Sourav Halder

Sourav Halder, Ethan M. Johnson, Jun Yamasaki et al.

Dynamic magnetic resonance imaging (MRI) is a popular medical imaging technique to generate image sequences of the flow of a contrast material inside tissues and organs. However, its application to imaging bolus movement through the esophagus has only been demonstrated in few feasibility studies and is relatively unexplored. In this work, we present a computational framework called mechanics-informed MRI (MRI-MECH) that enhances that capability thereby increasing the applicability of dynamic MRI for diagnosing esophageal disorders. Pineapple juice was used as the swallowed contrast material for the dynamic MRI and the MRI image sequence was used as input to the MRI-MECH. The MRI-MECH modeled the esophagus as a flexible one-dimensional tube and the elastic tube walls followed a linear tube law. Flow through the esophagus was then governed by one-dimensional mass and momentum conservation equations. These equations were solved using a physics-informed neural network (PINN). The PINN minimized the difference between the measurements from the MRI and model predictions ensuring that the physics of the fluid flow problem was always followed. MRI-MECH calculated the fluid velocity and pressure during esophageal transit and estimated the mechanical health of the esophagus by calculating wall stiffness and active relaxation. Additionally, MRI-MECH predicted missing information about the lower esophageal sphincter during the emptying process, demonstrating its applicability to scenarios with missing data or poor image resolution. In addition to potentially improving clinical decisions based on quantitative estimates of the mechanical health of the esophagus, MRI-MECH can also be enhanced for application to other medical imaging modalities to enhance their functionality as well.

Sourav Halder, Jinjun Tong, Xinyu Wu

Checks remain a foundational instrument in the financial ecosystem, facilitating substantial transaction volumes across institutions. However, their continued use also renders them a persistent target for fraud, underscoring the importance of robust check fraud detection mechanisms. At the core of such systems lies the accurate identification and localization of critical fields, such as the signature, magnetic ink character recognition (MICR) line, courtesy amount, legal amount, payee, and payer, which are essential for subsequent verification against reference checks belonging to the same customer. This field-level detection is traditionally dependent on object detection models trained on large, diverse, and meticulously labeled datasets, a resource that is scarce due to proprietary and privacy concerns. In this paper, we introduce a novel, training-free framework for automated check field detection, leveraging the power of a vision language model (VLM) in conjunction with a multimodal large language model (MLLM). Our approach enables zero-shot detection of check components, significantly lowering the barrier to deployment in real-world financial settings. Quantitative evaluation of our model on a hand-curated dataset of 110 checks spanning multiple formats and layouts demonstrates strong performance and generalization capability. Furthermore, this framework can serve as a bootstrap mechanism for generating high-quality labeled datasets, enabling the development of specialized real-time object detection models tailored to institutional needs.

Sourav Halder, Jun Yamasaki, Shashank Acharya et al.

The pathogenesis of esophageal disorders is related to the esophageal wall mechanics. Therefore, to understand the underlying fundamental mechanisms behind various esophageal disorders, it is crucial to map the esophageal wall mechanics-based parameters onto physiological and pathophysiological conditions corresponding to altered bolus transit and supraphysiologic IBP. In this work, we present a hybrid framework that combines fluid mechanics and machine learning to identify the underlying physics of the various esophageal disorders and maps them onto a parameter space which we call the virtual disease landscape (VDL). A one-dimensional inverse model processes the output from an esophageal diagnostic device called endoscopic functional lumen imaging probe (EndoFLIP) to estimate the mechanical "health" of the esophagus by predicting a set of mechanics-based parameters such as esophageal wall stiffness, muscle contraction pattern and active relaxation of esophageal walls. The mechanics-based parameters were then used to train a neural network that consists of a variational autoencoder (VAE) that generates a latent space and a side network that predicts mechanical work metrics for estimating esophagogastric junction motility. The latent vectors along with a set of discrete mechanics-based parameters define the VDL and form clusters corresponding to the various esophageal disorders. The VDL not only distinguishes different disorders but can also be used to predict disease progression in time. Finally, we also demonstrate the clinical applicability of this framework for estimating the effectiveness of a treatment and track patient condition after a treatment.