Sina Farsiu

Ziyun Yang, Sina Farsiu

Anatomical consistency in biomarker segmentation is crucial for many medical image analysis tasks. A promising paradigm for achieving anatomically consistent segmentation via deep networks is incorporating pixel connectivity, a basic concept in digital topology, to model inter-pixel relationships. However, previous works on connectivity modeling have ignored the rich channel-wise directional information in the latent space. In this work, we demonstrate that effective disentanglement of directional sub-space from the shared latent space can significantly enhance the feature representation in the connectivity-based network. To this end, we propose a directional connectivity modeling scheme for segmentation that decouples, tracks, and utilizes the directional information across the network. Experiments on various public medical image segmentation benchmarks show the effectiveness of our model as compared to the state-of-the-art methods. Code is available at https://github.com/Zyun-Y/DconnNet.

Reza Rasti, Armin Biglari, Mohammad Rezapourian et al.

Optical coherence tomography (OCT) helps ophthalmologists assess macular edema, accumulation of fluids, and lesions at microscopic resolution. Quantification of retinal fluids is necessary for OCT-guided treatment management, which relies on a precise image segmentation step. As manual analysis of retinal fluids is a time-consuming, subjective, and error-prone task, there is increasing demand for fast and robust automatic solutions. In this study, a new convolutional neural architecture named RetiFluidNet is proposed for multi-class retinal fluid segmentation. The model benefits from hierarchical representation learning of textural, contextual, and edge features using a new self-adaptive dual-attention (SDA) module, multiple self-adaptive attention-based skip connections (SASC), and a novel multi-scale deep self supervision learning (DSL) scheme. The attention mechanism in the proposed SDA module enables the model to automatically extract deformation-aware representations at different levels, and the introduced SASC paths further consider spatial-channel interdependencies for concatenation of counterpart encoder and decoder units, which improve representational capability. RetiFluidNet is also optimized using a joint loss function comprising a weighted version of dice overlap and edge-preserved connectivity-based losses, where several hierarchical stages of multi-scale local losses are integrated into the optimization process. The model is validated based on three publicly available datasets: RETOUCH, OPTIMA, and DUKE, with comparisons against several baselines. Experimental results on the datasets prove the effectiveness of the proposed model in retinal OCT fluid segmentation and reveal that the suggested method is more effective than existing state-of-the-art fluid segmentation algorithms in adapting to retinal OCT scans recorded by various image scanning instruments.

Fengyang Xiao, Peng Hu, Lei Xu et al.

Real-world image restoration aims to restore high-quality (HQ) images from degraded low-quality (LQ) inputs captured under uncontrolled conditions. Existing methods typically depend on ground-truth (GT) supervision, assuming that GT provides perfect reference quality. However, GT can still contain images with inconsistent perceptual fidelity, causing models to converge to the average quality level of the training data rather than achieving the highest perceptual quality attainable. To address these problems, we propose a novel framework, termed IQPIR, that introduces an Image Quality Prior (IQP)-extracted from pre-trained No-Reference Image Quality Assessment (NR-IQA) models-to guide the restoration process toward perceptually optimal outputs explicitly. Our approach synergistically integrates IQP with a learned codebook prior through three key mechanisms: (1) a quality-conditioned Transformer, where NR-IQA-derived scores serve as conditioning signals to steer the predicted representation toward maximal perceptual quality. This design provides a plug-and-play enhancement compatible with existing restoration architectures without structural modification; and (2) a dual-branch codebook structure, which disentangles common and HQ-specific features, ensuring a comprehensive representation of both generic structural information and quality-sensitive attributes; and (3) a discrete representation-based quality optimization strategy, which mitigates over-optimization effects commonly observed in continuous latent spaces. Extensive experiments on real-world image restoration demonstrate that our method not only surpasses cutting-edge methods but also serves as a generalizable quality-guided enhancement strategy for existing methods. The code is available.

Zihan Li, Yiqing Wang, Sina Farsiu et al.

Recent advances in image-text pretraining have significantly enhanced visual understanding by aligning visual and textual representations. Contrastive Language-Image Pretraining (CLIP) has played a pivotal role in multimodal learning. However, its focus on single-label, single-granularity alignment limits its effectiveness in complex domains such as medical imaging, where images often correspond to multiple high-level labels (e.g., disease categories) across different annotation granularities (e.g., diagnostic description, clinical explanation). To address this, we propose Multi-Granular Language Learning (MGLL), a contrastive learning framework designed to improve both multi-label and cross-granularity alignment. MGLL leverages structured multi-label supervision, integrates textual descriptions across granularities, and introduces soft-label supervision with point-wise constraints to enhance alignment. MGLL employs smooth Kullback-Leibler (KL) divergence to ensure cross-granularity consistency while maintaining computational efficiency as a plug-and-play module for vision-language models. Pretrained on our constructed large-scale multi-granular datasets and evaluated across multiple datasets, MGLL outperforms other state-of-the-art methods in downstream tasks. The code is available at \href{https://github.com/HUANGLIZI/MGLL}{https://github.com/HUANGLIZI/MGLL}.

Chunming He, Rihan Zhang, Fengyang Xiao et al.

Existing concealed object segmentation (COS) methods frequently utilize reversible strategies to address uncertain regions. However, these approaches are typically restricted to the mask domain, leaving the potential of the RGB domain underexplored. To address this, we propose the Reversible Unfolding Network (RUN), which applies reversible strategies across both mask and RGB domains through a theoretically grounded framework, enabling accurate segmentation. RUN first formulates a novel COS model by incorporating an extra residual sparsity constraint to minimize segmentation uncertainties. The iterative optimization steps of the proposed model are then unfolded into a multistage network, with each step corresponding to a stage. Each stage of RUN consists of two reversible modules: the Segmentation-Oriented Foreground Separation (SOFS) module and the Reconstruction-Oriented Background Extraction (ROBE) module. SOFS applies the reversible strategy at the mask level and introduces Reversible State Space to capture non-local information. ROBE extends this to the RGB domain, employing a reconstruction network to address conflicting foreground and background regions identified as distortion-prone areas, which arise from their separate estimation by independent modules. As the stages progress, RUN gradually facilitates reversible modeling of foreground and background in both the mask and RGB domains, directing the network's attention to uncertain regions and mitigating false-positive and false-negative results. Extensive experiments demonstrate the superior performance of RUN and highlight the potential of unfolding-based frameworks for COS and other high-level vision tasks. We will release the code and models.

Chunming He, Rihan Zhang, Fengyang Xiao et al.

Deep unfolding networks (DUNs) are widely employed in illumination degradation image restoration (IDIR) to merge the interpretability of model-based approaches with the generalization of learning-based methods. However, the performance of DUN-based methods remains considerably inferior to that of state-of-the-art IDIR solvers. Our investigation indicates that this limitation does not stem from structural shortcomings of DUNs but rather from the limited exploration of the unfolding structure, particularly for (1) constructing task-specific restoration models, (2) integrating advanced network architectures, and (3) designing DUN-specific loss functions. To address these issues, we propose a novel DUN-based method, UnfoldIR, for IDIR tasks. UnfoldIR first introduces a new IDIR model with dedicated regularization terms for smoothing illumination and enhancing texture. We unfold the iterative optimized solution of this model into a multistage network, with each stage comprising a reflectance-assisted illumination correction (RAIC) module and an illumination-guided reflectance enhancement (IGRE) module. RAIC employs a visual state space (VSS) to extract non-local features, enforcing illumination smoothness, while IGRE introduces a frequency-aware VSS to globally align similar textures, enabling mildly degraded regions to guide the enhancement of details in more severely degraded areas. This suppresses noise while enhancing details. Furthermore, given the multistage structure, we propose an inter-stage information consistent loss to maintain network stability in the final stages. This loss contributes to structural preservation and sustains the model's performance even in unsupervised settings. Experiments verify our effectiveness across 5 IDIR tasks and 3 downstream problems.

Fengyang Xiao, Jingjia Feng, Peng Hu et al.

Real-world image restoration (RWIR) is a highly challenging task due to the absence of clean ground-truth images. Many recent methods resort to pseudo-label (PL) supervision, often within a Mean-Teacher (MT) framework. However, these methods face a critical paradox: unconditionally trusting the often imperfect, low-quality PLs forces the student model to learn undesirable artifacts, while discarding them severely limits data diversity and impairs model generalization. In this paper, we propose QualiTeacher, a novel framework that transforms pseudo-label quality from a noisy liability into a conditional supervisory signal. Instead of filtering, QualiTeacher explicitly conditions the student model on the quality of the PLs, estimated by an ensemble of complementary non-reference image quality assessment (NR-IQA) models spanning low-level distortion and semantic-level assessment. This strategy teaches the student network to learn a quality-graded restoration manifold, enabling it to understand what constitutes different quality levels. Consequently, it can not only avoid mimicking artifacts from low-quality labels but also extrapolate to generate results of higher quality than the teacher itself. To ensure the robustness and accuracy of this quality-driven learning, we further enhance the process with a multi-augmentation scheme to diversify the PL quality spectrum, a score-based preference optimization strategy inspired by Direct Preference Optimization (DPO) to enforce a monotonically ordered quality separation, and a cropped consistency loss to prevent adversarial over-optimization (reward hacking) of the IQA models. Experiments on standard RWIR benchmarks demonstrate that QualiTeacher can serve as a plug-and-play strategy to improve the quality of the existing pseudo-labeling framework, establishing a new paradigm for learning from imperfect supervision. Code will be released.

Peng Hu, Chunming He, Lei Xu et al.

Blind Face Restoration (BFR) addresses the challenge of reconstructing degraded low-quality (LQ) facial images into high-quality (HQ) outputs. Conventional approaches predominantly rely on learning feature representations from ground-truth (GT) data; however, inherent imperfections in GT datasets constrain restoration performance to the mean quality level of the training data, rather than attaining maximally attainable visual quality. To overcome this limitation, we propose a novel framework that incorporates an Image Quality Prior (IQP) derived from No-Reference Image Quality Assessment (NR-IQA) models to guide the restoration process toward optimal HQ reconstructions. Our methodology synergizes this IQP with a learned codebook prior through two critical innovations: (1) During codebook learning, we devise a dual-branch codebook architecture that disentangles feature extraction into universal structural components and HQ-specific attributes, ensuring comprehensive representation of both common and high-quality facial characteristics. (2) In the codebook lookup stage, we implement a quality-conditioned Transformer-based framework. NR-IQA-derived quality scores act as dynamic conditioning signals to steer restoration toward the highest feasible quality standard. This score-conditioned paradigm enables plug-and-play enhancement of existing BFR architectures without modifying the original structure. We also formulate a discrete representation-based quality optimization strategy that circumvents over-optimization artifacts prevalent in continuous latent space approaches. Extensive experiments demonstrate that our method outperforms state-of-the-art techniques across multiple benchmarks. Besides, our quality-conditioned framework demonstrates consistent performance improvements when integrated with prior BFR models. The code will be released.

Chunming He, Fengyang Xiao, Rihan Zhang et al.

Existing methods for concealed visual perception (CVP) often leverage reversible strategies to decrease uncertainty, yet these are typically confined to the mask domain, leaving the potential of the RGB domain underexplored. To address this, we propose a reversible unfolding network with generative refinement, termed RUN++. Specifically, RUN++ first formulates the CVP task as a mathematical optimization problem and unfolds the iterative solution into a multi-stage deep network. This approach provides a principled way to apply reversible modeling across both mask and RGB domains while leveraging a diffusion model to resolve the resulting uncertainty. Each stage of the network integrates three purpose-driven modules: a Concealed Object Region Extraction (CORE) module applies reversible modeling to the mask domain to identify core object regions; a Context-Aware Region Enhancement (CARE) module extends this principle to the RGB domain to foster better foreground-background separation; and a Finetuning Iteration via Noise-based Enhancement (FINE) module provides a final refinement. The FINE module introduces a targeted Bernoulli diffusion model that refines only the uncertain regions of the segmentation mask, harnessing the generative power of diffusion for fine-detail restoration without the prohibitive computational cost of a full-image process. This unique synergy, where the unfolding network provides a strong uncertainty prior for the diffusion model, allows RUN++ to efficiently direct its focus toward ambiguous areas, significantly mitigating false positives and negatives. Furthermore, we introduce a new paradigm for building robust CVP systems that remain effective under real-world degradations and extend this concept into a broader bi-level optimization framework.

Ziyun Yang, Kevin Choy, Sina Farsiu

Generic object detection is a category-independent task that relies on accurate modeling of objectness. We show that for accurate semantic analysis, the network needs to learn all object-level predictions that appear at any stage of learning, including the pre-defined ground truth (GT) objects and the ambiguous decoy objects that the network misidentifies as foreground. Yet, most relevant models focused mainly on improving the learning of the GT objects. A few methods that consider decoy objects utilize loss functions that only focus on the single-response, i.e., the loss response of a single ambiguous pixel, and thus do not benefit from the wealth of information that an object-level ambiguity learning design can provide. Inspired by the human visual system, which first discerns the boundaries of ambiguous regions before delving into the semantic meaning, we propose a novel loss function, Spatial Coherence Loss (SCLoss), that incorporates the mutual response between adjacent pixels into the widely-used single-response loss functions. We demonstrate that the proposed SCLoss can gradually learn the ambiguous regions by detecting and emphasizing their boundaries in a self-adaptive manner. Through comprehensive experiments, we demonstrate that replacing popular loss functions with SCLoss can improve the performance of current state-of-the-art (SOTA) salient or camouflaged object detection (SOD or COD) models. We also demonstrate that combining SCLoss with other loss functions can further improve performance and result in SOTA outcomes for different applications.

Ziyun Yang, Somayyeh Soltanian-Zadeh, Sina Farsiu

Salient object detection (SOD) is viewed as a pixel-wise saliency modeling task by traditional deep learning-based methods. A limitation of current SOD models is insufficient utilization of inter-pixel information, which usually results in imperfect segmentation near edge regions and low spatial coherence. As we demonstrate, using a saliency mask as the only label is suboptimal. To address this limitation, we propose a connectivity-based approach called bilateral connectivity network (BiconNet), which uses connectivity masks together with saliency masks as labels for effective modeling of inter-pixel relationships and object saliency. Moreover, we propose a bilateral voting module to enhance the output connectivity map, and a novel edge feature enhancement method that efficiently utilizes edge-specific features. Through comprehensive experiments on five benchmark datasets, we demonstrate that our proposed method can be plugged into any existing state-of-the-art saliency-based SOD framework to improve its performance with negligible parameter increase.

Ali Hasan, Khalil Elkhalil, Yuting Ng et al.

We propose a novel neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distributional fit over large spatial and temporal scales based on data observed in intermediate scales. In turn, EVT dictates that $d$-max-decreasing, a stronger form of convexity, is an essential shape constraint in the characterization of MEVs. As far as we know, our proposed architecture provides the first class of non-parametric estimators for MEVs that preserve these essential shape constraints. We show that our architecture approximates the dependence structure encoded by MEVs at parametric rate. Moreover, we present a new method for sampling high-dimensional MEVs using a generative model. We demonstrate our methodology on a wide range of experimental settings, ranging from environmental sciences to financial mathematics and verify that the structural properties of MEVs are retained compared to existing methods.

Kevin C. Zhou, Colin Cooke, Jaehee Park et al.

We present a feature-free photogrammetric technique that enables quantitative 3D mesoscopic (mm-scale height variation) imaging with tens-of-micron accuracy from sequences of images acquired by a smartphone at close range (several cm) under freehand motion without additional hardware. Our end-to-end, pixel-intensity-based approach jointly registers and stitches all the images by estimating a coaligned height map, which acts as a pixel-wise radial deformation field that orthorectifies each camera image to allow homographic registration. The height maps themselves are reparameterized as the output of an untrained encoder-decoder convolutional neural network (CNN) with the raw camera images as the input, which effectively removes many reconstruction artifacts. Our method also jointly estimates both the camera's dynamic 6D pose and its distortion using a nonparametric model, the latter of which is especially important in mesoscopic applications when using cameras not designed for imaging at short working distances, such as smartphone cameras. We also propose strategies for reducing computation time and memory, applicable to other multi-frame registration problems. Finally, we demonstrate our method using sequences of multi-megapixel images captured by an unstabilized smartphone on a variety of samples (e.g., painting brushstrokes, circuit board, seeds).

Khalil Elkhalil, Ali Hasan, Jie Ding et al.

It has been conjectured that the Fisher divergence is more robust to model uncertainty than the conventional Kullback-Leibler (KL) divergence. This motivates the design of a new class of robust generative auto-encoders (AE) referred to as Fisher auto-encoders. Our approach is to design Fisher AEs by minimizing the Fisher divergence between the intractable joint distribution of observed data and latent variables, with that of the postulated/modeled joint distribution. In contrast to KL-based variational AEs (VAEs), the Fisher AE can exactly quantify the distance between the true and the model-based posterior distributions. Qualitative and quantitative results are provided on both MNIST and celebA datasets demonstrating the competitive performance of Fisher AEs in terms of robustness compared to other AEs such as VAEs and Wasserstein AEs.

Ali Hasan, João M. Pereira, Sina Farsiu et al.

We present a method for learning latent stochastic differential equations (SDEs) from high-dimensional time series data. Given a high-dimensional time series generated from a lower dimensional latent unknown Itô process, the proposed method learns the mapping from ambient to latent space, and the underlying SDE coefficients, through a self-supervised learning approach. Using the framework of variational autoencoders, we consider a conditional generative model for the data based on the Euler-Maruyama approximation of SDE solutions. Furthermore, we use recent results on identifiability of latent variable models to show that the proposed model can recover not only the underlying SDE coefficients, but also the original latent variables, up to an isometry, in the limit of infinite data. We validate the method through several simulated video processing tasks, where the underlying SDE is known, and through real world datasets.

Ali Hasan, João M. Pereira, Robert Ravier et al.

We develop a framework for estimating unknown partial differential equations from noisy data, using a deep learning approach. Given noisy samples of a solution to an unknown PDE, our method interpolates the samples using a neural network, and extracts the PDE by equating derivatives of the neural network approximation. Our method applies to PDEs which are linear combinations of user-defined dictionary functions, and generalizes previous methods that only consider parabolic PDEs. We introduce a regularization scheme that prevents the function approximation from overfitting the data and forces it to be a solution of the underlying PDE. We validate the model on simulated data generated by the known PDEs and added Gaussian noise, and we study our method under different levels of noise. We also compare the error of our method with a Cramer-Rao lower bound for an ordinary differential equation. Our results indicate that our method outperforms other methods in estimating PDEs, especially in the low signal-to-noise regime.