Yuxiao Yi

Yuxiao Yi, Qingyao Zhuang, Zhi-Qin John Xu et al.

Pediatric brain tumor segmentation presents unique challenges due to the rarity and heterogeneity of these malignancies, yet remains critical for clinical diagnosis and treatment planning. We propose an ensemble approach integrating nnU-Net, Swin UNETR, and HFF-Net for the BraTS-PED 2025 challenge. Our method incorporates three key extensions: adjustable initialization scales for optimal nnU-Net complexity control, transfer learning from BraTS 2021 pre-trained models to enhance Swin UNETR's generalization on pediatric dataset, and frequency domain decomposition for HFF-Net to separate low-frequency tissue contours from high-frequency texture details. Our final ensemble framework combines nnU-Net ($γ=0.7$), fine-tuned Swin UNETR, and HFF-Net, achieving Dice scores of 62.7% (CC), 83.2% (ED), 72.9% (ET), 85.7% (NET), 91.8% (TC), and 92.6% (WT) on the unseen test dataset, respectively. Our proposed method achieves first place (rank 1st) in the BraTS 2025 Pediatric Brain Tumor Segmentation Challenge.

Tianhan Zhang, Yuxiao Yi, Yifan Xu et al.

Machine learning has long been considered as a black box for predicting combustion chemical kinetics due to the extremely large number of parameters and the lack of evaluation standards and reproducibility. The current work aims to understand two basic questions regarding the deep neural network (DNN) method: what data the DNN needs and how general the DNN method can be. Sampling and preprocessing determine the DNN training dataset, further affect DNN prediction ability. The current work proposes using Box-Cox transformation (BCT) to preprocess the combustion data. In addition, this work compares different sampling methods with or without preprocessing, including the Monte Carlo method, manifold sampling, generative neural network method (cycle-GAN), and newly-proposed multi-scale sampling. Our results reveal that the DNN trained by the manifold data can capture the chemical kinetics in limited configurations but cannot remain robust toward perturbation, which is inevitable for the DNN coupled with the flow field. The Monte Carlo and cycle-GAN samplings can cover a wider phase space but fail to capture small-scale intermediate species, producing poor prediction results. A three-hidden-layer DNN, based on the multi-scale method without specific flame simulation data, allows predicting chemical kinetics in various scenarios and being stable during the temporal evolutions. This single DNN is readily implemented with several CFD codes and validated in various combustors, including (1). zero-dimensional autoignition, (2). one-dimensional freely propagating flame, (3). two-dimensional jet flame with triple-flame structure, and (4). three-dimensional turbulent lifted flames. The results demonstrate the satisfying accuracy and generalization ability of the pre-trained DNN. The Fortran and Python versions of DNN and example code are attached in the supplementary for reproducibility.