Nam H. Le

Nam H. Le, Richard Watson, Mike Levin et al.

This study facilitates the understanding of evolutionary transitions in individuality (ETIs) through a novel artificial life framework, named VitaNova, that intricately merges self-organization and natural selection to simulate the emergence of complex, reproductive groups. By dynamically modelling individual agents within an environment that challenges them with predators and spatial constraints, VitaNova elucidates the mechanisms by which simple agents evolve into cohesive units exhibiting collective reproduction. The findings underscore the synergy between self-organized behaviours and adaptive evolutionary strategies as fundamental drivers of ETIs. This approach not only contributes to a deeper understanding of higher-order biological individuality but also sets a new precedent in the empirical investigation of ETIs, challenging and extending current theoretical frameworks.

Nam H. Le, Patrick Erikson, Yanbo Zhang et al.

Guiding biological systems toward desired states, such as morphogenetic outcomes, remains a fundamental challenge with far-reaching implications for medicine and synthetic biology. While large language models (LLMs) have enabled natural language as an interface for interpretable control in AI systems, their use as mediators for steering biological or cellular dynamics remains largely unexplored. In this work, we present a functional pipeline that translates natural language prompts into spatial vector fields capable of directing simulated cellular collectives. Our approach combines a large language model with an evolvable neural controller (Prompt-to-Intervention, or P2I), optimized via evolutionary strategies to generate behaviors such as clustering or scattering in a simulated 2D environment. We demonstrate that even with constrained vocabulary and simplified cell models, evolved P2I networks can successfully align cellular dynamics with user-defined goals expressed in plain language. This work offers a complete loop from language input to simulated bioelectric-like intervention to behavioral output, providing a foundation for future systems capable of natural language-driven cellular control.

Nam H. Le, Patrick Erickson, Yanbo Zhang et al.

Human language is one of the most expressive tools for conveying intent, yet most artificial or biological systems lack mechanisms to interpret or respond meaningfully to it. Bridging this gap could enable more natural forms of control over complex, decentralized systems. In AI and artificial life, recent work explores how language can specify high-level goals, but most systems still depend on engineered rewards, task-specific supervision, or rigid command sets, limiting generalization to novel instructions. Similar constraints apply in synthetic biology and bioengineering, where the locus of control is often genomic rather than environmental perturbation. A key open question is whether artificial or biological collectives can be guided by free-form natural language alone, without task-specific tuning or carefully designed evaluation metrics. We provide one possible answer here by showing, for the first time, that simple agents' collective behavior can be guided by free-form language prompts: one AI model transforms an imperative prompt into an intervention that is applied to simulated cells; a second AI model scores how well the prompt describes the resulting cellular dynamics; and the former AI model is evolved to improve the scores generated by the latter. Unlike previous work, our method does not require engineered fitness functions or domain-specific prompt design. We show that the evolved system generalizes to unseen prompts without retraining. By treating natural language as a control layer, the system suggests a future in which spoken or written prompts could direct computational, robotic, or biological systems to desired behaviors. This work provides a concrete step toward this vision of AI-biology partnerships, in which language replaces mathematical objective functions, fixed rules, and domain-specific programming.

Nam H. Le, Josh Bongard

Genetic Programming (GP) has traditionally entangled the evolution of symbolic representations with their performance-based evaluation, often relying solely on raw fitness scores. This tight coupling makes GP solutions more fragile and prone to overfitting, reducing their ability to generalize. In this work, we propose LaSER (Latent Semantic Representation Regression)} -- a general framework that decouples representation evolution from lifetime learning. At each generation, candidate programs produce features which are passed to an external learner to model the target task. This approach enables any function approximator, from linear models to neural networks, to serve as a lifetime learner, allowing expressive modeling beyond conventional symbolic forms. Here we show for the first time that LaSER can outcompete standard GP and GP followed by linear regression when it employs non-linear methods to fit coefficients to GP-generated equations against complex data sets. Further, we explore how LaSER enables the emergence of innate representations, supporting long-standing hypotheses in evolutionary learning such as the Baldwin Effect. By separating the roles of representation and adaptation, LaSER offers a principled and extensible framework for symbolic regression and classification.