Guy Elisha

Pembe Gizem Özdil, Chuanfang Ning, Jasper S. Phelps et al.

Computational models are critical to advance our understanding of how neural, biomechanical, and physical systems interact to orchestrate animal behaviors. Despite the availability of near-complete reconstructions of the Drosophila melanogaster central nervous system, musculature, and exoskeleton, anatomically and physically grounded models of fly leg muscles are still missing. These models provide an indispensable bridge between motor neuron activity and joint movements. Here, we introduce the first 3D, data-driven musculoskeletal model of Drosophila legs, implemented in both OpenSim and MuJoCo simulation environments. Our model incorporates a Hill-type muscle representation based on high-resolution X-ray scans from multiple fixed specimens. We present a pipeline for constructing muscle models using morphological imaging data and for optimizing unknown muscle parameters specific to the fly. We then combine our musculoskeletal models with detailed 3D pose estimation data from behaving flies to achieve muscle-actuated behavioral replay in OpenSim. Simulations of muscle activity across diverse walking and grooming behaviors predict coordinated muscle synergies that can be tested experimentally. Furthermore, by training imitation learning policies in MuJoCo, we test the effect of different passive joint properties on learning speed and find that damping and stiffness facilitate learning. Overall, our model enables the investigation of motor control in an experimentally tractable model organism, providing insights into how biomechanics contribute to generation of complex limb movements. Moreover, our model can be used to control embodied artificial agents to generate naturalistic and compliant locomotion in simulated environments.

Sourav Halder, Jun Yamasaki, Shashank Acharya et al.

The pathogenesis of esophageal disorders is related to the esophageal wall mechanics. Therefore, to understand the underlying fundamental mechanisms behind various esophageal disorders, it is crucial to map the esophageal wall mechanics-based parameters onto physiological and pathophysiological conditions corresponding to altered bolus transit and supraphysiologic IBP. In this work, we present a hybrid framework that combines fluid mechanics and machine learning to identify the underlying physics of the various esophageal disorders and maps them onto a parameter space which we call the virtual disease landscape (VDL). A one-dimensional inverse model processes the output from an esophageal diagnostic device called endoscopic functional lumen imaging probe (EndoFLIP) to estimate the mechanical "health" of the esophagus by predicting a set of mechanics-based parameters such as esophageal wall stiffness, muscle contraction pattern and active relaxation of esophageal walls. The mechanics-based parameters were then used to train a neural network that consists of a variational autoencoder (VAE) that generates a latent space and a side network that predicts mechanical work metrics for estimating esophagogastric junction motility. The latent vectors along with a set of discrete mechanics-based parameters define the VDL and form clusters corresponding to the various esophageal disorders. The VDL not only distinguishes different disorders but can also be used to predict disease progression in time. Finally, we also demonstrate the clinical applicability of this framework for estimating the effectiveness of a treatment and track patient condition after a treatment.