Chen Ning

Yuxuan Zhou, Yubin Wang, Bin Wang et al.

Large language models (LLMs) have shown great promise in the medical domain, achieving strong performance on several benchmarks. However, they continue to underperform in real-world medical scenarios, which often demand stronger context-awareness, i.e., the ability to recognize missing or critical details (e.g., user identity, medical history, risk factors) and provide safe, helpful, and contextually appropriate responses. To address this issue, we propose Multifaceted Self-Refinement (MuSeR), a data-driven approach that enhances LLMs' context-awareness along three key facets (decision-making, communication, and safety) through self-evaluation and refinement. Specifically, we first design a attribute-conditioned query generator that simulates diverse real-world user contexts by varying attributes such as role, geographic region, intent, and degree of information ambiguity. An LLM then responds to these queries, self-evaluates its answers along three key facets, and refines its responses to better align with the requirements of each facet. Finally, the queries and refined responses are used for supervised fine-tuning to reinforce the model's context-awareness ability. Evaluation results on the latest HealthBench dataset demonstrate that our method significantly improves LLM performance across multiple aspects, with particularly notable gains in the context-awareness axis. Furthermore, by incorporating knowledge distillation with the proposed method, the performance of a smaller backbone LLM (e.g., Qwen3-32B) surpasses its teacher model, achieving a new SOTA across all open-source LLMs on HealthBench (63.8%) and its hard subset (43.1%). Code and dataset will be released at https://muser-llm.github.io.

Yuxuan Zhou, Xien Liu, Chen Ning et al.

Mastering medical knowledge is crucial for medical-specific LLMs. However, despite the existence of medical benchmarks like MedQA, a unified framework that fully leverages existing knowledge bases to evaluate LLMs' mastery of medical knowledge is still lacking. In the study, we propose a novel framework PretexEval that dynamically generates reliable and diverse test samples to evaluate LLMs for any given medical knowledge base. We notice that test samples produced directly from knowledge bases by templates or LLMs may introduce factual errors and also lack diversity. To address these issues, we introduce a novel schema into our proposed evaluation framework that employs predicate equivalence transformations to produce a series of variants for any given medical knowledge point. Finally, these produced predicate variants are converted into textual language, resulting in a series of reliable and diverse test samples to evaluate whether LLMs fully master the given medical factual knowledge point. Here, we use our proposed framework to systematically investigate the mastery of medical factual knowledge of 12 well-known LLMs, based on two knowledge bases that are crucial for clinical diagnosis and treatment. The evaluation results illustrate that current LLMs still exhibit significant deficiencies in fully mastering medical knowledge, despite achieving considerable success on some famous public benchmarks. These new findings provide valuable insights for developing medical-specific LLMs, highlighting that current LLMs urgently need to strengthen their comprehensive and in-depth mastery of medical knowledge before being applied to real-world medical scenarios.

Yuxuan Zhou, Xien Liu, Chen Ning et al.

Large language models (LLMs) have excelled across domains, also delivering notable performance on the medical evaluation benchmarks, such as MedQA. However, there still exists a significant gap between the reported performance and the practical effectiveness in real-world medical scenarios. In this paper, we aim to explore the causes of this gap by employing a multifaceted examination schema to systematically probe the actual mastery of medical knowledge by current LLMs. Specifically, we develop a novel evaluation framework MultifacetEval to examine the degree and coverage of LLMs in encoding and mastering medical knowledge at multiple facets (comparison, rectification, discrimination, and verification) concurrently. Based on the MultifacetEval framework, we construct two multifaceted evaluation datasets: MultiDiseK (by producing questions from a clinical disease knowledge base) and MultiMedQA (by rephrasing each question from a medical benchmark MedQA into multifaceted questions). The experimental results on these multifaceted datasets demonstrate that the extent of current LLMs in mastering medical knowledge is far below their performance on existing medical benchmarks, suggesting that they lack depth, precision, and comprehensiveness in mastering medical knowledge. Consequently, current LLMs are not yet ready for application in real-world medical tasks. The codes and datasets are available at https://github.com/THUMLP/MultifacetEval.

Yuxuan Zhou, Xien Liu, Chenwei Yan et al.

Large language models (LLMs) have demonstrated remarkable performance on various medical benchmarks, but their capabilities across different cognitive levels remain underexplored. Inspired by Bloom's Taxonomy, we propose a multi-cognitive-level evaluation framework for assessing LLMs in the medical domain in this study. The framework integrates existing medical datasets and introduces tasks targeting three cognitive levels: preliminary knowledge grasp, comprehensive knowledge application, and scenario-based problem solving. Using this framework, we systematically evaluate state-of-the-art general and medical LLMs from six prominent families: Llama, Qwen, Gemma, Phi, GPT, and DeepSeek. Our findings reveal a significant performance decline as cognitive complexity increases across evaluated models, with model size playing a more critical role in performance at higher cognitive levels. Our study highlights the need to enhance LLMs' medical capabilities at higher cognitive levels and provides insights for developing LLMs suited to real-world medical applications.