Hewen Pan

Xianlong Wang, Hewen Pan, Hangtao Zhang et al.

Robotic manipulation policies are increasingly empowered by \textit{large language models} (LLMs) and \textit{vision-language models} (VLMs), leveraging their understanding and perception capabilities. Recently, inference-time attacks against robotic manipulation have been extensively studied, yet backdoor attacks targeting model supply chain security in robotic policies remain largely unexplored. To fill this gap, we propose \texttt{TrojanRobot}, a backdoor injection framework for model supply chain attack scenarios, which embeds a malicious module into modular robotic policies via backdoor relationships to manipulate the LLM-to-VLM pathway and compromise the system. Our vanilla design instantiates this module as a backdoor-finetuned VLM. To further enhance attack performance, we propose a prime scheme by introducing the concept of \textit{LVLM-as-a-backdoor}, which leverages \textit{in-context instruction learning} (ICIL) to steer \textit{large vision-language model} (LVLM) behavior through backdoored system prompts. Moreover, we develop three types of prime attacks, \textit{permutation}, \textit{stagnation}, and \textit{intentional}, achieving flexible backdoor attack effects. Extensive physical-world and simulator experiments on 18 real-world manipulation tasks and 4 VLMs verify the superiority of proposed \texttt{TrojanRobot}

Hewen Pan, Cong Wei, Dashuang Liang et al.

With the advancement of multi-modal Large Language Models (LLMs), Video LLMs have been further developed to perform on holistic and specialized video understanding. However, existing works are limited to specialized video understanding tasks, failing to achieve a comprehensive and multi-grained video perception. To bridge this gap, we introduce UFVideo, the first Video LLM with unified multi-grained cooperative understanding capabilities. Specifically, we design unified visual-language guided alignment to flexibly handle video understanding across global, pixel and temporal scales within a single model. UFVideo dynamically encodes the visual and text inputs of different tasks and generates the textual response, temporal localization, or grounded mask. Additionally, to evaluate challenging multi-grained video understanding tasks, we construct the UFVideo-Bench consisting of three distinct collaborative tasks within the scales, which demonstrates UFVideo's flexibility and advantages over GPT-4o. Furthermore, we validate the effectiveness of our model across 9 public benchmarks covering various common video understanding tasks, providing valuable insights for future Video LLMs.

Peijin Guo, Minghui Li, Hewen Pan et al.

While deep learning models play a crucial role in predicting antibody-antigen interactions (AAI), the scarcity of publicly available sequence-structure pairings constrains their generalization. Current AAI methods often focus on residue-level static details, overlooking fine-grained structural representations of antibodies and their inter-antibody similarities. To tackle this challenge, we introduce a multi-modality representation approach that integates 3D structural and 1D sequence data to unravel intricate intra-antibody hierarchical relationships. By harnessing these representations, we present MuLAAIP, an AAI prediction framework that utilizes graph attention networks to illuminate graph-level structural features and normalized adaptive graph convolution networks to capture inter-antibody sequence associations. Furthermore, we have curated an AAI benchmark dataset comprising both structural and sequence information along with interaction labels. Through extensive experiments on this benchmark, our results demonstrate that MuLAAIP outperforms current state-of-the-art methods in terms of predictive performance. The implementation code and dataset are publicly available at https://github.com/trashTian/MuLAAIP for reproducibility.

Xianlong Wang, Hewen Pan, Hangtao Zhang et al.

Robotic manipulation in the physical world is increasingly empowered by \textit{large language models} (LLMs) and \textit{vision-language models} (VLMs), leveraging their understanding and perception capabilities. Recently, various attacks against such robotic policies have been proposed, with backdoor attacks drawing considerable attention for their high stealth and strong persistence capabilities. However, existing backdoor efforts are limited to simulators and suffer from physical-world realization. To address this, we propose \textit{TrojanRobot}, a highly stealthy and broadly effective robotic backdoor attack in the physical world. Specifically, we introduce a module-poisoning approach by embedding a backdoor module into the modular robotic policy, enabling backdoor control over the policy's visual perception module thereby backdooring the entire robotic policy. Our vanilla implementation leverages a backdoor-finetuned VLM to serve as the backdoor module. To enhance its generalization in physical environments, we propose a prime implementation, leveraging the LVLM-as-a-backdoor paradigm and developing three types of prime attacks, \ie, \textit{permutation}, \textit{stagnation}, and \textit{intentional} attacks, thus achieving finer-grained backdoors. Extensive experiments on the UR3e manipulator with 18 task instructions using robotic policies based on four VLMs demonstrate the broad effectiveness and physical-world stealth of TrojanRobot. Our attack's video demonstrations are available via a github link https://trojanrobot.github.io.

Yichen Wang, Hangtao Zhang, Hewen Pan et al.

Vision-Language Models (VLMs), with their strong reasoning and planning capabilities, are widely used in embodied decision-making (EDM) tasks in embodied agents, such as autonomous driving and robotic manipulation. Recent research has increasingly explored adversarial attacks on VLMs to reveal their vulnerabilities. However, these attacks either rely on overly strong assumptions, requiring full knowledge of the victim VLM, which is impractical for attacking VLM-based agents, or exhibit limited effectiveness. The latter stems from disrupting most semantic information in the image, which leads to a misalignment between the perception and the task context defined by system prompts. This inconsistency interrupts the VLM's reasoning process, resulting in invalid outputs that fail to affect interactions in the physical world. To this end, we propose a fine-grained adversarial attack framework, ADVEDM, which modifies the VLM's perception of only a few key objects while preserving the semantics of the remaining regions. This attack effectively reduces conflicts with the task context, making VLMs output valid but incorrect decisions and affecting the actions of agents, thus posing a more substantial safety threat in the physical world. We design two variants of based on this framework, ADVEDM-R and ADVEDM-A, which respectively remove the semantics of a specific object from the image and add the semantics of a new object into the image. The experimental results in both general scenarios and EDM tasks demonstrate fine-grained control and excellent attack performance.

Peijin Guo, Minghui Li, Hewen Pan et al.

Accurate prediction of molecular metabolic stability (MS) is critical for drug research and development but remains challenging due to the complex interplay of molecular interactions. Despite recent advances in graph neural networks (GNNs) for MS prediction, current approaches face two critical limitations: (1) incomplete molecular modeling due to atom-centric message-passing mechanisms that disregard bond-level topological features, and (2) prediction frameworks that lack reliable uncertainty quantification. To address these challenges, we propose TrustworthyMS, a novel contrastive learning framework designed for uncertainty-aware metabolic stability prediction. First, a molecular graph topology remapping mechanism synchronizes atom-bond interactions through edge-induced feature propagation, capturing both localized electronic effects and global conformational constraints. Second, contrastive topology-bond alignment enforces consistency between molecular topology views and bond patterns via feature alignment, enhancing representation robustness. Third, uncertainty modeling through Beta-Binomial uncertainty quantification enables simultaneous prediction and confidence calibration under epistemic uncertainty. Through extensive experiments, our results demonstrate that TrustworthyMS outperforms current state-of-the-art methods in terms of predictive performance.