Antoine Saporta

Antoine Saporta, Arthur Douillard, Tuan-Hung Vu et al.

Unsupervised Domain Adaptation (UDA) is a transfer learning task which aims at training on an unlabeled target domain by leveraging a labeled source domain. Beyond the traditional scope of UDA with a single source domain and a single target domain, real-world perception systems face a variety of scenarios to handle, from varying lighting conditions to many cities around the world. In this context, UDAs with several domains increase the challenges with the addition of distribution shifts within the different target domains. This work focuses on a novel framework for learning UDA, continuous UDA, in which models operate on multiple target domains discovered sequentially, without access to previous target domains. We propose MuHDi, for Multi-Head Distillation, a method that solves the catastrophic forgetting problem, inherent in continual learning tasks. MuHDi performs distillation at multiple levels from the previous model as well as an auxiliary target-specialist segmentation head. We report both extensive ablation and experiments on challenging multi-target UDA semantic segmentation benchmarks to validate the proposed learning scheme and architecture.

Asbjørn Munk, Stefano Cerri, Vardan Nersesjan et al.

Clinical deployment of automated brain MRI analysis faces a fundamental challenge: clinical data is heterogeneous and noisy, and high-quality labels are prohibitively costly to obtain. Self-supervised learning (SSL) can address this by leveraging the vast amounts of unlabeled data produced in clinical workflows to train robust \textit{foundation models} that adapt out-of-domain with minimal supervision. However, the development of foundation models for brain MRI has been limited by small pretraining datasets and in-domain benchmarking focused on high-quality, research-grade data. To address this gap, we organized the FOMO25 challenge as a satellite event at MICCAI 2025. FOMO25 provided participants with a large pretraining dataset, FOMO60K, and evaluated models on data sourced directly from clinical workflows in few-shot and out-of-domain settings. Tasks covered infarct classification, meningioma segmentation, and brain age regression, and considered both models trained on FOMO60K (method track) and any data (open track). Nineteen foundation models from sixteen teams were evaluated using a standardized containerized pipeline. Results show that (a) self-supervised pretraining improves generalization on clinical data under domain shift, with the strongest models trained \textit{out-of-domain} surpassing supervised baselines trained \textit{in-domain}. (b) No single pretraining objective benefits all tasks: MAE favors segmentation, hybrid reconstruction-contrastive objectives favor classification, and (c) strong performance was achieved by small pretrained models, and improvements from scaling model size and training duration did not yield reliable benefits.

Corentin Dancette, Julien Khlaut, Antoine Saporta et al.

AI-assisted radiological interpretation is based on predominantly narrow, single-task models. This approach is impractical for covering the vast spectrum of imaging modalities, diseases, and radiological findings. Foundation models (FMs) hold the promise of broad generalization across modalities and in low-data settings. However, this potential has remained largely unrealized in radiology. We introduce Curia, a foundation model trained on the entire cross-sectional imaging output of a major hospital over several years, which to our knowledge is the largest such corpus of real-world data-encompassing 150,000 exams (130 TB). On a newly curated 19-task external validation benchmark, Curia accurately identifies organs, detects conditions like brain hemorrhages and myocardial infarctions, and predicts outcomes in tumor staging. Curia meets or surpasses the performance of radiologists and recent foundation models, and exhibits clinically significant emergent properties in cross-modality, and low-data regimes. To accelerate progress, we release our base model's weights at https://huggingface.co/raidium/curia.

Antoine Saporta, Baptiste Callard, Corentin Dancette et al.

The rapid growth of medical imaging has fueled the development of Foundation Models (FMs) to reduce the growing, unsustainable workload on radiologists. While recent FMs have shown the power of large-scale pre-training to CT and MRI analysis, there remains significant room to optimize how these models learn from complex radiological volumes. Building upon the Curia framework, this work introduces Curia-2, which significantly improves the original pre-training strategy and representation quality to better capture the specificities of radiological data. The proposed methodology enables scaling the architecture up to billion-parameter Vision Transformers, marking a first for multi-modal CT and MRI FMs. Furthermore, we formalize the evaluation of these models by extending and restructuring CuriaBench into two distinct tracks: a 2D track tailored for slice-based vision models and a 3D track for volumetric benchmarking. Our results demonstrate that Curia-2 outperforms all FMs on vision-focused tasks and fairs competitively to vision-language models on clinically complex tasks such as finding detection. Weights will be made publicly available to foster further research.

Antoine Saporta, Tuan-Hung Vu, Matthieu Cord et al.

In this work, we address the task of unsupervised domain adaptation (UDA) for semantic segmentation in presence of multiple target domains: The objective is to train a single model that can handle all these domains at test time. Such a multi-target adaptation is crucial for a variety of scenarios that real-world autonomous systems must handle. It is a challenging setup since one faces not only the domain gap between the labeled source set and the unlabeled target set, but also the distribution shifts existing within the latter among the different target domains. To this end, we introduce two adversarial frameworks: (i) multi-discriminator, which explicitly aligns each target domain to its counterparts, and (ii) multi-target knowledge transfer, which learns a target-agnostic model thanks to a multi-teacher/single-student distillation mechanism.The evaluation is done on four newly-proposed multi-target benchmarks for UDA in semantic segmentation. In all tested scenarios, our approaches consistently outperform baselines, setting competitive standards for the novel task.

Charles Corbière, Nicolas Thome, Antoine Saporta et al.

Reliably quantifying the confidence of deep neural classifiers is a challenging yet fundamental requirement for deploying such models in safety-critical applications. In this paper, we introduce a novel target criterion for model confidence, namely the true class probability (TCP). We show that TCP offers better properties for confidence estimation than standard maximum class probability (MCP). Since the true class is by essence unknown at test time, we propose to learn TCP criterion from data with an auxiliary model, introducing a specific learning scheme adapted to this context. We evaluate our approach on the task of failure prediction and of self-training with pseudo-labels for domain adaptation, which both necessitate effective confidence estimates. Extensive experiments are conducted for validating the relevance of the proposed approach in each task. We study various network architectures and experiment with small and large datasets for image classification and semantic segmentation. In every tested benchmark, our approach outperforms strong baselines.

Antoine Saporta, Tuan-Hung Vu, Matthieu Cord et al.

While fully-supervised deep learning yields good models for urban scene semantic segmentation, these models struggle to generalize to new environments with different lighting or weather conditions for instance. In addition, producing the extensive pixel-level annotations that the task requires comes at a great cost. Unsupervised domain adaptation (UDA) is one approach that tries to address these issues in order to make such systems more scalable. In particular, self-supervised learning (SSL) has recently become an effective strategy for UDA in semantic segmentation. At the core of such methods lies `pseudo-labeling', that is, the practice of assigning high-confident class predictions as pseudo-labels, subsequently used as true labels, for target data. To collect pseudo-labels, previous works often rely on the highest softmax score, which we here argue as an unfavorable confidence measurement. In this work, we propose Entropy-guided Self-supervised Learning (ESL), leveraging entropy as the confidence indicator for producing more accurate pseudo-labels. On different UDA benchmarks, ESL consistently outperforms strong SSL baselines and achieves state-of-the-art results.

Antoine Saporta, Yifu Chen, Michael Blot et al.

Studies on generalization performance of machine learning algorithms under the scope of information theory suggest that compressed representations can guarantee good generalization, inspiring many compression-based regularization methods. In this paper, we introduce REVE, a new regularization scheme. Noting that compressing the representation can be sub-optimal, our first contribution is to identify a variable that is directly responsible for the final prediction. Our method aims at compressing the class conditioned entropy of this latter variable. Second, we introduce a variational upper bound on this conditional entropy term. Finally, we propose a scheme to instantiate a tractable loss that is integrated within the training procedure of the neural network and demonstrate its efficiency on different neural networks and datasets.