Xiao Kang

Yanfang Lyu, Xiaoyu Zhao, Zhiqiang Gong et al.

Data-driven prediction of fluid flow and temperature distribution in marine and aerospace engineering has received extensive research and demonstrated its potential in real-time prediction recently. However, usually large amounts of high-fidelity data are required to describe and accurately predict the complex physical information, while in reality, only limited high-fidelity data is available due to the high experiment/computational cost. Therefore, this work proposes a novel multi-fidelity learning method based on the Fourier Neural Operator by jointing abundant low-fidelity data and limited high-fidelity data under transfer learning paradigm. First, as a resolution-invariant operator, the Fourier Neural Operator is first and gainfully applied to integrate multi-fidelity data directly, which can utilize the scarce high-fidelity data and abundant low-fidelity data simultaneously. Then, the transfer learning framework is developed for the current task by extracting the rich low-fidelity data knowledge to assist high-fidelity modeling training, to further improve data-driven prediction accuracy. Finally, three typical fluid and temperature prediction problems are chosen to validate the accuracy of the proposed multi-fidelity model. The results demonstrate that our proposed method has high effectiveness when compared with other high-fidelity models, and has the high modeling accuracy of 99% for all the selected physical field problems. Significantly, the proposed multi-fidelity learning method has the potential of a simple structure with high precision, which can provide a reference for the construction of the subsequent model.

Xinxing Yang, Jiachen Li, Xiao Kang et al.

Drug combination refers to the use of two or more drugs to treat a specific disease at the same time. It is currently the mainstream way to treat complex diseases. Compared with single drugs, drug combinations have better efficacy and can better inhibit toxicity and drug resistance. The computational model based on deep learning concatenates the representation of multiple drugs and the corresponding cell line feature as input, and the output is whether the drug combination can have an inhibitory effect on the cell line. However, this strategy of concatenating multiple representations has the following defects: the alignment of drug representation and cell line representation is ignored, resulting in the synergistic relationship not being reflected positionally in the embedding space. Moreover, the alignment measurement function in deep learning cannot be suitable for drug synergy prediction tasks due to differences in input types. Therefore, in this work, we propose ALNSynergy, a graph convolutional network with multi-representation alignment for predicting drug synergy. In the ALNSynergy model, we designed a multi-representation alignment function suitable for the drug synergy prediction task so that the positional relationship between drug representations and cell line representation is reflected in the embedding space. In addition, the vector modulus of drug representations and cell line representation is considered to improve the accuracy of calculation results and accelerate model convergence. Finally, many relevant experiments were run on multiple drug synergy datasets to verify the effectiveness of the above innovative elements and the excellence of the ALNSynergy model.

Jiayi Han, Liang Du, Yinda Chen et al.

The Mixture of Experts (MoE) paradigm has been successfully integrated into Low-Rank Adaptation (LoRA) for parameter-efficient fine-tuning (PEFT), delivering performance gains with minimal parameter overhead. However, a key limitation of existing MoE-LoRA methods is their reliance on a discrete router, which prevents the integration of the MoE components into the backbone model. To overcome this, we propose FURINA, a novel Free from Unmergeable Router framework based on the LINear Aggregation of experts. FURINA eliminates the router by introducing a Self-Routing mechanism. This is achieved through three core innovations: (1) decoupled learning of the direction and magnitude for LoRA adapters, (2) a shared learnable magnitude vector for consistent activation scaling, and (3) expert selection loss that encourages divergent expert activation. The proposed mechanism leverages the angular similarity between the input and each adapter's directional component to activate experts, which are then scaled by the shared magnitude vector. This design allows the output norm to naturally reflect the importance of each expert, thereby enabling dynamic, router-free routing. The expert selection loss further sharpens this behavior by encouraging sparsity and aligning it with standard MoE activation patterns. We also introduce a shared expert within the MoE-LoRA block that provides stable, foundational knowledge. To the best of our knowledge, FURINA is the first router-free, MoE-enhanced LoRA method that can be fully merged into the backbone model, introducing zero additional inference-time cost or complexity. Extensive experiments demonstrate that FURINA not only significantly outperforms standard LoRA but also matches or surpasses the performance of existing MoE-LoRA methods, while eliminating the extra inference-time overhead of MoE.

Xiao Kang, Xingbo Liu, Xiushan Nie et al.

Breast cancer classification remains a challenging task due to inter-class ambiguity and intra-class variability. Existing deep learning-based methods try to confront this challenge by utilizing complex nonlinear projections. However, these methods typically extract global features from entire images, neglecting the fact that the subtle detail information can be crucial in extracting discriminative features. In this study, we propose a novel method named Attention Model Enhanced Network (AMEN), which is formulated in a multi-branch fashion with pixel-wised attention model and classification submodular. Specifically, the feature learning part in AMEN can generate pixel-wised attention map, while the classification submodular are utilized to classify the samples. To focus more on subtle detail information, the sample image is enhanced by the pixel-wised attention map generated from former branch. Furthermore, boosting strategy are adopted to fuse classification results from different branches for better performance. Experiments conducted on three benchmark datasets demonstrate the superiority of the proposed method under various scenarios.

Xiao Kang, Xingbo Liu, Xiushan Nie et al.

With the development of medical imaging technology and machine learning, computer-assisted diagnosis which can provide impressive reference to pathologists, attracts extensive research interests. The exponential growth of medical images and uninterpretability of traditional classification models have hindered the applications of computer-assisted diagnosis. To address these issues, we propose a novel method for Learning Binary Semantic Embedding (LBSE). Based on the efficient and effective embedding, classification and retrieval are performed to provide interpretable computer-assisted diagnosis for histology images. Furthermore, double supervision, bit uncorrelation and balance constraint, asymmetric strategy and discrete optimization are seamlessly integrated in the proposed method for learning binary embedding. Experiments conducted on three benchmark datasets validate the superiority of LBSE under various scenarios.