Xiaoyi Liu

Xiaoyi Liu, Hongpeng Yang, Chengwei Ai et al.

Incomplete knowledge of metabolic processes hinders the accuracy of GEnome-scale Metabolic models (GEMs), which in turn impedes advancements in systems biology and metabolic engineering. Existing gap-filling methods typically rely on phenotypic data to minimize the disparity between computational predictions and experimental results. However, there is still a lack of an automatic and precise gap-filling method for initial state GEMs before experimental data and annotated genomes become available. In this study, we introduce CLOSEgaps, a deep learning-driven tool that addresses the gap-filling issue by modeling it as a hyperedge prediction problem within GEMs. Specifically, CLOSEgaps maps metabolic networks as hypergraphs and learns their hyper-topology features to identify missing reactions and gaps by leveraging hypothetical reactions. This innovative approach allows for the characterization and curation of both known and hypothetical reactions within metabolic networks. Extensive results demonstrate that CLOSEgaps accurately gap-filling over 96% of artificially introduced gaps for various GEMs. Furthermore, CLOSEgaps enhances phenotypic predictions for 24 GEMs and also finds a notable improvement in producing four crucial metabolites (Lactate, Ethanol, Propionate, and Succinate) in two organisms. As a broadly applicable solution for any GEM, CLOSEgaps represents a promising model to automate the gap-filling process and uncover missing connections between reactions and observed metabolic phenotypes.

Lianghao Tan, Shubing Liu, Jing Gao et al.

With the rapid advancement of deep learning technologies, computer vision has shown immense potential in retail automation. This paper presents a novel self-checkout system for retail based on an improved YOLOv10 network, aimed at enhancing checkout efficiency and reducing labor costs. We propose targeted optimizations to the YOLOv10 model, by incorporating the detection head structure from YOLOv8, which significantly improves product recognition accuracy. Additionally, we develop a post-processing algorithm tailored for self-checkout scenarios, to further enhance the application of system. Experimental results demonstrate that our system outperforms existing methods in both product recognition accuracy and checkout speed. This research not only provides a new technical solution for retail automation but offers valuable insights into optimizing deep learning models for real-world applications.

Bojian Hou, Xiaolong Liu, Xiaoyi Liu et al.

Deriving predictable scaling laws that govern the relationship between model performance and computational investment is crucial for designing and allocating resources in massive-scale recommendation systems. While such laws are established for large language models, they remain challenging for recommendation systems, especially those processing both user history and context features. We identify poor scaling efficiency as the main barrier to predictable power-law scaling, stemming from inefficient modules with low Model FLOPs Utilization (MFU) and suboptimal resource allocation. We introduce Kunlun, a scalable architecture that systematically improves model efficiency and resource allocation. Our low-level optimizations include Generalized Dot-Product Attention (GDPA), Hierarchical Seed Pooling (HSP), and Sliding Window Attention. Our high-level innovations feature Computation Skip (CompSkip) and Event-level Personalization. These advances increase MFU from 17% to 37% on NVIDIA B200 GPUs and double scaling efficiency over state-of-the-art methods. Kunlun is now deployed in major Meta Ads models, delivering significant production impact.

Yun He, Xuxing Chen, Jiayi Xu et al.

In industrial recommendation systems, multi-task learning (learning multiple tasks simultaneously on a single model) is a predominant approach to save training/serving resources and improve recommendation performance via knowledge transfer between the joint learning tasks. However, multi-task learning often suffers from negative transfer: one or several tasks are less optimized than training them separately. To carefully balance the optimization, we propose a gradient balancing approach called MultiBalance, which is suitable for industrial-scale multi-task recommendation systems. It balances the per-task gradients to alleviate the negative transfer, while saving the huge cost for grid search or manual explorations for appropriate task weights. Moreover, compared with prior work that normally balance the per-task gradients of shared parameters, MultiBalance is more efficient since only requiring to access per-task gradients with respect to the shared feature representations. We conduct experiments on Meta's large-scale ads and feeds multi-task recommendation system, and observe that MultiBalance achieves significant gains (e.g., 0.738% improvement for normalized entropy (NE)) with neutral training cost in Queries Per Second (QPS), which is significantly more efficient than prior methods that balance per-task gradients of shared parameters with 70~80% QPS degradation.

Xiaoyi Liu, Hao Tang

Physical intelligence -- anticipating and shaping the world from partial, multisensory observations -- is critical for next-generation world models. We propose FOLIAGE, a physics-informed multimodal world model for unbounded accretive surface growth. In its Action-Perception loop, a unified context encoder maps images, mesh connectivity, and point clouds to a shared latent state. A physics-aware predictor, conditioned on physical control actions, advances this latent state in time to align with the target latent of the surface, yielding a Modality-Agnostic Growth Embedding (MAGE) that interfaces with critic heads for downstream objectives. FOLIAGE's Accretive Graph Network (AGN) captures dynamic connectivity through Age Positional Encoding and Energy-Gated Message-Passing. Geometry-Correspondence Fusion and Cross-Patch Masking enhance MAGE's expressiveness, while Hierarchical Pooling balances global context with local dynamics. We create SURF-GARDEN, a world model learning platform comprising a Counterfactual Physics Simulator, a Multimodal Correspondence Extractor, and Evolution Tracing, which generates 7,200 diverse surface-growth sequences. SURF-BENCH, our physical-intelligence evaluation suite, evaluates six core tasks -- topology recognition, inverse material estimation, growth-stage classification, latent roll-out, cross-modal retrieval, and dense correspondence -- and four stress tests -- sensor dropout, zero-shot modality transfer, long-horizon prediction, and physics ablation -- to probe resilience. FOLIAGE outperforms specialized baselines while remaining robust across dynamic environments, establishing a new world-model based, multimodal pathway to physical intelligence.

Xuxing Chen, Yun He, Jiayi Xu et al.

In machine learning, the goal of multi-task learning (MTL) is to optimize multiple objectives together. Recent works, for example, Multiple Gradient Descent Algorithm (MGDA) and its variants, show promising results with dynamically adjusted weights for different tasks to mitigate conflicts that may potentially degrade the performance on certain tasks. Despite the empirical success of MGDA-type methods, one major limitation of such methods is their computational inefficiency, as they require access to all task gradients. In this paper we introduce MARIGOLD, a unified algorithmic framework for efficiently solving MTL problems. Our method reveals that multi-task gradient balancing methods have a hierarchical structure, in which the model training and the gradient balancing are coupled during the whole optimization process and can be viewed as a bi-level optimization problem. Moreover, we showcase that the bi-level problem can be solved efficiently by leveraging zeroth-order method. Extensive experiments on both public datasets and industrial-scale datasets demonstrate the efficiency and superiority of our method.

Xiaoyi Liu, Diego Klabjan, Patrick NBless

Automatic data extraction from charts is challenging for two reasons: there exist many relations among objects in a chart, which is not a common consideration in general computer vision problems; and different types of charts may not be processed by the same model. To address these problems, we propose a framework of a single deep neural network, which consists of object detection, text recognition and object matching modules. The framework handles both bar and pie charts, and it may also be extended to other types of charts by slight revisions and by augmenting the training data. Our model performs successfully on 79.4% of test simulated bar charts and 88.0% of test simulated pie charts, while for charts outside of the training domain it degrades for 57.5% and 62.3%, respectively.