Mingyuan Liu

Mingyuan Liu, Lu Xu, Jicong Zhang

Fueled by deep learning, computer-aided diagnosis achieves huge advances. However, out of controlled lab environments, algorithms could face multiple challenges. Open set recognition (OSR), as an important one, states that categories unseen in training could appear in testing. In medical fields, it could derive from incompletely collected training datasets and the constantly emerging new or rare diseases. OSR requires an algorithm to not only correctly classify known classes, but also recognize unknown classes and forward them to experts for further diagnosis. To tackle OSR, we assume that known classes could densely occupy small parts of the embedding space and the remaining sparse regions could be recognized as unknowns. Following it, we propose Open Margin Cosine Loss (OMCL) unifying two mechanisms. The former, called Margin Loss with Adaptive Scale (MLAS), introduces angular margin for reinforcing intra-class compactness and inter-class separability, together with an adaptive scaling factor to strengthen the generalization capacity. The latter, called Open-Space Suppression (OSS), opens the classifier by recognizing sparse embedding space as unknowns using proposed feature space descriptors. Besides, since medical OSR is still a nascent field, two publicly available benchmark datasets are proposed for comparison. Extensive ablation studies and feature visualization demonstrate the effectiveness of each design. Compared with state-of-the-art methods, MLAS achieves superior performances, measured by ACC, AUROC, and OSCR.

Zhenliang Zhang, Yuxi Wang, Hongzhao Xie et al.

A key feature differentiating artificial general intelligence (AGI) from traditional AI is that AGI can perform composite tasks that require a wide range of capabilities. Although embodied agents powered by multimodal large language models (MLLMs) offer rich perceptual and interactive capabilities, it remains largely unexplored whether they can solve composite tasks. In the current work, we designed a set of composite tasks inspired by common daily activities observed in early childhood development. Within a dynamic and simulated home environment, these tasks span three core domains: object understanding, spatial intelligence, and social activity. We evaluated 17 leading proprietary and open-source MLLMs on these tasks. The results consistently showed poor performance across all three domains, indicating a substantial gap between current capabilities and general intelligence requirements. Together, our tasks offer a preliminary framework for evaluating the general capabilities of embodied agents, marking an early but significant step toward the development of embodied MLLMs and their real-world deployment.

Zhe Sun, Kunlun Wu, Chuanjian Fu et al.

As artificial intelligence (AI) rapidly advances, especially in multimodal large language models (MLLMs), research focus is shifting from single-modality text processing to the more complex domains of multimodal and embodied AI. Embodied intelligence focuses on training agents within realistic simulated environments, leveraging physical interaction and action feedback rather than conventionally labeled datasets. Yet, most existing simulation platforms remain narrowly designed, each tailored to specific tasks. A versatile, general-purpose training environment that can support everything from low-level embodied navigation to high-level composite activities, such as multi-agent social simulation and human-AI collaboration, remains largely unavailable. To bridge this gap, we introduce TongSIM, a high-fidelity, general-purpose platform for training and evaluating embodied agents. TongSIM offers practical advantages by providing over 100 diverse, multi-room indoor scenarios as well as an open-ended, interaction-rich outdoor town simulation, ensuring broad applicability across research needs. Its comprehensive evaluation framework and benchmarks enable precise assessment of agent capabilities, such as perception, cognition, decision-making, human-robot cooperation, and spatial and social reasoning. With features like customized scenes, task-adaptive fidelity, diverse agent types, and dynamic environmental simulation, TongSIM delivers flexibility and scalability for researchers, serving as a unified platform that accelerates training, evaluation, and advancement toward general embodied intelligence.

Handi Deng, Yucheng Zhou, Jiaxuan Xiang et al.

Foundation models have rapidly evolved and have achieved significant accomplishments in computer vision tasks. Specifically, the prompt mechanism conveniently allows users to integrate image prior information into the model, making it possible to apply models without any training. Therefore, we propose a method based on foundation models and zero training to solve the tasks of photoacoustic (PA) image segmentation. We employed the segment anything model (SAM) by setting simple prompts and integrating the model's outputs with prior knowledge of the imaged objects to accomplish various tasks, including: (1) removing the skin signal in three-dimensional PA image rendering; (2) dual speed-of-sound reconstruction, and (3) segmentation of finger blood vessels. Through these demonstrations, we have concluded that deep learning can be directly applied in PA imaging without the requirement for network design and training. This potentially allows for a hands-on, convenient approach to achieving efficient and accurate segmentation of PA images. This letter serves as a comprehensive tutorial, facilitating the mastery of the technique through the provision of code and sample datasets.

Spyridon Bakas, Mauricio Reyes, Andras Jakab et al.

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset.

Yan Xu, Yang Li, Yipei Wang et al.

Objective: A new image instance segmentation method is proposed to segment individual glands (instances) in colon histology images. This process is challenging since the glands not only need to be segmented from a complex background, they must also be individually identified. Methods: We leverage the idea of image-to-image prediction in recent deep learning by designing an algorithm that automatically exploits and fuses complex multichannel information - regional, location, and boundary cues - in gland histology images. Our proposed algorithm, a deep multichannel framework, alleviates heavy feature design due to the use of convolutional neural networks and is able to meet multifarious requirements by altering channels. Results: Compared with methods reported in the 2015 MICCAI Gland Segmentation Challenge and other currently prevalent instance segmentation methods, we observe state-of-the-art results based on the evaluation metrics. Conclusion: The proposed deep multichannel algorithm is an effective method for gland instance segmentation. Significance: The generalization ability of our model not only enable the algorithm to solve gland instance segmentation problems, but the channel is also alternative that can be replaced for a specific task.

Yan Xu, Yang Li, Mingyuan Liu et al.

In this paper, we propose a new image instance segmentation method that segments individual glands (instances) in colon histology images. This is a task called instance segmentation that has recently become increasingly important. The problem is challenging since not only do the glands need to be segmented from the complex background, they are also required to be individually identified. Here we leverage the idea of image-to-image prediction in recent deep learning by building a framework that automatically exploits and fuses complex multichannel information, regional, location and boundary patterns in gland histology images. Our proposed system, deep multichannel framework, alleviates heavy feature design due to the use of convolutional neural networks and is able to meet multifarious requirement by altering channels. Compared to methods reported in the 2015 MICCAI Gland Segmentation Challenge and other currently prevalent methods of instance segmentation, we observe state-of-the-art results based on a number of evaluation metrics.

Yan Xu, Yang Li, Mingyuan Liu et al.

In this paper, we propose a new image instance segmentation method that segments individual glands (instances) in colon histology images. This is a task called instance segmentation that has recently become increasingly important. The problem is challenging since not only do the glands need to be segmented from the complex background, they are also required to be individually identified. Here we leverage the idea of image-to-image prediction in recent deep learning by building a framework that automatically exploits and fuses complex multichannel information, regional and boundary patterns, with side supervision (deep supervision on side responses) in gland histology images. Our proposed system, deep multichannel side supervision (DMCS), alleviates heavy feature design due to the use of convolutional neural networks guided by side supervision. Compared to methods reported in the 2015 MICCAI Gland Segmentation Challenge, we observe state-of-the-art results based on a number of evaluation metrics.