Peilin Chen

Hao Luo, Baoliang Chen, Lingyu Zhu et al.

Scene observation from multiple perspectives would bring a more comprehensive visual experience. However, in the context of acquiring multiple views in the dark, the highly correlated views are seriously alienated, making it challenging to improve scene understanding with auxiliary views. Recent single image-based enhancement methods may not be able to provide consistently desirable restoration performance for all views due to the ignorance of potential feature correspondence among different views. To alleviate this issue, we make the first attempt to investigate multi-view low-light image enhancement. First, we construct a new dataset called Multi-View Low-light Triplets (MVLT), including 1,860 pairs of triple images with large illumination ranges and wide noise distribution. Each triplet is equipped with three different viewpoints towards the same scene. Second, we propose a deep multi-view enhancement framework based on the Recurrent Collaborative Network (RCNet). Specifically, in order to benefit from similar texture correspondence across different views, we design the recurrent feature enhancement, alignment and fusion (ReEAF) module, in which intra-view feature enhancement (Intra-view EN) followed by inter-view feature alignment and fusion (Inter-view AF) is performed to model the intra-view and inter-view feature propagation sequentially via multi-view collaboration. In addition, two different modules from enhancement to alignment (E2A) and from alignment to enhancement (A2E) are developed to enable the interactions between Intra-view EN and Inter-view AF, which explicitly utilize attentive feature weighting and sampling for enhancement and alignment, respectively. Experimental results demonstrate that our RCNet significantly outperforms other state-of-the-art methods. All of our dataset, code, and model will be available at https://github.com/hluo29/RCNet.

Zhen Chen, Yibing Liu, Weihao Xie et al.

Retrieval-augmented generation (RAG) systems expose numerous design choices spanning query rewriting, chunking, retrieval depth, reranking, and context compression. In practice, these choices are often configured through heuristics, hindering systematic evaluation and reproducibility across settings. We argue that this challenge is best formulated as RAG architecture search. To support controlled and reproducible study of this problem, we introduce the RAG Intelligence Search Engine (RAISE), a comprehensive framework and benchmark for RAG hyperparameter optimization, which evaluates optimization methods for RAG pipelines under standardized search spaces and budgets. RAISE implements 13 search algorithms and evaluates them across seven public text and multimodal datasets using three random seeds. Our experiments show that optimization performance is highly task-dependent: methods that perform strongly on one dataset may not generalize consistently across others, cautioning against interpreting aggregate rankings as evidence of universally superior strategies. RAISE provides a common experimental substrate for fair, reproducible, and systematic research on RAG hyperparameter optimization.

Yuhang Zhang, Keyan Ding, Peilin Chen et al.

Enzyme-reaction retrieval is a fundamental problem in computational biology, underpinning enzyme characterization, reaction mechanism elucidation, and the rational design of metabolic pathways and biocatalysts. As a bidirectional task, it entails both enzyme-to-reaction and reaction-to-enzyme mapping. However, existing approaches suffer from poor generalization across tasks and distributions, with performance highly sensitive to dataset splits and substantial asymmetry between retrieval directions. To address these challenges, we present TIGER, a Text-Informed Generalized Enzyme-Reaction Retrieval framework that leverages protein-to-text generation models to distill textual semantic knowledge from enzyme sequences, providing a generalized representation that bridges enzymes and biochemical reactions. To ensure the quality and reliability of textual semantics, we design a Dynamic Gating Network that adaptively fuses text-derived knowledge with sequence features, enabling more consistent and informative enzyme representations, while a Structure-Shared Feature Projector aligns enzyme and reaction representations within a unified latent space. Extensive experiments demonstrate that, under bidirectional retrieval supervision, TIGER significantly outperforms state-of-the-art baselines across diverse distributions and exhibits strong robustness and transferability across tasks.

Hanwei Zhu, Xiangjie Sui, Baoliang Chen et al.

While abundant research has been conducted on improving high-level visual understanding and reasoning capabilities of large multimodal models~(LMMs), their visual quality assessment~(IQA) ability has been relatively under-explored. Here we take initial steps towards this goal by employing the two-alternative forced choice~(2AFC) prompting, as 2AFC is widely regarded as the most reliable way of collecting human opinions of visual quality. Subsequently, the global quality score of each image estimated by a particular LMM can be efficiently aggregated using the maximum a posterior estimation. Meanwhile, we introduce three evaluation criteria: consistency, accuracy, and correlation, to provide comprehensive quantifications and deeper insights into the IQA capability of five LMMs. Extensive experiments show that existing LMMs exhibit remarkable IQA ability on coarse-grained quality comparison, but there is room for improvement on fine-grained quality discrimination. The proposed dataset sheds light on the future development of IQA models based on LMMs. The codes will be made publicly available at https://github.com/h4nwei/2AFC-LMMs.

Wei Dai, Peilin Chen, Malinda Lu et al.

Recent advances in clinical AI have enabled remarkable progress across many clinical domains. However, existing benchmarks and models are primarily limited to a small set of modalities and tasks, which hinders the development of large-scale multimodal methods that can make holistic assessments of patient health and well-being. To bridge this gap, we introduce Clinical Large-Scale Integrative Multimodal Benchmark (CLIMB), a comprehensive clinical benchmark unifying diverse clinical data across imaging, language, temporal, and graph modalities. CLIMB comprises 4.51 million patient samples totaling 19.01 terabytes distributed across 2D imaging, 3D video, time series, graphs, and multimodal data. Through extensive empirical evaluation, we demonstrate that multitask pretraining significantly improves performance on understudied domains, achieving up to 29% improvement in ultrasound and 23% in ECG analysis over single-task learning. Pretraining on CLIMB also effectively improves models' generalization capability to new tasks, and strong unimodal encoder performance translates well to multimodal performance when paired with task-appropriate fusion strategies. Our findings provide a foundation for new architecture designs and pretraining strategies to advance clinical AI research. Code is released at https://github.com/DDVD233/climb.

Wei Dai, Peilin Chen, Chanakya Ekbote et al.

Clinical decision-making routinely demands reasoning over heterogeneous data, yet existing multimodal language models (MLLMs) remain largely vision-centric and fail to generalize across clinical specialties. To bridge this gap, we introduce QoQ-Med-7B/32B, the first open generalist clinical foundation model that jointly reasons across medical images, time-series signals, and text reports. QoQ-Med is trained with Domain-aware Relative Policy Optimization (DRPO), a novel reinforcement-learning objective that hierarchically scales normalized rewards according to domain rarity and modality difficulty, mitigating performance imbalance caused by skewed clinical data distributions. Trained on 2.61 million instruction tuning pairs spanning 9 clinical domains, we show that DRPO training boosts diagnostic performance by 43% in macro-F1 on average across all visual domains as compared to other critic-free training methods like GRPO. Furthermore, with QoQ-Med trained on intensive segmentation data, it is able to highlight salient regions related to the diagnosis, with an IoU 10x higher than open models while reaching the performance of OpenAI o4-mini. To foster reproducibility and downstream research, we release (i) the full model weights, (ii) the modular training pipeline, and (iii) all intermediate reasoning traces at https://github.com/DDVD233/QoQ_Med.

Zhen Chen, Weihao Xie, Peilin Chen et al.

Retrieval-Augmented Generation (RAG) has proven effective for knowledge synthesis, yet it encounters significant challenges in practical scenarios where data is inherently discrete and fragmented. In most environments, information is distributed across isolated files like reports and logs that lack explicit links. Standard search engines process files independently, ignoring the connections between them. Furthermore, manually building Knowledge Graphs is impractical for such vast data. To bridge this gap, we present Orion-RAG. Our core insight is simple yet effective: we do not need heavy algorithms to organize this data. Instead, we use a low-complexity strategy to extract lightweight paths that naturally link related concepts. We demonstrate that this streamlined approach suffices to transform fragmented documents into semi-structured data, enabling the system to link information across different files effectively. Extensive experiments demonstrate that Orion-RAG consistently outperforms mainstream frameworks across diverse domains, supporting real-time updates and explicit Human-in-the-Loop verification with high cost-efficiency. Experiments on FinanceBench demonstrate superior precision with a 25.2% relative improvement over strong baselines.

Siyuan Xu, Yibing Liu, Peilin Chen et al.

Privacy leakage in Multimodal Large Language Models (MLLMs) has long been an intractable problem. Existing studies, though effectively obscure private information in MLLMs, often overlook the evaluation of the authenticity and recovery quality of user privacy. To this end, this work uniquely focuses on the critical challenge of how to restore surrogate-driven protected data in diverse MLLM scenarios. We first bridge this research gap by contributing the SPPE (Surrogate Privacy Protected Editable) dataset, which includes a wide range of privacy categories and user instructions to simulate real MLLM applications. This dataset offers protected surrogates alongside their various MLLM-edited versions, thus enabling the direct assessment of privacy recovery quality. By formulating privacy recovery as a guided generation task conditioned on complementary multimodal signals, we further introduce a unified approach that reliably reconstructs private content while preserving the fidelity of MLLM-generated edits. The experiments on both SPPE and InstructPix2Pix further show that our approach generalizes well across diverse visual content and editing tasks, achieving a strong balance between privacy protection and MLLM usability.

Bolin Chen, Shanzhi Yin, Peilin Chen et al.

Artificial Intelligence Generated Content (AIGC) is leading a new technical revolution for the acquisition of digital content and impelling the progress of visual compression towards competitive performance gains and diverse functionalities over traditional codecs. This paper provides a thorough review on the recent advances of generative visual compression, illustrating great potentials and promising applications in ultra-low bitrate communication, user-specified reconstruction/filtering, and intelligent machine analysis. In particular, we review the visual data compression methodologies with deep generative models, and summarize how compact representation and high-fidelity reconstruction could be actualized via generative techniques. In addition, we generalize related generative compression technologies for machine vision and intelligent analytics. Finally, we discuss the fundamental challenges on generative visual compression techniques and envision their future research directions.

Hanwei Zhu, Haoning Wu, Zicheng Zhang et al.

This paper presents a summary of the VQualA 2025 Challenge on Visual Quality Comparison for Large Multimodal Models (LMMs), hosted as part of the ICCV 2025 Workshop on Visual Quality Assessment. The challenge aims to evaluate and enhance the ability of state-of-the-art LMMs to perform open-ended and detailed reasoning about visual quality differences across multiple images. To this end, the competition introduces a novel benchmark comprising thousands of coarse-to-fine grained visual quality comparison tasks, spanning single images, pairs, and multi-image groups. Each task requires models to provide accurate quality judgments. The competition emphasizes holistic evaluation protocols, including 2AFC-based binary preference and multi-choice questions (MCQs). Around 100 participants submitted entries, with five models demonstrating the emerging capabilities of instruction-tuned LMMs on quality assessment. This challenge marks a significant step toward open-domain visual quality reasoning and comparison and serves as a catalyst for future research on interpretable and human-aligned quality evaluation systems.

Lingyu Zhu, Xiangrui Zeng, Bolin Chen et al.

By optimizing the rate-distortion-realism trade-off, generative image compression approaches produce detailed, realistic images instead of the only sharp-looking reconstructions produced by rate-distortion-optimized models. In this paper, we propose a novel deep learning-based generative image compression method injected with diffusion knowledge, obtaining the capacity to recover more realistic textures in practical scenarios. Efforts are made from three perspectives to navigate the rate-distortion-realism trade-off in the generative image compression task. First, recognizing the strong connection between image texture and frequency-domain characteristics, we design a Fractal Frequency-Aware Band Image Compression (FFAB-IC) network to effectively capture the directional frequency components inherent in natural images. This network integrates commonly used fractal band feature operations within a neural non-linear mapping design, enhancing its ability to retain essential given information and filter out unnecessary details. Then, to improve the visual quality of image reconstruction under limited bandwidth, we integrate diffusion knowledge into the encoder and implement diffusion iterations into the decoder process, thus effectively recovering lost texture details. Finally, to fully leverage the spatial and frequency intensity information, we incorporate frequency- and content-aware regularization terms to regularize the training of the generative image compression network. Extensive experiments in quantitative and qualitative evaluations demonstrate the superiority of the proposed method, advancing the boundaries of achievable distortion-realism pairs, i.e., our method achieves better distortions at high realism and better realism at low distortion than ever before.

Xiaoxuan Yang, Peilin Chen, Tergel Molom-Ochir et al.

Transformers have become central to natural language processing and large language models, but their deployment at scale faces three major challenges. First, the attention mechanism requires massive matrix multiplications and frequent movement of intermediate results between memory and compute units, leading to high latency and energy costs. Second, in long-context inference, the key-value cache (KV cache) can grow unpredictably and even surpass the model's weight size, creating severe memory and bandwidth bottlenecks. Third, the quadratic complexity of attention with respect to sequence length amplifies both data movement and compute overhead, making large-scale inference inefficient. To address these issues, this work introduces processing-in-memory solutions that restructure attention and feed-forward computation to minimize off-chip data transfers, dynamically compress and prune the KV cache to manage memory growth, and reinterpret attention as an associative memory operation to reduce complexity and hardware footprint. Moreover, we evaluate our processing-in-memory design against state-of-the-art accelerators and general-purpose GPUs, demonstrating significant improvements in energy efficiency and latency. Together, these approaches address computation overhead, memory scalability, and attention complexity, further enabling efficient, end-to-end acceleration of Transformer models.

Runwen Hu, Peilin Chen, Keyan Ding et al.

Artificial intelligence (AI) revolutionizes molecule generation in bioengineering and biological research, significantly accelerating discovery processes. However, this advancement introduces critical concerns regarding intellectual property protection. To address these challenges, we propose the first robust watermarking method designed for molecules, which utilizes atom-level features to preserve molecular integrity and invariant features to ensure robustness against affine transformations. Comprehensive experiments validate the effectiveness of our method using the datasets QM9 and GEOM-DRUG, and generative models GeoBFN and GeoLDM. We demonstrate the feasibility of embedding watermarks, maintaining basic properties higher than 90.00\% while achieving watermark accuracy greater than 95.00\%. Furthermore, downstream docking simulations reveal comparable performance between original and watermarked molecules, with binding affinities reaching -6.00 kcal/mol and root mean square deviations below 1.602 Å. These results confirm that our watermarking technique effectively safeguards molecular intellectual property without compromising scientific utility, enabling secure and responsible AI integration in molecular discovery and research applications.

Han Liu, Keyan Ding, Peilin Chen et al.

Accurate prediction of protein-ligand binding affinity is critical for drug discovery. While recent deep learning approaches have demonstrated promising results, they often rely solely on structural features of proteins and ligands, overlooking their valuable biochemical knowledge associated with binding affinity. To address this limitation, we propose KEPLA, a novel deep learning framework that explicitly integrates prior knowledge from Gene Ontology and ligand properties to enhance prediction performance. KEPLA takes protein sequences and ligand molecular graphs as input and optimizes two complementary objectives: (1) aligning global representations with knowledge graph relations to capture domain-specific biochemical insights, and (2) leveraging cross attention between local representations to construct fine-grained joint embeddings for prediction. Experiments on two benchmark datasets across both in-domain and cross-domain scenarios demonstrate that KEPLA consistently outperforms state-of-the-art baselines. Furthermore, interpretability analyses based on knowledge graph relations and cross attention maps provide valuable insights into the underlying predictive mechanisms.

Xihua Sheng, Peilin Chen, Meng Wang et al.

With the remarkable progress in neural P-frame video coding, neural B-frame coding has recently emerged as a critical research direction. However, most existing neural B-frame codecs directly adopt P-frame coding tools without adequately addressing the unique challenges of B-frame compression, leading to suboptimal performance. To bridge this gap, we propose novel enhancements for motion compression and temporal fusion for neural B-frame coding. First, we design a fine-grained motion compression method. This method incorporates an interactive dual-branch motion auto-encoder with per-branch adaptive quantization steps, which enables fine-grained compression of bi-directional motion vectors while accommodating their asymmetric bitrate allocation and reconstruction quality requirements. Furthermore, this method involves an interactive motion entropy model that exploits correlations between bi-directional motion latent representations by interactively leveraging partitioned latent segments as directional priors. Second, we propose a selective temporal fusion method that predicts bi-directional fusion weights to achieve discriminative utilization of bi-directional multi-scale temporal contexts with varying qualities. Additionally, this method introduces a hyperprior-based implicit alignment mechanism for contextual entropy modeling. By treating the hyperprior as a surrogate for the contextual latent representation, this mechanism implicitly mitigates the misalignment in the fused bi-directional temporal priors. Extensive experiments demonstrate that our proposed codec outperforms state-of-the-art neural B-frame codecs and achieves comparable or even superior compression performance to the H.266/VVC reference software under random-access configurations.

Yingwen Zhang, Meng Wang, Xihua Sheng et al.

Lossy image compression networks aim to minimize the latent entropy of images while adhering to specific distortion constraints. However, optimizing the neural network can be challenging due to its nature of learning quantized latent representations. In this paper, our key finding is that minimizing the latent entropy is, to some extent, equivalent to maximizing the conditional source entropy, an insight that is deeply rooted in information-theoretic equalities. Building on this insight, we propose a novel structural regularization method for the neural image compression task by incorporating the negative conditional source entropy into the training objective, such that both the optimization efficacy and the model's generalization ability can be promoted. The proposed information-theoretic regularizer is interpretable, plug-and-play, and imposes no inference overheads. Extensive experiments demonstrate its superiority in regularizing the models and further squeezing bits from the latent representation across various compression structures and unseen domains.

Yixuan Li, Peilin Chen, Hanwei Zhu et al.

Opinion-Unaware Blind Image Quality Assessment (OU-BIQA) models aim to predict image quality without training on reference images and subjective quality scores. Thereinto, image statistical comparison is a classic paradigm, while the performance is limited by the representation ability of visual descriptors. Deep features as visual descriptors have advanced IQA in recent research, but they are discovered to be highly texture-biased and lack of shape-bias. On this basis, we find out that image shape and texture cues respond differently towards distortions, and the absence of either one results in an incomplete image representation. Therefore, to formulate a well-round statistical description for images, we utilize the shapebiased and texture-biased deep features produced by Deep Neural Networks (DNNs) simultaneously. More specifically, we design a Shape-Texture Adaptive Fusion (STAF) module to merge shape and texture information, based on which we formulate qualityrelevant image statistics. The perceptual quality is quantified by the variant Mahalanobis Distance between the inner and outer Shape-Texture Statistics (DSTS), wherein the inner and outer statistics respectively describe the quality fingerprints of the distorted image and natural images. The proposed DSTS delicately utilizes shape-texture statistical relations between different data scales in the deep domain, and achieves state-of-the-art (SOTA) quality prediction performance on images with artificial and authentic distortions.

Xinju Wu, Pingping Zhang, Meng Wang et al.

The emergence of digital avatars has raised an exponential increase in the demand for human point clouds with realistic and intricate details. The compression of such data becomes challenging with overwhelming data amounts comprising millions of points. Herein, we leverage the human geometric prior in geometry redundancy removal of point clouds, greatly promoting the compression performance. More specifically, the prior provides topological constraints as geometry initialization, allowing adaptive adjustments with a compact parameter set that could be represented with only a few bits. Therefore, we can envisage high-resolution human point clouds as a combination of geometric priors and structural deviations. The priors could first be derived with an aligned point cloud, and subsequently the difference of features is compressed into a compact latent code. The proposed framework can operate in a play-and-plug fashion with existing learning based point cloud compression methods. Extensive experimental results show that our approach significantly improves the compression performance without deteriorating the quality, demonstrating its promise in a variety of applications.

Zhanhao Xiao, Hai Wan, Hankui Hankz Zhuo et al.

Hierarchical Task Network (HTN) planning is showing its power in real-world planning. Although domain experts have partial hierarchical domain knowledge, it is time-consuming to specify all HTN methods, leaving them incomplete. On the other hand, traditional HTN learning approaches focus only on declarative goals, omitting the hierarchical domain knowledge. In this paper, we propose a novel learning framework to refine HTN methods via task insertion with completely preserving the original methods. As it is difficult to identify incomplete methods without designating declarative goals for compound tasks, we introduce the notion of prioritized preference to capture the incompleteness possibility of methods. Specifically, the framework first computes the preferred completion profile w.r.t. the prioritized preference to refine the incomplete methods. Then it finds the minimal set of refined methods via a method substitution operation. Experimental analysis demonstrates that our approach is effective, especially in solving new HTN planning instances.

Peilin Chen, Hai Wan, Shaowei Cai et al.

The Maximum k-plex Problem is an important combinatorial optimization problem with increasingly wide applications. Due to its exponential time complexity, many heuristic methods have been proposed which can return a good-quality solution in a reasonable time. However, most of the heuristic algorithms are memoryless and unable to utilize the experience during the search. Inspired by the multi-armed bandit (MAB) problem in reinforcement learning (RL), we propose a novel perturbation mechanism named BLP, which can learn online to select a good vertex for perturbation when getting stuck in local optima. To our best of knowledge, this is the first attempt to combine local search with RL for the maximum $ k $-plex problem. Besides, we also propose a novel strategy, named Dynamic-threshold Configuration Checking (DTCC), which extends the original Configuration Checking (CC) strategy from two aspects. Based on the BLP and DTCC, we develop a local search algorithm named BDCC and improve it by a hyperheuristic strategy. The experimental result shows that our algorithms dominate on the standard DIMACS and BHOSLIB benchmarks and achieve state-of-the-art performance on massive graphs.