. Specifically, we select the intrinsic image decomposition as the complementary tasks, where the reflectance and shading prediction subtasks are used to extract the color-wise and texture-wise complementary features. To effectively aggregate these complementary features, we propose a complementary features selection module (CFSM) to select the more useful features for image dehazing. Furthermore, we introduce a new version of vision transformer block, named Hybrid Local-Global Vision Transformer (HyLoG-ViT), and incorporate it within our dehazing networks. The HyLoG-ViT block consists of the local and the global vision transformer paths used to capture local and global dependencies. As a result, the HyLoG-ViT introduces locality in the networks and captures the global and long-range dependencies. Extensive experiments on homogeneous, non-homogeneous, and nighttime dehazing tasks reveal that the proposed dehazing network can achieve comparable or even better performance than CNNs-based dehazing models.

Kaiwen Yu, Jia Li, Yu Zhang et al.

Along with the development of virtual reality (VR), omnidirectional images play an important role in producing multimedia content with immersive experience. However, despite various existing approaches for omnidirectional image stitching, how to quantitatively assess the quality of stitched images is still insufficiently explored. To address this problem, we establish a novel omnidirectional image dataset containing stitched images as well as dual-fisheye images captured from standard quarters of 0$^\circ$, 90$^\circ$, 180$^\circ$ and 270$^\circ$. In this manner, when evaluating the quality of an image stitched from a pair of fisheye images (e.g., 0$^\circ$ and 180$^\circ$), the other pair of fisheye images (e.g., 90$^\circ$ and 270$^\circ$) can be used as the cross-reference to provide ground-truth observations of the stitching regions. Based on this dataset, we further benchmark six widely used stitching models with seven evaluation metrics for IQA. To the best of our knowledge, it is the first dataset that focuses on assessing the stitching quality of omnidirectional images.

Jia Li, Daowei Li, Kui Fu et al.

Visual attention prediction is a classic problem that seems to be well addressed in the deep learning era. One compelling concern, however, gradually arise along with the rapidly growing performance scores over existing visual attention datasets: do existing deep models really capture the inherent mechanism of human visual attention? To address this concern, this paper proposes a new dataset, named VASUN, that records the free-viewing human attention on solar images. Different from previous datasets, images in VASUN contain many irregular visual patterns that existing deep models have never seen. By benchmarking existing models on VASUN, we find the performances of many state-of-the-art deep models drop remarkably, while many classic shallow models perform impressively. From these results, we find that the significant performance advance of existing deep attention models may come from their capabilities of memorizing and predicting the occurrence of some specific visual patterns other than learning the inherent mechanism of human visual attention. In addition, we also train several baseline models on VASUN to demonstrate the feasibility and key issues of predicting visual attention on the sun. These baseline models, together with the proposed dataset, can be used to revisit the problem of visual attention prediction from a novel perspective that are complementary to existing ones.

Zhuo Chen, Weisi Lin, Shiqi Wang et al.

For many computer vision problems, the deep neural networks are trained and validated based on the assumption that the input images are pristine (i.e., artifact-free). However, digital images are subject to a wide range of distortions in real application scenarios, while the practical issues regarding image quality in high level visual information understanding have been largely ignored. In this paper, in view of the fact that most widely deployed deep learning models are susceptible to various image distortions, the distorted images are involved for data augmentation in the deep neural network training process to learn a reliable model for practical applications. In particular, an image quality assessment based label smoothing method, which aims at regularizing the label distribution of training images, is further proposed to tune the objective functions in learning the neural network. Experimental results show that the proposed method is effective in dealing with both low and high quality images in the typical image classification task.