Amy Zhao

Jay Yu, Amy Zhao, Danning Sui

DeFi investment agents, systems that use AI for autonomous on-chain trading, have attained over USD 3 billion in combined token valuations since late 2024. We survey over 1,900 AI-tagged crypto projects, filter to investment-focused agents, and curate 10 representative projects spanning strategy and observability dimensions. We then conduct a deep-dive architectural analysis of two prominent agent frameworks, ElizaOS and Virtuals Protocol, and a quantitative on-chain performance analysis of 11 Solana-based agent treasuries with publicly attributable trading activity, covering 925,323 token holders. We find that current deployments remain early and heterogeneous: (1) in our sample, many projects do not yet provide clear evidence of autonomous trade execution, and developer interviews suggest that many visible deployments remain basic API integrations; (2) agent treasuries retain over USD 30M in paper gains while token holders collectively lost USD 191.7M, with the top 1% of wallets capturing 81.4% of all gains (USD 1.81B); (3) token valuations are weakly connected to treasury fundamentals, with market-cap-to-AUM ratios exceeding 10,000x versus below 1x for established DeFi protocols; and (4) aggregate user gains peaked at USD 2.4B before declining to net losses, with median returns negative on every platform and tokens declining 93% on average from all-time highs. We interpret these outcomes as characteristic of a permissionless, first-generation market in which open infrastructure enables rapid experimentation but also allows naive or speculative agents to launch before robust standards for autonomy, performance, and stakeholder alignment emerge. We therefore propose a maturity framework along three dimensions: autonomous execution, risk-adjusted profitability, and stakeholder alignment, to characterize the gap between current deployments and future investment-grade agent systems.

Shengao Wang, Wenqi Wang, Zecheng Wang et al.

Early children's developmental trajectories set up a natural goal for sample-efficient pretraining of vision foundation models. We introduce BabyVLM-V2, a developmentally grounded framework for infant-inspired vision-language modeling that extensively improves upon BabyVLM-V1 through a longitudinal, multifaceted pretraining set, a versatile model, and, most importantly, DevCV Toolbox for cognitive evaluation. The pretraining set maximizes coverage while minimizing curation of a longitudinal, infant-centric audiovisual corpus, yielding video-utterance, image-utterance, and multi-turn conversational data that mirror infant experiences. DevCV Toolbox adapts all vision-related measures of the recently released NIH Baby Toolbox into a benchmark suite of ten multimodal tasks, covering spatial reasoning, memory, and vocabulary understanding aligned with early children's capabilities. Experimental results show that a compact model pretrained from scratch can achieve competitive performance on DevCV Toolbox, outperforming GPT-4o on some tasks. We hope the principled, unified BabyVLM-V2 framework will accelerate research in developmentally plausible pretraining of vision foundation models.

Zhenyu Li, Sai Kumar Dwivedi, Filip Maric et al.

Egocentric human motion estimation is essential for AR/VR experiences, yet remains challenging due to limited body coverage from the egocentric viewpoint, frequent occlusions, and scarce labeled data. We present EgoPoseFormer v2, a method that addresses these challenges through two key contributions: (1) a transformer-based model for temporally consistent and spatially grounded body pose estimation, and (2) an auto-labeling system that enables the use of large unlabeled datasets for training. Our model is fully differentiable, introduces identity-conditioned queries, multi-view spatial refinement, causal temporal attention, and supports both keypoints and parametric body representations under a constant compute budget. The auto-labeling system scales learning to tens of millions of unlabeled frames via uncertainty-aware semi-supervised training. The system follows a teacher-student schema to generate pseudo-labels and guide training with uncertainty distillation, enabling the model to generalize to different environments. On the EgoBody3M benchmark, with a 0.8 ms latency on GPU, our model outperforms two state-of-the-art methods by 12.2% and 19.4% in accuracy, and reduces temporal jitter by 22.2% and 51.7%. Furthermore, our auto-labeling system further improves the wrist MPJPE by 13.1%.

Zekun Li, Sizhe An, Chengcheng Tang et al.

Recent progress in large models has led to significant advances in unified multimodal generation and understanding. However, the development of models that unify motion-language generation and understanding remains largely underexplored. Existing approaches often fine-tune large language models (LLMs) on paired motion-text data, which can result in catastrophic forgetting of linguistic capabilities due to the limited scale of available text-motion pairs. Furthermore, prior methods typically convert motion into discrete representations via quantization to integrate with language models, introducing substantial jitter artifacts from discrete tokenization. To address these challenges, we propose LLaMo, a unified framework that extends pretrained LLMs through a modality-specific Mixture-of-Transformers (MoT) architecture. This design inherently preserves the language understanding of the base model while enabling scalable multimodal adaptation. We encode human motion into a causal continuous latent space and maintain the next-token prediction paradigm in the decoder-only backbone through a lightweight flow-matching head, allowing for streaming motion generation in real-time (>30 FPS). Leveraging the comprehensive language understanding of pretrained LLMs and large-scale motion-text pretraining, our experiments demonstrate that LLaMo achieves high-fidelity text-to-motion generation and motion-to-text captioning in general settings, especially zero-shot motion generation, marking a significant step towards a general unified motion-language large model.

Amy Zhao, Guha Balakrishnan, Kathleen M. Lewis et al.

We introduce a new video synthesis task: synthesizing time lapse videos depicting how a given painting might have been created. Artists paint using unique combinations of brushes, strokes, and colors. There are often many possible ways to create a given painting. Our goal is to learn to capture this rich range of possibilities. Creating distributions of long-term videos is a challenge for learning-based video synthesis methods. We present a probabilistic model that, given a single image of a completed painting, recurrently synthesizes steps of the painting process. We implement this model as a convolutional neural network, and introduce a novel training scheme to enable learning from a limited dataset of painting time lapses. We demonstrate that this model can be used to sample many time steps, enabling long-term stochastic video synthesis. We evaluate our method on digital and watercolor paintings collected from video websites, and show that human raters find our synthetic videos to be similar to time lapse videos produced by real artists. Our code is available at https://xamyzhao.github.io/timecraft.

Amy Zhao, Guha Balakrishnan, Frédo Durand et al.

Image segmentation is an important task in many medical applications. Methods based on convolutional neural networks attain state-of-the-art accuracy; however, they typically rely on supervised training with large labeled datasets. Labeling medical images requires significant expertise and time, and typical hand-tuned approaches for data augmentation fail to capture the complex variations in such images. We present an automated data augmentation method for synthesizing labeled medical images. We demonstrate our method on the task of segmenting magnetic resonance imaging (MRI) brain scans. Our method requires only a single segmented scan, and leverages other unlabeled scans in a semi-supervised approach. We learn a model of transformations from the images, and use the model along with the labeled example to synthesize additional labeled examples. Each transformation is comprised of a spatial deformation field and an intensity change, enabling the synthesis of complex effects such as variations in anatomy and image acquisition procedures. We show that training a supervised segmenter with these new examples provides significant improvements over state-of-the-art methods for one-shot biomedical image segmentation. Our code is available at https://github.com/xamyzhao/brainstorm.

Guha Balakrishnan, Amy Zhao, Mert R. Sabuncu et al.

We present a fast learning-based algorithm for deformable, pairwise 3D medical image registration. Current registration methods optimize an objective function independently for each pair of images, which can be time-consuming for large data. We define registration as a parametric function, and optimize its parameters given a set of images from a collection of interest. Given a new pair of scans, we can quickly compute a registration field by directly evaluating the function using the learned parameters. We model this function using a convolutional neural network (CNN), and use a spatial transform layer to reconstruct one image from another while imposing smoothness constraints on the registration field. The proposed method does not require supervised information such as ground truth registration fields or anatomical landmarks. We demonstrate registration accuracy comparable to state-of-the-art 3D image registration, while operating orders of magnitude faster in practice. Our method promises to significantly speed up medical image analysis and processing pipelines, while facilitating novel directions in learning-based registration and its applications. Our code is available at https://github.com/balakg/voxelmorph .

Zhengdi Yu, Simone Foti, Linguang Zhang et al.

We introduce Neural Riemannian Motion Fields (NRMF), a novel 3D generative human motion prior that enables robust, temporally consistent, and physically plausible 3D motion recovery. Unlike existing VAE or diffusion-based methods, our higher-order motion prior explicitly models the human motion in the zero level set of a collection of neural distance fields (NDFs) corresponding to pose, transition (velocity), and acceleration dynamics. Our framework is rigorous in the sense that our NDFs are constructed on the product space of joint rotations, their angular velocities, and angular accelerations, respecting the geometry of the underlying articulations. We further introduce: (i) a novel adaptive-step hybrid algorithm for projecting onto the set of plausible motions, and (ii) a novel geometric integrator to "roll out" realistic motion trajectories during test-time-optimization and generation. Our experiments show significant and consistent gains: trained on the AMASS dataset, NRMF remarkably generalizes across multiple input modalities and to diverse tasks ranging from denoising to motion in-betweening and fitting to partial 2D / 3D observations.

Guha Balakrishnan, Adrian V. Dalca, Amy Zhao et al.

We introduce visual deprojection: the task of recovering an image or video that has been collapsed along a dimension. Projections arise in various contexts, such as long-exposure photography, where a dynamic scene is collapsed in time to produce a motion-blurred image, and corner cameras, where reflected light from a scene is collapsed along a spatial dimension because of an edge occluder to yield a 1D video. Deprojection is ill-posed-- often there are many plausible solutions for a given input. We first propose a probabilistic model capturing the ambiguity of the task. We then present a variational inference strategy using convolutional neural networks as functional approximators. Sampling from the inference network at test time yields plausible candidates from the distribution of original signals that are consistent with a given input projection. We evaluate the method on several datasets for both spatial and temporal deprojection tasks. We first demonstrate the method can recover human gait videos and face images from spatial projections, and then show that it can recover videos of moving digits from dramatically motion-blurred images obtained via temporal projection.

Guha Balakrishnan, Amy Zhao, Mert R. Sabuncu et al.

We present VoxelMorph, a fast learning-based framework for deformable, pairwise medical image registration. Traditional registration methods optimize an objective function for each pair of images, which can be time-consuming for large datasets or rich deformation models. In contrast to this approach, and building on recent learning-based methods, we formulate registration as a function that maps an input image pair to a deformation field that aligns these images. We parameterize the function via a convolutional neural network (CNN), and optimize the parameters of the neural network on a set of images. Given a new pair of scans, VoxelMorph rapidly computes a deformation field by directly evaluating the function. In this work, we explore two different training strategies. In the first (unsupervised) setting, we train the model to maximize standard image matching objective functions that are based on the image intensities. In the second setting, we leverage auxiliary segmentations available in the training data. We demonstrate that the unsupervised model's accuracy is comparable to state-of-the-art methods, while operating orders of magnitude faster. We also show that VoxelMorph trained with auxiliary data improves registration accuracy at test time, and evaluate the effect of training set size on registration. Our method promises to speed up medical image analysis and processing pipelines, while facilitating novel directions in learning-based registration and its applications. Our code is freely available at voxelmorph.csail.mit.edu.

Guha Balakrishnan, Amy Zhao, Adrian V. Dalca et al.

We address the computational problem of novel human pose synthesis. Given an image of a person and a desired pose, we produce a depiction of that person in that pose, retaining the appearance of both the person and background. We present a modular generative neural network that synthesizes unseen poses using training pairs of images and poses taken from human action videos. Our network separates a scene into different body part and background layers, moves body parts to new locations and refines their appearances, and composites the new foreground with a hole-filled background. These subtasks, implemented with separate modules, are trained jointly using only a single target image as a supervised label. We use an adversarial discriminator to force our network to synthesize realistic details conditioned on pose. We demonstrate image synthesis results on three action classes: golf, yoga/workouts and tennis, and show that our method produces accurate results within action classes as well as across action classes. Given a sequence of desired poses, we also produce coherent videos of actions.

Ronnachai Jaroensri, Amy Zhao, Guha Balakrishnan et al.

For many movement disorders, such as Parkinson's disease and ataxia, disease progression is visually assessed by a clinician using a numerical disease rating scale. These tests are subjective, time-consuming, and must be administered by a professional. This can be problematic where specialists are not available, or when a patient is not consistently evaluated by the same clinician. We present an automated method for quantifying the severity of motion impairment in patients with ataxia, using only video recordings. We consider videos of the finger-to-nose test, a common movement task used as part of the assessment of ataxia progression during the course of routine clinical checkups. Our method uses neural network-based pose estimation and optical flow techniques to track the motion of the patient's hand in a video recording. We extract features that describe qualities of the motion such as speed and variation in performance. Using labels provided by an expert clinician, we train a supervised learning model that predicts severity according to the Brief Ataxia Rating Scale (BARS). The performance of our system is comparable to that of a group of ataxia specialists in terms of mean error and correlation, and our system's predictions were consistently within the range of inter-rater variability. This work demonstrates the feasibility of using computer vision and machine learning to produce consistent and clinically useful measures of motor impairment.