Youcheng Li

Haojun Yu, Youcheng Li, Nan Zhang et al.

Data-driven deep learning models have shown great capabilities to assist radiologists in breast ultrasound (US) diagnoses. However, their effectiveness is limited by the long-tail distribution of training data, which leads to inaccuracies in rare cases. In this study, we address a long-standing challenge of improving the diagnostic model performance on rare cases using long-tailed data. Specifically, we introduce a pipeline, TAILOR, that builds a knowledge-driven generative model to produce tailored synthetic data. The generative model, using 3,749 lesions as source data, can generate millions of breast-US images, especially for error-prone rare cases. The generated data can be further used to build a diagnostic model for accurate and interpretable diagnoses. In the prospective external evaluation, our diagnostic model outperforms the average performance of nine radiologists by 33.5% in specificity with the same sensitivity, improving their performance by providing predictions with an interpretable decision-making process. Moreover, on ductal carcinoma in situ (DCIS), our diagnostic model outperforms all radiologists by a large margin, with only 34 DCIS lesions in the source data. We believe that TAILOR can potentially be extended to various diseases and imaging modalities.

Haojun Yu, Youcheng Li, QuanLin Wu et al.

During ultrasonic scanning processes, real-time lesion detection can assist radiologists in accurate cancer diagnosis. However, this essential task remains challenging and underexplored. General-purpose real-time object detection models can mistakenly report obvious false positives (FPs) when applied to ultrasound videos, potentially misleading junior radiologists. One key issue is their failure to utilize negative symptoms in previous frames, denoted as negative temporal contexts (NTC). To address this issue, we propose to extract contexts from previous frames, including NTC, with the guidance of inverse optical flow. By aggregating extracted contexts, we endow the model with the ability to suppress FPs by leveraging NTC. We call the resulting model UltraDet. The proposed UltraDet demonstrates significant improvement over previous state-of-the-arts and achieves real-time inference speed. We release the code, checkpoints, and high-quality labels of the CVA-BUS dataset in https://github.com/HaojunYu1998/UltraDet.

Xianchao Zeng, Xinyu Zhou, Youcheng Li et al.

Vision-Language-Action (VLA) models have recently achieved remarkable progress in robotic manipulation, yet they remain limited in failure diagnosis and learning from failures. Additionally, existing failure datasets are mostly generated programmatically in simulation, which limits their generalization to the real world. In light of these, we introduce ViFailback, a framework designed to diagnose robotic manipulation failures and provide both textual and visual correction guidance. Our framework utilizes explicit visual symbols to enhance annotation efficiency. We further release the ViFailback dataset, a large-scale collection of 58,126 Visual Question Answering (VQA) pairs along with their corresponding 5,202 real-world manipulation trajectories. Based on the dataset, we establish ViFailback-Bench, a benchmark of 11 fine-grained VQA tasks designed to assess the failure diagnosis and correction abilities of Vision-Language Models (VLMs), featuring ViFailback-Bench Lite for closed-ended and ViFailback-Bench Hard for open-ended evaluation. To demonstrate the effectiveness of our framework, we built the ViFailback-8B VLM, which not only achieves significant overall performance improvement on ViFailback-Bench but also generates visual symbols for corrective action guidance. Finally, by integrating ViFailback-8B with a VLA model, we conduct real-world robotic experiments demonstrating its ability to assist the VLA model in recovering from failures. Project Website: https://x1nyuzhou.github.io/vifailback.github.io/

Haojun Yu, Youcheng Li, Zihan Niu et al.

Breast ultrasound (BUS) is an essential tool for diagnosing breast lesions, with millions of examinations per year. However, publicly available high-quality BUS benchmarks for AI development are limited in data scale and annotation richness. In this work, we present BUS-CoT, a BUS dataset for chain-of-thought (CoT) reasoning analysis, which contains 11,439 images of 10,019 lesions from 4,838 patients and covers all 99 histopathology types. To facilitate research on incentivizing CoT reasoning, we construct the reasoning processes based on observation, feature, diagnosis and pathology labels, annotated and verified by experienced experts. Moreover, by covering lesions of all histopathology types, we aim to facilitate robust AI systems in rare cases, which can be error-prone in clinical practice.

Haojun Yu, Youcheng Li, Nan Zhang et al.

Foundational models have emerged as powerful tools for addressing various tasks in clinical settings. However, their potential development to breast ultrasound analysis remains untapped. In this paper, we present BUSGen, the first foundational generative model specifically designed for breast ultrasound image analysis. Pretrained on over 3.5 million breast ultrasound images, BUSGen has acquired extensive knowledge of breast structures, pathological features, and clinical variations. With few-shot adaptation, BUSGen can generate repositories of realistic and informative task-specific data, facilitating the development of models for a wide range of downstream tasks. Extensive experiments highlight BUSGen's exceptional adaptability, significantly exceeding real-data-trained foundational models in breast cancer screening, diagnosis, and prognosis. In breast cancer early diagnosis, our approach outperformed all board-certified radiologists (n=9), achieving an average sensitivity improvement of 16.5% (P-value<0.0001). Additionally, we characterized the scaling effect of using generated data which was as effective as the collected real-world data for training diagnostic models. Moreover, extensive experiments demonstrated that our approach improved the generalization ability of downstream models. Importantly, BUSGen protected patient privacy by enabling fully de-identified data sharing, making progress forward in secure medical data utilization. An online demo of BUSGen is available at https://aibus.bio.