Zhenghui Feng

Yiqiao Chen, Fazheng Xu, Zijian Huang et al.

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and sustained hypertension is an often silent risk factor, making cuffless continuous blood pressure (BP) monitoring with wearable devices important for early screening and long-term management. Most existing cuffless BP estimation methods use only photoplethysmography (PPG) and electrocardiography (ECG) signals, alone or in combination. These models are typically developed under resting or quasi-static conditions and struggle to maintain robust accuracy in multi-motion-state scenarios. In this study, we propose a six-modal BP estimation framework that jointly leverages ECG, multi-channel PPG, attachment pressure, sensor temperature, and triaxial acceleration and angular velocity. Each modality is processed by a lightweight branch encoder, contrastive learning enforces cross-modal semantic alignment, and a mixture-of-experts (MoE) regression head adaptively maps the fused features to BP across motion states. Comprehensive experiments on the public Pulse Transit Time PPG Dataset, which includes running, walking, and sitting data from 22 subjects, show that the proposed method achieves mean absolute errors (MAE) of 3.60 mmHg for systolic BP (SBP) and 3.01 mmHg for diastolic BP (DBP). From a clinical perspective, it attains Grade A for SBP, DBP, and mean arterial pressure (MAP) according to the British Hypertension Society (BHS) protocol and meets the numerical criteria of the Association for the Advancement of Medical Instrumentation (AAMI) standard for mean error (ME) and standard deviation of error (SDE).

Yiqiao Chen, Zijian Huang, Zhenghui Feng

Pediatric arrhythmias are a major risk factor for disability and sudden cardiac death, yet their automated classification remains challenging due to class imbalance, few-shot categories, and complex signal characteristics, which severely limit the efficiency and reliability of early screening and clinical intervention. To address this problem, we propose a multimodal end-to-end deep learning framework that combines dual-branch convolutional encoders for ECG and IEGM, semantic attention for cross-modal feature alignment, and a lightweight Transformer encoder for global dependency modeling. In addition, we introduce a new contrastive loss fucntion named Adaptive Global Class-Aware Contrastive Loss (AGCACL) to enhance intra-class compactness and inter-class separability through class prototypes and a global similarity matrix. To the best of our knowledge, this is the first systematic study based on the Leipzig Heart Center pediatric/congenital ECG+IEGM dataset, for which we also provide a complete and reproducible preprocessing pipeline. Experimental results demonstrate that the proposed method achieves the overall best performance on this dataset, including 97.76\% Top-1 Accuracy, 94.08\% Macro Precision, 91.97\% Macro Recall, 92.97\% Macro F1, and 92.36\% Macro F2, with improvements of +13.64, +15.96, +19.82, and +19.44 percentage points over the strongest baseline in Macro Precision/Recall/F1/F2, respectively. These findings indicate that the framework significantly improves the detectability and robustness for minority arrhythmia classes, offering potential clinical value for rhythm screening, pre-procedural assessment, and postoperative follow-up in pediatric and congenital heart disease populations.