Junhao Wen

Rongguang Wang, Vishnu Bashyam, Zhijian Yang et al.

Generative adversarial networks (GANs) are one powerful type of deep learning models that have been successfully utilized in numerous fields. They belong to a broader family called generative methods, which generate new data with a probabilistic model by learning sample distribution from real examples. In the clinical context, GANs have shown enhanced capabilities in capturing spatially complex, nonlinear, and potentially subtle disease effects compared to traditional generative methods. This review appraises the existing literature on the applications of GANs in imaging studies of various neurological conditions, including Alzheimer's disease, brain tumors, brain aging, and multiple sclerosis. We provide an intuitive explanation of various GAN methods for each application and further discuss the main challenges, open questions, and promising future directions of leveraging GANs in neuroimaging. We aim to bridge the gap between advanced deep learning methods and neurology research by highlighting how GANs can be leveraged to support clinical decision making and contribute to a better understanding of the structural and functional patterns of brain diseases.

Zhijian Yang, Junhao Wen, Christos Davatzikos

A plethora of machine learning methods have been applied to imaging data, enabling the construction of clinically relevant imaging signatures of neurological and neuropsychiatric diseases. Oftentimes, such methods don't explicitly model the heterogeneity of disease effects, or approach it via nonlinear models that are not interpretable. Moreover, unsupervised methods may parse heterogeneity that is driven by nuisance confounding factors that affect brain structure or function, rather than heterogeneity relevant to a pathology of interest. On the other hand, semi-supervised clustering methods seek to derive a dichotomous subtype membership, ignoring the truth that disease heterogeneity spatially and temporally extends along a continuum. To address the aforementioned limitations, herein, we propose a novel method, termed Surreal-GAN (Semi-SUpeRvised ReprEsentAtion Learning via GAN). Using cross-sectional imaging data, Surreal-GAN dissects underlying disease-related heterogeneity under the principle of semi-supervised clustering (cluster mappings from normal control to patient), proposes a continuously dimensional representation, and infers the disease severity of patients at individual level along each dimension. The model first learns a transformation function from normal control (CN) domain to the patient (PT) domain with latent variables controlling transformation directions. An inverse mapping function together with regularization on function continuity, pattern orthogonality and monotonicity was also imposed to make sure that the transformation function captures necessarily meaningful imaging patterns with clinical significance. We first validated the model through extensive semi-synthetic experiments, and then demonstrate its potential in capturing biologically plausible imaging patterns in Alzheimer's disease (AD).

Kun Zeng, Yu Huo, Siyu Zhang et al.

Skill-augmented agents increasingly rely on large reusable skill libraries, but retrieving relevant skills is not the same as presenting usable context. Existing methods typically return atomic skills or dependency-aware bundles whose internal roles remain implicit, leaving the agent to infer the execution entry point, support skills, visible requirements, and failure-avoidance guidance. We introduce Group of Skills (GoSkills), an inference-time group-structured retrieval method that changes the agent-facing retrieval object from a flat skill list to a compact, role-labeled execution context. GoSkills builds anchor-centered skill groups from a typed skill graph, expands support groups through a group graph, bottlenecks the selected group plan into a bounded set of atomic skill payloads, and renders a fixed execution contract with Start, Support, Check, and Avoid fields, without changing the downstream agent, skill payloads, or execution environment. Experiments on SkillsBench and ALFWorld show that GoSkills preserves visible-requirement coverage under a small skill budget, improves over flat skill-access baselines, and often improves reward and agent-only runtime relative to structural retrieval references.

Shutong Qiao, Wei Zhou, Junhao Wen et al.

Session-based recommendation (SBR) methods often rely on user behavior data, which can struggle with the sparsity of session data, limiting performance. Researchers have identified that beyond behavioral signals, rich semantic information in item descriptions is crucial for capturing hidden user intent. While large language models (LLMs) offer new ways to leverage this semantic data, the challenges of session anonymity, short-sequence nature, and high LLM training costs have hindered the development of a lightweight, efficient LLM framework for SBR. To address the above challenges, we propose an LLM-enhanced SBR framework that integrates semantic and behavioral signals from multiple views. This two-stage framework leverages the strengths of both LLMs and traditional SBR models while minimizing training costs. In the first stage, we use multi-view prompts to infer latent user intentions at the session semantic level, supported by an intent localization module to alleviate LLM hallucinations. In the second stage, we align and unify these semantic inferences with behavioral representations, effectively merging insights from both large and small models. Extensive experiments on two real datasets demonstrate that the LLM4SBR framework can effectively improve model performance. We release our codes along with the baselines at https://github.com/tsinghua-fib-lab/LLM4SBR.

Junhao Wen, Erdem Varol, Zhijian Yang et al.

The imaging community has increasingly adopted machine learning (ML) methods to provide individualized imaging signatures related to disease diagnosis, prognosis, and response to treatment. Clinical neuroscience and cancer imaging have been two areas in which ML has offered particular promise. However, many neurologic and neuropsychiatric diseases, as well as cancer, are often heterogeneous in terms of their clinical manifestations, neuroanatomical patterns or genetic underpinnings. Therefore, in such cases, seeking a single disease signature might be ineffectual in delivering individualized precision diagnostics. The current chapter focuses on ML methods, especially semi-supervised clustering, that seek disease subtypes using imaging data. Work from Alzheimer Disease and its prodromal stages, psychosis, depression, autism, and brain cancer are discussed. Our goal is to provide the readers with a broad overview in terms of methodology and clinical applications.

Min Gao, Junwei Zhang, Junliang Yu et al.

Recommender systems (RSs) now play a very important role in the online lives of people as they serve as personalized filters for users to find relevant items from an array of options. Owing to their effectiveness, RSs have been widely employed in consumer-oriented e-commerce platforms. However, despite their empirical successes, these systems still suffer from two limitations: data noise and data sparsity. In recent years, generative adversarial networks (GANs) have garnered increased interest in many fields, owing to their strong capacity to learn complex real data distributions; their abilities to enhance RSs by tackling the challenges these systems exhibit have also been demonstrated in numerous studies. In general, two lines of research have been conducted, and their common ideas can be summarized as follows: (1) for the data noise issue, adversarial perturbations and adversarial sampling-based training often serve as a solution; (2) for the data sparsity issue, data augmentation--implemented by capturing the distribution of real data under the minimax framework--is the primary coping strategy. To gain a comprehensive understanding of these research efforts, we review the corresponding studies and models, organizing them from a problem-driven perspective. More specifically, we propose a taxonomy of these models, along with their detailed descriptions and advantages. Finally, we elaborate on several open issues and current trends in GAN-based RSs.

Qilin Fan, Xiuhua Li, Jian Li et al.

As ubiquitous and personalized services are growing boomingly, an increasingly large amount of traffic is generated over the network by massive mobile devices. As a result, content caching is gradually extending to network edges to provide low-latency services, improve quality of service, and reduce redundant data traffic. Compared to the conventional content delivery networks, caches in edge networks with smaller sizes usually have to accommodate more bursty requests. In this paper, we propose an evolving learning-based content caching policy, named PA-Cache in edge networks. It adaptively learns time-varying content popularity and determines which contents should be replaced when the cache is full. Unlike conventional deep neural networks (DNNs), which learn a fine-tuned but possibly outdated or biased prediction model using the entire training dataset with high computational complexity, PA-Cache weighs a large set of content features and trains the multi-layer recurrent neural network from shallow to deeper when more requests arrive over time. We extensively evaluate the performance of our proposed PA-Cache on real-world traces from a large online video-on-demand service provider. \rb{The results show that PA-Cache outperforms existing popular caching algorithms and approximates the optimal algorithm with only a 3.8\% performance gap when the cache percentage is 1.0\%}. PA-Cache also significantly reduces the computational cost compared to conventional DNN-based approaches.

Pengdeng Li, Lu-Xing Yang, Xiaofan Yang et al.

The new cyber attack pattern of advanced persistent threat (APT) has posed a serious threat to modern society. This paper addresses the APT defense problem, i.e., the problem of how to effectively defend against an APT campaign. Based on a novel APT attack-defense model, the effectiveness of an APT defense strategy is quantified. Thereby, the APT defense problem is modeled as an optimal control problem, in which an optimal control stands for a most effective APT defense strategy. The existence of an optimal control is proved, and an optimality system is derived. Consequently, an optimal control can be figured out by solving the optimality system. Some examples of the optimal control are given. Finally, the influence of some factors on the effectiveness of an optimal control is examined through computer experiments. These findings help organizations to work out policies of defending against APTs.