Junhao Jia

Yifei Sun, Yuzhi He, Junhao Jia et al.

Microaneurysms (MAs), the earliest pathognomonic signs of Diabetic Retinopathy (DR), present as sub-60 $μm$ lesions in fundus images with highly variable photometric and morphological characteristics, rendering manual screening not only labor-intensive but inherently error-prone. While diffusion-based anomaly detection has emerged as a promising approach for automated MA screening, its clinical application is hindered by three fundamental limitations. First, these models often fall prey to "identity mapping", where they inadvertently replicate the input image. Second, they struggle to distinguish MAs from other anomalies, leading to high false positives. Third, their suboptimal reconstruction of normal features hampers overall performance. To address these challenges, we propose a Wavelet Diffusion Transformer framework for MA Detection (WDT-MD), which features three key innovations: a noise-encoded image conditioning mechanism to avoid "identity mapping" by perturbing image conditions during training; pseudo-normal pattern synthesis via inpainting to introduce pixel-level supervision, enabling discrimination between MAs and other anomalies; and a wavelet diffusion Transformer architecture that combines the global modeling capability of diffusion Transformers with multi-scale wavelet analysis to enhance reconstruction of normal retinal features. Comprehensive experiments on the IDRiD and e-ophtha MA datasets demonstrate that WDT-MD outperforms state-of-the-art methods in both pixel-level and image-level MA detection. This advancement holds significant promise for improving early DR screening.

Junhao Jia, Yifei Sun, Yunyou Liu et al.

Functional magnetic resonance imaging (fMRI) is a powerful tool for probing brain function, yet reliable clinical diagnosis is hampered by low signal-to-noise ratios, inter-subject variability, and the limited frequency awareness of prevailing CNN- and Transformer-based models. Moreover, most fMRI datasets lack textual annotations that could contextualize regional activation and connectivity patterns. We introduce RTGMFF, a framework that unifies automatic ROI-level text generation with multimodal feature fusion for brain-disorder diagnosis. RTGMFF consists of three components: (i) ROI-driven fMRI text generation deterministically condenses each subject's activation, connectivity, age, and sex into reproducible text tokens; (ii) Hybrid frequency-spatial encoder fuses a hierarchical wavelet-mamba branch with a cross-scale Transformer encoder to capture frequency-domain structure alongside long-range spatial dependencies; and (iii) Adaptive semantic alignment module embeds the ROI token sequence and visual features in a shared space, using a regularized cosine-similarity loss to narrow the modality gap. Extensive experiments on the ADHD-200 and ABIDE benchmarks show that RTGMFF surpasses current methods in diagnostic accuracy, achieving notable gains in sensitivity, specificity, and area under the ROC curve. Code is available at https://github.com/BeistMedAI/RTGMFF.

Junhao Jia, Yueyi Wu, Huangwei Chen et al.

Despite the success of deep learning in dermoscopy image analysis, its inherent black-box nature hinders clinical trust, motivating the use of prototypical networks for case-based visual transparency. However, inevitable selection bias in clinical data often drives these models toward shortcut learning, where environmental confounders are erroneously encoded as predictive prototypes, generating spurious visual evidence that misleads medical decision-making. To mitigate these confounding effects, we propose CausalProto, an Unsupervised Causal Prototypical Network that fundamentally purifies the visual evidence chain. Framed within a Structural Causal Model, we employ an Information Bottleneck-constrained encoder to enforce strict unsupervised orthogonal disentanglement between pathological features and environmental confounders. By mapping these decoupled representations into independent prototypical spaces, we leverage the learned spurious dictionary to perform backdoor adjustment via do-calculus, transforming complex causal interventions into efficient expectation pooling to marginalize environmental noise. Extensive experiments on multiple dermoscopy datasets demonstrate that CausalProto achieves superior diagnostic performance and consistently outperforms standard black box models, while simultaneously providing transparent and high purity visual interpretability without suffering from the traditional accuracy compromise.

Junhao Jia, Yunyou Liu, Yifei Sun et al.

Nonlinear manifolds are widespread in deep visual features, where Euclidean distances often fail to capture true similarity. This limitation becomes particularly severe in prototype-based interpretable fine-grained recognition, where subtle semantic distinctions are essential. To address this challenge, we propose a novel paradigm for prototype-based recognition that anchors similarity within the intrinsic geometry of deep features. Specifically, we distill the latent manifold structure of each class into a diffusion space and introduce a differentiable Nyström interpolation, making the geometry accessible to both unseen samples and learnable prototypes. To ensure efficiency, we employ compact per-class landmark sets with periodic updates. This design keeps the embedding aligned with the evolving backbone, enabling fast and scalable inference. Extensive experiments on the CUB-200-2011 and Stanford Cars datasets show that our GeoProto framework produces prototypes focusing on semantically aligned parts, significantly outperforming Euclidean prototype networks.