CVMay 20
Deep Learning-Based Automated Quantification of TIMI Myocardial Perfusion Frame Count (DL-TMPFC) from Coronary Angiography: A Novel Framework for Rapid Assessment of Microvascular DysfunctionSi Li, Yuanqing He, Chenkai Hu et al.
Aims: Coronary microvascular dysfunction (CMVD) affects approximately 40%-60% of patients with ischemia and non-obstructive coronary arteries, yet diagnosis remains challenging due to reliance on invasive functional testing or subjective Thrombolysis In Myocardial Infarction (TIMI) flow grade. The TIMI Myocardial Perfusion Frame Count (TMPFC) offers an objective, angiography-based quantitative measure of CMVD, but its clinical translation is hindered by cumbersome manual calculation and insufficient validation. This study aims to develop and validate a deep learning-powered TMPFC calculation (DL-TMPFC), enabling integration into clinical workflows. Methods and results: DL-TMPFC framework comprised two components. A stenosis detection network first excluded obstructive coronary artery disease (CAD). A territory-aware segmentation network then identified perfusion territories and TMPFC calculation module automatically determined the first and last frames from angiographic sequences. The framework was validated in a cohort of 655 patients (445 of obstructive CAD, 100 of confirmed CMVD, 110 of control group) from three independent institutions. DL-TMPFC showed excellent agreement with expert manual measurements (bias: -0.93 frames; 95% LoA: -5.33 to +3.47; r =0.98). DL-TMPFC markedly enhanced clinical feasibility by fully automating TMPFC and removing observer dependence. Clinically, DL-TMPFC accurately identified CMVD across a full spectrum of coronary pathologies and captured the continuous severity of CMVD beyond binary classification, enabling quantitative risk stratification. Conclusion: DL-TMPFC enabled automatic, standardized, and accurate quantification of CMVD directly from routine angiography. By providing an automatic and objective measure, this tool provided immediate diagnostic information for timely recognition and management of CMVD in clinical practice.
AIJan 7
ReEfBench: Quantifying the Reasoning Efficiency of LLMsZhizhang Fu, Yuancheng Gu, Chenkai Hu et al.
Test-time scaling has enabled Large Language Models (LLMs) to tackle complex reasoning, yet the limitations of current Chain-of-Thought (CoT) evaluation obscures whether performance gains stem from genuine reasoning or mere verbosity. To address this, (1) we propose a novel neuro-symbolic framework for the non-intrusive, comprehensive process-centric evaluation of reasoning. (2) Through this lens, we identify four distinct behavioral prototypes and diagnose the failure modes. (3) We examine the impact of inference mode, training strategy, and model scale. Our analysis reveals that extended token generation is not a prerequisite for deep reasoning. Furthermore, we reveal critical constraints: mixing long and short CoT data in training risks in premature saturation and collapse, while distillation into smaller models captures behavioral length but fails to replicate logical efficacy due to intrinsic capacity limits.
AISep 22, 2025Code
Correlation or Causation: Analyzing the Causal Structures of LLM and LRM Reasoning ProcessZhizhang FU, Guangsheng Bao, Hongbo Zhang et al.
LLMs suffer from critical reasoning issues such as unfaithfulness, bias, and inconsistency, since they lack robust causal underpinnings and may rely on superficial correlations rather than genuine understanding. Successive LRMs have emerged as a promising alternative, leveraging advanced training techniques such as reinforcement learning (RL) and distillation to improve task accuracy. However, the impact of these training methods on causality remains largely unexplored. In this study, we conduct a systematic causal analysis on LLMs and LRMs, examining structural causal models (SCMs) of four key variables: problem instruction (Z), thinking process (T), reasoning steps (X), and answer (Y). Our findings reveal that RLVR-trained LRMs exhibit enhanced causal reasoning capabilities, aligning more closely with ideal causal structures, while LLMs and distilled LRMs fail to address causality-related deficiencies. Our further investigation indicates that RLVR reduces spurious correlations and strengthens genuine causal patterns, thereby mitigating unfaithfulness and bias. In addition, our inspection on the dynamics of the RLVR training process observes a high correlation between reduced spurious features and improved causal structures, where the causal relationships consistently improve in the training process. This study contributes to the understanding of causality in reasoning models, highlights the critical role of RLVR in enhancing causal reasoning, and provides insights for designing future AI systems with stronger causal foundations. We release our code and data at https://github.com/Harryking1999/CoT_Causal_Analysis.
ASJun 1, 2025
Multimodal Fusion with Semi-Supervised Learning Minimizes Annotation Quantity for Modeling Videoconference Conversation ExperienceAndrew Chang, Chenkai Hu, Ji Qi et al.
Group conversations over videoconferencing are a complex social behavior. However, the subjective moments of negative experience, where the conversation loses fluidity or enjoyment remain understudied. These moments are infrequent in naturalistic data, and thus training a supervised learning (SL) model requires costly manual data annotation. We applied semi-supervised learning (SSL) to leverage targeted labeled and unlabeled clips for training multimodal (audio, facial, text) deep features to predict non-fluid or unenjoyable moments in holdout videoconference sessions. The modality-fused co-training SSL achieved an ROC-AUC of 0.9 and an F1 score of 0.6, outperforming SL models by up to 4% with the same amount of labeled data. Remarkably, the best SSL model with just 8% labeled data matched 96% of the SL model's full-data performance. This shows an annotation-efficient framework for modeling videoconference experience.
CRDec 7, 2021
BlockGC: A Joint Learning Framework for Account Identity Inference on Blockchain with Graph ContrastJiajun Zhou, Chenkai Hu, Shenbo Gong et al.
Blockchain technology has the characteristics of decentralization, traceability and tamper proof, which creates a reliable decentralized transaction mode, further accelerating the development of the blockchain platforms. However, with the popularization of various financial applications, security problems caused by blockchain digital assets, such as money laundering, illegal fundraising and phishing fraud, are constantly on the rise. Therefore, financial security has become an important issue in the blockchain ecosystem, and identifying the types of accounts in blockchain (e.g. miners, phishing accounts, Ponzi contracts, etc.) is of great significance in risk assessment and market supervision. In this paper, we construct an account interaction graph using raw blockchain data in a graph perspective, and proposes a joint learning framework for account identity inference on blockchain with graph contrast. We first capture transaction feature and correlation feature from interaction graph, and then perform sampling and data augmentation to generate multiple views for account subgraphs, finally jointly train the subgraph contrast and account classification task. Extensive experiments on Ethereum datasets show that our method achieves significant advantages in account identity inference task in terms of classification performance, scalability and generalization.