Zhibo Yao

Chenxi Li, Xianggan Liu, Dake Shen et al.

Despite the rapid progress of Large Vision-Language Models (LVLMs), the integration of visual modalities introduces new safety vulnerabilities that adversaries can exploit to elicit biased or malicious outputs. In this paper, we demonstrate an underexplored vulnerability via semantic slot filling, where LVLMs complete missing slot values with unsafe content even when the slot types are deliberately crafted to appear benign. Building on this finding, we propose StructAttack, a simple yet effective single-query jailbreak framework under black-box settings. StructAttack decomposes a harmful query into a central topic and a set of benign-looking slot types, then embeds them as structured visual prompts (e.g., mind maps, tables, or sunburst diagrams) with small random perturbations. Paired with a completion-guided instruction, LVLMs automatically recompose the concealed semantics and generate unsafe outputs without triggering safety mechanisms. Although each slot appears benign in isolation (local benignness), StructAttack exploits LVLMs' reasoning to assemble these slots into coherent harmful semantics. Extensive experiments on multiple models and benchmarks show the efficacy of our proposed StructAttack.

Xiuqi Ge, Zhibo Yao, Yaosong Du

Clinical machine learning faces a critical dilemma in high-stakes medical applications: algorithms achieving optimal diagnostic performance typically sacrifice the interpretability essential for physician decision-making, while interpretable methods compromise sensitivity in complex scenarios. This paradox becomes particularly acute in non-invasive prenatal testing (NIPT), where missed chromosomal abnormalities carry profound clinical consequences yet regulatory frameworks mandate explainable AI systems. We introduce Medical Priority Fusion (MPF), a constrained multi-objective optimization framework that resolves this fundamental trade-off by systematically integrating Naive Bayes probabilistic reasoning with Decision Tree rule-based logic through mathematically-principled weighted fusion under explicit medical constraints. Rigorous validation on 1,687 real-world NIPT samples characterized by extreme class imbalance (43.4:1 normal-to-abnormal ratio) employed stratified 5-fold cross-validation with comprehensive ablation studies and statistical hypothesis testing using McNemar's paired comparisons. MPF achieved simultaneous optimization of dual objectives: 89.3% sensitivity (95% CI: 83.9-94.7%) with 80% interpretability score, significantly outperforming individual algorithms (McNemar's test, p < 0.001). The optimal fusion configuration achieved Grade A clinical deployment criteria with large effect size (d = 1.24), establishing the first clinically-deployable solution that maintains both diagnostic accuracy and decision transparency essential for prenatal care. This work demonstrates that medical-constrained algorithm fusion can resolve the interpretability-performance trade-off, providing a mathematical framework for developing high-stakes medical decision support systems that meet both clinical efficacy and explainability requirements.