Hongming Chen

Zhiguang Fan, Yuedong Yang, Mingyuan Xu et al.

The embedding of Biomedical Knowledge Graphs (BKGs) generates robust representations, valuable for a variety of artificial intelligence applications, including predicting drug combinations and reasoning disease-drug relationships. Meanwhile, contrastive learning (CL) is widely employed to enhance the distinctiveness of these representations. However, constructing suitable contrastive pairs for CL, especially within Knowledge Graphs (KGs), has been challenging. In this paper, we proposed a novel node-based contrastive learning method for knowledge graph embedding, NC-KGE. NC-KGE enhances knowledge extraction in embeddings and speeds up training convergence by constructing appropriate contrastive node pairs on KGs. This scheme can be easily integrated with other knowledge graph embedding (KGE) methods. For downstream task such as biochemical relationship prediction, we have incorporated a relation-aware attention mechanism into NC-KGE, focusing on the semantic relationships and node interactions. Extensive experiments show that NC-KGE performs competitively with state-of-the-art models on public datasets like FB15k-237 and WN18RR. Particularly in biomedical relationship prediction tasks, NC-KGE outperforms all baselines on datasets such as PharmKG8k-28, DRKG17k-21, and BioKG72k-14, especially in predicting drug combination relationships. We release our code at https://github.com/zhi520/NC-KGE.

Shuhong Liu, Xiang Chen, Hongming Chen et al.

Reconstruction under adverse rainy conditions poses significant challenges due to reduced visibility and the distortion of visual perception. These conditions can severely impair the quality of geometric maps, which is essential for applications ranging from autonomous planning to environmental monitoring. In response to these challenges, this study introduces the novel task of 3D Reconstruction in Rainy Environments (3DRRE), specifically designed to address the complexities of reconstructing 3D scenes under rainy conditions. To benchmark this task, we construct the HydroViews dataset that comprises a diverse collection of both synthesized and real-world scene images characterized by various intensities of rain streaks and raindrops. Furthermore, we propose DeRainGS, the first 3DGS method tailored for reconstruction in adverse rainy environments. Extensive experiments across a wide range of rain scenarios demonstrate that our method delivers state-of-the-art performance, remarkably outperforming existing occlusion-free methods.

Wenhui Chang, Hongming Chen, Xin He et al.

Raindrops adhering to the lens of UAVs can obstruct visibility of the background scene and degrade image quality. Despite recent progress in image deraining methods and datasets, there is a lack of focus on raindrop removal from UAV aerial imagery due to the unique challenges posed by varying angles and rapid movement during drone flight. To fill the gap in this research, we first construct a new benchmark dataset for removing raindrops from UAV images, called UAV-Rain1k. In this letter, we provide a dataset generation pipeline, which includes modeling raindrop shapes using Blender, collecting background images from various UAV angles, random sampling of rain masks and etc. Based on the proposed benchmark, we further present a comprehensive evaluation of existing representative image deraining algorithms, and reveal future research opportunities worth exploring. The proposed dataset is publicly available at https://github.com/cschenxiang/UAV-Rain1k.

Zhentao Fan, Hongming Chen, Yufeng Li

Recently, Transformer-based architecture has been introduced into single image deraining task due to its advantage in modeling non-local information. However, existing approaches tend to integrate global features based on a dense self-attention strategy since it tend to uses all similarities of the tokens between the queries and keys. In fact, this strategy leads to ignoring the most relevant information and inducing blurry effect by the irrelevant representations during the feature aggregation. To this end, this paper proposes an effective image deraining Transformer with dynamic dual self-attention (DDSA), which combines both dense and sparse attention strategies to better facilitate clear image reconstruction. Specifically, we only select the most useful similarity values based on top-k approximate calculation to achieve sparse attention. In addition, we also develop a novel spatial-enhanced feed-forward network (SEFN) to further obtain a more accurate representation for achieving high-quality derained results. Extensive experiments on benchmark datasets demonstrate the effectiveness of our proposed method.

Wenhui Chang, Hongming Chen

Smoke generated by surgical instruments during laparoscopic surgery can obscure the visual field, impairing surgeons' ability to perform operations accurately and safely. Thus, smoke removal task for laparoscopic images is highly desirable. Despite laparoscopic image desmoking has attracted the attention of researchers in recent years and several algorithms have emerged, the lack of publicly available high-quality benchmark datasets is the main bottleneck to hamper the development progress of this task. To advance this field, we construct a new high-quality dataset for Laparoscopic Surgery image Desmoking, named LSD3K, consisting of 3,000 paired synthetic non-homogeneous smoke images. In this paper, we provide a dataset generation pipeline, which includes modeling smoke shape using Blender, collecting ground-truth images from the Cholec80 dataset, random sampling of smoke masks and etc. Based on the proposed benchmark, we further conducted a comprehensive evaluation of the existing representative desmoking algorithms. The proposed dataset is publicly available at https://drive.google.com/file/d/1v0U5_3S4nJpaUiP898Q0pc-MfEAtnbOq/view?usp=sharing

Wenzhuo Jin, Qianfeng Yang, Xianhao Wu et al.

Early-stage fire scenes (0-15 minutes after ignition) represent a crucial temporal window for emergency interventions. During this stage, the smoke produced by combustion significantly reduces the visibility of surveillance systems, severely impairing situational awareness and hindering effective emergency response and rescue operations. Consequently, there is an urgent need to remove smoke from images to obtain clear scene information. However, the development of smoke removal algorithms remains limited due to the lack of large-scale, real-world datasets comprising paired smoke-free and smoke-degraded images. To address these limitations, we present a real-world surveillance image desmoking benchmark dataset named SmokeBench, which contains image pairs captured under diverse scenes setup and smoke concentration. The curated dataset provides precisely aligned degraded and clean images, enabling supervised learning and rigorous evaluation. We conduct comprehensive experiments by benchmarking a variety of desmoking methods on our dataset. Our dataset provides a valuable foundation for advancing robust and practical image desmoking in real-world fire scenes. This dataset has been released to the public and can be downloaded from https://github.com/ncfjd/SmokeBench.

Daniil Polykovskiy, Alexander Zhebrak, Benjamin Sanchez-Lengeling et al.

Generative models are becoming a tool of choice for exploring the molecular space. These models learn on a large training dataset and produce novel molecular structures with similar properties. Generated structures can be utilized for virtual screening or training semi-supervised predictive models in the downstream tasks. While there are plenty of generative models, it is unclear how to compare and rank them. In this work, we introduce a benchmarking platform called Molecular Sets (MOSES) to standardize training and comparison of molecular generative models. MOSES provides a training and testing datasets, and a set of metrics to evaluate the quality and diversity of generated structures. We have implemented and compared several molecular generation models and suggest to use our results as reference points for further advancements in generative chemistry research. The platform and source code are available at https://github.com/molecularsets/moses.

Xiaoning Liu, Zongwei Wu, Ao Li et al.

This paper reviews the NTIRE 2024 low light image enhancement challenge, highlighting the proposed solutions and results. The aim of this challenge is to discover an effective network design or solution capable of generating brighter, clearer, and visually appealing results when dealing with a variety of conditions, including ultra-high resolution (4K and beyond), non-uniform illumination, backlighting, extreme darkness, and night scenes. A notable total of 428 participants registered for the challenge, with 22 teams ultimately making valid submissions. This paper meticulously evaluates the state-of-the-art advancements in enhancing low-light images, reflecting the significant progress and creativity in this field.

Huiling Zhou, Xianhao Wu, Hongming Chen et al.

Remote sensing image dehazing (RSID) aims to remove nonuniform and physically irregular haze factors for high-quality image restoration. The emergence of CNNs and Transformers has taken extraordinary strides in the RSID arena. However, these methods often struggle to demonstrate the balance of adequate long-range dependency modeling and maintaining computational efficiency. To this end, we propose the first lightweight network on the mamba-based model called RSDhamba in the field of RSID. Greatly inspired by the recent rise of Selective State Space Model (SSM) for its superior performance in modeling linear complexity and remote dependencies, our designed RSDehamba integrates the SSM framework into the U-Net architecture. Specifically, we propose the Vision Dehamba Block (VDB) as the core component of the overall network, which utilizes the linear complexity of SSM to achieve the capability of global context encoding. Simultaneously, the Direction-aware Scan Module (DSM) is designed to dynamically aggregate feature exchanges over different directional domains to effectively enhance the flexibility of sensing the spatially varying distribution of haze. In this way, our RSDhamba fully demonstrates the superiority of spatial distance capture dependencies and channel information exchange for better extraction of haze features. Extensive experimental results on widely used benchmarks validate the surpassing performance of our RSDehamba against existing state-of-the-art methods.

Haolong Yan, Jia Wang, Xin Huang et al.

Recent advances in multimodal large language models unlock unprecedented opportunities for GUI automation. However, a fundamental challenge remains: how to efficiently acquire high-quality training data while maintaining annotation reliability? We introduce a self-evolving training pipeline powered by the Calibrated Step Reward System, which converts model-generated trajectories into reliable training signals through trajectory-level calibration, achieving >90% annotation accuracy with 10-100x lower cost. Leveraging this pipeline, we introduce Step-GUI, a family of models (4B/8B) that achieves state-of-the-art GUI performance (8B: 80.2% AndroidWorld, 48.5% OSWorld, 62.6% ScreenShot-Pro) while maintaining robust general capabilities. As GUI agent capabilities improve, practical deployment demands standardized interfaces across heterogeneous devices while protecting user privacy. To this end, we propose GUI-MCP, the first Model Context Protocol for GUI automation with hierarchical architecture that combines low-level atomic operations and high-level task delegation to local specialist models, enabling high-privacy execution where sensitive data stays on-device. Finally, to assess whether agents can handle authentic everyday usage, we introduce AndroidDaily, a benchmark grounded in real-world mobile usage patterns with 3146 static actions and 235 end-to-end tasks across high-frequency daily scenarios (8B: static 89.91%, end-to-end 52.50%). Our work advances the development of practical GUI agents and demonstrates strong potential for real-world deployment in everyday digital interactions.

Ying Fu, Yu Li, Shaodi You et al.

The intersection of physics-based vision and deep learning presents an exciting frontier for advancing computer vision technologies. By leveraging the principles of physics to inform and enhance deep learning models, we can develop more robust and accurate vision systems. Physics-based vision aims to invert the processes to recover scene properties such as shape, reflectance, light distribution, and medium properties from images. In recent years, deep learning has shown promising improvements for various vision tasks, and when combined with physics-based vision, these approaches can enhance the robustness and accuracy of vision systems. This technical report summarizes the outcomes of the Physics-Based Vision Meets Deep Learning (PBDL) 2024 challenge, held in CVPR 2024 workshop. The challenge consisted of eight tracks, focusing on Low-Light Enhancement and Detection as well as High Dynamic Range (HDR) Imaging. This report details the objectives, methodologies, and results of each track, highlighting the top-performing solutions and their innovative approaches.

Philip T. Jackson, Yinhai Wang, Sinead Knight et al.

While deep learning has seen many recent applications to drug discovery, most have focused on predicting activity or toxicity directly from chemical structure. Phenotypic changes exhibited in cellular images are also indications of the mechanism of action (MoA) of chemical compounds. In this paper, we show how pre-trained convolutional image features can be used to assist scientists in discovering interesting chemical clusters for further investigation. Our method reduces the dimensionality of raw fluorescent stained images from a high throughput imaging (HTI) screen, producing an embedding space that groups together images with similar cellular phenotypes. Running standard unsupervised clustering on this embedding space yields a set of distinct phenotypic clusters. This allows scientists to further select and focus on interesting clusters for downstream analyses. We validate the consistency of our embedding space qualitatively with t-sne visualizations, and quantitatively by measuring embedding variance among images that are known to be similar. Results suggested the usefulness of our proposed workflow using deep learning and clustering and it can lead to robust HTI screening and compound triage.

Thomas Blaschke, Marcus Olivecrona, Ola Engkvist et al.

A major challenge in computational chemistry is the generation of novel molecular structures with desirable pharmacological and physiochemical properties. In this work, we investigate the potential use of autoencoder, a deep learning methodology, for de novo molecular design. Various generative autoencoders were used to map molecule structures into a continuous latent space and vice versa and their performance as structure generator was assessed. Our results show that the latent space preserves chemical similarity principle and thus can be used for the generation of analogue structures. Furthermore, the latent space created by autoencoders were searched systematically to generate novel compounds with predicted activity against dopamine receptor type 2 and compounds similar to known active compounds not included in the training set were identified.

Marcus Olivecrona, Thomas Blaschke, Ola Engkvist et al.

This work introduces a method to tune a sequence-based generative model for molecular de novo design that through augmented episodic likelihood can learn to generate structures with certain specified desirable properties. We demonstrate how this model can execute a range of tasks such as generating analogues to a query structure and generating compounds predicted to be active against a biological target. As a proof of principle, the model is first trained to generate molecules that do not contain sulphur. As a second example, the model is trained to generate analogues to the drug Celecoxib, a technique that could be used for scaffold hopping or library expansion starting from a single molecule. Finally, when tuning the model towards generating compounds predicted to be active against the dopamine receptor type 2, the model generates structures of which more than 95% are predicted to be active, including experimentally confirmed actives that have not been included in either the generative model nor the activity prediction model.