Morten Rieger Hannemose

Morten Rieger Hannemose, Josefine Vilsbøll Sundgaard, Niels Kvorning Ternov et al.

When doctors are trained to diagnose a specific disease, they learn faster when presented with cases in order of increasing difficulty. This creates the need for automatically estimating how difficult it is for doctors to classify a given case. In this paper, we introduce methods for estimating how hard it is for a doctor to diagnose a case represented by a medical image, both when ground truth difficulties are available for training, and when they are not. Our methods are based on embeddings obtained with deep metric learning. Additionally, we introduce a practical method for obtaining ground truth human difficulty for each image case in a dataset using self-assessed certainty. We apply our methods to two different medical datasets, achieving high Kendall rank correlation coefficients, showing that we outperform existing methods by a large margin on our problem and data.

Christian Keilstrup Ingwersen, Christian Mikkelstrup, Janus Nørtoft Jensen et al.

Accurate 3D human pose estimation is essential for sports analytics, coaching, and injury prevention. However, existing datasets for monocular pose estimation do not adequately capture the challenging and dynamic nature of sports movements. In response, we introduce SportsPose, a large-scale 3D human pose dataset consisting of highly dynamic sports movements. With more than 176,000 3D poses from 24 different subjects performing 5 different sports activities, SportsPose provides a diverse and comprehensive set of 3D poses that reflect the complex and dynamic nature of sports movements. Contrary to other markerless datasets we have quantitatively evaluated the precision of SportsPose by comparing our poses with a commercial marker-based system and achieve a mean error of 34.5 mm across all evaluation sequences. This is comparable to the error reported on the commonly used 3DPW dataset. We further introduce a new metric, local movement, which describes the movement of the wrist and ankle joints in relation to the body. With this, we show that SportsPose contains more movement than the Human3.6M and 3DPW datasets in these extremum joints, indicating that our movements are more dynamic. The dataset with accompanying code can be downloaded from our website. We hope that SportsPose will allow researchers and practitioners to develop and evaluate more effective models for the analysis of sports performance and injury prevention. With its realistic and diverse dataset, SportsPose provides a valuable resource for advancing the state-of-the-art in pose estimation in sports.

Thor Vestergaard Christiansen, Karran Pandey, Alba Reinders et al.

We introduce Text Encoded Extrusion (TEE), a text-based representation that expresses mesh construction as sequences of face extrusions rather than polygon lists, and a method for generating 3D meshes from TEE using a large language model (LLM). By learning extrusion sequences that assemble a mesh, similar to the way artists create meshes, our approach naturally supports arbitrary output face counts and produces manifold meshes by design, in contrast to recent transformer-based models. The learnt extrusion sequences can also be applied to existing meshes - enabling editing in addition to generation. To train our model, we decompose a library of quadrilateral meshes with non-self-intersecting face loops into constituent loops, which can be viewed as their building blocks, and finetune an LLM on the steps for reassembling the meshes by performing a sequence of extrusions. We demonstrate that our representation enables reconstruction, novel shape synthesis, and the addition of new features to existing meshes.

Christian Keilstrup Ingwersen, Rasmus Tirsgaard, Rasmus Nylander et al.

Deducing a 3D human pose from a single 2D image is inherently challenging because multiple 3D poses can correspond to the same 2D representation. 3D data can resolve this pose ambiguity, but it is expensive to record and requires an intricate setup that is often restricted to controlled lab environments. We propose a method that improves the performance of deep learning-based monocular 3D human pose estimation models by using multiview data only during training, but not during inference. We introduce a novel loss function, consistency loss, which operates on two synchronized views. This approach is simpler than previous models that require 3D ground truth or intrinsic and extrinsic camera parameters. Our consistency loss penalizes differences in two pose sequences after rigid alignment. We also demonstrate that our consistency loss substantially improves performance for fine-tuning without requiring 3D data. Furthermore, we show that using our consistency loss can yield state-of-the-art performance when training models from scratch in a semi-supervised manner. Our findings provide a simple way to capture new data, e.g in a new domain. This data can be added using off-the-shelf cameras with no calibration requirements. We make all our code and data publicly available.

Jakob Lønborg Christensen, Vedrana Andersen Dahl, Morten Rieger Hannemose et al.

Uncertainty quantification (UQ) is crucial in safety-critical applications such as medical image segmentation. Total uncertainty is typically decomposed into data-related aleatoric uncertainty (AU) and model-related epistemic uncertainty (EU). Many methods exist for modeling AU (such as Probabilistic UNet, Diffusion) and EU (such as ensembles, MC Dropout), but it is unclear how they interact when combined. Additionally, recent work has revealed substantial entanglement between AU and EU, undermining the interpretability and practical usefulness of the decomposition. We present a comprehensive empirical study covering a broad range of AU-EU model combinations, propose a metric to quantify uncertainty entanglement, and evaluate both across downstream UQ tasks. For out-of-distribution detection, ensembles exhibit consistently lower entanglement and superior performance. For ambiguity modeling and calibration the best models are dataset-dependent, with softmax/SSN-based methods performing well and Probabilistic UNets being less entangled. A softmax ensemble fares remarkably well on all tasks. Finally, we analyze potential sources of uncertainty entanglement and outline directions for mitigating this effect.

Changlu Guo, Anders Nymark Christensen, Morten Rieger Hannemose

Text-to-image generative models have achieved remarkable breakthroughs in recent years. However, their application in medical image generation still faces significant challenges, including small dataset sizes, and scarcity of medical textual data. To address these challenges, we propose Med-Art, a framework specifically designed for medical image generation with limited data. Med-Art leverages vision-language models to generate visual descriptions of medical images which overcomes the scarcity of applicable medical textual data. Med-Art adapts a large-scale pre-trained text-to-image model, PixArt-$α$, based on the Diffusion Transformer (DiT), achieving high performance under limited data. Furthermore, we propose an innovative Hybrid-Level Diffusion Fine-tuning (HLDF) method, which enables pixel-level losses, effectively addressing issues such as overly saturated colors. We achieve state-of-the-art performance on two medical image datasets, measured by FID, KID, and downstream classification performance.

Changlu Guo, Anders Nymark Christensen, Anders Bjorholm Dahl et al.

Visual counterfactual explanations aim to reveal the minimal semantic modifications that can alter a model's prediction, providing causal and interpretable insights into deep neural networks. However, existing diffusion-based counterfactual generation methods are often computationally expensive, slow to sample, and imprecise in localizing the modified regions. To address these limitations, we propose MaskDiME, a simple, fast, and effective diffusion framework that unifies semantic consistency and spatial precision through localized sampling. Our approach adaptively focuses on decision-relevant regions to achieve localized and semantically consistent counterfactual generation while preserving high image fidelity. Our training-free framework, MaskDiME, achieves over 30x faster inference than the baseline method and achieves comparable or state-of-the-art performance across five benchmark datasets spanning diverse visual domains, establishing a practical and generalizable solution for efficient counterfactual explanation.

Changlu Guo, Anders Nymark Christensen, Anders Bjorholm Dahl et al.

Retinal vessel segmentation is essential for early diagnosis of diseases such as diabetic retinopathy, hypertension, and neurodegenerative disorders. Although SA-UNet introduces spatial attention in the bottleneck, it underuses attention in skip connections and does not address the severe foreground-background imbalance. We propose SA-UNetv2, a lightweight model that injects cross-scale spatial attention into all skip connections to strengthen multi-scale feature fusion and adopts a weighted Binary Cross-Entropy (BCE) plus Matthews Correlation Coefficient (MCC) loss to improve robustness to class imbalance. On the public DRIVE and STARE datasets, SA-UNetv2 achieves state-of-the-art performance with only 1.2MB memory and 0.26M parameters (less than 50% of SA-UNet), and 1 second CPU inference on 592 x 592 x 3 images, demonstrating strong efficiency and deployability in resource-constrained, CPU-only settings.

Jakob Lønborg Christensen, Morten Rieger Hannemose, Anders Bjorholm Dahl et al.

Medical image segmentation often involves inherent uncertainty due to variations in expert annotations. Capturing this uncertainty is an important goal and previous works have used various generative image models for the purpose of representing the full distribution of plausible expert ground truths. In this work, we explore the design space of diffusion models for generative segmentation, investigating the impact of noise schedules, prediction types, and loss weightings. Notably, we find that making the noise schedule harder with input scaling significantly improves performance. We conclude that x- and v-prediction outperform epsilon-prediction, likely because the diffusion process is in the discrete segmentation domain. Many loss weightings achieve similar performance as long as they give enough weight to the end of the diffusion process. We base our experiments on the LIDC-IDRI lung lesion dataset and obtain state-of-the-art (SOTA) performance. Additionally, we introduce a randomly cropped variant of the LIDC-IDRI dataset that is better suited for uncertainty in image segmentation. Our model also achieves SOTA in this harder setting.

Josefine Vilsbøll Sundgaard, Morten Rieger Hannemose, Søren Laugesen et al.

We present a deep metric variational autoencoder for multi-modal data generation. The variational autoencoder employs triplet loss in the latent space, which allows for conditional data generation by sampling in the latent space within each class cluster. The approach is evaluated on a multi-modal dataset consisting of otoscopy images of the tympanic membrane with corresponding wideband tympanometry measurements. The modalities in this dataset are correlated, as they represent different aspects of the state of the middle ear, but they do not present a direct pixel-to-pixel correlation. The approach shows promising results for the conditional generation of pairs of images and tympanograms, and will allow for efficient data augmentation of data from multi-modal sources.