Craig H. Ganoe

Steven Jiang, Weiyi Wu, Naofumi Tomita et al.

Objective: Currently, a major limitation for natural language processing (NLP) analyses in clinical applications is that a concept can be referenced in various forms across different texts. This paper introduces Multi-Ontology Refined Embeddings (MORE), a novel hybrid framework for incorporating domain knowledge from multiple ontologies into a distributional semantic model, learned from a corpus of clinical text. Materials and Methods: We use the RadCore and MIMIC-III free-text datasets for the corpus-based component of MORE. For the ontology-based part, we use the Medical Subject Headings (MeSH) ontology and three state-of-the-art ontology-based similarity measures. In our approach, we propose a new learning objective, modified from the Sigmoid cross-entropy objective function. Results and Discussion: We evaluate the quality of the generated word embeddings using two established datasets of semantic similarities among biomedical concept pairs. On the first dataset with 29 concept pairs, with the similarity scores established by physicians and medical coders, MORE's similarity scores have the highest combined correlation (0.633), which is 5.0% higher than that of the baseline model and 12.4% higher than that of the best ontology-based similarity measure.On the second dataset with 449 concept pairs, MORE's similarity scores have a correlation of 0.481, with the average of four medical residents' similarity ratings, and that outperforms the skip-gram model by 8.1% and the best ontology measure by 6.9%.

Xing Meng, Craig H. Ganoe, Ryan T. Sieberg et al.

Machine learning methods have recently achieved high-performance in biomedical text analysis. However, a major bottleneck in the widespread application of these methods is obtaining the required large amounts of annotated training data, which is resource intensive and time consuming. Recent progress in self-supervised learning has shown promise in leveraging large text corpora without explicit annotations. In this work, we built a self-supervised contextual language representation model using BERT, a deep bidirectional transformer architecture, to identify radiology reports requiring prompt communication to the referring physicians. We pre-trained the BERT model on a large unlabeled corpus of radiology reports and used the resulting contextual representations in a final text classifier for communication urgency. Our model achieved a precision of 97.0%, recall of 93.3%, and F-measure of 95.1% on an independent test set in identifying radiology reports for prompt communication, and significantly outperformed the previous state-of-the-art model based on word2vec representations.