Steven Mascaro

Steven Mascaro, Owen Woodberry, Charlie McLeod et al.

Loss of lung function in cystic fibrosis (CF) occurs progressively, punctuated by acute pulmonary exacerbations (PEx) in which abrupt declines in lung function are not fully recovered. A key component of CF management over the past half century has been the treatment of PEx to slow lung function decline. This has been credited with improvements in survival for people with CF (PwCF), but there is no consensus on the optimal approach to PEx management. BEAT-CF (Bayesian evidence-adaptive treatment of CF) was established to build an evidence-informed knowledge base for CF management. The BEAT-CF causal model is a directed acyclic graph (DAG) and Bayesian network (BN) for PEx that aims to inform the design and analysis of clinical trials comparing the effectiveness of alternative approaches to PEx management. The causal model describes relationships between background risk factors, treatments, and pathogen colonisation of the airways that affect the outcome of an individual PEx episode. The key factors, outcomes, and causal relationships were elicited from CF clinical experts and together represent current expert understanding of the pathophysiology of a PEx episode, guiding the design of data collection and studies and enabling causal inference. Here, we present the DAG that documents this understanding, along with the processes used in its development, providing transparency around our trial design and study processes, as well as a reusable framework for others.

Steven Mascaro, Owen Woodberry, Yue Wu et al.

The typical phases of Bayesian network (BN) structured development include specification of purpose and scope, structure development, parameterisation and validation. Structure development is typically focused on qualitative issues and parameterisation quantitative issues, however there are qualitative and quantitative issues that arise in both phases. A common step that occurs after the initial structure has been developed is to perform a rough parameterisation that only captures and illustrates the intended qualitative behaviour of the model. This is done prior to a more rigorous parameterisation, ensuring that the structure is fit for purpose, as well as supporting later development and validation. In our collective experience and in discussions with other modellers, this step is an important part of the development process, but is under-reported in the literature. Since the practice focuses on qualitative issues, despite being quantitative in nature, we call this step qualitative parameterisation and provide an outline of its role in the BN development process.

Erik P. Nyberg, Steven Mascaro, Ingrid Zukerman et al.

Bayesian Networks (BNs) are an important tool for assisting probabilistic reasoning, but despite being considered transparent models, people have trouble understanding them. Further, current User Interfaces (UIs) still do not clarify the reasoning of BNs. To address this problem, we have designed verbal and visual extensions to the standard BN UI, which can guide users through common inference patterns. We conducted a user study to compare our verbal, visual and combined UI extensions, and a baseline UI. Our main findings are: (1) users did better with all three types of extensions than with the baseline UI for questions about the impact of an observation, the paths that enable this impact, and the way in which an observation influences the impact of other observations; and (2) using verbal and visual modalities together is better than using either modality alone for some of these question types.

Steven Mascaro, Yue Wu, Ross Pearson et al.

COVID-19 appeared abruptly in early 2020, requiring a rapid response amid a context of great uncertainty. Good quality data and knowledge was initially lacking, and many early models had to be developed with causal assumptions and estimations built in to supplement limited data, often with no reliable approach for identifying, validating and documenting these causal assumptions. Our team embarked on a knowledge engineering process to develop a causal knowledge base consisting of several causal BNs for diverse aspects of COVID-19. The unique challenges of the setting lead to experiments with the elicitation approach, and what emerged was a knowledge engineering method we call Causal Knowledge Engineering (CKE). The CKE provides a structured approach for building a causal knowledge base that can support the development of a variety of application-specific models. Here we describe the CKE method, and use our COVID-19 work as a case study to provide a detailed discussion and analysis of the method.

Xuhui Zhang, Kevin B. Korb, Ann E. Nicholson et al.

The causal discovery of Bayesian networks is an active and important research area, and it is based upon searching the space of causal models for those which can best explain a pattern of probabilistic dependencies shown in the data. However, some of those dependencies are generated by causal structures involving variables which have not been measured, i.e., latent variables. Some such patterns of dependency "reveal" themselves, in that no model based solely upon the observed variables can explain them as well as a model using a latent variable. That is what latent variable discovery is based upon. Here we did a search for finding them systematically, so that they may be applied in latent variable discovery in a more rigorous fashion.