Ningtao Liu

Ningtao Liu, Ruoxi Gao, Jing Yuan et al.

Electronic health records (EHRs) are usually highly dimensional, heterogeneous, and multimodal. Besides, the random recording of clinical variables results in high missing rates and uneven time intervals between adjacent records in the multivariate clinical time-series data extracted from EHRs. Current works using clinical time-series data for patient representation regard the patients' physiological status as a discrete process described by sporadically collected records. However, changes in the patient's physiological condition are continuous and dynamic processes. The perception of time and velocity of change is crucial for patient representation learning. In this study, we propose a time- and velocity-aware gated recurrent unit model (GRU-TV) for patient representation learning of clinical multivariate time-series data in a time-continuous manner. The neural ordinary differential equations (ODEs) and velocity perception mechanism are applied to perceive the time interval between adjacent records and changing rate of the patient's physiological status, respectively. Our experiments on two real clinical EHR datasets (PhysioNet2012, MIMIC-III) establish that GRU-TV is a robust model on computer-aided diagnosis (CAD) tasks, especially on sequences with high-variance time intervals.

Ningtao Liu

The traditional manual age estimation method is crucial labor based on many kinds of the X-Ray image. Some current studies have shown that lateral cephalometric(LC) images can be used to estimate age. However, these methods are based on manually measuring some image features and making age estimates based on experience or scoring. Therefore, these methods are time-consuming and labor-intensive, and the effect will be affected by subjective opinions. In this work, we propose a saliency map-enhanced age estimation method, which can automatically perform age estimation based on LC images. Meanwhile, it can also show the importance of each region in the image for age estimation, which undoubtedly increases the method's Interpretability. Our method was tested on 3014 LC images from 4 to 40 years old. The MEA of the experimental result is 1.250, which is less than the result of the state-of-the-art benchmark because it performs significantly better in the age group with fewer data. Besides, our model is trained in each area with a high contribution to age estimation in LC images, so the effect of these different areas on the age estimation task was verified. Consequently, we conclude that the proposed saliency map enhancements chronological age estimation method of lateral cephalometric radiographs can work well in chronological age estimation task, especially when the amount of data is small. Besides, compared with traditional deep learning, our method is also interpretable.