YingLiang Ma

Fazli Wahid, Yingliang Ma, Dawar Khan et al.

Biomedical image segmentation plays a vital role in diagnosis of diseases across various organs. Deep learning-based object detection methods are commonly used for such segmentation. There exists an extensive research in this topic. However, there is no standard review on this topic. Existing surveys often lack a standardized approach or focus on broader segmentation techniques. In this paper, we conducted a systematic literature review (SLR), collected and analysed 148 articles that explore deep learning object detection methods for biomedical image segmentation. We critically analyzed these methods, identified the key challenges, and discussed the future directions. From the selected articles we extracted the results including the deep learning models, targeted imaging modalities, targeted diseases, and the metrics for the analysis of the methods. The results have been presented in tabular and/or charted forms. The results are presented in three major categories including two stage detection models, one stage detection models and point-based detection models. Each article is individually analyzed along with its pros and cons. Finally, we discuss open challenges, potential benefits, and future research directions. This SLR aims to provide the research community with a quick yet deeper understanding of these segmentation models, ultimately facilitating the development of more powerful solutions for biomedical image analysis.

YingLiang Ma, Sandra Howell, Aldo Rinaldi et al.

Objective: Interventional devices, catheters and insertable imaging devices such as transesophageal echo (TOE) probes are routinely used in minimally invasive cardiovascular procedures. Detecting their positions and orientations in X-ray fluoroscopic images is important for many clinical applications. Method: In this paper, a novel attention mechanism was designed to guide a convolution neural network (CNN) model to the areas of wires in X-ray images, as nearly all interventional devices and catheters used in cardiovascular procedures contain wires. The attention mechanism includes multi-scale Gaussian derivative filters and a dot-product-based attention layer. By utilizing the proposed attention mechanism, a lightweight foundation model can be created to detect multiple objects simultaneously with higher precision and real-time speed. Results: The proposed model was trained and tested on a total of 12,438 X-ray images. An accuracy of 0.88 was achieved for detecting an echo probe and 0.87 for detecting an artificial valve at 58 FPS. The accuracy was measured by intersection-over-union (IoU). We also achieved a 99.8% success rate in detecting a 10-electrode catheter and a 97.8% success rate in detecting an ablation catheter. Conclusion: Our detection foundation model can simultaneously detect and identify both interventional devices and flexible catheters in real-time X-ray fluoroscopic images. Significance: The proposed model employs a novel attention mechanism to achieve high-performance object detection, making it suitable for various clinical applications and robotic-assisted surgeries. Codes are available at https://github.com/YingLiangMa/AttWire.

Lin Xi, Yingliang Ma, Xiahai Zhuang

We introduce a novel FSVOS model that employs a local matching strategy to restrict the search space to the most relevant neighboring pixels. Rather than relying on inefficient standard im2col-like implementations (e.g., spatial convolutions, depthwise convolutions and feature-shifting mechanisms) or hardware-specific CUDA kernels (e.g., deformable and neighborhood attention), which often suffer from limited portability across non-CUDA devices, we reorganize the local sampling process through a direction-based sampling perspective. Specifically, we implement a non-parametric sampling mechanism that enables dynamically varying sampling regions. This approach provides the flexibility to adapt to diverse spatial structures without the computational costs of parametric layers and the need for model retraining. To further enhance feature coherence across frames, we design a supervised spatio-temporal contrastive learning scheme that enforces consistency in feature representations. In addition, we introduce a publicly available benchmark dataset for multi-object segmentation in X-ray angiography videos (MOSXAV), featuring detailed, manually labeled segmentation ground truth. Extensive experiments on the CADICA, XACV, and MOSXAV datasets show that our proposed FSVOS method outperforms current state-of-the-art video segmentation methods in terms of segmentation accuracy and generalization capability (i.e., seen and unseen categories). This work offers enhanced flexibility and potential for a wide range of clinical applications.

Lin Xi, Yingliang Ma, Ethan Koland et al.

Automated detection and segmentation of surgical devices, such as catheters or wires, in X-ray fluoroscopic images have the potential to enhance image guidance in minimally invasive heart surgeries. In this paper, we present a convolutional neural network model that integrates a resnet architecture with multiple prediction heads to achieve real-time, accurate localization of electrodes on catheters and catheter segmentation in an end-to-end deep learning framework. We also propose a multi-task learning strategy in which our model is trained to perform both accurate electrode detection and catheter segmentation simultaneously. A key challenge with this approach is achieving optimal performance for both tasks. To address this, we introduce a novel multi-level dynamic resource prioritization method. This method dynamically adjusts sample and task weights during training to effectively prioritize more challenging tasks, where task difficulty is inversely proportional to performance and evolves throughout the training process. Experiments on both public and private datasets have demonstrated that the accuracy of our method surpasses the existing state-of-the-art methods in both single segmentation task and in the detection and segmentation multi-task. Our approach achieves a good trade-off between accuracy and efficiency, making it well-suited for real-time surgical guidance applications.

Ethan Koland, Lin Xi, Nadeev Wijesuriya et al.

X-ray angiography is widely used in cardiac interventions to visualize coronary vessels, assess integrity, detect stenoses and guide treatment. We propose a framework for reconstructing 3D vessel trees from biplanar X-ray images which are extracted from two X-ray videos captured at different C-arm angles. The proposed framework consists of three main components: image segmentation, motion phase matching, and 3D reconstruction. An automatic video segmentation method for X-ray angiography to enable semantic segmentation for image segmentation and motion phase matching. The goal of the motion phase matching is to identify a pair of X-ray images that correspond to a similar respiratory and cardiac motion phase to reduce errors in 3D reconstruction. This is achieved by tracking a stationary object such as a catheter or lead within the X-ray video. The semantic segmentation approach assigns different labels to different object classes enabling accurate differentiation between blood vessels, balloons, and catheters. Once a suitable image pair is selected, key anatomical landmarks (vessel branching points and endpoints) are matched between the two views using a heuristic method that minimizes reconstruction errors. This is followed by a novel geometric reconstruction algorithm to generate the 3D vessel tree. The algorithm computes the 3D vessel centrelines by determining the intersection of two 3D surfaces. Compared to traditional methods based on epipolar constraints, the proposed approach simplifies there construction workflow and improves overall accuracy. We trained and validated our segmentation method on 62 X-ray angiography video sequences. On the test set, our method achieved a segmentation accuracy of 0.703. The 3D reconstruction framework was validated by measuring the reconstruction error of key anatomical landmarks, achieving a reprojection errors of 0.62mm +/- 0.38mm.

Lin Xi, Yingliang Ma, Cheng Wang et al.

Obtaining pixel-level annotations in the medical domain is both expensive and time-consuming, often requiring close collaboration between clinical experts and developers. Semi-supervised medical image segmentation aims to leverage limited annotated data alongside abundant unlabeled data to achieve accurate segmentation. However, existing semi-supervised methods often struggle to structure semantic distributions in the latent space due to noise introduced by pseudo-labels. In this paper, we propose a novel diffusion-based framework for semi-supervised medical image segmentation. Our method introduces a constraint into the latent structure of semantic labels during the denoising diffusion process by enforcing prototype-based contrastive consistency. Rather than explicitly delineating semantic boundaries, the model leverages class prototypes centralized semantic representations in the latent space as anchors. This strategy improves the robustness of dense predictions, particularly in the presence of noisy pseudo-labels. We also introduce a new publicly available benchmark: Multi-Object Segmentation in X-ray Angiography Videos (MOSXAV), which provides detailed, manually annotated segmentation ground truth for multiple anatomical structures in X-ray angiography videos. Extensive experiments on the EndoScapes2023 and MOSXAV datasets demonstrate that our method outperforms state-of-the-art medical image segmentation approaches under the semi-supervised learning setting. This work presents a robust and data-efficient diffusion model that offers enhanced flexibility and strong potential for a wide range of clinical applications.

Anh Nguyen, Dennis Kundrat, Giulio Dagnino et al.

Accurate real-time catheter segmentation is an important pre-requisite for robot-assisted endovascular intervention. Most of the existing learning-based methods for catheter segmentation and tracking are only trained on small-scale datasets or synthetic data due to the difficulties of ground-truth annotation. Furthermore, the temporal continuity in intraoperative imaging sequences is not fully utilised. In this paper, we present FW-Net, an end-to-end and real-time deep learning framework for endovascular intervention. The proposed FW-Net has three modules: a segmentation network with encoder-decoder architecture, a flow network to extract optical flow information, and a novel flow-guided warping function to learn the frame-to-frame temporal continuity. We show that by effectively learning temporal continuity, the network can successfully segment and track the catheters in real-time sequences using only raw ground-truth for training. Detailed validation results confirm that our FW-Net outperforms state-of-the-art techniques while achieving real-time performance.