Jie Zheng

Zonglin Yang, Xinya Du, Junxian Li et al.

Hypothetical induction is recognized as the main reasoning type when scientists make observations about the world and try to propose hypotheses to explain those observations. Past research on hypothetical induction is under a constrained setting: (1) the observation annotations in the dataset are carefully manually handpicked sentences (resulting in a close-domain setting); and (2) the ground truth hypotheses are mostly commonsense knowledge, making the task less challenging. In this work, we tackle these problems by proposing the first dataset for social science academic hypotheses discovery, with the final goal to create systems that automatically generate valid, novel, and helpful scientific hypotheses, given only a pile of raw web corpus. Unlike previous settings, the new dataset requires (1) using open-domain data (raw web corpus) as observations; and (2) proposing hypotheses even new to humanity. A multi-module framework is developed for the task, including three different feedback mechanisms to boost performance, which exhibits superior performance in terms of both GPT-4 based and expert-based evaluation. To the best of our knowledge, this is the first work showing that LLMs are able to generate novel (''not existing in literature'') and valid (''reflecting reality'') scientific hypotheses.

Hasin Rehana, Nur Bengisu Çam, Mert Basmaci et al.

Detecting protein-protein interactions (PPIs) is crucial for understanding genetic mechanisms, disease pathogenesis, and drug design. However, with the fast-paced growth of biomedical literature, there is a growing need for automated and accurate extraction of PPIs to facilitate scientific knowledge discovery. Pre-trained language models, such as generative pre-trained transformers (GPT) and bidirectional encoder representations from transformers (BERT), have shown promising results in natural language processing (NLP) tasks. We evaluated the performance of PPI identification of multiple GPT and BERT models using three manually curated gold-standard corpora: Learning Language in Logic (LLL) with 164 PPIs in 77 sentences, Human Protein Reference Database with 163 PPIs in 145 sentences, and Interaction Extraction Performance Assessment with 335 PPIs in 486 sentences. BERT-based models achieved the best overall performance, with BioBERT achieving the highest recall (91.95%) and F1-score (86.84%) and PubMedBERT achieving the highest precision (85.25%). Interestingly, despite not being explicitly trained for biomedical texts, GPT-4 achieved commendable performance, comparable to the top-performing BERT models. It achieved a precision of 88.37%, a recall of 85.14%, and an F1-score of 86.49% on the LLL dataset. These results suggest that GPT models can effectively detect PPIs from text data, offering promising avenues for application in biomedical literature mining. Further research could explore how these models might be fine-tuned for even more specialized tasks within the biomedical domain.

Xiangyue Wang, Hanxuan Chen, Songsheng Cheng et al.

Recent aerial vision-language navigation (VLN) datasets have grown rapidly, but they primarily address goal-oriented navigation to static destinations, leaving UAV visual tracking -- continuously following a moving target while maintaining visibility -- largely without dedicated training data. We introduce CosFlyTrack, a large-scale multi-modal dataset and scalable generation pipeline for UAV visual tracking in urban environments. The dataset provides approximately 12,000 expert and perturbed UAV trajectories generated from 6,000 pedestrian paths, comprising 2.4 million timesteps (approximately 334 hours) with seven aligned data channels: RGB, metric depth, semantic segmentation, six-degree-of-freedom drone pose, target state with visibility flag, bilingual (Chinese-English) instructions, and trajectory-pair metadata. To generate high-quality expert trajectories, we develop MuCO, a multi-constraint optimizer that plans directly in continuous three-dimensional space with BVH-accelerated collision and visibility queries, jointly enforcing target visibility, viewpoint quality, collision avoidance, smoothness, and kinematic feasibility, avoiding the discretization artifacts and post-hoc smoothing of grid-based planners. Fine-tuning experiments on seven vision-language models show that CosFlyTrack improves tracking performance to 78.3 to 95.6 percent SR@1 meter, a 53 to 69 percentage point gain over zero-shot baselines, supporting the dataset as a training resource for dynamic target-following agents. The dataset is publicly available at https://huggingface.co/datasets/AutelRobotics/CosFly; evaluation scripts and pre-trained checkpoints are hosted at https://huggingface.co/AutelRobotics/CosFly-Track.

Jie Zheng, Ruichen Zhang, Dusit Niyato et al.

Enhancing future wireless networks presents a significant challenge for networking systems due to diverse user demands and the emergence of 6G technology. While reinforcement learning (RL) is a powerful framework, it often encounters difficulties with high-dimensional state spaces and complex environments, leading to substantial computational demands, distributed intelligence, and potentially inconsistent outcomes. Large language models (LLMs), with their extensive pretrained knowledge and advanced reasoning capabilities, offer promising tools to enhance RL in optimizing 6G wireless networks. We explore RL models augmented by LLMs, emphasizing their roles and the potential benefits of their synergy in wireless network optimization. We then examine LLM-enabled RL across various protocol layers: physical, data link, network, transport, and application layers. Additionally, we propose an LLM-assisted state representation and semantic extraction to enhance the multi-agent reinforcement learning (MARL) framework. This approach is applied to service migration and request routing, as well as topology graph generation in unmanned aerial vehicle (UAV)-satellite networks. Through case studies, we demonstrate that our framework effectively performs optimization of wireless network. Finally, we outline prospective research directions for LLM-enabled RL in wireless network optimization.

Qingpeng Cai, Ruohan Zhan, Chi Zhang et al.

The wide popularity of short videos on social media poses new opportunities and challenges to optimize recommender systems on the video-sharing platforms. Users provide complex and multi-faceted responses towards recommendations, including watch time and various types of interactions with videos. As a result, established recommendation algorithms that concern a single objective are not adequate to meet this new demand of optimizing comprehensive user experiences. In this paper, we formulate the problem of short video recommendation as a constrained Markov Decision Process (MDP), where platforms want to optimize the main goal of user watch time in long term, with the constraint of accommodating the auxiliary responses of user interactions such as sharing/downloading videos. To solve the constrained MDP, we propose a two-stage reinforcement learning approach based on actor-critic framework. At stage one, we learn individual policies to optimize each auxiliary response. At stage two, we learn a policy to (i) optimize the main response and (ii) stay close to policies learned at the first stage, which effectively guarantees the performance of this main policy on the auxiliaries. Through extensive simulations, we demonstrate effectiveness of our approach over alternatives in both optimizing the main goal as well as balancing the others. We further show the advantage of our approach in live experiments of short video recommendations, where it significantly outperforms other baselines in terms of watch time and interactions from video views. Our approach has been fully launched in the production system to optimize user experiences on the platform.

Zehua Zhao, Zhixian Huang, Junren Li et al.

Current benchmarks for evaluating the chemical reasoning capabilities of Large Language Models (LLMs) are limited by oversimplified tasks, lack of process-level evaluation, and misalignment with expert-level chemistry skills. To address these issues, we introduce SUPERChem, a benchmark of 500 expert-curated reasoning-intensive chemistry problems, covering diverse subfields and provided in both multimodal and text-only formats. Original content and an iterative curation pipeline eliminate flawed items and mitigate data contamination. Each problem is paired with an expert-authored solution path, enabling Reasoning Path Fidelity (RPF) scoring to evaluate reasoning quality beyond final-answer accuracy. Evaluations against a human baseline of 40.3% accuracy show that even the best-performing model, GPT-5 (High), reaches only 38.5%, followed closely by Gemini 2.5 Pro (37.9%) and DeepSeek-V3.1-Think (37.3%). SUPERChem elicits multi-step, multimodal reasoning, reveals model-dependent effects of visual information, and distinguishes high-fidelity reasoners from heuristic ones. By providing a challenging benchmark and a reliable evaluation framework, SUPERChem aims to facilitate the advancement of LLMs toward expert-level chemical intelligence. The dataset of the benchmark is available at https://huggingface.co/datasets/ZehuaZhao/SUPERChem.

Yijiong Yu, Shuai Yuan, Jie Zheng et al.

Soft context compression reduces the computational workload of processing long contexts in LLMs by encoding long context into a smaller number of latent tokens. However, existing frameworks apply uniform compression ratios, failing to account for the extreme variance in natural language information density. While adopting a density-aware dynamic compression ratio seems intuitive, empirical investigations reveal that models struggle intrinsically with operations parameterized by input dependent, continuous structural hyperparameters. To resolve this pitfall, we introduce Semi-Dynamic Context Compression framework. Our approach features a Discrete Ratio Selector, which predicts a compression target based on intrinsic information density and quantizes it to a predefined set of discrete compression ratios. It is efficiently jointly trained with the compressor on synthetic data, with the summary lengths as a proxy to create labels for compression ratio prediction. Extensive evaluations confirm that our density-aware framework, utilizing mean pooling as the backbone, consistently outperforms static baselines, establishing a robust Pareto frontier for context compression techniques. Our code, data and model weights are available at https://github.com/yuyijiong/semi-dynamic-context-compress

Xinnan Dai, Caihua Shan, Jie Zheng et al.

Genes are fundamental for analyzing biological systems and many recent works proposed to utilize gene expression for various biological tasks by deep learning models. Despite their promising performance, it is hard for deep neural networks to provide biological insights for humans due to their black-box nature. Recently, some works integrated biological knowledge with neural networks to improve the transparency and performance of their models. However, these methods can only incorporate partial biological knowledge, leading to suboptimal performance. In this paper, we propose the Biological Factor Regulatory Neural Network (BFReg-NN), a generic framework to model relations among biological factors in cell systems. BFReg-NN starts from gene expression data and is capable of merging most existing biological knowledge into the model, including the regulatory relations among genes or proteins (e.g., gene regulatory networks (GRN), protein-protein interaction networks (PPI)) and the hierarchical relations among genes, proteins and pathways (e.g., several genes/proteins are contained in a pathway). Moreover, BFReg-NN also has the ability to provide new biologically meaningful insights because of its white-box characteristics. Experimental results on different gene expression-based tasks verify the superiority of BFReg-NN compared with baselines. Our case studies also show that the key insights found by BFReg-NN are consistent with the biological literature.

Hanxuan Chen, Jie Zheng, Siqi Yang et al.

Vision-and-Language Navigation for Unmanned Aerial Vehicles (UAV-VLN) represents a pivotal challenge in embodied artificial intelligence, focused on enabling UAVs to interpret high-level human commands and execute long-horizon tasks in complex 3D environments. This paper provides a comprehensive and structured survey of the field, from its formal task definition to the current state of the art. We establish a methodological taxonomy that charts the technological evolution from early modular and deep learning approaches to contemporary agentic systems driven by large foundation models, including Vision-Language Models (VLMs), Vision-Language-Action (VLA) models, and the emerging integration of generative world models with VLA architectures for physically-grounded reasoning. The survey systematically reviews the ecosystem of essential resources simulators, datasets, and evaluation metrics that facilitates standardized research. Furthermore, we conduct a critical analysis of the primary challenges impeding real-world deployment: the simulation-to-reality gap, robust perception in dynamic outdoor settings, reasoning with linguistic ambiguity, and the efficient deployment of large models on resource-constrained hardware. By synthesizing current benchmarks and limitations, this survey concludes by proposing a forward-looking research roadmap to guide future inquiry into key frontiers such as multi-agent swarm coordination and air-ground collaborative robotics.

Hanxuan Chen, Xiangyue Wang, Songsheng Cheng et al.

We present CosFly, a box-structured planning and multimodal simulation pipeline for aerial tracking, together with CosFly-Track, a large-scale UAV dataset for dynamic target tracking across diverse environments including urban centers, highways, rural landscapes, forests, and coastal towns. In our current implementation on CARLA, CosFly provides a modular 7-step construction pipeline that converts complex 3D worlds into structured obstacle representations for planning, then projects the resulting trajectories back into multi-modal sensor data -- including RGB images, high-precision depth maps, and semantic segmentation masks -- paired with natural language navigation instructions. A key feature is the support for configurable fixed-FOV zoom levels (one FOV setting drawn per trajectory and held constant throughout), enabling simulation of various focal lengths through camera-intrinsic adjustments. The pipeline covers the complete workflow from 3D map export through grid simplification, pedestrian and drone trajectory planning, multi-modal rendering with 6-DOF pose annotations, quality inspection, and teacher-student caption generation. We analyze two trajectory-planning paradigms for aerial target tracking: a conventional two-stage pipeline with front-end candidate generation and backend refinement, and a direct gradient-based formulation that optimizes multiple tracking constraints in a single objective. The public CosFly-Track release contains 250 validated trajectories and approximately 100,000 rendered images with complete 6-DOF drone pose annotations (position x, y, z and orientation yaw, pitch, roll). Together, the pipeline and dataset establish a scalable foundation for aerial-ground collaborative research, supporting dynamic target tracking, UAV navigation, and multi-modal perception across diverse environments.

Jianan Xie, Ji Liu, Chi Zhang et al.

Serial femtosecond crystallography at X-ray free electron laser facilities opens a new era for the determination of crystal structure. However, the data processing of those experiments is facing unprecedented challenge, because the total number of diffraction patterns needed to determinate a high-resolution structure is huge. Machine learning methods are very likely to play important roles in dealing with such a large volume of data. Convolutional neural networks have made a great success in the field of pattern classification, however, training of the networks need very large datasets with labels. Th is heavy dependence on labeled datasets will seriously restrict the application of networks, because it is very costly to annotate a large number of diffraction patterns. In this article we present our job on the classification of diffraction pattern by weakly supervised algorithms, with the aim of reducing as much as possible the size of the labeled dataset required for training. Our result shows that weakly supervised methods can significantly reduce the need for the number of labeled patterns while achieving comparable accuracy to fully supervised methods.

Jie Zheng, Ru Wen, Haiqin Hu et al.

Existing Masked Image Modeling (MIM) depends on a spatial patch-based masking-reconstruction strategy to perceive objects'features from unlabeled images, which may face two limitations when applied to chest CT: 1) inefficient feature learning due to complex anatomical details presented in CT images, and 2) suboptimal knowledge transfer owing to input disparity between upstream and downstream models. To address these issues, we propose a new MIM method named Tissue-Contrastive Semi-Masked Autoencoder (TCS-MAE) for modeling chest CT images. Our method has two novel designs: 1) a tissue-based masking-reconstruction strategy to capture more fine-grained anatomical features, and 2) a dual-AE architecture with contrastive learning between the masked and original image views to bridge the gap of the upstream and downstream models. To validate our method, we systematically investigate representative contrastive, generative, and hybrid self-supervised learning methods on top of tasks involving segmenting pneumonia, mediastinal tumors, and various organs. The results demonstrate that, compared to existing methods, our TCS-MAE more effectively learns tissue-aware representations, thereby significantly enhancing segmentation performance across all tasks.

Yang Yang, Xijie Xu, Yixun Zhou et al.

Cell instance segmentation is a fundamental task in digital pathology with broad clinical applications. Recently, vision foundation models, which are predominantly based on Vision Transformers (ViTs), have achieved remarkable success in pathology image analysis. However, their improvements in cell instance segmentation remain limited. A key challenge arises from the tokenization process in ViTs, which substantially reduces the spatial resolution of input images, leading to suboptimal segmentation quality, especially for small and densely packed cells. To address this problem, we propose CellVTA (Cell Vision Transformer with Adapter), a novel method that improves the performance of vision foundation models for cell instance segmentation by incorporating a CNN-based adapter module. This adapter extracts high-resolution spatial information from input images and injects it into the ViT through a cross-attention mechanism. Our method preserves the core architecture of ViT, ensuring seamless integration with pretrained foundation models. Extensive experiments show that CellVTA achieves 0.538 mPQ on the CoNIC dataset and 0.506 mPQ on the PanNuke dataset, which significantly outperforms the state-of-the-art cell segmentation methods. Ablation studies confirm the superiority of our approach over other fine-tuning strategies, including decoder-only fine-tuning and full fine-tuning. Our code and models are publicly available at https://github.com/JieZheng-ShanghaiTech/CellVTA.

Rui Cao, Yihao Wang, Yuxin Liang et al.

Contrastive learning is emerging as a powerful technique for extracting knowledge from unlabeled data. This technique requires a balanced mixture of two ingredients: positive (similar) and negative (dissimilar) samples. This is typically achieved by maintaining a queue of negative samples during training. Prior works in the area typically uses a fixed-length negative sample queue, but how the negative sample size affects the model performance remains unclear. The opaque impact of the number of negative samples on performance when employing contrastive learning aroused our in-depth exploration. This paper presents a momentum contrastive learning model with negative sample queue for sentence embedding, namely MoCoSE. We add the prediction layer to the online branch to make the model asymmetric and together with EMA update mechanism of the target branch to prevent the model from collapsing. We define a maximum traceable distance metric, through which we learn to what extent the text contrastive learning benefits from the historical information of negative samples. Our experiments find that the best results are obtained when the maximum traceable distance is at a certain range, demonstrating that there is an optimal range of historical information for a negative sample queue. We evaluate the proposed unsupervised MoCoSE on the semantic text similarity (STS) task and obtain an average Spearman's correlation of $77.27\%$. Source code is available at https://github.com/xbdxwyh/mocose.

Jie Zheng, Dusit Niyato, Changyuan Zhao et al.

The rapid evolution toward 6G and beyond communication systems is accelerating the convergence of digital twins and world models at the network edge. Traditional digital twins provide high-fidelity representations of physical systems and support monitoring, analysis, and offline optimization. However, in highly dynamic edge environments, they face limitations in autonomy, adaptability, and scalability. This paper presents a systematic survey of the transition from digital twins to world models and discusses its role in enabling edge general intelligence (EGI). First, the paper clarifies the conceptual differences between digital twins and world models and highlights the shift from physics-based, centralized, and system-centric replicas to data-driven, decentralized, and agent-centric internal models. This discussion helps readers gain a clear understanding of how this transition enables more adaptive, autonomous, and resource-efficient intelligence at the network edge. The paper reviews the design principles, architectures, and key components of world models, including perception, latent state representation, dynamics learning, imagination-based planning, and memory. In addition, it examines the integration of world models and digital twins in wireless EGI systems and surveys emerging applications in integrated sensing and communications, semantic communication, air-ground networks, and low-altitude wireless networks. Finally, this survey provides a systematic roadmap and practical insights for designing world-model-driven edge intelligence systems in wireless and edge computing environments. It also outlines key research challenges and future directions toward scalable, reliable, and interoperable world models for edge-native agentic AI.

Jieming Di, Xiaoyu Chen, Ying She et al.

Large-scale ranking systems depend on thousands of features derived from user behavior across multiple time horizons. Typically requires model retraining -- resulting in long iteration cycles (3--6 months), substantial GPU resource consumption, and limited rollout throughput. We introduce Intelligent Elastic Feature Fading (IEFF), a production infrastructure system that enables retrain-free feature efficiency rollouts by elastically controlling feature coverage and distribution at serving time. IEFF supports incremental feature coverage adjustments while models adapt through recurring training, eliminating dependencies on explicit retraining cycles. The system incorporates strict safety guardrails, reversibility mechanisms, and comprehensive monitoring to ensure stability at scale. Across multiple production use cases, IEFF accelerates efficiency-related rollouts by 5$\times$, eliminates retraining-related GPU overhead, and enables faster capacity recycling. Extensive offline and online experiments demonstrate that gradual feature fading prevents 50--55\% of online performance degradation compared to abrupt feature removal, while maintaining stable model behavior. These results establish elastic, system-level feature fading as a practical and scalable approach for managing feature efficiency in modern industrial ranking systems.

Yufei Yin, Jie Zheng, Qianke Meng et al.

Zero-shot 3D Visual Grounding (3DVG) is a critical capability for open-world embodied AI. However, existing methods are fundamentally bottlenecked by the poor quality of open-vocabulary 3D proposals, suffering from inaccurate categories and imprecise geometries, as well as the spatial redundancy of exhaustive multi-view reasoning. To address these challenges, we propose MCM-VG, a novel framework that achieves robust zero-shot 3DVG by explicitly establishing Multiple Consistent 2D-3D Mappings. Instead of passively relying on noisy 3D segments, MCM-VG enforces 2D-3D consistency across three fundamental dimensions to achieve precise target localization and reliable reasoning. First, a Semantic Alignment module corrects category mismatches via LLM-driven query parsing and coarse-to-fine 2D-3D matching. Second, an Instance Rectification module leverages VLM-guided 2D segmentations to reconstruct missing targets, back-projecting these reliable visual priors to establish accurate 3D geometries. Finally, to eliminate spatial redundancy, a Viewpoint Distillation module clusters 3D camera directions to extract optimal frames. By pairing these optimal RGB frames with Bird's Eye View maps into concise visual prompt sets, we formulate the final target disambiguation as a multiple-choice reasoning task for Vision-Language Models. Extensive evaluations on ScanRefer and Nr3D benchmarks demonstrate that MCM-VG sets a new state-of-the-art for zero-shot 3D visual grounding. Remarkably, it achieves 62.0\% and 53.6\% in Acc@0.25 and Acc@0.5 on ScanRefer, outperforming previous baselines by substantial margins of 6.4\% and 4.0\%.

Mingfu Liang, Xi Liu, Rong Jin et al.

Ads recommendation is a prominent service of online advertising systems and has been actively studied. Recent studies indicate that scaling-up and advanced design of the recommendation model can bring significant performance improvement. However, with a larger model scale, such prior studies have a significantly increasing gap from industry as they often neglect two fundamental challenges in industrial-scale applications. First, training and inference budgets are restricted for the model to be served, exceeding which may incur latency and impair user experience. Second, large-volume data arrive in a streaming mode with data distributions dynamically shifting, as new users/ads join and existing users/ads leave the system. We propose the External Large Foundation Model (ExFM) framework to address the overlooked challenges. Specifically, we develop external distillation and a data augmentation system (DAS) to control the computational cost of training/inference while maintaining high performance. We design the teacher in a way like a foundation model (FM) that can serve multiple students as vertical models (VMs) to amortize its building cost. We propose Auxiliary Head and Student Adapter to mitigate the data distribution gap between FM and VMs caused by the streaming data issue. Comprehensive experiments on internal industrial-scale applications and public datasets demonstrate significant performance gain by ExFM.

Huan Cai, Ziqing Lu, Catherine Xu et al.

With recent development of artificial intelligence, it is more common to adopt AI agents in economic activities. This paper explores the economic actions of agents, including human agents and AI agents, in an economic game of trading products/services, and the equilibria in this economy involving multiple agents. We derive a range of equilibrium results and their corresponding conditions using a Markov chain stationary distribution based model. One distinct feature of our model is that we consider the long-term utility generated by economic activities instead of their short-term benefits. For the model consisting of two agents, we fully characterize all the possible economic equilibria and conditions. Interestingly, we show that unless each agent can at least double (not merely increase) its marginal utility by purchasing the other agent's products/services, purchasing the other agent's products/services will not happen in any economic equilibrium. We further extend our results to three and more agents, where we characterize more economic equilibria. We find that in some equilibria, the ``more powerful'' AI agents contribute zero utility to ``less capable'' agents.

Xiaohan Chen, Hongrui Gu, Cunshi Wang et al.

With the rapid increase in the number of artificial satellites, astronomical imaging is experiencing growing interference. When these satellites reflect sunlight, they produce streak-like artifacts in photometry images. Such satellite trails can introduce false sources and cause significant photometric errors. As a result, accurately identifying the positions of satellite trails in observational data has become essential. In this work, we propose a satellite trail detection model that combines the U-Net deep neural network for image segmentation with the Line Segment Detector (LSD) algorithm. The model is trained on 375 simulated images of satellite trails, generated using data from the Mini-SiTian Array. Experimental results show that for trails with a signal-to-noise ratio (SNR) greater than 3, the detection rate exceeds 99. Additionally, when applied to real observational data from the Mini-SiTian Array, the model achieves a recall of 79.57 and a precision of 74.56.

Xuexin Chen, Ruichu Cai, Zhengting Huang et al.

Synthetic lethality (SL) is a promising gene interaction for cancer therapy. Recent SL prediction methods integrate knowledge graphs (KGs) into graph neural networks (GNNs) and employ attention mechanisms to extract local subgraphs as explanations for target gene pairs. However, attention mechanisms often lack fidelity, typically generate a single explanation per gene pair, and fail to ensure trustworthy high-order structures in their explanations. To overcome these limitations, we propose Diverse Graph Information Bottleneck for Synthetic Lethality (DGIB4SL), a KG-based GNN that generates multiple faithful explanations for the same gene pair and effectively encodes high-order structures. Specifically, we introduce a novel DGIB objective, integrating a Determinant Point Process (DPP) constraint into the standard IB objective, and employ 13 motif-based adjacency matrices to capture high-order structures in gene representations. Experimental results show that DGIB4SL outperforms state-of-the-art baselines and provides multiple explanations for SL prediction, revealing diverse biological mechanisms underlying SL inference.

Hasin Rehana, Jie Zheng, Leo Yeh et al.

Motivation: An adjuvant is a chemical incorporated into vaccines that enhances their efficacy by improving the immune response. Identifying adjuvant names from cancer vaccine studies is essential for furthering research and enhancing immunotherapies. However, the manual curation from the constantly expanding biomedical literature poses significant challenges. This study explores the automated recognition of vaccine adjuvant names using Large Language Models (LLMs), specifically Generative Pretrained Transformers (GPT) and Large Language Model Meta AI (Llama). Methods: We utilized two datasets: 97 clinical trial records from AdjuvareDB and 290 abstracts annotated with the Vaccine Adjuvant Compendium (VAC). GPT-4o and Llama 3.2 were employed in zero-shot and few-shot learning paradigms with up to four examples per prompt. Prompts explicitly targeted adjuvant names, testing the impact of contextual information such as substances or interventions. Outputs underwent automated and manual validation for accuracy and consistency. Results: GPT-4o attained 100% Precision across all situations while exhibiting notable improve in Recall and F1-scores, particularly with incorporating interventions. On the VAC dataset, GPT-4o achieved a maximum F1-score of 77.32% with interventions, surpassing Llama-3.2-3B by approximately 2%. On the AdjuvareDB dataset, GPT-4o reached an F1-score of 81.67% for three-shot prompting with interventions, surpassing Llama-3.2-3 B's maximum F1-score of 65.62%. Conclusion: Our findings demonstrate that LLMs excel at identifying adjuvant names, including rare variations of naming representation. This study emphasizes the capability of LLMs to enhance cancer vaccine development by efficiently extracting insights. Future work aims to broaden the framework to encompass various biomedical literature and enhance model generalizability across various vaccines and adjuvants.

Cunshi Wang, Yu Zhang, Yuyang Li et al.

The exponential growth of large-scale telescope arrays has boosted time-domain astronomy development but introduced operational bottlenecks, including labor-intensive observation planning, data processing, and real-time decision-making. Here we present the StarWhisper Telescope system, an AI agent framework automating end-to-end astronomical observations for surveys like the Nearby Galaxy Supernovae Survey. By integrating large language models with specialized function calls and modular workflows, StarWhisper Telescope autonomously generates site-specific observation lists, executes real-time image analysis via pipelines, and dynamically triggers follow-up proposals upon transient detection. The system reduces human intervention through automated observation planning, telescope controlling and data processing, while enabling seamless collaboration between amateur and professional astronomers. Deployed across Nearby Galaxy Supernovae Survey's network of 10 amateur telescopes, the StarWhisper Telescope has detected transients with promising response times relative to existing surveys. Furthermore, StarWhisper Telescope's scalable agent architecture provides a blueprint for future facilities like the Global Open Transient Telescope Array, where AI-driven autonomy will be critical for managing 60 telescopes.

John Beverley, Robin McGill, Sam Smith et al.

The term credential encompasses educational certificates, degrees, certifications, and government-issued licenses. An occupational credential is a verification of an individuals qualification or competence issued by a third party with relevant authority. Job seekers often leverage such credentials as evidence that desired qualifications are satisfied by their holders. Many U.S. education and workforce development organizations have recognized the importance of credentials for employment and the challenges of understanding the value of credentials. In this study, we identified and ontologically defined credential and credential-related terms at the textual and semantic levels based on the Occupation Ontology (OccO), a BFO-based ontology. Different credential types and their authorization logic are modeled. We additionally defined a high-level hierarchy of credential related terms and relations among many terms, which were initiated in concert with the Alabama Talent Triad (ATT) program, which aims to connect learners, earners, employers and education/training providers through credentials and skills. To our knowledge, our research provides for the first time systematic ontological modeling of the important domain of credentials and related contents, supporting enhanced credential data and knowledge integration in the future.

Yihao Wang, Ling Gao, Jie Ren et al.

Object Detection on the mobile system is a challenge in terms of everything. Nowadays, many object detection models have been designed, and most of them concentrate on precision. However, the computation burden of those models on mobile systems is unacceptable. Researchers have designed some lightweight networks for mobiles by sacrificing precision. We present a novel edge-based task scheduling framework for object detection (termed as ESOD). In detail, we train a DNN model (termed as pre-model) to predict which object detection model to use for the coming task and offloads to which edge servers by physical characteristics of the image task (e.g., brightness, saturation). The results show that ESOD can reduce latency and energy consumption by an average of 22.13% and 29.60% and improve the mAP to 45.8(with 0.9 mAP better), respectively, compared with the SOTA DETR model.

Weicong Ding, Hanlin Tang, Jingshuo Feng et al.

Real-world recommendation systems often consist of two phases. In the first phase, multiple predictive models produce the probability of different immediate user actions. In the second phase, these predictions are aggregated according to a set of 'strategic parameters' to meet a diverse set of business goals, such as longer user engagement, higher revenue potential, or more community/network interactions. In addition to building accurate predictive models, it is also crucial to optimize this set of 'strategic parameters' so that primary goals are optimized while secondary guardrails are not hurt. In this setting with multiple and constrained goals, this paper discovers that a probabilistic strategic parameter regime can achieve better value compared to the standard regime of finding a single deterministic parameter. The new probabilistic regime is to learn the best distribution over strategic parameter choices and sample one strategic parameter from the distribution when each user visits the platform. To pursue the optimal probabilistic solution, we formulate the problem into a stochastic compositional optimization problem, in which the unbiased stochastic gradient is unavailable. Our approach is applied in a popular social network platform with hundreds of millions of daily users and achieves +0.22% lift of user engagement in a recommendation task and +1.7% lift in revenue in an advertising optimization scenario comparing to using the best deterministic parameter strategy.

Yuxin Liang, Rui Cao, Jie Zheng et al.

Pre-trained language models such as BERT have become a more common choice of natural language processing (NLP) tasks. Research in word representation shows that isotropic embeddings can significantly improve performance on downstream tasks. However, we measure and analyze the geometry of pre-trained BERT embedding and find that it is far from isotropic. We find that the word vectors are not centered around the origin, and the average cosine similarity between two random words is much higher than zero, which indicates that the word vectors are distributed in a narrow cone and deteriorate the representation capacity of word embedding. We propose a simple, and yet effective method to fix this problem: remove several dominant directions of BERT embedding with a set of learnable weights. We train the weights on word similarity tasks and show that processed embedding is more isotropic. Our method is evaluated on three standardized tasks: word similarity, word analogy, and semantic textual similarity. In all tasks, the word embedding processed by our method consistently outperforms the original embedding (with average improvement of 13% on word analogy and 16% on semantic textual similarity) and two baseline methods. Our method is also proven to be more robust to changes of hyperparameter.

Jie Ren, Lu Yuan, Petteri Nurmi et al.

Web technology underpins many interactive mobile applications. However, energy-efficient mobile web interactions is an outstanding challenge. Given the increasing diversity and complexity of mobile hardware, any practical optimization scheme must work for a wide range of users, mobile platforms and web workloads. This paper presents CAMEL , a novel energy optimization system for mobile web interactions. CAMEL leverages machine learning techniques to develop a smart, adaptive scheme to judiciously trade performance for reduced power consumption. Unlike prior work, C AMEL directly models how a given web content affects the user expectation and uses this to guide energy optimization. It goes further by employing transfer learning and conformal predictions to tune a previously learned model in the end-user environment and improve it over time. We apply CAMEL to Chromium and evaluate it on four distinct mobile systems involving 1,000 testing webpages and 30 users. Compared to four state-of-the-art web-event optimizers, CAMEL delivers 22% more energy savings, but with 49% fewer violations on the quality of user experience, and exhibits orders of magnitudes less overhead when targeting a new computing environment.

Qing Qin, Jie Ren, Jialong Yu et al.

The recent advances in deep neural networks (DNNs) make them attractive for embedded systems. However, it can take a long time for DNNs to make an inference on resource-constrained computing devices. Model compression techniques can address the computation issue of deep inference on embedded devices. This technique is highly attractive, as it does not rely on specialized hardware, or computation-offloading that is often infeasible due to privacy concerns or high latency. However, it remains unclear how model compression techniques perform across a wide range of DNNs. To design efficient embedded deep learning solutions, we need to understand their behaviors. This work develops a quantitative approach to characterize model compression techniques on a representative embedded deep learning architecture, the NVIDIA Jetson Tx2. We perform extensive experiments by considering 11 influential neural network architectures from the image classification and the natural language processing domains. We experimentally show that how two mainstream compression techniques, data quantization and pruning, perform on these network architectures and the implications of compression techniques to the model storage size, inference time, energy consumption and performance metrics. We demonstrate that there are opportunities to achieve fast deep inference on embedded systems, but one must carefully choose the compression settings. Our results provide insights on when and how to apply model compression techniques and guidelines for designing efficient embedded deep learning systems.

Yong Liu, Min Wu, Chenghao Liu et al.

Synthetic lethality (SL) is a promising concept for novel discovery of anti-cancer drug targets. However, wet-lab experiments for detecting SLs are faced with various challenges, such as high cost, low consistency across platforms or cell lines. Therefore, computational prediction methods are needed to address these issues. This paper proposes a novel SL prediction method, named SL2MF, which employs logistic matrix factorization to learn latent representations of genes from the observed SL data. The probability that two genes are likely to form SL is modeled by the linear combination of gene latent vectors. As known SL pairs are more trustworthy than unknown pairs, we design importance weighting schemes to assign higher importance weights for known SL pairs and lower importance weights for unknown pairs in SL2MF. Moreover, we also incorporate biological knowledge about genes from protein-protein interaction (PPI) data and Gene Ontology (GO). In particular, we calculate the similarity between genes based on their GO annotations and topological properties in the PPI network. Extensive experiments on the SL interaction data from SynLethDB database have been conducted to demonstrate the effectiveness of SL2MF.

Shenghua He, Jie Zheng, Akiko Maehara et al.

Optical coherence tomography (OCT) can provide high-resolution cross-sectional images for analyzing superficial plaques in coronary arteries. Commonly, plaque characterization using intra-coronary OCT images is performed manually by expert observers. This manual analysis is time consuming and its accuracy heavily relies on the experience of human observers. Traditional machine learning based methods, such as the least squares support vector machine and random forest methods, have been recently employed to automatically characterize plaque regions in OCT images. Several processing steps, including feature extraction, informative feature selection, and final pixel classification, are commonly used in these traditional methods. Therefore, the final classification accuracy can be jeopardized by error or inaccuracy within each of these steps. In this study, we proposed a convolutional neural network (CNN) based method to automatically characterize plaques in OCT images. Unlike traditional methods, our method uses the image as a direct input and performs classification as a single-step process. The experiments on 269 OCT images showed that the average prediction accuracy of CNN-based method was 0.866, which indicated a great promise for clinical translation.