Di Miao

Di Miao, Michael J. Borden, Michael A. Scott et al.

In this paper we demonstrate the use of Bézier projection to alleviate locking phenomena in structural mechanics applications of isogeometric analysis. Interpreting the well-known $\bar{B}$ projection in two different ways we develop two formulations for locking problems in beams and nearly incompressible elastic solids. One formulation leads to a sparse symmetric symmetric system and the other leads to a sparse non-symmetric system. To demonstrate the utility of Bézier projection for both geometry and material locking phenomena we focus on transverse shear locking in Timoshenko beams and volumetric locking in nearly compressible linear elasticity although the approach can be applied generally to other types of locking phenemona as well. Bézier projection is a local projection technique with optimal approximation properties, which in many cases produces solutions that are comparable to global $L^2$ projection. In the context of $\bar{B}$ methods, the use of Bézier projection produces sparse stiffness matrices with only a slight increase in bandwidth when compared to standard displacement-based methods. Of particular importance is that the approach is applicable to any spline representation that can be written in Bézier form like NURBS, T-splines, LR-splines, etc. We discuss in detail how to integrate this approach into an existing finite element framework with minimal disruption through the use of Bézier extraction operators and a newly introduced dual basis for the Bézierprojection operator. We then demonstrate the behavior of the two proposed formulations through several challenging benchmark problems.

Siqi Li, Di Miao, Qiming Wu et al.

Federated learning (FL) has shown promising potential in safeguarding data privacy in healthcare collaborations. While the term "FL" was originally coined by the engineering community, the statistical field has also explored similar privacy-preserving algorithms. Statistical FL algorithms, however, remain considerably less recognized than their engineering counterparts. Our goal was to bridge the gap by presenting the first comprehensive comparison of FL frameworks from both engineering and statistical domains. We evaluated five FL frameworks using both simulated and real-world data. The results indicate that statistical FL algorithms yield less biased point estimates for model coefficients and offer convenient confidence interval estimations. In contrast, engineering-based methods tend to generate more accurate predictions, sometimes surpassing central pooled and statistical FL models. This study underscores the relative strengths and weaknesses of both types of methods, emphasizing the need for increased awareness and their integration in future FL applications.

Yilin Ning, Salinelat Teixayavong, Yuqing Shang et al.

The widespread use of ChatGPT and other emerging technology powered by generative artificial intelligence (GenAI) has drawn much attention to potential ethical issues, especially in high-stakes applications such as healthcare, but ethical discussions are yet to translate into operationalisable solutions. Furthermore, ongoing ethical discussions often neglect other types of GenAI that have been used to synthesise data (e.g., images) for research and practical purposes, which resolved some ethical issues and exposed others. We conduct a scoping review of ethical discussions on GenAI in healthcare to comprehensively analyse gaps in the current research, and further propose to reduce the gaps by developing a checklist for comprehensive assessment and transparent documentation of ethical discussions in GenAI research. The checklist can be readily integrated into the current peer review and publication system to enhance GenAI research, and may be used for ethics-related disclosures for GenAI-powered products, healthcare applications of such products and beyond.

Siqi Li, Xin Li, Kunyu Yu et al.

Clinical and biomedical research in low-resource settings often faces significant challenges due to the need for high-quality data with sufficient sample sizes to construct effective models. These constraints hinder robust model training and prompt researchers to seek methods for leveraging existing knowledge from related studies to support new research efforts. Transfer learning (TL), a machine learning technique, emerges as a powerful solution by utilizing knowledge from pre-trained models to enhance the performance of new models, offering promise across various healthcare domains. Despite its conceptual origins in the 1990s, the application of TL in medical research has remained limited, especially beyond image analysis. In our review of TL applications in structured clinical and biomedical data, we screened 3,515 papers, with 55 meeting the inclusion criteria. Among these, only 2% (one out of 55) utilized external studies, and 7% (four out of 55) addressed scenarios involving multi-site collaborations with privacy constraints. To achieve actionable TL with structured medical data while addressing regional disparities, inequality, and privacy constraints in healthcare research, we advocate for the careful identification of appropriate source data and models, the selection of suitable TL frameworks, and the validation of TL models with proper baselines.

Yichao Tang, Mingyang Li, Di Miao et al.

The advancement of artificial intelligence generated content (AIGC) has created a pressing need for robust image watermarking that can withstand both conventional signal processing and novel semantic editing attacks. Current deep learning-based methods rely on training with hand-crafted noise simulation layers, which inherently limit their generalization to unforeseen distortions. In this work, we propose $\textbf{SimuFreeMark}$, a noise-$\underline{\text{simu}}$lation-$\underline{\text{free}}$ water$\underline{\text{mark}}$ing framework that circumvents this limitation by exploiting the inherent stability of image low-frequency components. We first systematically establish that low-frequency components exhibit significant robustness against a wide range of attacks. Building on this foundation, SimuFreeMark embeds watermarks directly into the deep feature space of the low-frequency components, leveraging a pre-trained variational autoencoder (VAE) to bind the watermark with structurally stable image representations. This design completely eliminates the need for noise simulation during training. Extensive experiments demonstrate that SimuFreeMark outperforms state-of-the-art methods across a wide range of conventional and semantic attacks, while maintaining superior visual quality.

Siqi Li, Yuqing Shang, Ziwen Wang et al.

Survival analysis serves as a fundamental component in numerous healthcare applications, where the determination of the time to specific events (such as the onset of a certain disease or death) for patients is crucial for clinical decision-making. Scoring systems are widely used for swift and efficient risk prediction. However, existing methods for constructing survival scores presume that data originates from a single source, posing privacy challenges in collaborations with multiple data owners. We propose a novel framework for building federated scoring systems for multi-site survival outcomes, ensuring both privacy and communication efficiency. We applied our approach to sites with heterogeneous survival data originating from emergency departments in Singapore and the United States. Additionally, we independently developed local scores at each site. In testing datasets from each participant site, our proposed federated scoring system consistently outperformed all local models, evidenced by higher integrated area under the receiver operating characteristic curve (iAUC) values, with a maximum improvement of 11.6%. Additionally, the federated score's time-dependent AUC(t) values showed advantages over local scores, exhibiting narrower confidence intervals (CIs) across most time points. The model developed through our proposed method exhibits effective performance on each local site, signifying noteworthy implications for healthcare research. Sites participating in our proposed federated scoring model training gained benefits by acquiring survival models with enhanced prediction accuracy and efficiency. This study demonstrates the effectiveness of our privacy-preserving federated survival score generation framework and its applicability to real-world heterogeneous survival data.