Hyeon‐Min Bae

Minsu Ji, Jihoon Kang, Seongkwon Yu et al.

Photon scattering has traditionally limited the ability of near-infrared spectroscopy (NIRS) to extract accurate, layer-specific information from the brain. This limitation restricts its clinical utility for precise neurological monitoring. To address this, we introduce an AI-driven, high-density NIRS system optimized to provide real-time, layer-specific oxygenation data from the brain cortex, specifically targeting acute neuro-emergencies. Our system integrates high-density NIRS reflectance data with a neural network trained on MRI-based synthetic datasets. This approach achieves robust cortical oxygenation accuracy across diverse anatomical variations. In simulations, our AI-assisted NIRS demonstrated a strong correlation (R2=0.913) with actual cortical oxygenation, markedly outperforming conventional methods (R2=0.469). Furthermore, biomimetic phantom experiments confirmed its superior anatomical reliability (R2=0.986) compared to standard commercial devices (R2=0.823). In clinical validation with healthy subjects and ischemic stroke patients, the system distinguished between the two groups with an AUC of 0.943. This highlights its potential as an accessible, high-accuracy diagnostic tool for emergency and point-of-care settings. These results underscore the system's capability to advance neuro-monitoring precision through AI, enabling timely, data-driven decisions in critical care environments.

Seok-Hwan Oh, Guil Jung, Myeong-Gee Kim et al.

In this paper, we introduce a Key-point-guided Diffusion probabilistic Model (KDM) that gains precise control over images by manipulating the object's key-point. We propose a two-stage generative model incorporating an optical flow map as an intermediate output. By doing so, a dense pixel-wise understanding of the semantic relation between the image and sparse key point is configured, leading to more realistic image generation. Additionally, the integration of optical flow helps regulate the inter-frame variance of sequential images, demonstrating an authentic sequential image generation. The KDM is evaluated with diverse key-point conditioned image synthesis tasks, including facial image generation, human pose synthesis, and echocardiography video prediction, demonstrating the KDM is proving consistency enhanced and photo-realistic images compared with state-of-the-art models.