Amritpal Singh

Syed Ahmad Chan Bukhari, Amritpal Singh, Shifath Hossain et al.

Intensive Care Unit (ICU) patients often present with complex, overlapping signs of physiological deterioration that require timely escalation of care. Traditional early warning systems, such as SOFA or MEWS, are limited by their focus on single outcomes and fail to capture the multi-dimensional nature of clinical decline. This study proposes a multi-label classification framework to predict Care Escalation Triggers (CETs), including respiratory failure, hemodynamic instability, renal compromise, and neurological deterioration, using the first 24 hours of ICU data. Using the MIMIC-IV database, CETs are defined through rule-based criteria applied to data from hours 24 to 72 (for example, oxygen saturation below 90, mean arterial pressure below 65 mmHg, creatinine increase greater than 0.3 mg/dL, or a drop in Glasgow Coma Scale score greater than 2). Features are extracted from the first 24 hours and include vital sign aggregates, laboratory values, and static demographics. We train and evaluate multiple classification models on a cohort of 85,242 ICU stays (80 percent training: 68,193; 20 percent testing: 17,049). Evaluation metrics include per-label precision, recall, F1-score, and Hamming loss. XGBoost, the best performing model, achieves F1-scores of 0.66 for respiratory, 0.72 for hemodynamic, 0.76 for renal, and 0.62 for neurologic deterioration, outperforming baseline models. Feature analysis shows that clinically relevant parameters such as respiratory rate, blood pressure, and creatinine are the most influential predictors, consistent with the clinical definitions of the CETs. The proposed framework demonstrates practical potential for early, interpretable clinical alerts without requiring complex time-series modeling or natural language processing.

Iram Wajahat, Amritpal Singh, Fazel Keshtkar et al.

Metabolic disorders, particularly type 2 diabetes mellitus (T2DM), represent a significant global health burden, disproportionately impacting genetically predisposed populations such as the Pima Indians (a Native American tribe from south central Arizona). This study introduces a novel machine learning (ML) framework that integrates predictive modeling with gene-agnostic pathway mapping to identify high-risk individuals and uncover potential therapeutic targets. Using the Pima Indian dataset, logistic regression and t-tests were applied to identify key predictors of T2DM, yielding an overall model accuracy of 78.43%. To bridge predictive analytics with biological relevance, we developed a pathway mapping strategy that links identified predictors to critical signaling networks, including insulin signaling, AMPK, and PPAR pathways. This approach provides mechanistic insights without requiring direct molecular data. Building upon these connections, we propose therapeutic strategies such as dual GLP-1/GIP receptor agonists, AMPK activators, SIRT1 modulators, and phytochemical, further validated through pathway enrichment analyses. Overall, this framework advances precision medicine by offering interpretable and scalable solutions for early detection and targeted intervention in metabolic disorders. The key contributions of this work are: (1) development of an ML framework combining logistic regression and principal component analysis (PCA) for T2DM risk prediction; (2) introduction of a gene-agnostic pathway mapping approach to generate mechanistic insights; and (3) identification of novel therapeutic strategies tailored for high-risk populations.

Rajeev Bedi, Mohit Marwaha, Tajinder Singh et al.

Privacy Security of data in Cloud Storage is one of the main issues. Many Frameworks and Technologies are used to preserve data security in cloud storage. [1] Proposes a framework which includes the design of data organization structure, the generation and management of keys, the treatment of change of user's access right and dynamic operations of data, and the interaction between participants. It also design an interactive protocol and an extirpation-based key derivation algorithm, which are combined with lazy revocation, it uses multi-tree structure and symmetric encryption to form a privacy-preserving, efficient framework for cloud storage. [2] Proposes a framework which design a privacy-preserving cloud storage framework in which he designed an interaction protocol among participants, use key derivation algorithm to generate and manage keys, use both symmetric and asymmetric encryption to hide the sensitive data of users, and apply Bloom filter for cipher text retrieval. A system based on this framework is realized. This paper analyzes both the frameworks in terms of the feasibility of the frameworks, running overhead of the system and the privacy security of the frameworks.