Mark W. Ball

Pouria Yazdian Anari, Fiona Obiezu, Nathan Lay et al.

Introduction This study explores the use of the latest You Only Look Once (YOLO V7) object detection method to enhance kidney detection in medical imaging by training and testing a modified YOLO V7 on medical image formats. Methods Study includes 878 patients with various subtypes of renal cell carcinoma (RCC) and 206 patients with normal kidneys. A total of 5657 MRI scans for 1084 patients were retrieved. 326 patients with 1034 tumors recruited from a retrospective maintained database, and bounding boxes were drawn around their tumors. A primary model was trained on 80% of annotated cases, with 20% saved for testing (primary test set). The best primary model was then used to identify tumors in the remaining 861 patients and bounding box coordinates were generated on their scans using the model. Ten benchmark training sets were created with generated coordinates on not-segmented patients. The final model used to predict the kidney in the primary test set. We reported the positive predictive value (PPV), sensitivity, and mean average precision (mAP). Results The primary training set showed an average PPV of 0.94 +/- 0.01, sensitivity of 0.87 +/- 0.04, and mAP of 0.91 +/- 0.02. The best primary model yielded a PPV of 0.97, sensitivity of 0.92, and mAP of 0.95. The final model demonstrated an average PPV of 0.95 +/- 0.03, sensitivity of 0.98 +/- 0.004, and mAP of 0.95 +/- 0.01. Conclusion Using a semi-supervised approach with a medical image library, we developed a high-performing model for kidney detection. Further external validation is required to assess the model's generalizability.

Adrian Arnaiz-Rodriguez, Miguel Baidal, Erik Derner et al.

The widespread use of chatbots powered by large language models (LLMs) such as ChatGPT and Llama has fundamentally reshaped how people seek information and advice across domains. Increasingly, these chatbots are being used in high-stakes contexts, including emotional support and mental health concerns. While LLMs can offer scalable support, their ability to safely detect and respond to acute mental health crises remains poorly understood. Progress is hampered by the absence of unified crisis taxonomies, robust annotated benchmarks, and empirical evaluations grounded in clinical best practices. In this work, we address these gaps by introducing a unified taxonomy of six clinically-informed mental health crisis categories, curating a diverse evaluation dataset, and establishing an expert-designed protocol for assessing response appropriateness. We systematically benchmark three state-of-the-art LLMs for their ability to classify crisis types and generate safe, appropriate responses. The results reveal that while LLMs are highly consistent and generally reliable in addressing explicit crisis disclosures, significant risks remain. A non-negligible proportion of responses are rated as inappropriate or harmful, with responses generated by an open-weight model exhibiting higher failure rates than those generated by the commercial ones. We also identify systemic weaknesses in handling indirect or ambiguous risk signals, a reliance on formulaic and inauthentic default replies, and frequent misalignment with user context. These findings underscore the urgent need for enhanced safeguards, improved crisis detection, and context-aware interventions in LLM deployments. Our taxonomy, datasets, and evaluation framework lay the groundwork for ongoing research and responsible innovation in AI-driven mental health support, helping to minimize harm and better protect vulnerable users.