Dimitrios Papadopoulos

Petros Stylianos Giouroukis, Dimitris Dimitriadis, Dimitrios Papadopoulos et al.

Slide decks, serving as digital reports that bridge the gap between presentation slides and written documents, are a prevalent medium for conveying information in both academic and corporate settings. Their multimodal nature, combining text, images, and charts, presents challenges for retrieval-augmented generation systems, where the quality of retrieval directly impacts downstream performance. Traditional approaches to slide retrieval often involve separate indexing of modalities, which can increase complexity and lose contextual information. This paper investigates various methodologies for effective slide retrieval, including visual late-interaction embedding models like ColPali, the use of visual rerankers, and hybrid retrieval techniques that combine dense retrieval with BM25, further enhanced by textual rerankers and fusion methods like Reciprocal Rank Fusion. A novel Vision-Language Models-based captioning pipeline is also evaluated, demonstrating significantly reduced embedding storage requirements compared to visual late-interaction techniques, alongside comparable retrieval performance. Our analysis extends to the practical aspects of these methods, evaluating their runtime performance and storage demands alongside retrieval efficacy, thus offering practical guidance for the selection and development of efficient and robust slide retrieval systems for real-world applications.

Bin Liu, Dimitrios Papadopoulos, Fragkiskos D. Malliaros et al.

The discovery of drug-target interactions (DTIs) is a very promising area of research with great potential. The accurate identification of reliable interactions among drugs and proteins via computational methods, which typically leverage heterogeneous information retrieved from diverse data sources, can boost the development of effective pharmaceuticals. Although random walk and matrix factorization techniques are widely used in DTI prediction, they have several limitations. Random walk-based embedding generation is usually conducted in an unsupervised manner, while the linear similarity combination in matrix factorization distorts individual insights offered by different views. To tackle these issues, we take a multi-layered network approach to handle diverse drug and target similarities, and propose a novel optimization framework, called Multiple similarity DeepWalk-based Matrix Factorization (MDMF), for DTI prediction. The framework unifies embedding generation and interaction prediction, learning vector representations of drugs and targets that not only retain higher-order proximity across all hyper-layers and layer-specific local invariance, but also approximate the interactions with their inner product. Furthermore, we develop an ensemble method (MDMF2A) that integrates two instantiations of the MDMF model, optimizing the area under the precision-recall curve (AUPR) and the area under the receiver operating characteristic curve (AUC) respectively. The empirical study on real-world DTI datasets shows that our method achieves statistically significant improvement over current state-of-the-art approaches in four different settings. Moreover, the validation of highly ranked non-interacting pairs also demonstrates the potential of MDMF2A to discover novel DTIs.

Javad Ghareh Chamani, Dimitrios Papadopoulos

In federated learning, multiple parties collaborate in order to train a global model over their respective datasets. Even though cryptographic primitives (e.g., homomorphic encryption) can help achieve data privacy in this setting, some partial information may still be leaked across parties if this is done non-judiciously. In this work, we study the federated learning framework of SecureBoost [Cheng et al., FL@IJCAI'19] as a specific such example, demonstrate a leakage-abuse attack based on its leakage profile, and experimentally evaluate the effectiveness of our attack. We then propose two secure versions relying on trusted execution environments. We implement and benchmark our protocols to demonstrate that they are 1.2-5.4X faster in computation and need 5-49X less communication than SecureBoost.

Xianrui Meng, Dimitrios Papadopoulos, Alina Oprea et al.

In collaborative learning, multiple parties contribute their datasets to jointly deduce global machine learning models for numerous predictive tasks. Despite its efficacy, this learning paradigm fails to encompass critical application domains that involve highly sensitive data, such as healthcare and security analytics, where privacy risks limit entities to individually train models using only their own datasets. In this work, we target privacy-preserving collaborative hierarchical clustering. We introduce a formal security definition that aims to achieve the balance between utility and privacy and present a two-party protocol that provably satisfies it. We then extend our protocol with: (i) an optimized version for the single-linkage clustering, and (ii) scalable approximation variants. We implement all our schemes and experimentally evaluate their performance and accuracy on synthetic and real datasets, obtaining very encouraging results. For example, end-to-end execution of our secure approximate protocol for over 1M 10-dimensional data samples requires 35sec of computation and achieves 97.09% accuracy.

Kewei Cheng, Tao Fan, Yilun Jin et al.

The protection of user privacy is an important concern in machine learning, as evidenced by the rolling out of the General Data Protection Regulation (GDPR) in the European Union (EU) in May 2018. The GDPR is designed to give users more control over their personal data, which motivates us to explore machine learning frameworks for data sharing that do not violate user privacy. To meet this goal, in this paper, we propose a novel lossless privacy-preserving tree-boosting system known as SecureBoost in the setting of federated learning. SecureBoost first conducts entity alignment under a privacy-preserving protocol and then constructs boosting trees across multiple parties with a carefully designed encryption strategy. This federated learning system allows the learning process to be jointly conducted over multiple parties with common user samples but different feature sets, which corresponds to a vertically partitioned data set. An advantage of SecureBoost is that it provides the same level of accuracy as the non-privacy-preserving approach while at the same time, reveals no information of each private data provider. We show that the SecureBoost framework is as accurate as other non-federated gradient tree-boosting algorithms that require centralized data and thus it is highly scalable and practical for industrial applications such as credit risk analysis. To this end, we discuss information leakage during the protocol execution and propose ways to provably reduce it.