Thalea Schlender

Thalea Schlender, Peter A. N. Bosman, Tanja Alderliesten

Survival analysis concerns the task of predicting the time until an event occurs. Often used in the medical field, survival analysis deals with incomplete (i.e., censored) data, for instance, from patients who did not experience the event during the duration of the study. For practical use, both accuracy and interpretability are important. Survival trees are easy-to-follow survival models that split the patient cohort recursively into discrete patient groups. Whilst survival trees can capture complex relationships, they typically need to grow large, threatening interpretability. Moreover, survival trees are often built using greedy approaches that may overlook globally optimal split combinations, limiting predictive performance. Shallow survival trees require expressive, higher-order feature combinations to achieve competitive accuracy. We therefore use genetic programming to multi-objectively evolve inherently inspectable feature sets and study how they interact with different tree induction strategies. We further introduce an evolutionary approach that jointly optimises the survival tree structure and the non-linear split logic. Our findings demonstrate that evolutionary feature construction improves predictive performance across different tree induction strategies on two real-world datasets and two different survival tree depths. Full joint evolution has the overall highest potential to propose multiple inherently inspectable shallow survival trees of good performance.

Mafalda Malafaia, Thalea Schlender, Peter A. N. Bosman et al.

In the health domain, decisions are often based on different data modalities. Thus, when creating prediction models, multimodal fusion approaches that can extract and combine relevant features from different data modalities, can be highly beneficial. Furthermore, it is important to understand how each modality impacts the final prediction, especially in high-stake domains, so that these models can be used in a trustworthy and responsible manner. We propose MultiFIX: a new interpretability-focused multimodal data fusion pipeline that explicitly induces separate features from different data types that can subsequently be combined to make a final prediction. An end-to-end deep learning architecture is used to train a predictive model and extract representative features of each modality. Each part of the model is then explained using explainable artificial intelligence techniques. Attention maps are used to highlight important regions in image inputs. Inherently interpretable symbolic expressions, learned with GP-GOMEA, are used to describe the contribution of tabular inputs. The fusion of the extracted features to predict the target label is also replaced by a symbolic expression, learned with GP-GOMEA. Results on synthetic problems demonstrate the strengths and limitations of MultiFIX. Lastly, we apply MultiFIX to a publicly available dataset for the detection of malignant skin lesions.

Thalea Schlender, Catharina J. A. Romme, Yvette M. van der Linden et al.

Survival analysis is central to clinical research, informing patient prognoses, guiding treatment decisions, and optimising resource allocation. Accurate time-to-event predictions not only improve quality of life but also reveal risk factors that shape clinical practice. For these models to be relevant in healthcare, interpretability is critical: predictions must be traceable to patient-specific characteristics, and risk factors should be identifiable to generate actionable insights for both clinicians and researchers. Traditional survival models often fail to capture non-linear interactions, while modern deep learning approaches, though powerful, are limited by poor interpretability. We propose a Pipeline for Interpretable Survival Analysis (PISA) - a pipeline that provides multiple survival analysis models that trade off complexity and performance. Using multiple-feature, multi-objective feature engineering, PISA transforms patient characteristics and time-to-event data into multiple survival analysis models, providing valuable insights into the survival prediction task. Crucially, every model is converted into simple patient stratification flowcharts supported by Kaplan-Meier curves, whilst not compromising on performance. While PISA is model-agnostic, we illustrate its flexibility through applications of Cox regression and shallow survival trees, the latter avoiding proportional hazards assumptions. Applied to two clinical benchmark datasets, PISA produced interpretable survival models and intuitive stratification flowcharts whilst achieving state-of-the-art performances. Revisiting a prior departmental study further demonstrated its capacity to automate survival analysis workflows in real-world clinical research.

Thalea Schlender, Gerasimos Spanakis

With the vast development and employment of artificial intelligence applications, research into the fairness of these algorithms has been increased. Specifically, in the natural language processing domain, it has been shown that social biases persist in word embeddings and are thus in danger of amplifying these biases when used. As an example of social bias, religious biases are shown to persist in word embeddings and the need for its removal is highlighted. This paper investigates the state-of-the-art multiclass debiasing techniques: Hard debiasing, SoftWEAT debiasing and Conceptor debiasing. It evaluates their performance when removing religious bias on a common basis by quantifying bias removal via the Word Embedding Association Test (WEAT), Mean Average Cosine Similarity (MAC) and the Relative Negative Sentiment Bias (RNSB). By investigating the religious bias removal on three widely used word embeddings, namely: Word2Vec, GloVe, and ConceptNet, it is shown that the preferred method is ConceptorDebiasing. Specifically, this technique manages to decrease the measured religious bias on average by 82,42%, 96,78% and 54,76% for the three word embedding sets respectively.