Xinhua Liu

Zhuoran Li, Zhen Gao, Xinhua Liu et al.

The advent of sixth-generation (6G) places intelligence at the core of wireless architecture, fusing perception, communication, and computation into a single closed-loop. This paper argues that large artificial intelligence models (LAMs) can endow base stations with perception, reasoning, and acting capabilities, thus transforming them into intelligent base station agents (IBSAs). We first review the historical evolution of BSs from single-functional analog infrastructure to distributed, software-defined, and finally LAM-empowered IBSA, highlighting the accompanying changes in architecture, hardware platforms, and deployment. We then present an IBSA architecture that couples a perception-cognition-execution pipeline with cloud-edge-end collaboration and parameter-efficient adaptation. Subsequently,we study two representative scenarios: (i) cooperative vehicle-road perception for autonomous driving, and (ii) ubiquitous base station support for low-altitude uncrewed aerial vehicle safety monitoring and response against unauthorized drones. On this basis, we analyze key enabling technologies spanning LAM design and training, efficient edge-cloud inference, multi-modal perception and actuation, as well as trustworthy security and governance. We further propose a holistic evaluation framework and benchmark considerations that jointly cover communication performance, perception accuracy, decision-making reliability, safety, and energy efficiency. Finally, we distill open challenges on benchmarks, continual adaptation, trustworthy decision-making, and standardization. Together, this work positions LAM-enabled IBSAs as a practical path toward integrated perception, communication, and computation native, safety-critical 6G systems.

Yuyan Pi, Min Jin, Wentao Xie et al.

Computational biology offers immense potential for reducing the high costs and protracted cycles of new drug development through adverse drug reaction (ADR) prediction. However, current methods remain impeded by drug data scarcity-induced cold-start challenge, closed label sets, and inadequate modeling of label dependencies. Here we propose an open-ended ADR prediction paradigm based on Graph-Motif feature fusion and Multi-Label Generation (GM-MLG). Leveraging molecular structure as an intrinsic and inherent feature, GM-MLG constructs a dual-graph representation architecture spanning the atomic level, the local molecular level (utilizing fine-grained motifs dynamically extracted via the BRICS algorithm combined with additional fragmentation rules), and the global molecular level. Uniquely, GM-MLG pioneers transforming ADR prediction from multi-label classification into Transformer Decoder-based multi-label generation. By treating ADR labels as discrete token sequences, it employs positional embeddings to explicitly capture dependencies and co-occurrence relationships within large-scale label spaces, generating predictions via autoregressive decoding to dynamically expand the prediction space. Experiments demonstrate GM-MLG achieves up to 38% improvement and an average gain of 20%, expanding the prediction space from 200 to over 10,000 types. Furthermore, it elucidates non-linear structure-activity relationships between ADRs and motifs via retrosynthetic motif analysis, providing interpretable and innovative support for systematic risk reduction in drug safety.