Zhitao Zeng

Zhitao Zeng, Mengya Xu, Jian Jiang et al.

Surgical intelligence has the potential to improve the safety and consistency of surgical care, yet most existing surgical AI frameworks remain task-specific and struggle to generalize across procedures and institutions. Although multimodal foundation models, particularly multimodal large language models, have demonstrated strong cross-task capabilities across various medical domains, their advancement in surgery remains constrained by the lack of large-scale, systematically curated multimodal data. To address this challenge, we introduce Surg$Σ$, a spectrum of large-scale multimodal data and foundation models for surgical intelligence. At the core of this framework lies Surg$Σ$-DB, a large-scale multimodal data foundation designed to support diverse surgical tasks. Surg$Σ$-DB consolidates heterogeneous surgical data sources (including open-source datasets, curated in-house clinical collections and web-source data) into a unified schema, aiming to improve label consistency and data standardization across heterogeneous datasets. Surg$Σ$-DB spans 6 clinical specialties and diverse surgical types, providing rich image- and video-level annotations across 18 practical surgical tasks covering understanding, reasoning, planning, and generation, at an unprecedented scale (over 5.98M conversations). Beyond conventional multimodal conversations, Surg$Σ$-DB incorporates hierarchical reasoning annotations, providing richer semantic cues to support deeper contextual understanding in complex surgical scenarios. We further provide empirical evidence through recently developed surgical foundation models built upon Surg$Σ$-DB, illustrating the practical benefits of large-scale multimodal annotations, unified semantic design, and structured reasoning annotations for improving cross-task generalization and interpretability.

Xun Huang, Simeng Qin, Xiaoshuang Jia et al.

As Large Language Models (LLMs) are increasingly used, their security risks have drawn increasing attention. Existing research reveals that LLMs are highly susceptible to jailbreak attacks, with effectiveness varying across language contexts. This paper investigates the role of classical Chinese in jailbreak attacks. Owing to its conciseness and obscurity, classical Chinese can partially bypass existing safety constraints, exposing notable vulnerabilities in LLMs. Based on this observation, this paper proposes a framework, CC-BOS, for the automatic generation of classical Chinese adversarial prompts based on multi-dimensional fruit fly optimization, facilitating efficient and automated jailbreak attacks in black-box settings. Prompts are encoded into eight policy dimensions-covering role, behavior, mechanism, metaphor, expression, knowledge, trigger pattern and context; and iteratively refined via smell search, visual search, and cauchy mutation. This design enables efficient exploration of the search space, thereby enhancing the effectiveness of black-box jailbreak attacks. To enhance readability and evaluation accuracy, we further design a classical Chinese to English translation module. Extensive experiments demonstrate that effectiveness of the proposed CC-BOS, consistently outperforming state-of-the-art jailbreak attack methods.

Yibing Fu, Yunpeng Zhao, Zhitao Zeng et al.

Multi-modal learning integrating medical images and tabular data has significantly advanced clinical decision-making in recent years. Self-Supervised Learning (SSL) has emerged as a powerful paradigm for pretraining these models on large-scale unlabeled image-tabular data, aiming to learn discriminative representations. However, existing SSL methods for image-tabular representation learning are often confined to specific data cohorts, mainly due to their rigid tabular modeling mechanisms when modeling heterogeneous tabular data. This inter-tabular barrier hinders the multi-modal SSL methods from effectively learning transferrable medical knowledge shared across diverse cohorts. In this paper, we propose a novel SSL framework, namely CITab, designed to learn powerful multi-modal feature representations in a cross-tabular manner. We design the tabular modeling mechanism from a semantic-awareness perspective by integrating column headers as semantic cues, which facilitates transferrable knowledge learning and the scalability in utilizing multiple data sources for pretraining. Additionally, we propose a prototype-guided mixture-of-linear layer (P-MoLin) module for tabular feature specialization, empowering the model to effectively handle the heterogeneity of tabular data and explore the underlying medical concepts. We conduct comprehensive evaluations on Alzheimer's disease diagnosis task across three publicly available data cohorts containing 4,461 subjects. Experimental results demonstrate that CITab outperforms state-of-the-art approaches, paving the way for effective and scalable cross-tabular multi-modal learning.

Chang Han Low, Ziyue Wang, Tianyi Zhang et al.

Integration of Vision-Language Models (VLMs) in surgical intelligence is hindered by hallucinations, domain knowledge gaps, and limited understanding of task interdependencies within surgical scenes, undermining clinical reliability. While recent VLMs demonstrate strong general reasoning and thinking capabilities, they still lack the domain expertise and task-awareness required for precise surgical scene interpretation. Although Chain-of-Thought (CoT) can structure reasoning more effectively, current approaches rely on self-generated CoT steps, which often exacerbate inherent domain gaps and hallucinations. To overcome this, we present SurgRAW, a CoT-driven multi-agent framework that delivers transparent, interpretable insights for most tasks in robotic-assisted surgery. By employing specialized CoT prompts across five tasks: instrument recognition, action recognition, action prediction, patient data extraction, and outcome assessment, SurgRAW mitigates hallucinations through structured, domain-aware reasoning. Retrieval-Augmented Generation (RAG) is also integrated to external medical knowledge to bridge domain gaps and improve response reliability. Most importantly, a hierarchical agentic system ensures that CoT-embedded VLM agents collaborate effectively while understanding task interdependencies, with a panel discussion mechanism promotes logical consistency. To evaluate our method, we introduce SurgCoTBench, the first reasoning-based dataset with structured frame-level annotations. With comprehensive experiments, we demonstrate the effectiveness of proposed SurgRAW with 29.32% accuracy improvement over baseline VLMs on 12 robotic procedures, achieving the state-of-the-art performance and advancing explainable, trustworthy, and autonomous surgical assistance.

Zhitao Zeng, Zhu Zhuo, Xiaojun Jia et al. · pku

Foundation models have achieved transformative success across biomedical domains by enabling holistic understanding of multimodal data. However, their application in surgery remains underexplored. Surgical intelligence presents unique challenges - requiring surgical visual perception, temporal analysis, and reasoning. Existing general-purpose vision-language models fail to address these needs due to insufficient domain-specific supervision and the lack of a large-scale high-quality surgical database. To bridge this gap, we propose SurgVLM, one of the first large vision-language foundation models for surgical intelligence, where this single universal model can tackle versatile surgical tasks. To enable this, we construct a large-scale multimodal surgical database, SurgVLM-DB, comprising over 1.81 million frames with 7.79 million conversations, spanning more than 16 surgical types and 18 anatomical structures. We unify and reorganize 23 public datasets across 10 surgical tasks, followed by standardizing labels and doing hierarchical vision-language alignment to facilitate comprehensive coverage of gradually finer-grained surgical tasks, from visual perception, temporal analysis, to high-level reasoning. Building upon this comprehensive dataset, we propose SurgVLM, which is built upon Qwen2.5-VL, and undergoes instruction tuning to 10+ surgical tasks. We further construct a surgical multimodal benchmark, SurgVLM-Bench, for method evaluation. SurgVLM-Bench consists of 6 popular and widely-used datasets in surgical domain, covering several crucial downstream tasks. Based on SurgVLM-Bench, we evaluate the performance of our SurgVLM (3 SurgVLM variants: SurgVLM-7B, SurgVLM-32B, and SurgVLM-72B), and conduct comprehensive comparisons with 14 mainstream commercial VLMs (e.g., GPT-4o, Gemini 2.0 Flash, Qwen2.5-Max).

Jian Jiang, Chenxi Lin, Yiming Gu et al.

Surgical scene understanding demands not only accurate predictions but also interpretable reasoning that surgeons can verify against clinical expertise. However, existing surgical vision-language models generate predictions without reasoning chains, and general-purpose reasoning models fail on compositional surgical tasks without domain-specific knowledge. We present Surg-R1, a surgical Vision-Language Model that addresses this gap through hierarchical reasoning trained via a four-stage pipeline. Our approach introduces three key contributions: (1) a three-level reasoning hierarchy decomposing surgical interpretation into perceptual grounding, relational understanding, and contextual reasoning; (2) the largest surgical chain-of-thought dataset with 320,000 reasoning pairs; and (3) a four-stage training pipeline progressing from supervised fine-tuning to group relative policy optimization and iterative self-improvement. Evaluation on SurgBench, comprising six public benchmarks and six multi-center external validation datasets from five institutions, demonstrates that Surg-R1 achieves the highest Arena Score (64.9%) on public benchmarks versus Gemini 3.0 Pro (46.1%) and GPT-5.1 (37.9%), outperforming both proprietary reasoning models and specialized surgical VLMs on the majority of tasks spanning instrument localization, triplet recognition, phase recognition, action recognition, and critical view of safety assessment, with a 15.2 percentage point improvement over the strongest surgical baseline on external validation.

Zhitao Zeng, Guojian Yuan, Junyuan Mao et al.

Accurate temporal prediction is the bridge between comprehensive scene understanding and embodied artificial intelligence. However, predicting multiple fine-grained states of a scene at multiple temporal scales is difficult for vision-language models. We formalize the Multi-Scale Temporal Prediction (MSTP) task in general and surgical scenes by decomposing multi-scale into two orthogonal dimensions: the temporal scale, forecasting states of humans and surgery at varying look-ahead intervals, and the state scale, modeling a hierarchy of states in general and surgical scenes. For example, in general scenes, states of contact relationships are finer-grained than states of spatial relationships. In surgical scenes, medium-level steps are finer-grained than high-level phases yet remain constrained by their encompassing phase. To support this unified task, we introduce the first MSTP Benchmark, featuring synchronized annotations across multiple state scales and temporal scales. We further propose a method, Incremental Generation and Multi-agent Collaboration (IG-MC), which integrates two key innovations. First, we present a plug-and-play incremental generation module that continuously synthesizes up-to-date visual previews at expanding temporal scales to inform multiple decision-making agents, keeping decisions and generated visuals synchronized and preventing performance degradation as look-ahead intervals lengthen. Second, we present a decision-driven multi-agent collaboration framework for multi-state prediction, comprising generation, initiation, and multi-state assessment agents that dynamically trigger and evaluate prediction cycles to balance global coherence and local fidelity.