Bing Su

Wen Yin, Cencen Liu, Dingrui Liu et al.

Unifying Image Quality Assessment (IQA) and Image Aesthetic Assessment (IAA) in a single multimodal large language model is appealing, yet existing methods adopt a task-agnostic recipe that applies the same reasoning strategy and reward to both tasks. We show this is fundamentally misaligned: IQA relies on low-level, objective perceptual cues and benefits from concise distortion-focused reasoning, whereas IAA requires deliberative semantic judgment and is poorly served by point-wise score regression. We identify these as a reasoning mismatch and an optimization mismatch, and provide empirical evidence for both through controlled probes. Motivated by these findings, we propose TATAR (Task-Aware Thinking with Asymmetric Rewards), a unified framework that shares the visual-language backbone while conditioning post-training on each task's nature. TATAR combines three components: fast--slow task-specific reasoning construction that pairs IQA with concise perceptual rationales and IAA with deliberative aesthetic narratives; two-stage SFT+GRPO learning that establishes task-aware behavioral priors before reward-driven refinement; and asymmetric rewards that apply Gaussian score shaping for IQA and Thurstone-style completion ranking for IAA. Extensive experiments across eight benchmarks demonstrate that TATAR consistently outperforms prior unified baselines on both tasks under in-domain and cross-domain settings, remains competitive with task-specific specialized models, and yields more stable training dynamics for aesthetic assessment. Our results establish task-conditioned post-training as a principled paradigm for unified perceptual scoring. Our code is publicly available at https://github.com/yinwen2019/TATAR.

Zhao Yang, Bing Su, Chuan Cao et al.

Cis-regulatory elements (CREs), such as promoters and enhancers, are relatively short DNA sequences that directly regulate gene expression. The fitness of CREs, measured by their ability to modulate gene expression, highly depends on the nucleotide sequences, especially specific motifs known as transcription factor binding sites (TFBSs). Designing high-fitness CREs is crucial for therapeutic and bioengineering applications. Current CRE design methods are limited by two major drawbacks: (1) they typically rely on iterative optimization strategies that modify existing sequences and are prone to local optima, and (2) they lack the guidance of biological prior knowledge in sequence optimization. In this paper, we address these limitations by proposing a generative approach that leverages reinforcement learning (RL) to fine-tune a pre-trained autoregressive (AR) model. Our method incorporates data-driven biological priors by deriving computational inference-based rewards that simulate the addition of activator TFBSs and removal of repressor TFBSs, which are then integrated into the RL process. We evaluate our method on promoter design tasks in two yeast media conditions and enhancer design tasks for three human cell types, demonstrating its ability to generate high-fitness CREs while maintaining sequence diversity. The code is available at https://github.com/yangzhao1230/TACO.

Zongzhao Li, Jiacheng Cen, Bing Su et al.

Accurately predicting 3D structures and dynamics of physical systems is crucial in scientific applications. Existing approaches that rely on geometric Graph Neural Networks (GNNs) effectively enforce $\mathrm{E}(3)$-equivariance, but they often fall in leveraging extensive broader information. While direct application of Large Language Models (LLMs) can incorporate external knowledge, they lack the capability for spatial reasoning with guaranteed equivariance. In this paper, we propose EquiLLM, a novel framework for representing 3D physical systems that seamlessly integrates E(3)-equivariance with LLM capabilities. Specifically, EquiLLM comprises four key components: geometry-aware prompting, an equivariant encoder, an LLM, and an equivariant adaptor. Essentially, the LLM guided by the instructive prompt serves as a sophisticated invariant feature processor, while 3D directional information is exclusively handled by the equivariant encoder and adaptor modules. Experimental results demonstrate that EquiLLM delivers significant improvements over previous methods across molecular dynamics simulation, human motion simulation, and antibody design, highlighting its promising generalizability.

Jiexin Wang, Yiju Guo, Bing Su

Exploring the bridge between historical and future motion behaviors remains a central challenge in human motion prediction. While most existing methods incorporate a reconstruction task as an auxiliary task into the decoder, thereby improving the modeling of spatio-temporal dependencies, they overlook the potential conflicts between reconstruction and prediction tasks. In this paper, we propose a novel approach: Temporal Decoupling Decoding with Inverse Processing (\textbf{$TD^2IP$}). Our method strategically separates reconstruction and prediction decoding processes, employing distinct decoders to decode the shared motion features into historical or future sequences. Additionally, inverse processing reverses motion information in the temporal dimension and reintroduces it into the model, leveraging the bidirectional temporal correlation of human motion behaviors. By alleviating the conflicts between reconstruction and prediction tasks and enhancing the association of historical and future information, \textbf{$TD^2IP$} fosters a deeper understanding of motion patterns. Extensive experiments demonstrate the adaptability of our method within existing methods.