Wangkai Li

Jun Ma, Ronald Xie, Shamini Ayyadhury et al.

Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to specify hyper-parameters in different experimental settings. Here, we present a multi-modality cell segmentation benchmark, comprising over 1500 labeled images derived from more than 50 diverse biological experiments. The top participants developed a Transformer-based deep-learning algorithm that not only exceeds existing methods but can also be applied to diverse microscopy images across imaging platforms and tissue types without manual parameter adjustments. This benchmark and the improved algorithm offer promising avenues for more accurate and versatile cell analysis in microscopy imaging.

Wangkai Li, Rui Sun, Bohao Liao et al.

Unsupervised domain adaptation (UDA) for semantic segmentation aims to transfer knowledge from a labeled source domain to an unlabeled target domain. Despite the effectiveness of self-training techniques in UDA, they struggle to learn each class in a balanced manner due to inherent class imbalance and distribution shift in both data and label space between domains. To address this issue, we propose Balanced Learning for Domain Adaptation (BLDA), a novel approach to directly assess and alleviate class bias without requiring prior knowledge about the distribution shift. First, we identify over-predicted and under-predicted classes by analyzing the distribution of predicted logits. Subsequently, we introduce a post-hoc approach to align the logits distributions across different classes using shared anchor distributions. To further consider the network's need to generate unbiased pseudo-labels during self-training, we estimate logits distributions online and incorporate logits correction terms into the loss function. Moreover, we leverage the resulting cumulative density as domain-shared structural knowledge to connect the source and target domains. Extensive experiments on two standard UDA semantic segmentation benchmarks demonstrate that BLDA consistently improves performance, especially for under-predicted classes, when integrated into various existing methods. Code is available at https://github.com/Woof6/BLDA.

Wangkai Li, Rui Sun, Zhaoyang Li et al.

Pseudo-label learning is widely used in semantic segmentation, particularly in label-scarce scenarios such as unsupervised domain adaptation (UDA) and semisupervised learning (SSL). Despite its success, this paradigm can generate erroneous pseudo-labels, which are further amplified during training due to utilization of one-hot encoding. To address this issue, we propose ECOCSeg, a novel perspective for segmentation models that utilizes error-correcting output codes (ECOC) to create a fine-grained encoding for each class. ECOCSeg offers several advantages. First, an ECOC-based classifier is introduced, enabling model to disentangle classes into attributes and handle partial inaccurate bits, improving stability and generalization in pseudo-label learning. Second, a bit-level label denoising mechanism is developed to generate higher-quality pseudo-labels, providing adequate and robust supervision for unlabeled images. ECOCSeg can be easily integrated with existing methods and consistently demonstrates significant improvements on multiple UDA and SSL benchmarks across different segmentation architectures. Code is available at https://github.com/Woof6/ECOCSeg.

Bin Ren, Yawei Li, Nancy Mehta et al.

This paper provides a comprehensive review of the NTIRE 2024 challenge, focusing on efficient single-image super-resolution (ESR) solutions and their outcomes. The task of this challenge is to super-resolve an input image with a magnification factor of x4 based on pairs of low and corresponding high-resolution images. The primary objective is to develop networks that optimize various aspects such as runtime, parameters, and FLOPs, while still maintaining a peak signal-to-noise ratio (PSNR) of approximately 26.90 dB on the DIV2K_LSDIR_valid dataset and 26.99 dB on the DIV2K_LSDIR_test dataset. In addition, this challenge has 4 tracks including the main track (overall performance), sub-track 1 (runtime), sub-track 2 (FLOPs), and sub-track 3 (parameters). In the main track, all three metrics (ie runtime, FLOPs, and parameter count) were considered. The ranking of the main track is calculated based on a weighted sum-up of the scores of all other sub-tracks. In sub-track 1, the practical runtime performance of the submissions was evaluated, and the corresponding score was used to determine the ranking. In sub-track 2, the number of FLOPs was considered. The score calculated based on the corresponding FLOPs was used to determine the ranking. In sub-track 3, the number of parameters was considered. The score calculated based on the corresponding parameters was used to determine the ranking. RLFN is set as the baseline for efficiency measurement. The challenge had 262 registered participants, and 34 teams made valid submissions. They gauge the state-of-the-art in efficient single-image super-resolution. To facilitate the reproducibility of the challenge and enable other researchers to build upon these findings, the code and the pre-trained model of validated solutions are made publicly available at https://github.com/Amazingren/NTIRE2024_ESR/.

Zhaoyang Li, Yuan Wang, Wangkai Li et al.

Point cloud few-shot semantic segmentation (PC-FSS) aims to segment targets of novel categories in a given query point cloud with only a few annotated support samples. The current top-performing prototypical learning methods employ prototypes originating from support samples to direct the classification of query points. However, the inherent fragility of point-level matching and the prevalent intra-class diversity pose great challenges to this cross-instance matching paradigm, leading to erroneous background activations or incomplete target excavation. In this work, we propose a simple yet effective framework in the spirit of Decoupled Localization and Expansion (DLE). The proposed DLE, including a structural localization module (SLM) and a self-expansion module (SEM), enjoys several merits. First, structural information is injected into the matching process through the agent-level correlation in SLM, and the confident target region can thus be precisely located. Second, more reliable intra-object similarity is harnessed in SEM to derive the complete target, and the conservative expansion strategy is introduced to reasonably constrain the expansion. Extensive experiments on two challenging benchmarks under different settings demonstrate that DLE outperforms previous state-of-the-art approaches by large margins.

Wangkai Li, Rui Sun, Zhaoyang Li et al.

While existing unsupervised domain adaptation (UDA) methods greatly enhance target domain performance in semantic segmentation, they often neglect network calibration quality, resulting in misalignment between prediction confidence and actual accuracy -- a significant risk in safety-critical applications. Our key insight emerges from observing that performance degrades substantially when soft pseudo-labels replace hard pseudo-labels in cross-domain scenarios due to poor calibration, despite the theoretical equivalence of perfectly calibrated soft pseudo-labels to hard pseudo-labels. Based on this finding, we propose DA-Cal, a dedicated cross-domain calibration framework that transforms target domain calibration into soft pseudo-label optimization. DA-Cal introduces a Meta Temperature Network to generate pixel-level calibration parameters and employs bi-level optimization to establish the relationship between soft pseudo-labels and UDA supervision, while utilizing complementary domain-mixing strategies to prevent overfitting and reduce domain discrepancies. Experiments demonstrate that DA-Cal seamlessly integrates with existing self-training frameworks across multiple UDA segmentation benchmarks, significantly improving target domain calibration while delivering performance gains without inference overhead. The code will be released.

Wangkai Li, Zhaoyang Li, Yuwen Pan et al.

Adverse weather conditions significantly degrade the performance of LiDAR point cloud semantic segmentation networks by introducing large distribution shifts. Existing augmentation-based methods attempt to enhance robustness by simulating weather interference during training. However, they struggle to fully exploit the potential of augmentations due to the trade-off between minor and aggressive augmentations. To address this, we propose A3Point, an adaptive augmentation-aware latent learning framework that effectively utilizes a diverse range of augmentations while mitigating the semantic shift, which refers to the change in the semantic meaning caused by augmentations. A3Point consists of two key components: semantic confusion prior (SCP) latent learning, which captures the model's inherent semantic confusion information, and semantic shift region (SSR) localization, which decouples semantic confusion and semantic shift, enabling adaptive optimization strategies for different disturbance levels. Extensive experiments on multiple standard generalized LiDAR segmentation benchmarks under adverse weather demonstrate the effectiveness of our method, setting new state-of-the-art results.

Ruining Deng, Tianyuan Yao, Yucheng Tang et al.

Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality. While kidney biopsy remains the gold standard for CKD diagnosis and treatment, the lack of comprehensive benchmarks for kidney pathology segmentation hinders progress in the field. To address this, we organized the Kidney Pathology Image Segmentation (KPIs) Challenge, introducing a dataset that incorporates preclinical rodent models of CKD with over 10,000 annotated glomeruli from 60+ Periodic Acid Schiff (PAS)-stained whole slide images. The challenge includes two tasks, patch-level segmentation and whole slide image segmentation and detection, evaluated using the Dice Similarity Coefficient (DSC) and F1-score. By encouraging innovative segmentation methods that adapt to diverse CKD models and tissue conditions, the KPIs Challenge aims to advance kidney pathology analysis, establish new benchmarks, and enable precise, large-scale quantification for disease research and diagnosis.

JaeWoong Shin, Jeongun Ryu, Aaron Valero Puche et al.

Pathologists routinely alternate between different magnifications when examining Whole-Slide Images, allowing them to evaluate both broad tissue morphology and intricate cellular details to form comprehensive diagnoses. However, existing deep learning-based cell detection models struggle to replicate these behaviors and learn the interdependent semantics between structures at different magnifications. A key barrier in the field is the lack of datasets with multi-scale overlapping cell and tissue annotations. The OCELOT 2023 challenge was initiated to gather insights from the community to validate the hypothesis that understanding cell and tissue (cell-tissue) interactions is crucial for achieving human-level performance, and to accelerate the research in this field. The challenge dataset includes overlapping cell detection and tissue segmentation annotations from six organs, comprising 673 pairs sourced from 306 The Cancer Genome Atlas (TCGA) Whole-Slide Images with hematoxylin and eosin staining, divided into training, validation, and test subsets. Participants presented models that significantly enhanced the understanding of cell-tissue relationships. Top entries achieved up to a 7.99 increase in F1-score on the test set compared to the baseline cell-only model that did not incorporate cell-tissue relationships. This is a substantial improvement in performance over traditional cell-only detection methods, demonstrating the need for incorporating multi-scale semantics into the models. This paper provides a comparative analysis of the methods used by participants, highlighting innovative strategies implemented in the OCELOT 2023 challenge.

Wangkai Li, Rui Sun, Tianzhu Zhang

Semantic segmentation often suffers from significant performance degradation when the trained network is applied to a different domain. To address this issue, unsupervised domain adaptation (UDA) has been extensively studied. Existing methods introduce the domain bridging techniques to mitigate substantial domain gap, which construct intermediate domains to facilitate the gradual transfer of knowledge across different domains. However, these strategies often require dataset-specific designs and may generate unnatural intermediate distributions that lead to semantic shift. In this paper, we propose DiDA, a universal degradation-based bridging technique formalized as a diffusion forward process. DiDA consists of two key modules: (1) Degradation-based Intermediate Domain Construction, which creates continuous intermediate domains through simple image degradation operations to encourage learning domain-invariant features as domain differences gradually diminish; (2) Semantic Shift Compensation, which leverages a diffusion encoder to encode and compensate for semantic shift information with degraded time-steps, preserving discriminative representations in the intermediate domains. As a plug-and-play solution, DiDA supports various degradation operations and seamlessly integrates with existing UDA methods. Extensive experiments on prevalent synthetic-to-real semantic segmentation benchmarks demonstrate that DiDA consistently improves performance across different settings and achieves new state-of-the-art results when combined with existing methods.