Goran Nenadic

Viktor Schlegel, Hao Li, Yuping Wu et al. · tencent-ai

This paper describes PULSAR, our system submission at the ImageClef 2023 MediQA-Sum task on summarising patient-doctor dialogues into clinical records. The proposed framework relies on domain-specific pre-training, to produce a specialised language model which is trained on task-specific natural data augmented by synthetic data generated by a black-box LLM. We find limited evidence towards the efficacy of domain-specific pre-training and data augmentation, while scaling up the language model yields the best performance gains. Our approach was ranked second and third among 13 submissions on task B of the challenge. Our code is available at https://github.com/yuping-wu/PULSAR.

Zihao Li, Samuel Belkadi, Nicolo Micheletti et al.

Biomedical literature often uses complex language and inaccessible professional terminologies. That is why simplification plays an important role in improving public health literacy. Applying Natural Language Processing (NLP) models to automate such tasks allows for quick and direct accessibility for lay readers. In this work, we investigate the ability of state-of-the-art large language models (LLMs) on the task of biomedical abstract simplification, using the publicly available dataset for plain language adaptation of biomedical abstracts (\textbf{PLABA}). The methods applied include domain fine-tuning and prompt-based learning (PBL) on: 1) Encoder-decoder models (T5, SciFive, and BART), 2) Decoder-only GPT models (GPT-3.5 and GPT-4) from OpenAI and BioGPT, and 3) Control-token mechanisms on BART-based models. We used a range of automatic evaluation metrics, including BLEU, ROUGE, SARI, and BERTscore, and also conducted human evaluations. BART-Large with Control Token (BART-L-w-CT) mechanisms reported the highest SARI score of 46.54 and T5-base reported the highest BERTscore 72.62. In human evaluation, BART-L-w-CTs achieved a better simplicity score over T5-Base (2.9 vs. 2.2), while T5-Base achieved a better meaning preservation score over BART-L-w-CTs (3.1 vs. 2.6). We also categorised the system outputs with examples, hoping this will shed some light for future research on this task. Our code, fine-tuned models, and data splits are available at \url{https://github.com/HECTA-UoM/PLABA-MU} \begin{IEEEkeywords} Large Language Models, Text Simplification, Biomedical NLP, Control Mechanisms, Health Informatics \end{IEEEkeywords}

Samuel Belkadi, Lifeng Han, Yuping Wu et al.

The practice of fine-tuning Pre-trained Language Models (PLMs) from general or domain-specific data to a specific task with limited resources, has gained popularity within the field of natural language processing (NLP). In this work, we re-visit this assumption and carry out an investigation in clinical NLP, specifically Named Entity Recognition on drugs and their related attributes. We compare Transformer models that are trained from scratch to fine-tuned BERT-based LLMs namely BERT, BioBERT, and ClinicalBERT. Furthermore, we examine the impact of an additional CRF layer on such models to encourage contextual learning. We use n2c2-2018 shared task data for model development and evaluations. The experimental outcomes show that 1) CRF layers improved all language models; 2) referring to BIO-strict span level evaluation using macro-average F1 score, although the fine-tuned LLMs achieved 0.83+ scores, the TransformerCRF model trained from scratch achieved 0.78+, demonstrating comparable performances with much lower cost - e.g. with 39.80\% less training parameters; 3) referring to BIO-strict span-level evaluation using weighted-average F1 score, ClinicalBERT-CRF, BERT-CRF, and TransformerCRF exhibited lower score differences, with 97.59\%/97.44\%/96.84\% respectively. 4) applying efficient training by down-sampling for better data distribution further reduced the training cost and need for data, while maintaining similar scores - i.e. around 0.02 points lower compared to using the full dataset. Our models will be hosted at \url{https://github.com/HECTA-UoM/TransformerCRF}

Haifa Alrdahi, Lifeng Han, Hendrik Šuvalov et al.

Automatic medication mining from clinical and biomedical text has become a popular topic due to its real impact on healthcare applications and the recent development of powerful language models (LMs). However, fully-automatic extraction models still face obstacles to be overcome such that they can be deployed directly into clinical practice for better impacts. Such obstacles include their imbalanced performances on different entity types and clinical events. In this work, we examine current state-of-the-art pre-trained language models (PLMs) on such tasks, via fine-tuning including the monolingual model Med7 and multilingual large language model (LLM) XLM-RoBERTa. We compare their advantages and drawbacks using historical medication mining shared task data sets from n2c2-2018 challenges. We report the findings we get from these fine-tuning experiments such that they can facilitate future research on addressing them, for instance, how to combine their outputs, merge such models, or improve their overall accuracy by ensemble learning and data augmentation. MedMine is part of the M3 Initiative \url{https://github.com/HECTA-UoM/M3}

Hao Li, Yuping Wu, Viktor Schlegel et al. · tencent-ai

Medical progress notes play a crucial role in documenting a patient's hospital journey, including his or her condition, treatment plan, and any updates for healthcare providers. Automatic summarisation of a patient's problems in the form of a problem list can aid stakeholders in understanding a patient's condition, reducing workload and cognitive bias. BioNLP 2023 Shared Task 1A focuses on generating a list of diagnoses and problems from the provider's progress notes during hospitalisation. In this paper, we introduce our proposed approach to this task, which integrates two complementary components. One component employs large language models (LLMs) for data augmentation; the other is an abstractive summarisation LLM with a novel pre-training objective for generating the patients' problems summarised as a list. Our approach was ranked second among all submissions to the shared task. The performance of our model on the development and test datasets shows that our approach is more robust on unknown data, with an improvement of up to 3.1 points over the same size of the larger model.

Angel Paul, Dhivin Shaji, Lifeng Han et al.

The increasing availability of sensitive textual data has created an urgent need for robust de-identification methods that enable compliant data sharing while preserving downstream utility. This paper presents DeID-Clinic, a multi-layered framework for automated pseudonymization and re-identification risk assessment of clinical free-text data. Our approach integrates domain-adapted transformer models, including BioBERT and ClinicalBERT, into the MASK de-identification framework to improve the detection and masking of protected health information (PHI). Beyond entity recognition, we introduce a novel document-level risk assessment module that quantifies residual re-identification risk using a combination of k-anonymity, l-diversity, t-closeness, contextual similarity, and entity co-occurrence analysis. Experiments conducted on the i2b2 2014 de-identification dataset demonstrate strong performance, achieving macro-level F1 scores above 0.96 for several entity categories, while enabling quantitative prioritization of high-risk documents for further review. Our results highlight the effectiveness of combining neural de-identification with explicit risk modeling, supporting privacy-preserving data sharing in sensitive domains. Although evaluated on clinical text, the proposed framework is generalizable to other privacy-critical domains such as legal and administrative documents, where reliable pseudonymization and risk-aware anonymization are essential. Keywords{Automated De-Identification, Risk Assessment, Patient Privacy, Pseudonymization, Personal Health Information}

Shengwei Tian, Lifeng Han, Goran Nenadic

With the rapid growth of the Natural Language Processing (NLP) field, a vast variety of Large Language Models (LLMs) continue to emerge for diverse NLP tasks. As more papers are published, researchers and developers face the challenge of information overload. Thus, developing a system that can automatically extract and organise key information about LLMs from academic papers is particularly important. The standard format for documenting information about LLMs is the LLM model card (\textbf{LLM-Card}). We propose a method for automatically generating LLM model cards from scientific publications. We use Named Entity Recognition (\textbf{NER}) and Relation Extraction (\textbf{RE}) methods that automatically extract key information about LLMs from the papers, helping researchers to access information about LLMs efficiently. These features include model \textit{licence}, model \textit{name}, and model \textit{application}. With these features, we can form a model card for each paper. We processed 106 academic papers by defining three dictionaries -- LLM's name, licence, and application. 11,051 sentences were extracted through dictionary lookup, and the dataset was constructed through manual review of the final selection of 129 sentences with a link between the name and the \textit{licence}, and 106 sentences with a link between the model name and the \textit{application}. The resulting resource is relevant for LLM card illustrations using relational knowledge graphs. Our code and findings can contribute to automatic LLM card generation. Data and code in \textsc{autoLLM-Card} will be shared and freely available at \url{https://github.com/shengwei-tian/dependency-parser-visualization}

Samuel Belkadi, Nicolo Micheletti, Lifeng Han et al.

Access to real-world medication prescriptions is essential for medical research and healthcare quality improvement. However, access to real medication prescriptions is often limited due to the sensitive nature of the information expressed. Additionally, manually labelling these instructions for training and fine-tuning Natural Language Processing (NLP) models can be tedious and expensive. We introduce a novel task-specific model architecture, Label-To-Text-Transformer (\textbf{LT3}), tailored to generate synthetic medication prescriptions based on provided labels, such as a vocabulary list of medications and their attributes. LT3 is trained on a set of around 2K lines of medication prescriptions extracted from the MIMIC-III database, allowing the model to produce valuable synthetic medication prescriptions. We evaluate LT3's performance by contrasting it with a state-of-the-art Pre-trained Language Model (PLM), T5, analysing the quality and diversity of generated texts. We deploy the generated synthetic data to train the SpacyNER model for the Named Entity Recognition (NER) task over the n2c2-2018 dataset. The experiments show that the model trained on synthetic data can achieve a 96-98\% F1 score at Label Recognition on Drug, Frequency, Route, Strength, and Form. LT3 codes and data will be shared at \url{https://github.com/HECTA-UoM/Label-To-Text-Transformer}

Bernadeta Griciūtė, Lifeng Han, Goran Nenadic

Topic Modelling (TM) is from the research branches of natural language understanding (NLU) and natural language processing (NLP) that is to facilitate insightful analysis from large documents and datasets, such as a summarisation of main topics and the topic changes. This kind of discovery is getting more popular in real-life applications due to its impact on big data analytics. In this study, from the social-media and healthcare domain, we apply popular Latent Dirichlet Allocation (LDA) methods to model the topic changes in Swedish newspaper articles about Coronavirus. We describe the corpus we created including 6515 articles, methods applied, and statistics on topic changes over approximately 1 year and two months period of time from 17th January 2020 to 13th March 2021. We hope this work can be an asset for grounding applications of topic modelling and can be inspiring for similar case studies in an era with pandemics, to support socio-economic impact research as well as clinical and healthcare analytics. Our data and source code are openly available at https://github. com/poethan/Swed_Covid_TM Keywords: Latent Dirichlet Allocation (LDA); Topic Modelling; Coronavirus; Pandemics; Natural Language Understanding; BERT-topic

Lifeng Han, Gleb Erofeev, Irina Sorokina et al.

Pre-trained language models (PLMs) often take advantage of the monolingual and multilingual dataset that is freely available online to acquire general or mixed domain knowledge before deployment into specific tasks. Extra-large PLMs (xLPLMs) are proposed very recently to claim supreme performances over smaller-sized PLMs such as in machine translation (MT) tasks. These xLPLMs include Meta-AI's wmt21-dense-24-wide-en-X (2021) and NLLB (2022). In this work, we examine if xLPLMs are absolutely superior to smaller-sized PLMs in fine-tuning toward domain-specific MTs. We use two different in-domain data of different sizes: commercial automotive in-house data and clinical shared task data from the ClinSpEn2022 challenge at WMT2022. We choose popular Marian Helsinki as smaller sized PLM and two massive-sized Mega-Transformers from Meta-AI as xLPLMs. Our experimental investigation shows that 1) on smaller-sized in-domain commercial automotive data, xLPLM wmt21-dense-24-wide-en-X indeed shows much better evaluation scores using SacreBLEU and hLEPOR metrics than smaller-sized Marian, even though its score increase rate is lower than Marian after fine-tuning; 2) on relatively larger-size well prepared clinical data fine-tuning, the xLPLM NLLB tends to lose its advantage over smaller-sized Marian on two sub-tasks (clinical terms and ontology concepts) using ClinSpEn offered metrics METEOR, COMET, and ROUGE-L, and totally lost to Marian on Task-1 (clinical cases) on all official metrics including SacreBLEU and BLEU; 3) metrics do not always agree with each other on the same tasks using the same model outputs; 4) clinic-Marian ranked No.2 on Task- 1 (via SACREBLEU/BLEU) and Task-3 (via METEOR and ROUGE) among all submissions.

Hangyu Tu, Lifeng Han, Goran Nenadic

Clinical texts, represented in electronic medical records (EMRs), contain rich medical information and are essential for disease prediction, personalised information recommendation, clinical decision support, and medication pattern mining and measurement. Relation extractions between medication mentions and temporal information can further help clinicians better understand the patients' treatment history. To evaluate the performances of deep learning (DL) and large language models (LLMs) in medication extraction and temporal relations classification, we carry out an empirical investigation of \textbf{MedTem} project using several advanced learning structures including BiLSTM-CRF and CNN-BiLSTM for a clinical domain named entity recognition (NER), and BERT-CNN for temporal relation extraction (RE), in addition to the exploration of different word embedding techniques. Furthermore, we also designed a set of post-processing roles to generate structured output on medications and the temporal relation. Our experiments show that CNN-BiLSTM slightly wins the BiLSTM-CRF model on the i2b2-2009 clinical NER task yielding 75.67, 77.83, and 78.17 for precision, recall, and F1 scores using Macro Average. BERT-CNN model also produced reasonable evaluation scores 64.48, 67.17, and 65.03 for P/R/F1 using Macro Avg on the temporal relation extraction test set from i2b2-2012 challenges. Code and Tools from MedTem will be hosted at \url{https://github.com/HECTA-UoM/MedTem}

Lifeng Han, Gleb Erofeev, Irina Sorokina et al.

Massively multilingual pre-trained language models (MMPLMs) are developed in recent years demonstrating superpowers and the pre-knowledge they acquire for downstream tasks. This work investigates whether MMPLMs can be applied to clinical domain machine translation (MT) towards entirely unseen languages via transfer learning. We carry out an experimental investigation using Meta-AI's MMPLMs ``wmt21-dense-24-wide-en-X and X-en (WMT21fb)'' which were pre-trained on 7 language pairs and 14 translation directions including English to Czech, German, Hausa, Icelandic, Japanese, Russian, and Chinese, and the opposite direction. We fine-tune these MMPLMs towards English-\textit{Spanish} language pair which \textit{did not exist at all} in their original pre-trained corpora both implicitly and explicitly. We prepare carefully aligned \textit{clinical} domain data for this fine-tuning, which is different from their original mixed domain knowledge. Our experimental result shows that the fine-tuning is very successful using just 250k well-aligned in-domain EN-ES segments for three sub-task translation testings: clinical cases, clinical terms, and ontology concepts. It achieves very close evaluation scores to another MMPLM NLLB from Meta-AI, which included Spanish as a high-resource setting in the pre-training. To the best of our knowledge, this is the first work on using MMPLMs towards \textit{clinical domain transfer-learning NMT} successfully for totally unseen languages during pre-training.

Serge Gladkoff, Lifeng Han, Goran Nenadic

In natural language processing (NLP) we always rely on human judgement as the golden quality evaluation method. However, there has been an ongoing debate on how to better evaluate inter-rater reliability (IRR) levels for certain evaluation tasks, such as translation quality evaluation (TQE), especially when the data samples (observations) are very scarce. In this work, we first introduce the study on how to estimate the confidence interval for the measurement value when only one data (evaluation) point is available. Then, this leads to our example with two human-generated observational scores, for which, we introduce ``Student's \textit{t}-Distribution'' method and explain how to use it to measure the IRR score using only these two data points, as well as the confidence intervals (CIs) of the quality evaluation. We give quantitative analysis on how the evaluation confidence can be greatly improved by introducing more observations, even if only one extra observation. We encourage researchers to report their IRR scores in all possible means, e.g. using Student's \textit{t}-Distribution method whenever possible; thus making the NLP evaluation more meaningful, transparent, and trustworthy. This \textit{t}-Distribution method can be also used outside of NLP fields to measure IRR level for trustworthy evaluation of experimental investigations, whenever the observational data is scarce. Keywords: Inter-Rater Reliability (IRR); Scarce Observations; Confidence Intervals (CIs); Natural Language Processing (NLP); Translation Quality Evaluation (TQE); Student's \textit{t}-Distribution

Yuping Wu, Ching-Hsun Tseng, Jiayu Shang et al.

Extractive models usually formulate text summarization as extracting fixed top-$k$ salient sentences from the document as a summary. Few works exploited extracting finer-grained Elementary Discourse Unit (EDU) with little analysis and justification for the extractive unit selection. Further, the selection strategy of the fixed top-$k$ salient sentences fits the summarization need poorly, as the number of salient sentences in different documents varies and therefore a common or best $k$ does not exist in reality. To fill these gaps, this paper first conducts the comparison analysis of oracle summaries based on EDUs and sentences, which provides evidence from both theoretical and experimental perspectives to justify and quantify that EDUs make summaries with higher automatic evaluation scores than sentences. Then, considering this merit of EDUs, this paper further proposes an EDU-level extractive model with Varying summary Lengths and develops the corresponding learning algorithm. EDU-VL learns to encode and predict probabilities of EDUs in the document, generate multiple candidate summaries with varying lengths based on various $k$ values, and encode and score candidate summaries, in an end-to-end training manner. Finally, EDU-VL is experimented on single and multi-document benchmark datasets and shows improved performances on ROUGE scores in comparison with state-of-the-art extractive models, and further human evaluation suggests that EDU-constituent summaries maintain good grammaticality and readability.

Jamie Glen, Lifeng Han, Paul Rayson et al.

This study aims to explore the implementation of Natural Language Processing (NLP) and machine learning (ML) techniques to automate the coding of medical letters with visualised explainability and light-weighted local computer settings. Currently in clinical settings, coding is a manual process that involves assigning codes to each condition, procedure, and medication in a patient's paperwork (e.g., 56265001 heart disease using SNOMED CT code). There are preliminary research on automatic coding in this field using state-of-the-art ML models; however, due to the complexity and size of the models, the real-world deployment is not achieved. To further facilitate the possibility of automatic coding practice, we explore some solutions in a local computer setting; in addition, we explore the function of explainability for transparency of AI models. We used the publicly available MIMIC-III database and the HAN/HLAN network models for ICD code prediction purposes. We also experimented with the mapping between ICD and SNOMED CT knowledge bases. In our experiments, the models provided useful information for 97.98\% of codes. The result of this investigation can shed some light on implementing automatic clinical coding in practice, such as in hospital settings, on the local computers used by clinicians , project page \url{https://github.com/Glenj01/Medical-Coding}.

Pablo Romero, Lifeng Han, Goran Nenadic

Medication Extraction and Mining play an important role in healthcare NLP research due to its practical applications in hospital settings, such as their mapping into standard clinical knowledge bases (SNOMED-CT, BNF, etc.). In this work, we investigate state-of-the-art LLMs in text mining tasks on medications and their related attributes such as dosage, route, strength, and adverse effects. In addition, we explore different ensemble learning methods (\textsc{Stack-Ensemble} and \textsc{Voting-Ensemble}) to augment the model performances from individual LLMs. Our ensemble learning result demonstrated better performances than individually fine-tuned base models BERT, RoBERTa, RoBERTa-L, BioBERT, BioClinicalBERT, BioMedRoBERTa, ClinicalBERT, and PubMedBERT across general and specific domains. Finally, we build up an entity linking function to map extracted medical terminologies into the SNOMED-CT codes and the British National Formulary (BNF) codes, which are further mapped to the Dictionary of Medicines and Devices (dm+d), and ICD. Our model's toolkit and desktop applications are publicly available (at \url{https://github.com/HECTA-UoM/ensemble-NER}).

Lifeng Han, Paul Rayson, Suzan Verberne et al.

This proposed tutorial focuses on Healthcare Domain Applications of NLP, what we have achieved around HealthcareNLP, and the challenges that lie ahead for the future. Existing reviews in this domain either overlook some important tasks, such as synthetic data generation for addressing privacy concerns, or explainable clinical NLP for improved integration and implementation, or fail to mention important methodologies, including retrieval augmented generation and the neural symbolic integration of LLMs and KGs. In light of this, the goal of this tutorial is to provide an introductory overview of the most important sub-areas of a patient- and resource-oriented HealthcareNLP, with three layers of hierarchy: data/resource layer: annotation guidelines, ethical approvals, governance, synthetic data; NLP-Eval layer: NLP tasks such as NER, RE, sentiment analysis, and linking/coding with categorised methods, leading to explainable HealthAI; patients layer: Patient Public Involvement and Engagement (PPIE), health literacy, translation, simplification, and summarisation (also NLP tasks), and shared decision-making support. A hands-on session will be included in the tutorial for the audience to use HealthcareNLP applications. The target audience includes NLP practitioners in the healthcare application domain, NLP researchers who are interested in domain applications, healthcare researchers, and students from NLP fields. The type of tutorial is "Introductory to CL/NLP topics (HealthcareNLP)" and the audience does not need prior knowledge to attend this. Tutorial materials: https://github.com/4dpicture/HealthNLP

Jie Yang, Soyeon Caren Han, Siqu Long et al.

Extracting meaningful drug-related information chunks, such as adverse drug events (ADE), is crucial for preventing morbidity and saving many lives. Most ADEs are reported via an unstructured conversation with the medical context, so applying a general entity recognition approach is not sufficient enough. In this paper, we propose a new multi-aspect cross-integration framework for drug entity/event detection by capturing and aligning different context/language/knowledge properties from drug-related documents. We first construct multi-aspect encoders to describe semantic, syntactic, and medical document contextual information by conducting those slot tagging tasks, main drug entity/event detection, part-of-speech tagging, and general medical named entity recognition. Then, each encoder conducts cross-integration with other contextual information in three ways: the key-value cross, attention cross, and feedforward cross, so the multi-encoders are integrated in depth. Our model outperforms all SOTA on two widely used tasks, flat entity detection and discontinuous event extraction.

Zihao Li, Samuel Belkadi, Nicolo Micheletti et al.

In this system report, we describe the models and methods we used for our participation in the PLABA2023 task on biomedical abstract simplification, part of the TAC 2023 tracks. The system outputs we submitted come from the following three categories: 1) domain fine-tuned T5-like models including Biomedical-T5 and Lay-SciFive; 2) fine-tuned BARTLarge model with controllable attributes (via tokens) BART-w-CTs; 3) ChatGPTprompting. We also present the work we carried out for this task on BioGPT finetuning. In the official automatic evaluation using SARI scores, BeeManc ranks 2nd among all teams and our model LaySciFive ranks 3rd among all 13 evaluated systems. In the official human evaluation, our model BART-w-CTs ranks 2nd on Sentence-Simplicity (score 92.84), 3rd on Term-Simplicity (score 82.33) among all 7 evaluated systems; It also produced a high score 91.57 on Fluency in comparison to the highest score 93.53. In the second round of submissions, our team using ChatGPT-prompting ranks the 2nd in several categories including simplified term accuracy score 92.26 and completeness score 96.58, and a very similar score on faithfulness score 95.3 to re-evaluated PLABA-base-1 (95.73) via human evaluations. Our codes, fine-tuned models, prompts, and data splits from the system development stage will be available at https://github.com/ HECTA-UoM/PLABA-MU

Yang Cui, Jingyuan Sun, Yizheng Sun et al.

How the brain supports language across different languages is a basic question in neuroscience and a useful test for multilingual artificial intelligence. Neuroimaging has identified language-responsive brain regions across languages, but it cannot by itself show whether the underlying processing is shared or language-specific. Here we use six multilingual large language models (LLMs) as controllable systems and create targeted ``computational lesions'' by zeroing small parameter sets that are important across languages or especially important for one language. We then compare intact and lesioned models in predicting functional magnetic resonance imaging (fMRI) responses during 100 minutes of naturalistic story listening in native English, Chinese and French (112 participants). Lesioning a compact shared core reduces whole-brain encoding correlation by 60.32% relative to intact models, whereas language-specific lesions preserve cross-language separation in embedding space but selectively weaken brain predictivity for the matched native language. These results support a shared backbone with embedded specializations and provide a causal framework for studying multilingual brain-model alignment.

Warren Del-Pinto, George Demetriou, Meghna Jani et al.

Coding of unstructured clinical free-text to produce interoperable structured data is essential to improve direct care, support clinical communication and to enable clinical research.However, manual clinical coding is difficult and time consuming, which motivates the development and use of natural language processing for automated coding. This work evaluates the quality and consistency of both manual and automated clinical coding of diagnoses from hospital outpatient letters. Using 100 randomly selected letters, two human clinicians performed coding of diagnosis lists to SNOMED CT. Automated coding was also performed using IMO's Concept Tagger. A gold standard was constructed by a panel of clinicians from a subset of the annotated diagnoses. This was used to evaluate the quality and consistency of both manual and automated coding via (1) a distance-based metric, treating SNOMED CT as a graph, and (2) a qualitative metric agreed upon by the panel of clinicians. Correlation between the two metrics was also evaluated. Comparing human and computer-generated codes to the gold standard, the results indicate that humans slightly out-performed automated coding, while both performed notably better when there was only a single diagnosis contained in the free-text description. Automated coding was considered acceptable by the panel of clinicians in approximately 90% of cases.

Viktor Schlegel, Goran Nenadic, Riza Batista-Navarro

Performance of NLP systems is typically evaluated by collecting a large-scale dataset by means of crowd-sourcing to train a data-driven model and evaluate it on a held-out portion of the data. This approach has been shown to suffer from spurious correlations and the lack of challenging examples that represent the diversity of natural language. Instead, we examine a framework for evaluating optimised models in training-set free setting on synthetically generated challenge sets. We find that despite the simplicity of the generation method, the data can compete with crowd-sourced datasets with regard to naturalness and lexical diversity for the purpose of evaluating the linguistic capabilities of MRC models. We conduct further experiments and show that state-of-the-art language model-based MRC systems can learn to succeed on the challenge set correctly, although, without capturing the general notion of the evaluated phenomenon.

Lifeng Han, Serge Gladkoff, Gleb Erofeev et al.

We conduct investigations on clinical text machine translation by examining multilingual neural network models using deep learning such as Transformer based structures. Furthermore, to address the language resource imbalance issue, we also carry out experiments using a transfer learning methodology based on massive multilingual pre-trained language models (MMPLMs). The experimental results on three subtasks including 1) clinical case (CC), 2) clinical terminology (CT), and 3) ontological concept (OC) show that our models achieved top-level performances in the ClinSpEn-2022 shared task on English-Spanish clinical domain data. Furthermore, our expert-based human evaluations demonstrate that the small-sized pre-trained language model (PLM) won over the other two extra-large language models by a large margin, in the clinical domain fine-tuning, which finding was never reported in the field. Finally, the transfer learning method works well in our experimental setting using the WMT21fb model to accommodate a new language space Spanish that was not seen at the pre-training stage within WMT21fb itself, which deserves more exploitation for clinical knowledge transformation, e.g. to investigate into more languages. These research findings can shed some light on domain-specific machine translation development, especially in clinical and healthcare fields. Further research projects can be carried out based on our work to improve healthcare text analytics and knowledge transformation. Our data will be openly available for research purposes at https://github.com/HECTA-UoM/ClinicalNMT

Libo Ren, Samuel Belkadi, Lifeng Han et al.

Since clinical letters contain sensitive information, clinical-related datasets can not be widely applied in model training, medical research, and teaching. This work aims to generate reliable, various, and de-identified synthetic clinical letters. To achieve this goal, we explored different pre-trained language models (PLMs) for masking and generating text. After that, we worked on Bio\_ClinicalBERT, a high-performing model, and experimented with different masking strategies. Both qualitative and quantitative methods were used for evaluation. Additionally, a downstream task, Named Entity Recognition (NER), was also implemented to assess the usability of these synthetic letters. The results indicate that 1) encoder-only models outperform encoder-decoder models. 2) Among encoder-only models, those trained on general corpora perform comparably to those trained on clinical data when clinical information is preserved. 3) Additionally, preserving clinical entities and document structure better aligns with our objectives than simply fine-tuning the model. 4) Furthermore, different masking strategies can impact the quality of synthetic clinical letters. Masking stopwords has a positive impact, while masking nouns or verbs has a negative effect. 5) For evaluation, BERTScore should be the primary quantitative evaluation metric, with other metrics serving as supplementary references. 6) Contextual information does not significantly impact the models' understanding, so the synthetic clinical letters have the potential to replace the original ones in downstream tasks.

Yuping Wu, Hao Li, Goran Nenadic et al.

Extract-then-Abstract is a naturally coherent paradigm to conduct abstractive summarization with the help of salient information identified by the extractive model. Previous works that adopt this paradigm train the extractor and abstractor separately and introduce extra parameters to highlight the extracted salients to the abstractor, which results in error accumulation and additional training costs. In this paper, we first introduce a parameter-free highlight method into the encoder-decoder framework: replacing the encoder attention mask with a saliency mask in the cross-attention module to force the decoder to focus only on salient parts of the input. A preliminary analysis compares different highlight methods, demonstrating the effectiveness of our saliency mask. We further propose the novel extract-and-abstract paradigm, ExtAbs., which jointly and seamlessly performs Extractive and Abstractive summarization tasks within single encoder-decoder model to reduce error accumulation. In ExtAbs, the vanilla encoder is augmented to extract salients, and the vanilla decoder is modified with the proposed saliency mask to generate summaries. Built upon BART and PEGASUS, experiments on three datasets show that ExtAbs can achieve superior performance than baselines on the extractive task and performs comparable, or even better than the vanilla models on the abstractive task.

Samuel Belkadi, Libo Ren, Nicolo Micheletti et al.

The vast amount of available medical records has the potential to improve healthcare and biomedical research. However, privacy restrictions make these data accessible for internal use only. Recent works have addressed this problem by generating synthetic data using Causal Language Modeling. Unfortunately, by taking this approach, it is often impossible to guarantee patient privacy while offering the ability to control the diversity of generations without increasing the cost of generating such data. In contrast, we present a system for generating synthetic free-text medical records using Masked Language Modeling. The system preserves critical medical information while introducing diversity in the generations and minimising re-identification risk. The system's size is about 120M parameters, minimising inference cost. The results demonstrate high-quality synthetic data with a HIPAA-compliant PHI recall rate of 96% and a re-identification risk of 3.5%. Moreover, downstream evaluations show that the generated data can effectively train a model with performance comparable to real data.

Serge Gladkoff, Lifeng Han, Gleb Erofeev et al.

Translation Quality Evaluation (TQE) is an essential step of the modern translation production process. TQE is critical in assessing both machine translation (MT) and human translation (HT) quality without reference translations. The ability to evaluate or even simply estimate the quality of translation automatically may open significant efficiency gains through process optimisation. This work examines whether the state-of-the-art large language models (LLMs) can be used for this purpose. We take OpenAI models as the best state-of-the-art technology and approach TQE as a binary classification task. On eight language pairs including English to Italian, German, French, Japanese, Dutch, Portuguese, Turkish, and Chinese, our experimental results show that fine-tuned gpt3.5 can demonstrate good performance on translation quality prediction tasks, i.e. whether the translation needs to be edited. Another finding is that simply increasing the sizes of LLMs does not lead to apparent better performances on this task by comparing the performance of three different versions of OpenAI models: curie, davinci, and gpt3.5 with 13B, 175B, and 175B parameters, respectively.

Kung Yin Hong, Lifeng Han, Riza Batista-Navarro et al.

Neural Machine Translation (NMT) for low-resource languages is still a challenging task in front of NLP researchers. In this work, we deploy a standard data augmentation methodology by back-translation to a new language translation direction Cantonese-to-English. We present the models we fine-tuned using the limited amount of real data and the synthetic data we generated using back-translation including OpusMT, NLLB, and mBART. We carried out automatic evaluation using a range of different metrics including lexical-based and embedding-based. Furthermore. we create a user-friendly interface for the models we included in this\textsc{ CantonMT} research project and make it available to facilitate Cantonese-to-English MT research. Researchers can add more models into this platform via our open-source\textsc{ CantonMT} toolkit \url{https://github.com/kenrickkung/CantoneseTranslation}.

Zhidong Ling, Zihao Li, Pablo Romero et al.

This report is the system description of the MaLei team (Manchester and Leiden) for the shared task Plain Language Adaptation of Biomedical Abstracts (PLABA) 2024 (we had an earlier name BeeManc following last year), affiliated with TREC2024 (33rd Text REtrieval Conference https://ir.nist.gov/evalbase/conf/trec-2024). This report contains two sections corresponding to the two sub-tasks in PLABA-2024. In task one (term replacement), we applied fine-tuned ReBERTa-Base models to identify and classify the difficult terms, jargon, and acronyms in the biomedical abstracts and reported the F1 score (Task 1A and 1B). In task two (complete abstract adaptation), we leveraged Llamma3.1-70B-Instruct and GPT-4o with the one-shot prompts to complete the abstract adaptation and reported the scores in BLEU, SARI, BERTScore, LENS, and SALSA. From the official Evaluation from PLABA-2024 on Task 1A and 1B, our much smaller fine-tuned RoBERTa-Base model ranked 3rd and 2nd respectively on the two sub-tasks, and the 1st on averaged F1 scores across the two tasks from 9 evaluated systems. Our LLaMA-3.1-70B-instructed model achieved the highest Completeness score for Task 2. We share our source codes, fine-tuned models, and related resources at https://github.com/HECTA-UoM/PLABA2024

Hao Li, Yuping Wu, Viktor Schlegel et al.

With the recent advances of large language models (LLMs), it is no longer infeasible to build an automated debate system that helps people to synthesise persuasive arguments. Previous work attempted this task by integrating multiple components. In our work, we introduce an argument mining dataset that captures the end-to-end process of preparing an argumentative essay for a debate, which covers the tasks of claim and evidence identification (Task 1 ED), evidence convincingness ranking (Task 2 ECR), argumentative essay summarisation and human preference ranking (Task 3 ASR) and metric learning for automated evaluation of resulting essays, based on human feedback along argument quality dimensions (Task 4 SQE). Our dataset contains 14k examples of claims that are fully annotated with the various properties supporting the aforementioned tasks. We evaluate multiple generative baselines for each of these tasks, including representative LLMs. We find, that while they show promising results on individual tasks in our benchmark, their end-to-end performance on all four tasks in succession deteriorates significantly, both in automated measures as well as in human-centred evaluation. This challenge presented by our proposed dataset motivates future research on end-to-end argument mining and summarisation. The repository of this project is available at https://github.com/HaoBytes/ArgSum-Datatset

Kung Yin Hong, Lifeng Han, Riza Batista-Navarro et al.

This paper investigates the development and evaluation of machine translation models from Cantonese to English, where we propose a novel approach to tackle low-resource language translations. The main objectives of the study are to develop a model that can effectively translate Cantonese to English and evaluate it against state-of-the-art commercial models. To achieve this, a new parallel corpus has been created by combining different available corpora online with preprocessing and cleaning. In addition, a monolingual Cantonese dataset has been created through web scraping to aid the synthetic parallel corpus generation. Following the data collection process, several approaches, including fine-tuning models, back-translation, and model switch, have been used. The translation quality of models has been evaluated with multiple quality metrics, including lexicon-based metrics (SacreBLEU and hLEPOR) and embedding-space metrics (COMET and BERTscore). Based on the automatic metrics, the best model is selected and compared against the 2 best commercial translators using the human evaluation framework HOPES. The best model proposed in this investigation (NLLB-mBART) with model switch mechanisms has reached comparable and even better automatic evaluation scores against State-of-the-art commercial models (Bing and Baidu Translators), with a SacreBLEU score of 16.8 on our test set. Furthermore, an open-source web application has been developed to allow users to translate between Cantonese and English, with the different trained models available for effective comparisons between models from this investigation and users. CANTONMT is available at https://github.com/kenrickkung/CantoneseTranslation

Michele Filannino, Gavin Brown, Goran Nenadic

This paper describes a temporal expression identification and normalization system, ManTIME, developed for the TempEval-3 challenge. The identification phase combines the use of conditional random fields along with a post-processing identification pipeline, whereas the normalization phase is carried out using NorMA, an open-source rule-based temporal normalizer. We investigate the performance variation with respect to different feature types. Specifically, we show that the use of WordNet-based features in the identification task negatively affects the overall performance, and that there is no statistically significant difference in using gazetteers, shallow parsing and propositional noun phrases labels on top of the morphological features. On the test data, the best run achieved 0.95 (P), 0.85 (R) and 0.90 (F1) in the identification phase. Normalization accuracies are 0.84 (type attribute) and 0.77 (value attribute). Surprisingly, the use of the silver data (alone or in addition to the gold annotated ones) does not improve the performance.

Hao Li, Yu-Hao Huang, Chang Xu et al.

Time-series Generation (TSG) is a prominent research area with broad applications in simulations, data augmentation, and counterfactual analysis. While existing methods have shown promise in unconditional single-domain TSG, real-world applications demand for cross-domain approaches capable of controlled generation tailored to domain-specific constraints and instance-level requirements. In this paper, we argue that text can provide semantic insights, domain information and instance-specific temporal patterns, to guide and improve TSG. We introduce ``Text-Controlled TSG'', a task focused on generating realistic time series by incorporating textual descriptions. To address data scarcity in this setting, we propose a novel LLM-based Multi-Agent framework that synthesizes diverse, realistic text-to-TS datasets. Furthermore, we introduce BRIDGE, a hybrid text-controlled TSG framework that integrates semantic prototypes with text description for supporting domain-level guidance. This approach achieves state-of-the-art generation fidelity on 11 of 12 datasets, and improves controllability by up to 12% on MSE and 6% MAE compared to no text input generation, highlighting its potential for generating tailored time-series data.

Nicolo Micheletti, Samuel Belkadi, Lifeng Han et al.

Large Language Models (LLMs) have revolutionised the field of Natural Language Processing (NLP) and have achieved state-of-the-art performance in practically every task in this field. However, the prevalent approach used in text generation, Causal Language Modelling (CLM), which generates text sequentially from left to right, inherently limits the freedom of the model, which does not decide when and where each token is generated. In contrast, Masked Language Modelling (MLM), primarily used for language understanding tasks, can generate tokens anywhere in the text and any order. This paper conducts an extensive comparison of MLM and CLM approaches for text generation tasks. To do so, we pre-train several language models of comparable sizes on three different datasets, namely 1) medical discharge summaries, 2) movie plot synopses, and 3) authorship verification datasets. To assess the quality of the generations, we first employ quantitative metrics and then perform a qualitative human evaluation to analyse coherence and grammatical correctness. In addition, we evaluate the usefulness of the generated texts by using them in three different downstream tasks: 1) Entity Recognition, 2) Text Classification, and 3) Authorship Verification. The results show that MLM consistently outperforms CLM in text generation across all datasets, with higher quantitative scores and better coherence in the generated text. The study also finds \textit{no strong correlation} between the quality of the generated text and the performance of the models in the downstream tasks. With this study, we show that MLM for text generation has great potential for future research and provides direction for future studies in this area.

Hao Li, Viktor Schlegel, Yizheng Sun et al.

Argument Mining (AM), a critical subfield of Natural Language Processing (NLP), focuses on extracting argumentative structures from text. The advent of Large Language Models (LLMs) has profoundly transformed AM, enabling advanced in-context learning, prompt-based generation, and robust cross-domain adaptability. This survey systematically synthesizes recent advancements in LLM-driven AM. We provide a concise review of foundational theories and annotation frameworks, alongside a meticulously curated catalog of datasets. A key contribution is our comprehensive taxonomy of AM subtasks, elucidating how contemporary LLM techniques -- such as prompting, chain-of-thought reasoning, and retrieval augmentation -- have reconfigured their execution. We further detail current LLM architectures and methodologies, critically assess evaluation practices, and delineate pivotal challenges including long-context reasoning, interpretability, and annotation bottlenecks. Conclusively, we highlight emerging trends and propose a forward-looking research agenda for LLM-based computational argumentation, aiming to strategically guide researchers in this rapidly evolving domain.

Yuping Wu, Viktor Schlegel, Warren Del-Pinto et al.

Training data is fundamental to the success of modern machine learning models, yet in high-stakes domains such as healthcare, the use of real-world training data is severely constrained by concerns over privacy leakage. A promising solution to this challenge is the use of differentially private (DP) synthetic data, which offers formal privacy guarantees while maintaining data utility. However, striking the right balance between privacy protection and utility remains challenging in clinical note synthesis, given its domain specificity and the complexity of long-form text generation. In this paper, we present Term2Note, a methodology to synthesise long clinical notes under strong DP constraints. By structurally separating content and form, Term2Note generates section-wise note content conditioned on DP medical terms, with each governed by separate DP constraints. A DP quality maximiser further enhances synthetic notes by selecting high-quality outputs. Experimental results show that Term2Note produces synthetic notes with statistical properties closely aligned with real clinical notes, demonstrating strong fidelity. In addition, multi-label classification models trained on these synthetic notes perform comparably to those trained on real data, confirming their high utility. Compared to existing DP text generation baselines, Term2Note achieves substantial improvements in both fidelity and utility while operating under fewer assumptions, suggesting its potential as a viable privacy-preserving alternative to using sensitive clinical notes.

Yidan Sun, Viktor Schlegel, Srinivasan Nandakumar et al.

Generative AI offers transformative potential for high-stakes domains such as healthcare and finance, yet privacy and regulatory barriers hinder the use of real-world data. To address this, differentially private synthetic data generation has emerged as a promising alternative. In this work, we introduce a unified benchmark to systematically evaluate the utility and fidelity of text datasets generated under formal Differential Privacy (DP) guarantees. Our benchmark addresses key challenges in domain-specific benchmarking, including choice of representative data and realistic privacy budgets, accounting for pre-training and a variety of evaluation metrics. We assess state-of-the-art privacy-preserving generation methods across five domain-specific datasets, revealing significant utility and fidelity degradation compared to real data, especially under strict privacy constraints. These findings underscore the limitations of current approaches, outline the need for advanced privacy-preserving data sharing methods and set a precedent regarding their evaluation in realistic scenarios.

Hao Li, Yizheng Sun, Viktor Schlegel et al.

Argument summarization aims to generate concise, structured representations of complex, multi-perspective debates. While recent work has advanced the identification and clustering of argumentative components, the generation stage remains underexplored. Existing approaches typically rely on single-pass generation, offering limited support for factual correction or structural refinement. To address this gap, we introduce Arg-LLaDA, a novel large language diffusion framework that iteratively improves summaries via sufficiency-guided remasking and regeneration. Our method combines a flexible masking controller with a sufficiency-checking module to identify and revise unsupported, redundant, or incomplete spans, yielding more faithful, concise, and coherent outputs. Empirical results on two benchmark datasets demonstrate that Arg-LLaDA surpasses state-of-the-art baselines in 7 out of 10 automatic evaluation metrics. In addition, human evaluations reveal substantial improvements across core dimensions, coverage, faithfulness, and conciseness, validating the effectiveness of our iterative, sufficiency-aware generation strategy.

Rina Carines Cabral, Soyeon Caren Han, Areej Alhassan et al.

Discontinuous Named Entity Recognition (DNER) presents a challenging problem where entities may be scattered across multiple non-adjacent tokens, making traditional sequence labelling approaches inadequate. Existing methods predominantly rely on custom tagging schemes to handle these discontinuous entities, resulting in models tightly coupled to specific tagging strategies and lacking generalisability across diverse datasets. To address these challenges, we propose TriG-NER, a novel Triplet-Grid Framework that introduces a generalisable approach to learning robust token-level representations for discontinuous entity extraction. Our framework applies triplet loss at the token level, where similarity is defined by word pairs existing within the same entity, effectively pulling together similar and pushing apart dissimilar ones. This approach enhances entity boundary detection and reduces the dependency on specific tagging schemes by focusing on word-pair relationships within a flexible grid structure. We evaluate TriG-NER on three benchmark DNER datasets and demonstrate significant improvements over existing grid-based architectures. These results underscore our framework's effectiveness in capturing complex entity structures and its adaptability to various tagging schemes, setting a new benchmark for discontinuous entity extraction.

Yanan Ma, Chenghao Xiao, Chenhan Yuan et al.

Topic modelling is a pivotal unsupervised machine learning technique for extracting valuable insights from large document collections. Existing neural topic modelling methods often encode contextual information of documents, while ignoring contextual details of candidate centroid words, leading to the inaccurate selection of topic words due to the contextualization gap. In parallel, it is found that functional words are frequently selected over topical words. To address these limitations, we introduce CAST: Corpus-Aware Self-similarity Enhanced Topic modelling, a novel topic modelling method that builds upon candidate centroid word embeddings contextualized on the dataset, and a novel self-similarity-based method to filter out less meaningful tokens. Inspired by findings in contrastive learning that self-similarities of functional token embeddings in different contexts are much lower than topical tokens, we find self-similarity to be an effective metric to prevent functional words from acting as candidate topic words. Our approach significantly enhances the coherence and diversity of generated topics, as well as the topic model's ability to handle noisy data. Experiments on news benchmark datasets and one Twitter dataset demonstrate the method's superiority in generating coherent, diverse topics, and handling noisy data, outperforming strong baselines.

Yidan Sun, Viktor Schlegel, Srinivasan Nandakumar et al.

Data-driven decision support in high-stakes domains like healthcare and finance faces significant barriers to data sharing due to regulatory, institutional, and privacy concerns. While recent generative AI models, such as large language models, have shown impressive performance in open-domain tasks, their adoption in sensitive environments remains limited by unpredictable behaviors and insufficient privacy-preserving datasets for benchmarking. Existing anonymization methods are often inadequate, especially for unstructured text, as redaction and masking can still allow re-identification. Differential Privacy (DP) offers a principled alternative, enabling the generation of synthetic data with formal privacy assurances. In this work, we address these challenges through three key contributions. First, we introduce a comprehensive evaluation framework with standardized utility and fidelity metrics, encompassing nine curated datasets that capture domain-specific complexities such as technical jargon, long-context dependencies, and specialized document structures. Second, we conduct a large-scale empirical study benchmarking state-of-the-art DP text generation methods and LLMs of varying sizes and different fine-tuning strategies, revealing that high-quality domain-specific synthetic data generation under DP constraints remains an unsolved challenge, with performance degrading as domain complexity increases. Third, we develop a membership inference attack (MIA) methodology tailored for synthetic text, providing first empirical evidence that the use of public datasets - potentially present in pre-training corpora - can invalidate claimed privacy guarantees. Our findings underscore the urgent need for rigorous privacy auditing and highlight persistent gaps between open-domain and specialist evaluations, informing responsible deployment of generative AI in privacy-sensitive, high-stakes settings.

Mingyang Li, Viktor Schlegel, Tingting Mu et al.

Mapping clinical documents to standardised clinical vocabularies is an important task, as it provides structured data for information retrieval and analysis, which is essential to clinical research, hospital administration and improving patient care. However, manual coding is both difficult and time-consuming, making it impractical at scale. Automated coding can potentially alleviate this burden, improving the availability and accuracy of structured clinical data. The task is difficult to automate, as it requires mapping to high-dimensional and long-tailed target spaces, such as the International Classification of Diseases (ICD). While external knowledge sources have been readily utilised to enhance output code representation, the use of external resources for representing the input documents has been underexplored. In this work, we compute a structured representation of the input documents, making use of document-level knowledge graphs (KGs) that provide a comprehensive structured view of a patient's condition. The resulting knowledge graph efficiently represents the patient-centred input documents with 23\% of the original text while retaining 90\% of the information. We assess the effectiveness of this graph for automated ICD-9 coding by integrating it into the state-of-the-art ICD coding architecture PLM-ICD. Our experiments yield improved Macro-F1 scores by up to 3.20\% on popular benchmarks, while improving training efficiency. We attribute this improvement to different types of entities and relationships in the KG, and demonstrate the improved explainability potential of the approach over the text-only baseline.

Mingyang Li, Viktor Schlegel, Tingting Mu et al.

Automated clinical coding involves mapping unstructured text from Electronic Health Records (EHRs) to standardized code systems such as the International Classification of Diseases (ICD). While recent advances in deep learning have significantly improved the accuracy and efficiency of ICD coding, the lack of explainability in these models remains a major limitation, undermining trust and transparency. Current explorations about explainability largely rely on attention-based techniques and qualitative assessments by physicians, yet lack systematic evaluation using consistent criteria on high-quality rationale datasets, as well as dedicated approaches explicitly trained to generate rationales for further enhancing explanation. In this work, we conduct a comprehensive evaluation of the explainability of the rationales for ICD coding through two key lenses: faithfulness that evaluates how well explanations reflect the model's actual reasoning and plausibility that measures how consistent the explanations are with human expert judgment. To facilitate the evaluation of plausibility, we construct a new rationale-annotated dataset, offering denser annotations with diverse granularity and aligns better with current clinical practice, and conduct evaluation across three types of rationales of ICD coding. Encouraged by the promising plausibility of LLM-generated rationales for ICD coding, we further propose new rationale learning methods to improve the quality of model-generated rationales, where rationales produced by prompting LLMs with/without annotation examples are used as distant supervision signals. We empirically find that LLM-generated rationales align most closely with those of human experts. Moreover, incorporating few-shot human-annotated examples not only further improves rationale generation but also enhances rationale-learning approaches.

Yusuf Yildiz, Goran Nenadic, Meghna Jani et al.

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on their ability to process longitudinal electronic health record (EHR) data. Findings: LLMs show promise in handling multimodal and longitudinal EHR data and can support multi-outcome predictions for diverse health conditions. However, methodological, validation, infrastructural, and regulatory chal- lenges remain. These include inadequate methods for time-to-event modelling, poor calibration of predictions, limited external validation, and bias affecting underrepresented groups. High infrastructure costs and the absence of clear regulatory frameworks further prevent adoption. Implications: Further work and interdisciplinary collaboration are needed to support equitable and effective integra- tion into the clinical prediction. Developing temporally aware, fair, and explainable models should be a priority focus for transforming clinical prediction workflow.

Hao Li, Viktor Schlegel, Riza Batista-Navarro et al.

Argument summarisation is a promising but currently under-explored field. Recent work has aimed to provide textual summaries in the form of concise and salient short texts, i.e., key points (KPs), in a task known as Key Point Analysis (KPA). One of the main challenges in KPA is finding high-quality key point candidates from dozens of arguments even in a small corpus. Furthermore, evaluating key points is crucial in ensuring that the automatically generated summaries are useful. Although automatic methods for evaluating summarisation have considerably advanced over the years, they mainly focus on sentence-level comparison, making it difficult to measure the quality of a summary (a set of KPs) as a whole. Aggravating this problem is the fact that human evaluation is costly and unreproducible. To address the above issues, we propose a two-step abstractive summarisation framework based on neural topic modelling with an iterative clustering procedure, to generate key points which are aligned with how humans identify key points. Our experiments show that our framework advances the state of the art in KPA, with performance improvement of up to 14 (absolute) percentage points, in terms of both ROUGE and our own proposed evaluation metrics. Furthermore, we evaluate the generated summaries using a novel set-based evaluation toolkit. Our quantitative analysis demonstrates the effectiveness of our proposed evaluation metrics in assessing the quality of generated KPs. Human evaluation further demonstrates the advantages of our approach and validates that our proposed evaluation metric is more consistent with human judgment than ROUGE scores.

Viktor Schlegel, Goran Nenadic, Riza Batista-Navarro

Advances in NLP have yielded impressive results for the task of machine reading comprehension (MRC), with approaches having been reported to achieve performance comparable to that of humans. In this paper, we investigate whether state-of-the-art MRC models are able to correctly process Semantics Altering Modifications (SAM): linguistically-motivated phenomena that alter the semantics of a sentence while preserving most of its lexical surface form. We present a method to automatically generate and align challenge sets featuring original and altered examples. We further propose a novel evaluation methodology to correctly assess the capability of MRC systems to process these examples independent of the data they were optimised on, by discounting for effects introduced by domain shift. In a large-scale empirical study, we apply the methodology in order to evaluate extractive MRC models with regard to their capability to correctly process SAM-enriched data. We comprehensively cover 12 different state-of-the-art neural architecture configurations and four training datasets and find that -- despite their well-known remarkable performance -- optimised models consistently struggle to correctly process semantically altered data.

Lifeng Han, Najet Hadj Mohamed, Malak Rassem et al.

In this work, we introduce the construction of a machine translation (MT) assisted and human-in-the-loop multilingual parallel corpus with annotations of multi-word expressions (MWEs), named AlphaMWE. The MWEs include verbal MWEs (vMWEs) defined in the PARSEME shared task that have a verb as the head of the studied terms. The annotated vMWEs are also bilingually and multilingually aligned manually. The languages covered include Arabic, Chinese, English, German, Italian, and Polish, of which, the Arabic corpus includes both standard and dialectal variations from Egypt and Tunisia. Our original English corpus is extracted from the PARSEME shared task in 2018. We performed machine translation of this source corpus followed by human post-editing and annotation of target MWEs. Strict quality control was applied for error limitation, i.e., each MT output sentence received first manual post-editing and annotation plus a second manual quality rechecking till annotators' consensus is reached. One of our findings during corpora preparation is that accurate translation of MWEs presents challenges to MT systems, as reflected by the outcomes of human-in-the-loop metric HOPE. To facilitate further MT research, we present a categorisation of the error types encountered by MT systems in performing MWE-related translation. To acquire a broader view of MT issues, we selected four popular state-of-the-art MT systems for comparison, namely Microsoft Bing Translator, GoogleMT, Baidu Fanyi, and DeepL MT. Because of the noise removal, translation post-editing, and MWE annotation by human professionals, we believe the AlphaMWE data set will be an asset for both monolingual and cross-lingual research, such as multi-word term lexicography, MT, and information extraction.

Andrey Kormilitzin, Nemanja Vaci, Qiang Liu et al.

In this work we addressed the problem of capturing sequential information contained in longitudinal electronic health records (EHRs). Clinical notes, which is a particular type of EHR data, are a rich source of information and practitioners often develop clever solutions how to maximise the sequential information contained in free-texts. We proposed a systematic methodology for learning from chronological events available in clinical notes. The proposed methodological {\it path signature} framework creates a non-parametric hierarchical representation of sequential events of any type and can be used as features for downstream statistical learning tasks. The methodology was developed and externally validated using the largest in the UK secondary care mental health EHR data on a specific task of predicting survival risk of patients diagnosed with Alzheimer's disease. The signature-based model was compared to a common survival random forest model. Our results showed a 15.4$\%$ increase of risk prediction AUC at the time point of 20 months after the first admission to a specialist memory clinic and the signature method outperformed the baseline mixed-effects model by 13.2 $\%$.

Viktor Schlegel, Goran Nenadic, Riza Batista-Navarro

Recent years have seen a growing number of publications that analyse Natural Language Inference (NLI) datasets for superficial cues, whether they undermine the complexity of the tasks underlying those datasets and how they impact those models that are optimised and evaluated on this data. This structured survey provides an overview of the evolving research area by categorising reported weaknesses in models and datasets and the methods proposed to reveal and alleviate those weaknesses for the English language. We summarise and discuss the findings and conclude with a set of recommendations for possible future research directions. We hope it will be a useful resource for researchers who propose new datasets, to have a set of tools to assess the suitability and quality of their data to evaluate various phenomena of interest, as well as those who develop novel architectures, to further understand the implications of their improvements with respect to their model's acquired capabilities.

Nikola Milosevic, Gangamma Kalappa, Hesam Dadafarin et al.

Medical health records and clinical summaries contain a vast amount of important information in textual form that can help advancing research on treatments, drugs and public health. However, the majority of these information is not shared because they contain private information about patients, their families, or medical staff treating them. Regulations such as HIPPA in the US, PHIPPA in Canada and GDPR regulate the protection, processing and distribution of this information. In case this information is de-identified and personal information are replaced or redacted, they could be distributed to the research community. In this paper, we present MASK, a software package that is designed to perform the de-identification task. The software is able to perform named entity recognition using some of the state-of-the-art techniques and then mask or redact recognized entities. The user is able to select named entity recognition algorithm (currently implemented are two versions of CRF-based techniques and BiLSTM-based neural network with pre-trained GLoVe and ELMo embedding) and masking algorithm (e.g. shift dates, replace names/locations, totally redact entity).