Shurong Sheng

Linyong Zou, Liang Zhang, Xiongfei Wang et al.

An essential technique for diagnosing brain disorders is electrophysiological source imaging (ESI). While model-based optimization and deep learning methods have achieved promising results in this field, the accurate selection and refinement of features remains a central challenge for precise ESI. This paper proposes FAIR-ESI, a novel framework that adaptively refines feature importance across different views, including FFT-based spectral feature refinement, weighted temporal feature refinement, and self-attention-based patch-wise feature refinement. Extensive experiments on two simulation datasets with diverse configurations and two real-world clinical datasets validate our framework's efficacy, highlighting its potential to advance brain disorder diagnosis and offer new insights into brain function.

Hanyang Dong, Shurong Sheng, Xiongfei Wang et al.

A Magnetoencephalography (MEG) time-series recording consists of multi-channel signals collected by superconducting sensors, with each signal's intensity reflecting magnetic field changes over time at the sensor location. Automating epileptic MEG spike detection significantly reduces manual assessment time and effort, yielding substantial clinical benefits. Existing research addresses MEG spike detection by encoding neural network inputs with signals from all channel within a time segment, followed by classification. However, these methods overlook simultaneous spiking occurred from nearby sensors. We introduce a simple yet effective paradigm that first clusters MEG channels based on their sensor's spatial position. Next, a novel convolutional input module is designed to integrate the spatial clustering and temporal changes of the signals. This module is fed into a custom MEEG-ResNet3D developed by the authors, which learns to extract relevant features and classify the input as a spike clip or not. Our method achieves an F1 score of 94.73% on a large real-world MEG dataset Sanbo-CMR collected from two centers, outperforming state-of-the-art approaches by 1.85%. Moreover, it demonstrates efficacy and stability in the Electroencephalographic (EEG) seizure detection task, yielding an improved weighted F1 score of 1.4% compared to current state-of-the-art techniques evaluated on TUSZ, whch is the largest EEG seizure dataset.

Liang Zhang, Hanyang Dong, Jia-Hong Gao et al.

Deep learning-based EEG classification is crucial for the automated detection of neurological disorders, improving diagnostic accuracy and enabling early intervention. However, the low signal-to-noise ratio of EEG signals limits model performance, making feature selection (FS) vital for optimizing representations learned by neural network encoders. Existing FS methods are seldom designed specifically for EEG diagnosis; many are architecture-dependent and lack interpretability, limiting their applicability. Moreover, most rely on single-iteration data, resulting in limited robustness to variability. To address these issues, we propose IEFS-GMB, an Information Entropy-based Feature Selection method guided by a Gradient Memory Bank. This approach constructs a dynamic memory bank storing historical gradients, computes feature importance via information entropy, and applies entropy-based weighting to select informative EEG features. Experiments on four public neurological disease datasets show that encoders enhanced with IEFS-GMB achieve accuracy improvements of 0.64% to 6.45% over baseline models. The method also outperforms four competing FS techniques and improves model interpretability, supporting its practical use in clinical settings.

Kuntao Xiao, Xiongfei Wang, Pengfei Teng et al.

The analysis of interictal epileptiform discharges (IEDs) in magnetoencephalography (MEG) or electroencephalogram (EEG) recordings represents a critical component in the diagnosis of epilepsy. However, manual analysis of these IEDs, which appear as epileptic spikes, from the large amount of MEG/EEG data is labor intensive and requires high expertise. Although automated methods have been developed to address this challenge, current approaches fail to fully emulate clinical experts' diagnostic intelligence in two key aspects: (1) their analysis on the input signals is limited to short temporal windows matching individual spike durations, missing the extended contextual patterns clinicians use to assess significance; and (2) they fail to adequately capture the dipole patterns with simultaneous positive-negative potential distributions across adjacent sensors that serve as clinicians' key diagnostic criterion for IED identification. To bridge this artificial-human intelligence gap, we propose a novel deep learning framework LV-CadeNet that integrates two key innovations: (1) a Long-View morphological feature representation that mimics expert clinicians' comprehensive assessment of both local spike characteristics and long-view contextual information, and (2) a hierarchical Encoder-Decoder NETwork that employs Convolution-Attention blocks for multi-scale spatiotemporal feature learning with progressive abstraction. Extensive evaluations confirm the superior performance of LV-CadeNet, which outperforms six state-of-the-art methods in EEG spike classification on TUEV, the largest public EEG spike dataset. Additionally, LV-CadeNet attains a significant improvement of 13.58% in balanced accuracy over the leading baseline for MEG spike detection on a clinical MEG dataset from Sanbo Brain Hospital, Capital Medical University.