Youngsun Kong

Yongbin Lee, Andrew Peitzsch, Youngsun Kong et al.

Electrodermal activity (EDA) is widely used in wearable Internet of Medical Things (IoMT) systems for continuous health monitoring, including autonomic assessment. However, EDA signals are highly vulnerable to motion artifacts and environmental noise, limiting reliable deployment in harsh operating conditions such as underwater. This study proposes a robust, deployable EDA denoising framework that generalizes across multiple measurement locations and harsh environments. The framework integrates a hybrid CNN-Transformer teacher model with a lightweight depth-wise separable CNN student model via a knowledge distillation (KD) strategy. To further improve robustness, a realistic data augmentation scheme is introduced to simulate diverse motion artifacts and environmental distortions. The KD-based student model significantly reduces model size (7.87 MB to 0.51 MB) and computational cost (105.1M to 11.61M FLOPs) while maintaining denoising performance (MAE: 0.144, SNR improvement: 12.08 dB) using the public dataset validation. In real-world underwater conditions (UMAC dataset) testing, the proposed method substantially improves skin conductance response reconstruction, reducing mean absolute error from 2.809 to 0.215. Furthermore, on independent testing using the CNS-OT dataset, the denoised signals enhanced downstream CNS-OT prediction performance, achieving the highest AUROC (0.806) compared to prior denoising methods. The proposed method also improved the early prediction rate (sensitivity) from 0.550 to 0.767, enabling CNS-OT prediction up to a median of 6.9 minutes before symptom onset. These results demonstrate that the proposed framework not only improves EDA signal quality but also enhances clinically relevant prediction performance while remaining suitable for deployment in resource-constrained wearable Internet of Things systems operating in harsh environments.

Farnoush Baghestani, Mahdi Pirayesh Shirazi Nejad, Youngsun Kong et al.

Continuous monitoring of non-invasive skin sympathetic nerve activity (SKNA) holds promise for understanding the sympathetic nervous system (SNS) dynamics in various physiological and pathological conditions. However, muscle noise artifacts present a challenge in accurate SKNA analysis, particularly in real-life scenarios. This study proposes a deep convolutional neural network (CNN) approach to detect and remove muscle noise from SKNA recordings obtained via ECG electrodes. Twelve healthy participants underwent controlled experimental protocols involving cognitive stress induction and voluntary muscle movements, while collecting SKNA data. Power spectral analysis revealed significant muscle noise interference within the SKNA frequency band (500-1000 Hz). A 2D CNN model was trained on the spectrograms of the data segments to classify them into baseline, stress-induced SKNA, and muscle noise-contaminated periods, achieving an average accuracy of 89.85% across all subjects. Our findings underscore the importance of addressing muscle noise for accurate SKNA monitoring, advancing towards wearable SKNA sensors for real-world applications.

Farnoush Baghestani, Jihye Moon, Youngsun Kong et al.

The sympathetic nervous system (SNS) plays a central role in regulating the body's responses to stress and maintaining physiological stability. Its dysregulation is associated with a wide range of conditions, from cardiovascular disease to anxiety disorders. Skin nerve activity (SKNA) extracted from high-frequency electrocardiogram (ECG) recordings provides a noninvasive window into SNS dynamics, but its measurement is highly susceptible to electromyographic (EMG) contamination. Traditional preprocessing based on bandpass filtering within a fixed range (e.g., 500--1000 Hz) is susceptible to overlapping EMG and SKNA spectral components, especially during sustained muscle activity. We present a denoising approach using a lightweight one-dimensional convolutional autoencoder with a long short-term memory (LSTM) bottleneck to reconstruct clean SKNA from EMG-contaminated recordings. Using clean ECG-derived SKNA data from cognitive stress experiments and EMG noise from chaotic muscle stimulation recordings, we simulated contamination at realistic noise levels (--4 dB, --8 dB signal-to-noise ratio) and trained the model in the leave-one-subject-out cross-validation framework. The method improved signal-to-noise ratio by up to 9.65 dB, increased cross correlation with clean SKNA from 0.40 to 0.72, and restored burst-based SKNA features to near-clean discriminability (AUROC $\geq$ 0.96). Classification of baseline versus sympathetic stimulation (cognitive stress) conditions reached accuracies of 91--98\% across severe noise levels, comparable to clean data. These results demonstrate that deep learning--based reconstruction can preserve physiologically relevant sympathetic bursts during substantial EMG interference, enabling more robust SKNA monitoring in naturalistic, movement-rich environments.