Si Wu

Liang Peng, Haopeng Liu, Yixuan Ye et al.

Unsupervised cell type identification is crucial for uncovering and characterizing heterogeneous populations in single cell omics studies. Although a range of clustering methods have been developed, most focus exclusively on intrinsic cellular structure and ignore the pivotal role of cell-gene associations, which limits their ability to distinguish closely related cell types. To this end, we propose a Refinement Contrastive Learning framework (scRCL) that explicitly incorporates cell-gene interactions to derive more informative representations. Specifically, we introduce two contrastive distribution alignment components that reveal reliable intrinsic cellular structures by effectively exploiting cell-cell structural relationships. Additionally, we develop a refinement module that integrates gene-correlation structure learning to enhance cell embeddings by capturing underlying cell-gene associations. This module strengthens connections between cells and their associated genes, refining the representation learning to exploiting biologically meaningful relationships. Extensive experiments on several single-cell RNA-seq and spatial transcriptomics benchmark datasets demonstrate that our method consistently outperforms state-of-the-art baselines in cell-type identification accuracy. Moreover, downstream biological analyses confirm that the recovered cell populations exhibit coherent gene-expression signatures, further validating the biological relevance of our approach. The code is available at https://github.com/THPengL/scRCL.

Si Wu, David A. Smith

Although psycholinguists and psychologists have long studied the tendency of linguistic strings to evoke mental images in hearers or readers, most computational studies have applied this concept of imageability only to isolated words. Using recent developments in text-to-image generation models, such as DALLE mini, we propose computational methods that use generated images to measure the imageability of both single English words and connected text. We sample text prompts for image generation from three corpora: human-generated image captions, news article sentences, and poem lines. We subject these prompts to different deformances to examine the model's ability to detect changes in imageability caused by compositional change. We find high correlation between the proposed computational measures of imageability and human judgments of individual words. We also find the proposed measures more consistently respond to changes in compositionality than baseline approaches. We discuss possible effects of model training and implications for the study of compositionality in text-to-image models.

Chaoming Wang, Tianqiu Zhang, Sichao He et al.

Brain simulation builds dynamical models to mimic the structure and functions of the brain, while brain-inspired computing (BIC) develops intelligent systems by learning from the structure and functions of the brain. The two fields are intertwined and should share a common programming framework to facilitate each other's development. However, none of the existing software in the fields can achieve this goal, because traditional brain simulators lack differentiability for training, while existing deep learning (DL) frameworks fail to capture the biophysical realism and complexity of brain dynamics. In this paper, we introduce BrainPy, a differentiable brain simulator developed using JAX and XLA, with the aim of bridging the gap between brain simulation and BIC. BrainPy expands upon the functionalities of JAX, a powerful AI framework, by introducing complete capabilities for flexible, efficient, and scalable brain simulation. It offers a range of sparse and event-driven operators for efficient and scalable brain simulation, an abstraction for managing the intricacies of synaptic computations, a modular and flexible interface for constructing multi-scale brain models, and an object-oriented just-in-time compilation approach to handle the memory-intensive nature of brain dynamics. We showcase the efficiency and scalability of BrainPy on benchmark tasks, highlight its differentiable simulation for biologically plausible spiking models, and discuss its potential to support research at the intersection of brain simulation and BIC.

Tianqiu Zhang, Muyang Lyu, Xiao Liu et al.

Humans abstract experiences into structured representations to facilitate pattern inference and knowledge transfer. While the hippocampal-entorhinal (HPC-MEC) circuit is known to represent both spatial and conceptual spaces, the mechanisms for concurrently extracting abstract structures from continuous, high-dimensional dynamics remain poorly understood. We propose a brain-inspired hierarchical model that simultaneously infers latent transitions and constructs a predictive visual world model. Our architecture employs an inverse model for structural extraction alongside an HPC-MEC coupling model that dissociates relational structures (MEC) from integrated episodic scenes (HPC). Using primitive transformation dynamics as a benchmark, we demonstrate the model's capacity for structural abstraction. By leveraging velocity-driven path integration, the framework enables robust prediction and structural reuse across diverse contexts, thereby achieving structural generalization. This work provides a novel computational framework for understanding how brain-inspired, self-supervised learning of world models facilitates the acquisition of reusable abstract knowledge.

Tianqiu Zhang, Muyang Lyu, Yufan Zhang et al.

Latent Action Models (LAMs) enable the learning of world models from unlabeled video by inferring abstract actions between consecutive frames. However, LAMs face a fundamental trade-off between action abstraction and generation fidelity. Existing methods typically circumvent this issue by using two-stage training with pre-trained world models or by limiting predictions to optical flow. In this paper, we introduce DiLA, a novel Disentangled Latent Action world model that aims to resolve this trade-off via content-structure disentanglement. Our key insight is that disentanglement and latent action learning are co-evolving: the predictive bottleneck inherent in latent action learning serves as a driving force for disentanglement, compelling the model to distill spatial layouts into the structure pathway while offloading visual details to a separate content pathway for generation. This synergy yields a continuous, semantically structured latent action space without compromising generative quality. DiLA achieves superior results in video generation quality, action transfer, visual planning, and manifold interpretability. These findings establish DiLA as a unified framework that simultaneously achieves high-level action abstraction and high-fidelity generation, advancing the frontier of self-supervised world model learning.

Rui Li, Qianfen Jiao, Wenming Cao et al.

In this paper, we investigate a challenging unsupervised domain adaptation setting -- unsupervised model adaptation. We aim to explore how to rely only on unlabeled target data to improve performance of an existing source prediction model on the target domain, since labeled source data may not be available in some real-world scenarios due to data privacy issues. For this purpose, we propose a new framework, which is referred to as collaborative class conditional generative adversarial net to bypass the dependence on the source data. Specifically, the prediction model is to be improved through generated target-style data, which provides more accurate guidance for the generator. As a result, the generator and the prediction model can collaborate with each other without source data. Furthermore, due to the lack of supervision from source data, we propose a weight constraint that encourages similarity to the source model. A clustering-based regularization is also introduced to produce more discriminative features in the target domain. Compared to conventional domain adaptation methods, our model achieves superior performance on multiple adaptation tasks with only unlabeled target data, which verifies its effectiveness in this challenging setting.

Xingsi Dong, Si Wu

Bayesian brain theory suggests that the brain employs generative models to understand the external world. The sampling-based perspective posits that the brain infers the posterior distribution through samples of stochastic neuronal responses. Additionally, the brain continually updates its generative model to approach the true distribution of the external world. In this study, we introduce the Hierarchical Exponential-family Energy-based (HEE) model, which captures the dynamics of inference and learning. In the HEE model, we decompose the partition function into individual layers and leverage a group of neurons with shorter time constants to sample the gradient of the decomposed normalization term. This allows our model to estimate the partition function and perform inference simultaneously, circumventing the negative phase encountered in conventional energy-based models (EBMs). As a result, the learning process is localized both in time and space, and the model is easy to converge. To match the brain's rapid computation, we demonstrate that neural adaptation can serve as a momentum term, significantly accelerating the inference process. On natural image datasets, our model exhibits representations akin to those observed in the biological visual system. Furthermore, for the machine learning community, our model can generate observations through joint or marginal generation. We show that marginal generation outperforms joint generation and achieves performance on par with other EBMs.

Liang Peng, Yixuan Ye, Cheng Liu et al.

Multi-view clustering has been empirically shown to improve learning performance by leveraging the inherent complementary information across multiple views of data. However, in real-world scenarios, collecting strictly aligned views is challenging, and learning from both aligned and unaligned data becomes a more practical solution. Partially View-aligned Clustering aims to learn correspondences between misaligned view samples to better exploit the potential consistency and complementarity across views, including both aligned and unaligned data. However, most existing PVC methods fail to leverage unaligned data to capture the shared semantics among samples from the same cluster. Moreover, the inherent heterogeneity of multi-view data induces distributional shifts in representations, leading to inaccuracies in establishing meaningful correspondences between cross-view latent features and, consequently, impairing learning effectiveness. To address these challenges, we propose a Semantic MAtching contRasTive learning model (SMART) for PVC. The main idea of our approach is to alleviate the influence of cross-view distributional shifts, thereby facilitating semantic matching contrastive learning to fully exploit semantic relationships in both aligned and unaligned data. Extensive experiments on eight benchmark datasets demonstrate that our method consistently outperforms existing approaches on the PVC problem.

Jin Chen, Yifeng Lin, Chao Zeng et al.

The standardization of vibrotactile data by IEEE P1918.1 workgroup has greatly advanced its applications in virtual reality, human-computer interaction and embodied artificial intelligence. Despite these efforts, the semantic interpretation and understanding of vibrotactile signals remain an unresolved challenge. In this paper, we make the first attempt to address vibrotactile captioning, {\it i.e.}, generating natural language descriptions from vibrotactile signals. We propose Vibrotactile Periodic-Aperiodic Captioning (ViPAC), a method designed to handle the intrinsic properties of vibrotactile data, including hybrid periodic-aperiodic structures and the lack of spatial semantics. Specifically, ViPAC employs a dual-branch strategy to disentangle periodic and aperiodic components, combined with a dynamic fusion mechanism that adaptively integrates signal features. It also introduces an orthogonality constraint and weighting regularization to ensure feature complementarity and fusion consistency. Additionally, we construct LMT108-CAP, the first vibrotactile-text paired dataset, using GPT-4o to generate five constrained captions per surface image from the popular LMT-108 dataset. Experiments show that ViPAC significantly outperforms the baseline methods adapted from audio and image captioning, achieving superior lexical fidelity and semantic alignment.

Yifeng Lin, Aiping Huang, Wenxi Liu et al.

Few-Shot Class-Incremental Learning (FSCIL) can be particularly susceptible to acquisition contexts with only a few labeled samples. A typical scenario is tactile sensing, where the acquisition context ({\it e.g.}, diverse devices, contact state, and interaction settings) degrades performance due to a lack of standardization. In this paper, we propose Context-as-Transform FSCIL (CaT-FSCIL) to tackle the above problem. We decompose the acquisition context into a structured low-dimensional component and a high-dimensional residual component. The former can be easily affected by tactile interaction features, which are modeled as an approximately invertible Context-as-Transform family and handled via inverse-transform canonicalization optimized with a pseudo-context consistency loss. The latter mainly arises from platform and device differences, which can be mitigated with an Uncertainty-Conditioned Prototype Calibration (UCPC) that calibrates biased prototypes and decision boundaries based on context uncertainty. Comprehensive experiments on the standard benchmarks HapTex and LMT108 have demonstrated the superiority of the proposed CaT-FSCIL.

Si Wu, John Wieting, David A. Smith

While a source sentence can be translated in many ways, most machine translation (MT) models are trained with only a single reference. Previous work has shown that using synthetic paraphrases can improve MT. This paper investigates best practices for employing multiple references by analyzing the semantic similarity among different English translations of world literature in the Par3 dataset. We classify the semantic similarity between paraphrases into three levels: low, medium, and high, and fine-tune three different models (mT5-large, LLaMA-2-7B, and Opus-MT) for literary MT tasks. Across different models, holding the total training instances constant, single-reference but more source texts only marginally outperforms multiple-reference with half of the source texts. Moreover, when fine-tuning an LLM, using paraphrases with medium and high semantic similarity outperforms an unfiltered dataset, with improvements in BLEU (0.3-0.5), COMET (0.1-0.9), and chrF++ (0.17-0.32). Our code is publicly available on GitHub.

Si Wu, Sebastian Bruch

Imageability (potential of text to evoke a mental image) and concreteness (perceptibility of text) are two psycholinguistic properties that link visual and semantic spaces. It is little surprise that computational methods that estimate them do so using parallel visual and semantic spaces, such as collections of image-caption pairs or multi-modal models. In this paper, we work on the supposition that text itself in an image-caption dataset offers sufficient signals to accurately estimate these properties. We hypothesize, in particular, that the peakedness of the neighborhood of a word in the semantic embedding space reflects its degree of imageability and concreteness. We then propose an unsupervised, distribution-free measure, which we call Neighborhood Stability Measure (NSM), that quantifies the sharpness of peaks. Extensive experiments show that NSM correlates more strongly with ground-truth ratings than existing unsupervised methods, and is a strong predictor of these properties for classification. Our code and data are available on GitHub (https://github.com/Artificial-Memory-Lab/imageability).

Zirui Zhao, Junchao Xia, Si Wu et al.

In recent years, researchers have increasingly sought batteries as an efficient and cost-effective solution for energy storage and supply, owing to their high energy density, low cost, and environmental resilience. However, the issue of dendrite growth has emerged as a significant obstacle in battery development. Excessive dendrite growth during charging and discharging processes can lead to battery short-circuiting, degradation of electrochemical performance, reduced cycle life, and abnormal exothermic events. Consequently, understanding the dendrite growth process has become a key challenge for researchers. In this study, we investigated dendrite growth mechanisms in batteries using a combined machine learning approach, specifically a two-dimensional artificial convolutional neural network (CNN) model, along with computational methods. We developed two distinct computer models to predict dendrite growth in batteries. The CNN-1 model employs standard convolutional neural network techniques for dendritic growth prediction, while CNN-2 integrates additional physical parameters to enhance model robustness. Our results demonstrate that CNN-2 significantly enhances prediction accuracy, offering deeper insights into the impact of physical factors on dendritic growth. This improved model effectively captures the dynamic nature of dendrite formation, exhibiting high accuracy and sensitivity. These findings contribute to the advancement of safer and more reliable energy storage systems.

Yao Lu, Si Wu

The brain is targeted for processing temporal sequence information. It remains largely unclear how the brain learns to store and retrieve sequence memories. Here, we study how recurrent networks of binary neurons learn sequence attractors to store predefined pattern sequences and retrieve them robustly. We show that to store arbitrary pattern sequences, it is necessary for the network to include hidden neurons even though their role in displaying sequence memories is indirect. We develop a local learning algorithm to learn sequence attractors in the networks with hidden neurons. The algorithm is proven to converge and lead to sequence attractors. We demonstrate that the network model can store and retrieve sequences robustly on synthetic and real-world datasets. We hope that this study provides new insights in understanding sequence memory and temporal information processing in the brain.

Xingsi Dong, Xiangyuan Peng, Si Wu

Predictive models are highly advanced in understanding the mechanisms of brain function. Recent advances in machine learning further underscore the power of prediction for optimal representation in learning. However, there remains a gap in creating a biologically plausible model that explains how the neural system achieves prediction. In this paper, we introduce a framework that employs an energy-based model (EBM) to capture the nuanced processes of predicting observation after action within the neural system, encompassing prediction, learning, and inference. We implement the EBM with a hierarchical structure and integrate a continuous attractor neural network for memory, constructing a biologically plausible model. In experimental evaluations, our model demonstrates efficacy across diverse scenarios. The range of actions includes eye movement, motion in environments, head turning, and static observation while the environment changes. Our model not only makes accurate predictions for environments it was trained on, but also provides reasonable predictions for unseen environments, matching the performances of machine learning methods in multiple tasks. We hope that this study contributes to a deep understanding of how the neural system performs prediction.

Xiangyuan Peng, Xingsi Dong, Si Wu

We propose Grid-like Code Quantization (GCQ), a brain-inspired method for compressing observation-action sequences into discrete representations using grid-like patterns in attractor dynamics. Unlike conventional vector quantization approaches that operate on static inputs, GCQ performs spatiotemporal compression through an action-conditioned codebook, where codewords are derived from continuous attractor neural networks and dynamically selected based on actions. This enables GCQ to jointly compress space and time, serving as a unified world model. The resulting representation supports long-horizon prediction, goal-directed planning, and inverse modeling. Experiments across diverse tasks demonstrate GCQ's effectiveness in compact encoding and downstream performance. Our work offers both a computational tool for efficient sequence modeling and a theoretical perspective on the formation of grid-like codes in neural systems.

Lianxin Xie, Bingbing Zheng, Wen Xue et al.

Blind face video restoration aims to restore high-fidelity details from videos subjected to complex and unknown degradations. This task poses a significant challenge of managing temporal heterogeneity while at the same time maintaining stable face attributes. In this paper, we introduce a Discrete Prior-based Temporal-Coherent content prediction transformer to address the challenge, and our model is referred to as DP-TempCoh. Specifically, we incorporate a spatial-temporal-aware content prediction module to synthesize high-quality content from discrete visual priors, conditioned on degraded video tokens. To further enhance the temporal coherence of the predicted content, a motion statistics modulation module is designed to adjust the content, based on discrete motion priors in terms of cross-frame mean and variance. As a result, the statistics of the predicted content can match with that of real videos over time. By performing extensive experiments, we verify the effectiveness of the design elements and demonstrate the superior performance of our DP-TempCoh in both synthetically and naturally degraded video restoration.

Chaoming Wang, Muyang Lyu, Tianqiu Zhang et al.

We present a multi-scale differentiable brain modeling workflow utilizing BrainPy, a unique differentiable brain simulator that combines accurate brain simulation with powerful gradient-based optimization. We leverage this capability of BrainPy across different brain scales. At the single-neuron level, we implement differentiable neuron models and employ gradient methods to optimize their fit to electrophysiological data. On the network level, we incorporate connectomic data to construct biologically constrained network models. Finally, to replicate animal behavior, we train these models on cognitive tasks using gradient-based learning rules. Experiments demonstrate that our approach achieves superior performance and speed in fitting generalized leaky integrate-and-fire and Hodgkin-Huxley single neuron models. Additionally, training a biologically-informed network of excitatory and inhibitory spiking neurons on working memory tasks successfully replicates observed neural activity and synaptic weight distributions. Overall, our differentiable multi-scale simulation approach offers a promising tool to bridge neuroscience data across electrophysiological, anatomical, and behavioral scales.

Fan Yang, Tianyi Chen, Xiaosheng He et al.

Editable 3D-aware generation, which supports user-interacted editing, has witnessed rapid development recently. However, existing editable 3D GANs either fail to achieve high-accuracy local editing or suffer from huge computational costs. We propose AttriHuman-3D, an editable 3D human generation model, which address the aforementioned problems with attribute decomposition and indexing. The core idea of the proposed model is to generate all attributes (e.g. human body, hair, clothes and so on) in an overall attribute space with six feature planes, which are then decomposed and manipulated with different attribute indexes. To precisely extract features of different attributes from the generated feature planes, we propose a novel attribute indexing method as well as an orthogonal projection regularization to enhance the disentanglement. We also introduce a hyper-latent training strategy and an attribute-specific sampling strategy to avoid style entanglement and misleading punishment from the discriminator. Our method allows users to interactively edit selected attributes in the generated 3D human avatars while keeping others fixed. Both qualitative and quantitative experiments demonstrate that our model provides a strong disentanglement between different attributes, allows fine-grained image editing and generates high-quality 3D human avatars.

Tiejun Huang, Yajing Zheng, Zhaofei Yu et al.

In digital cameras, we find a major limitation: the image and video form inherited from a film camera obstructs it from capturing the rapidly changing photonic world. Here, we present vidar, a bit sequence array where each bit represents whether the accumulation of photons has reached a threshold, to record and reconstruct the scene radiance at any moment. By employing only consumer-level CMOS sensors and integrated circuits, we have developed a vidar camera that is 1,000x faster than conventional cameras. By treating vidar as spike trains in biological vision, we have further developed a spiking neural network-based machine vision system that combines the speed of the machine and the mechanism of biological vision, achieving high-speed object detection and tracking 1,000x faster than human vision. We demonstrate the utility of the vidar camera and the super vision system in an assistant referee and target pointing system. Our study is expected to fundamentally revolutionize the image and video concepts and related industries, including photography, movies, and visual media, and to unseal a new spiking neural network-enabled speed-free machine vision era.

Alejandro H. Toselli, Si Wu, David A. Smith

Archivists, textual scholars, and historians often produce digital editions of historical documents. Using markup schemes such as those of the Text Encoding Initiative and EpiDoc, these digital editions often record documents' semantic regions (such as notes and figures) and physical features (such as page and line breaks) as well as transcribing their textual content. We describe methods for exploiting this semantic markup as distant supervision for training and evaluating layout analysis models. In experiments with several model architectures on the half-million pages of the Deutsches Textarchiv (DTA), we find a high correlation of these region-level evaluation methods with pixel-level and word-level metrics. We discuss the possibilities for improving accuracy with self-training and the ability of models trained on the DTA to generalize to other historical printed books.

Nikita Srivatsan, Si Wu, Jonathan T. Barron et al.

We propose a deep generative model that performs typography analysis and font reconstruction by learning disentangled manifolds of both font style and character shape. Our approach enables us to massively scale up the number of character types we can effectively model compared to previous methods. Specifically, we infer separate latent variables representing character and font via a pair of inference networks which take as input sets of glyphs that either all share a character type, or belong to the same font. This design allows our model to generalize to characters that were not observed during training time, an important task in light of the relative sparsity of most fonts. We also put forward a new loss, adapted from prior work that measures likelihood using an adaptive distribution in a projected space, resulting in more natural images without requiring a discriminator. We evaluate on the task of font reconstruction over various datasets representing character types of many languages, and compare favorably to modern style transfer systems according to both automatic and manually-evaluated metrics.

Zilong Ji, Xiaolong Zou, Tiejun Huang et al.

Object recognition is often viewed as a feedforward, bottom-up process in machine learning, but in real neural systems, object recognition is a complicated process which involves the interplay between two signal pathways. One is the parvocellular pathway (P-pathway), which is slow and extracts fine features of objects; the other is the magnocellular pathway (M-pathway), which is fast and extracts coarse features of objects. It has been suggested that the interplay between the two pathways endows the neural system with the capacity of processing visual information rapidly, adaptively, and robustly. However, the underlying computational mechanisms remain largely unknown. In this study, we build a computational model to elucidate the computational advantages associated with the interactions between two pathways. Our model consists of two convolution neural networks: one mimics the P-pathway, referred to as FineNet, which is deep, has small-size kernels, and receives detailed visual inputs; the other mimics the M-pathway, referred to as CoarseNet, which is shallow, has large-size kernels, and receives low-pass filtered or binarized visual inputs. The two pathways interact with each other via a Restricted Boltzmann Machine. We find that: 1) FineNet can teach CoarseNet through imitation and improve its performance considerably; 2) CoarseNet can improve the noise robustness of FineNet through association; 3) the output of CoarseNet can serve as a cognitive bias to improve the performance of FineNet. We hope that this study will provide insight into understanding visual information processing and inspire the development of new object recognition architectures.

Zilong Ji, Xiaolong Zou, Tiejun Huang et al.

Learning from limited exemplars (few-shot learning) is a fundamental, unsolved problem that has been laboriously explored in the machine learning community. However, current few-shot learners are mostly supervised and rely heavily on a large amount of labeled examples. Unsupervised learning is a more natural procedure for cognitive mammals and has produced promising results in many machine learning tasks. In the current study, we develop a method to learn an unsupervised few-shot learner via self-supervised training (UFLST), which can effectively generalize to novel but related classes. The proposed model consists of two alternate processes, progressive clustering and episodic training. The former generates pseudo-labeled training examples for constructing episodic tasks; and the later trains the few-shot learner using the generated episodic tasks which further optimizes the feature representations of data. The two processes facilitate with each other, and eventually produce a high quality few-shot learner. Using the benchmark dataset Omniglot and Mini-ImageNet, we show that our model outperforms other unsupervised few-shot learning methods. Using the benchmark dataset Market1501, we further demonstrate the feasibility of our model to a real-world application on person re-identification.

Yuanyuan Mi, Xiaohan Lin, Xiaolong Zou et al.

Spatiotemporal information processing is fundamental to brain functions. The present study investigates a canonic neural network model for spatiotemporal pattern recognition. Specifically, the model consists of two modules, a reservoir subnetwork and a decision-making subnetwork. The former projects complex spatiotemporal patterns into spatially separated neural representations, and the latter reads out these neural representations via integrating information over time; the two modules are combined together via supervised-learning using known examples. We elucidate the working mechanism of the model and demonstrate its feasibility for discriminating complex spatiotemporal patterns. Our model reproduces the phenomenon of recognizing looming patterns in the neural system, and can learn to discriminate gait with very few training examples. We hope this study gives us insight into understanding how spatiotemporal information is processed in the brain and helps us to develop brain-inspired application algorithms.