Soumyanil Banerjee

Soumyanil Banerjee, Nicholas Summerfield, Ming Dong et al.

U-shaped networks and its variants have demonstrated exceptional results for medical image segmentation. In this paper, we propose a novel dual self-distillation (DSD) framework in U-shaped networks for volumetric medical image segmentation. DSD distills knowledge from the ground-truth segmentation labels to the decoder layers. Additionally, DSD also distills knowledge from the deepest decoder and encoder layer to the shallower decoder and encoder layers respectively of a single U-shaped network. DSD is a general training strategy that could be attached to the backbone architecture of any U-shaped network to further improve its segmentation performance. We attached DSD on several state-of-the-art U-shaped backbones, and extensive experiments on various public 3D medical image segmentation datasets (cardiac substructure, brain tumor and Hippocampus) demonstrated significant improvement over the same backbones without DSD. On average, after attaching DSD to the U-shaped backbones, we observed an increase of 2.82\%, 4.53\% and 1.3\% in Dice similarity score, a decrease of 7.15 mm, 6.48 mm and 0.76 mm in the Hausdorff distance, for cardiac substructure, brain tumor and Hippocampus segmentation, respectively. These improvements were achieved with negligible increase in the number of trainable parameters and training time. Our proposed DSD framework also led to significant qualitative improvements for cardiac substructure, brain tumor and Hippocampus segmentation over the U-shaped backbones. The source code is publicly available at https://github.com/soumbane/DualSelfDistillation.

Soumyanil Banerjee, Ming Dong, Weisong Shi

COVID-19 has become a matter of serious concern over the last few years. It has adversely affected numerous people around the globe and has led to the loss of billions of dollars of business capital. In this paper, we propose a novel Spatial-Temporal Synchronous Graph Transformer network (STSGT) to capture the complex spatial and temporal dependency of the COVID-19 time series data and forecast the future status of an evolving pandemic. The layers of STSGT combine the graph convolution network (GCN) with the self-attention mechanism of transformers on a synchronous spatial-temporal graph to capture the dynamically changing pattern of the COVID time series. The spatial-temporal synchronous graph simultaneously captures the spatial and temporal dependencies between the vertices of the graph at a given and subsequent time-steps, which helps capture the heterogeneity in the time series and improve the forecasting accuracy. Our extensive experiments on two publicly available real-world COVID-19 time series datasets demonstrate that STSGT significantly outperforms state-of-the-art algorithms that were designed for spatial-temporal forecasting tasks. Specifically, on average over a 12-day horizon, we observe a potential improvement of 12.19% and 3.42% in Mean Absolute Error(MAE) over the next best algorithm while forecasting the daily infected and death cases respectively for the 50 states of US and Washington, D.C. Additionally, STSGT also outperformed others when forecasting the daily infected cases at the state level, e.g., for all the counties in the State of Michigan. The code and models are publicly available at https://github.com/soumbane/STSGT.

Behzad Hejrati, Soumyanil Banerjee, Carri Glide-Hurst et al.

Diffusion models have been used extensively for high quality image and video generation tasks. In this paper, we propose a novel conditional diffusion model with spatial attention and latent embedding (cDAL) for medical image segmentation. In cDAL, a convolutional neural network (CNN) based discriminator is used at every time-step of the diffusion process to distinguish between the generated labels and the real ones. A spatial attention map is computed based on the features learned by the discriminator to help cDAL generate more accurate segmentation of discriminative regions in an input image. Additionally, we incorporated a random latent embedding into each layer of our model to significantly reduce the number of training and sampling time-steps, thereby making it much faster than other diffusion models for image segmentation. We applied cDAL on 3 publicly available medical image segmentation datasets (MoNuSeg, Chest X-ray and Hippocampus) and observed significant qualitative and quantitative improvements with higher Dice scores and mIoU over the state-of-the-art algorithms. The source code is publicly available at https://github.com/Hejrati/cDAL/.

Yiwei Lyu, Chenhui Zhao, Soumyanil Banerjee et al.

Training vision models with language supervision enables general and transferable representations. However, many visual domains, especially non-object-centric domains such as medical imaging and remote sensing, contain itemized text annotations: multiple text items describing distinct and semantically independent findings within a single image. Such supervision differs from standard multi-caption supervision, where captions are redundant or highly overlapping. Here, we introduce ItemizedCLIP, a framework for learning complete and explainable visual representations from itemized text supervision. ItemizedCLIP employs a cross-attention module to produce text item-conditioned visual embeddings and a set of tailored objectives that jointly enforce item independence (distinct regions for distinct items) and representation completeness (coverage of all items). Across four domains with naturally itemized text supervision (brain MRI, head CT, chest CT, remote sensing) and one additional synthetically itemized dataset, ItemizedCLIP achieves substantial improvements in zero-shot performance and fine-grained interpretability over baselines. The resulting ItemizedCLIP representations are semantically grounded, item-differentiable, complete, and visually interpretable. Our code is available at https://github.com/MLNeurosurg/ItemizedCLIP.

Akhil Kondepudi, Akshay Rao, Chenhui Zhao et al.

Frontier artificial intelligence (AI) models, such as OpenAI's GPT-5 and Meta's DINOv3, have advanced rapidly through training on internet-scale public data, yet such systems lack access to private clinical data. Neuroimaging, in particular, is underrepresented in the public domain due to identifiable facial features within MRI and CT scans, fundamentally restricting model performance in clinical medicine. Here, we show that frontier models underperform on neuroimaging tasks and that learning directly from uncurated data generated during routine clinical care at health systems, a paradigm we call health system learning, yields high-performance, generalist neuroimaging models. We introduce NeuroVFM, a visual foundation model trained on 5.24 million clinical MRI and CT volumes using a scalable volumetric joint-embedding predictive architecture. NeuroVFM learns comprehensive representations of brain anatomy and pathology, achieving state-of-the-art performance across multiple clinical tasks, including radiologic diagnosis and report generation. The model exhibits emergent neuroanatomic understanding and interpretable visual grounding of diagnostic findings. When paired with open-source language models through lightweight visual instruction tuning, NeuroVFM generates radiology reports that surpass frontier models in accuracy, clinical triage, and expert preference. Through clinically grounded visual understanding, NeuroVFM reduces hallucinated findings and critical errors, offering safer clinical decision support. These results establish health system learning as a paradigm for building generalist medical AI and provide a scalable framework for clinical foundation models.

Yiwei Lyu, Samir Harake, Asadur Chowdury et al.

Neuroimaging is a ubiquitous tool for evaluating patients with neurological diseases. The global demand for magnetic resonance imaging (MRI) studies has risen steadily, placing significant strain on health systems, prolonging turnaround times, and intensifying physician burnout \cite{Chen2017-bt, Rula2024-qp-1}. These challenges disproportionately impact patients in low-resource and rural settings. Here, we utilized a large academic health system as a data engine to develop Prima, the first vision language model (VLM) serving as an AI foundation for neuroimaging that supports real-world, clinical MRI studies as input. Trained on over 220,000 MRI studies, Prima uses a hierarchical vision architecture that provides general and transferable MRI features. Prima was tested in a 1-year health system-wide study that included 30K MRI studies. Across 52 radiologic diagnoses from the major neurologic disorders, including neoplastic, inflammatory, infectious, and developmental lesions, Prima achieved a mean diagnostic area under the ROC curve of 92.0, outperforming other state-of-the-art general and medical AI models. Prima offers explainable differential diagnoses, worklist priority for radiologists, and clinical referral recommendations across diverse patient demographics and MRI systems. Prima demonstrates algorithmic fairness across sensitive groups and can help mitigate health system biases, such as prolonged turnaround times for low-resource populations. These findings highlight the transformative potential of health system-scale VLMs and Prima's role in advancing AI-driven healthcare.