Lihong V. Wang

Chao Huang, Kun Wang, Liming Nie et al.

Existing approaches to image reconstruction in photoacoustic computed tomography (PACT) with acoustically heterogeneous media are limited to weakly varying media, are computationally burdensome, and/or cannot effectively mitigate the effects of measurement data incompleteness and noise. In this work, we develop and investigate a discrete imaging model for PACT that is based on the exact photoacoustic (PA) wave equation and facilitates the circumvention of these limitations. A key contribution of the work is the establishment of a procedure to implement a matched forward and backprojection operator pair associated with the discrete imaging model, which permits application of a wide-range of modern image reconstruction algorithms that can mitigate the effects of data incompleteness and noise. The forward and backprojection operators are based on the k-space pseudospectral method for computing numerical solutions to the PA wave equation in the time domain. The developed reconstruction methodology is investigated by use of both computer-simulated and experimental PACT measurement data.

Sreemanti Dey, Snigdha Saha, Berthy T. Feng et al.

Photoacoustic tomography (PAT) is a rapidly-evolving medical imaging modality that combines optical absorption contrast with ultrasound imaging depth. One challenge in PAT is image reconstruction with inadequate acoustic signals due to limited sensor coverage or due to the density of the transducer array. Such cases call for solving an ill-posed inverse reconstruction problem. In this work, we use score-based diffusion models to solve the inverse problem of reconstructing an image from limited PAT measurements. The proposed approach allows us to incorporate an expressive prior learned by a diffusion model on simulated vessel structures while still being robust to varying transducer sparsity conditions.

Yushen Zuo, Qi Zheng, Mingyang Wu et al.

We present 4KAgent, a unified agentic super-resolution generalist system designed to universally upscale any image to 4K resolution (and even higher, if applied iteratively). Our system can transform images from extremely low resolutions with severe degradations, for example, highly distorted inputs at 256x256, into crystal-clear, photorealistic 4K outputs. 4KAgent comprises three core components: (1) Profiling, a module that customizes the 4KAgent pipeline based on bespoke use cases; (2) A Perception Agent, which leverages vision-language models alongside image quality assessment experts to analyze the input image and make a tailored restoration plan; and (3) A Restoration Agent, which executes the plan, following a recursive execution-reflection paradigm, guided by a quality-driven mixture-of-expert policy to select the optimal output for each step. Additionally, 4KAgent embeds a specialized face restoration pipeline, significantly enhancing facial details in portrait and selfie photos. We rigorously evaluate our 4KAgent across 11 distinct task categories encompassing a total of 26 diverse benchmarks, setting new state-of-the-art on a broad spectrum of imaging domains. Our evaluations cover natural images, portrait photos, AI-generated content, satellite imagery, fluorescence microscopy, and medical imaging like fundoscopy, ultrasound, and X-ray, demonstrating superior performance in terms of both perceptual (e.g., NIQE, MUSIQ) and fidelity (e.g., PSNR) metrics. By establishing a novel agentic paradigm for low-level vision tasks, we aim to catalyze broader interest and innovation within vision-centric autonomous agents across diverse research communities. We will release all the code, models, and results at: https://4kagent.github.io.

Jiayun Wang, Yousuf Aborahama, Arya Khokhar et al.

Photoacoustic computed tomography (PACT) combines optical contrast with ultrasonic resolution, achieving deep-tissue imaging beyond the optical diffusion limit. While three-dimensional PACT systems enable high-resolution volumetric imaging for applications spanning transcranial to breast imaging, current implementations require dense transducer arrays and prolonged acquisition times, limiting clinical translation. We introduce Pano (PACT imaging neural operator), an end-to-end physics-aware model that directly learns the inverse acoustic mapping from sensor measurements to volumetric reconstructions. Unlike existing approaches (e.g. universal back-projection algorithm), Pano learns both physics and data priors while also being agnostic to the input data resolution. Pano employs spherical discrete-continuous convolutions to preserve hemispherical sensor geometry, incorporates Helmholtz equation constraints to ensure physical consistency and operates resolutionindependently across varying sensor configurations. We demonstrate the robustness and efficiency of Pano in reconstructing high-quality images from both simulated and real experimental data, achieving consistent performance even with significantly reduced transducer counts and limited-angle acquisition configurations. The framework maintains reconstruction fidelity across diverse sparse sampling patterns while enabling real-time volumetric imaging capabilities. This advancement establishes a practical pathway for making 3D PACT more accessible and feasible for both preclinical research and clinical applications, substantially reducing hardware requirements without compromising image reconstruction quality.