Daniel Roth

Jarrid Rector-Brooks, Théophile Lambert, Marta Skreta et al.

Evolution is an extraordinary engine for enzymatic diversity, yet the chemistry it has explored remains a narrow slice of what DNA can encode. Deep generative models can design new proteins that bind ligands, but none have created enzymes without pre-specifying catalytic residues. We introduce DISCO (DIffusion for Sequence-structure CO-design), a multimodal model that co-designs protein sequence and 3D structure around arbitrary biomolecules, as well as inference-time scaling methods that optimize objectives across both modalities. Conditioned solely on reactive intermediates, DISCO designs diverse heme enzymes with novel active-site geometries. These enzymes catalyze new-to-nature carbene-transfer reactions, including alkene cyclopropanation, spirocyclopropanation, B-H, and C(sp$^3$)-H insertions, with high activities exceeding those of engineered enzymes. Random mutagenesis of a selected design further confirmed that enzyme activity can be improved through directed evolution. By providing a scalable route to evolvable enzymes, DISCO broadens the potential scope of genetically encodable transformations. Code is available at https://github.com/DISCO-design/DISCO.

Shiyu Li, Julian Kreimeier, Hannah Schieber et al.

The handling and assembly of instruments during surgery imposes high cognitive demands on scrub nurses, particularly when instruments are unfamiliar. We present a supporting guidance system for surgical instrumentation that combines multi-camera 6D pose estimation with augmented reality in-situ visualization on a head-mounted display without the requirement for additional markers. Pose estimation and consecutive camera calibration are achieved through known objects. The 6D pose estimation network is trained purely on synthetic data, aiming for better generalizability and real-world applicability. The AR guidance displays tooltip localization cues and step-wise assembly animations. Via gaze-based selection and a foot pedal, users can switch between assembly steps in intraoperative use. In a technical evaluation, our approach outperforms state-of-art 6D pose estimation. A user study with 29 scrub nurses was conducted in a surgical simulation of knee arthroplasty, comparing the system against a paper manual. AR guidance significantly reduced the perceived workload compared. Objectively, AR guidance reduced task completion time by 21.3\% (4.76 minutes). Specifically, scrub nurses less experienced with the instrument set benefited when using the system. Error frequencies were comparable between conditions. Qualitative feedback highlighted improved process clarity, reduced information overload, and perceived independence. To summarize, our marker-free multi-camera AR guidance approach for surgical instruments can, subjectively and objectively, improve intraoperative instrumentation performance, particularly for untrained scrub nurses.

HyunJun Jung, Guangyao Zhai, Shun-Cheng Wu et al.

Estimating 6D object poses is a major challenge in 3D computer vision. Building on successful instance-level approaches, research is shifting towards category-level pose estimation for practical applications. Current category-level datasets, however, fall short in annotation quality and pose variety. Addressing this, we introduce HouseCat6D, a new category-level 6D pose dataset. It features 1) multi-modality with Polarimetric RGB and Depth (RGBD+P), 2) encompasses 194 diverse objects across 10 household categories, including two photometrically challenging ones, and 3) provides high-quality pose annotations with an error range of only 1.35 mm to 1.74 mm. The dataset also includes 4) 41 large-scale scenes with comprehensive viewpoint and occlusion coverage, 5) a checkerboard-free environment, and 6) dense 6D parallel-jaw robotic grasp annotations. Additionally, we present benchmark results for leading category-level pose estimation networks.

Nicolas Schischka, Hannah Schieber, Mert Asim Karaoglu et al.

The accurate reconstruction of dynamic scenes with neural radiance fields is significantly dependent on the estimation of camera poses. Widely used structure-from-motion pipelines encounter difficulties in accurately tracking the camera trajectory when faced with separate dynamics of the scene content and the camera movement. To address this challenge, we propose Dynamic Motion-Aware Fast and Robust Camera Localization for Dynamic Neural Radiance Fields (DynaMoN). DynaMoN utilizes semantic segmentation and generic motion masks to handle dynamic content for initial camera pose estimation and statics-focused ray sampling for fast and accurate novel-view synthesis. Our novel iterative learning scheme switches between training the NeRF and updating the pose parameters for an improved reconstruction and trajectory estimation quality. The proposed pipeline shows significant acceleration of the training process. We extensively evaluate our approach on two real-world dynamic datasets, the TUM RGB-D dataset and the BONN RGB-D Dynamic dataset. DynaMoN improves over the state-of-the-art both in terms of reconstruction quality and trajectory accuracy. We plan to make our code public to enhance research in this area.

Shiyu Li, Hannah Schieber, Kristoffer Waldow et al.

Multi-camera dynamic Augmented Reality (AR) applications require a camera pose estimation to leverage individual information from each camera in one common system. This can be achieved by combining contextual information, such as markers or objects, across multiple views. While commonly cameras are calibrated in an initial step or updated through the constant use of markers, another option is to leverage information already present in the scene, like known objects. Another downside of marker-based tracking is that markers have to be tracked inside the field-of-view (FoV) of the cameras. To overcome these limitations, we propose a constant dynamic camera pose estimation leveraging spatiotemporal FoV overlaps of known objects on the fly. To achieve that, we enhance the state-of-the-art object pose estimator to update our spatiotemporal scene graph, enabling a relation even among non-overlapping FoV cameras. To evaluate our approach, we introduce a multi-camera, multi-object pose estimation dataset with temporal FoV overlap, including static and dynamic cameras. Furthermore, in FoV overlapping scenarios, we outperform the state-of-the-art on the widely used YCB-V and T-LESS dataset in camera pose accuracy. Our performance on both previous and our proposed datasets validates the effectiveness of our marker-less approach for AR applications. The code and dataset are available on https://github.com/roth-hex-lab/IEEE-VR-2026-MultiCam.

Hannah Schieber, Jacob Young, Tobias Langlotz et al.

Advancements in 3D rendering like Gaussian Splatting (GS) allow novel view synthesis and real-time rendering in virtual reality (VR). However, GS-created 3D environments are often difficult to edit. For scene enhancement or to incorporate 3D assets, segmenting Gaussians by class is essential. Existing segmentation approaches are typically limited to certain types of scenes, e.g., ''circular'' scenes, to determine clear object boundaries. However, this method is ineffective when removing large objects in non-''circling'' scenes such as large outdoor scenes. We propose Semantics-Controlled GS (SCGS), a segmentation-driven GS approach, enabling the separation of large scene parts in uncontrolled, natural environments. SCGS allows scene editing and the extraction of scene parts for VR. Additionally, we introduce a challenging outdoor dataset, overcoming the ''circling'' setup. We outperform the state-of-the-art in visual quality on our dataset and in segmentation quality on the 3D-OVS dataset. We conducted an exploratory user study, comparing a 360-video, plain GS, and SCGS in VR with a fixed viewpoint. In our subsequent main study, users were allowed to move freely, evaluating plain GS and SCGS. Our main study results show that participants clearly prefer SCGS over plain GS. We overall present an innovative approach that surpasses the state-of-the-art both technically and in user experience.

Hannah Schieber, Dominik Frischmann, Victor Schaack et al.

Autonomous robots in unknown indoor environments require both reliable collision avoidance and object-level understanding. Classical representations such as TSDF support safe planning but lack semantics, while photorealistic methods like Gaussian Splatting (GS) provide rich appearance yet suffer from soft geometry, limiting precise obstacle avoidance. We present LiftNav, a hybrid navigation framework built on GSFusion's TSDF+GS dual map, augmented with a real-time pipeline of YOLO-based detection, TSDF-based 3D lifting, and B-spline trajectory optimization. This design enables flexible semantic navigation without dense 3D embeddings. We further introduce a hinge-loss-based collision penalty that improves trajectory smoothness and safety. We evaluate our approach in a simulation using the Replica dataset. Compared against a state-of-the-art radiance field baseline we show a 100% feasibility rate and shorter trajectories.

Manoj Biswanath, Chenxin Cai, Hannah Schieber et al.

Efficient and robust 3D scene representation is crucial in autonomous driving, robotics, and related fields. While RGB images provide valuable content for 3D reconstruction, other modalities like thermal or depth can enable additional information on the environment. Lately, novel view synthesis methods like 3D Gaussian Splatting have started using multiple modalities to further boost their performance. But fusing or combining multimodal data can make the process slower and can bring in additional challenges. Therefore, our project aims to use single modality based on thermal infrared domain, by removing the reliance on visible light as much as possible. This single modality can be expected to be faster as it does not rely on multimodal data. We propose a method, Thermal-to-Depth Gaussian Splatting (TDg), that uses only thermal images and depth estimation in its architecture to derive the radiance fields. Our TDg method outperforms the MSMG (Multiple Single-Modal Gaussians) baseline in most cases on our test datasets, RGBT-Scenes and ThermalMix. On average, the rendering quality metrics such as learned perceptual image patch similarity (LPIPS), structural similarity index measure (SSIM), and peak signal-to-noise ratio (PSNR) of TDg are 1.12%, 0.034%, and 0.01% better than the baseline MSMG values. It also reduces the training time significantly, by 12 mins 47 secs (55% improvement). Overall, our method is successful in deriving these thermal radiance fields, which can ultimately have several applications, such as identifying heat sources critical in surveillance, search or rescue operations, and industrial inspections where temperature is widely used to monitor machines.

Hannah Schieber, Fabian Deuser, Bernhard Egger et al.

Novel view synthesis using neural radiance fields (NeRF) is the state-of-the-art technique for generating high-quality images from novel viewpoints. Existing methods require a priori knowledge about extrinsic and intrinsic camera parameters. This limits their applicability to synthetic scenes, or real-world scenarios with the necessity of a preprocessing step. Current research on the joint optimization of camera parameters and NeRF focuses on refining noisy extrinsic camera parameters and often relies on the preprocessing of intrinsic camera parameters. Further approaches are limited to cover only one single camera intrinsic. To address these limitations, we propose a novel end-to-end trainable approach called NeRFtrinsic Four. We utilize Gaussian Fourier features to estimate extrinsic camera parameters and dynamically predict varying intrinsic camera parameters through the supervision of the projection error. Our approach outperforms existing joint optimization methods on LLFF and BLEFF. In addition to these existing datasets, we introduce a new dataset called iFF with varying intrinsic camera parameters. NeRFtrinsic Four is a step forward in joint optimization NeRF-based view synthesis and enables more realistic and flexible rendering in real-world scenarios with varying camera parameters.

Constantin Kleinbeck, Luisa Theelke, Hannah Schieber et al.

Volumetric medical imaging offers great potential for understanding complex pathologies. Yet, traditional 2D slices provide little support for interpreting spatial relationships, forcing users to mentally reconstruct anatomy into three dimensions. Direct volumetric path tracing and VR rendering can improve perception but are computationally expensive, while precomputed representations, like Gaussian Splatting, require planning ahead. Both approaches limit interactive use. We propose a hybrid rendering approach for high-quality, interactive, and immersive anatomical visualization. Our method combines streamed foveated path tracing with a lightweight Gaussian Splatting approximation of the periphery. The peripheral model generation is optimized with volume data and continuously refined using foveal renderings, enabling interactive updates. Depth-guided reprojection further improves robustness to latency and allows users to balance fidelity with refresh rate. We compare our method against direct path tracing and Gaussian Splatting. Our results highlight how their combination can preserve strengths in visual quality while re-generating the peripheral model in under a second, eliminating extensive preprocessing and approximations. This opens new options for interactive medical visualization.

Shiyu Li, Hannah Schieber, Niklas Corell et al.

Guidance for assemblable parts is a promising field for augmented reality. Augmented reality assembly guidance requires 6D object poses of target objects in real time. Especially in time-critical medical or industrial settings, continuous and markerless tracking of individual parts is essential to visualize instructions superimposed on or next to the target object parts. In this regard, occlusions by the user's hand or other objects and the complexity of different assembly states complicate robust and real-time markerless multi-object tracking. To address this problem, we present Graph-based Object Tracking (GBOT), a novel graph-based single-view RGB-D tracking approach. The real-time markerless multi-object tracking is initialized via 6D pose estimation and updates the graph-based assembly poses. The tracking through various assembly states is achieved by our novel multi-state assembly graph. We update the multi-state assembly graph by utilizing the relative poses of the individual assembly parts. Linking the individual objects in this graph enables more robust object tracking during the assembly process. For evaluation, we introduce a synthetic dataset of publicly available and 3D printable assembly assets as a benchmark for future work. Quantitative experiments in synthetic data and further qualitative study in real test data show that GBOT can outperform existing work towards enabling context-aware augmented reality assembly guidance. Dataset and code will be made publically available.

Constantin Kleinbeck, Hannah Schieber, Klaus Engel et al.

In medical image visualization, path tracing of volumetric medical data like CT scans produces lifelike three-dimensional visualizations. Immersive VR displays can further enhance the understanding of complex anatomies. Going beyond the diagnostic quality of traditional 2D slices, they enable interactive 3D evaluation of anatomies, supporting medical education and planning. Rendering high-quality visualizations in real-time, however, is computationally intensive and impractical for compute-constrained devices like mobile headsets. We propose a novel approach utilizing GS to create an efficient but static intermediate representation of CT scans. We introduce a layered GS representation, incrementally including different anatomical structures while minimizing overlap and extending the GS training to remove inactive Gaussians. We further compress the created model with clustering across layers. Our approach achieves interactive frame rates while preserving anatomical structures, with quality adjustable to the target hardware. Compared to standard GS, our representation retains some of the explorative qualities initially enabled by immersive path tracing. Selective activation and clipping of layers are possible at rendering time, adding a degree of interactivity to otherwise static GS models. This could enable scenarios where high computational demands would otherwise prohibit using path-traced medical volumes.

Hannah Schieber, Shiyu Li, Niklas Corell et al.

In medical and industrial domains, providing guidance for assembly processes can be critical to ensure efficiency and safety. Errors in assembly can lead to significant consequences such as extended surgery times and prolonged manufacturing or maintenance times in industry. Assembly scenarios can benefit from in-situ augmented reality visualization, i.e., augmentations in close proximity to the target object, to provide guidance, reduce assembly times, and minimize errors. In order to enable in-situ visualization, 6D pose estimation can be leveraged to identify the correct location for an augmentation. Existing 6D pose estimation techniques primarily focus on individual objects and static captures. However, assembly scenarios have various dynamics, including occlusion during assembly and dynamics in the appearance of assembly objects. Existing work focus either on object detection combined with state detection, or focus purely on the pose estimation. To address the challenges of 6D pose estimation in combination with assembly state detection, our approach ASDF builds upon the strengths of YOLOv8, a real-time capable object detection framework. We extend this framework, refine the object pose, and fuse pose knowledge with network-detected pose information. Utilizing our late fusion in our Pose2State module results in refined 6D pose estimation and assembly state detection. By combining both pose and state information, our Pose2State module predicts the final assembly state with precision. The evaluation of our ASDF dataset shows that our Pose2State module leads to an improved assembly state detection and that the improvement of the assembly state further leads to a more robust 6D pose estimation. Moreover, on the GBOT dataset, we outperform the pure deep learning-based network and even outperform the hybrid and pure tracking-based approaches.

Hannah Schieber, Dominik Frischmann, Victor Schaack et al.

Mobile reconstruction has the potential to support time-critical tasks such as tele-guidance and disaster response, where operators must quickly gain an accurate understanding of the environment. Full high-fidelity scene reconstruction is computationally expensive and often unnecessary when only specific points of interest (POIs) matter for timely decision making. We address this challenge with CoRe-GS, a semantic POI-focused extension of Gaussian Splatting (GS). Instead of optimizing every scene element uniformly, CoRe-GS first produces a fast segmentation-ready GS representation and then selectively refines splats belonging to semantically relevant POIs detected during data acquisition. This targeted refinement reduces training time to 25\% compared to full semantic GS while improving novel view synthesis quality in the areas that matter most. We validate CoRe-GS on both real-world (SCRREAM) and synthetic (NeRDS 360) datasets, demonstrating that prioritizing POIs enables faster and higher-quality mobile reconstruction tailored to operational needs.

Laura Schütz, Sasan Matinfar, Ulrich Eck et al.

In Augmented Reality (AR), virtual objects interact with real objects. However, the lack of physicality of virtual objects leads to the absence of natural sonic interactions. When virtual and real objects collide, either no sound or a generic sound is played. Both lead to an incongruent multisensory experience, reducing interaction and object realism. Unlike in Virtual Reality (VR) and games, where predefined scenes and interactions allow for the playback of pre-recorded sound samples, AR requires real-time sound synthesis that dynamically adapts to novel contexts and objects to provide audiovisual congruence during interaction. To enhance real-virtual object interactions in AR, we propose a framework for context-aware sounds using methods from computer vision to recognize and segment the materials of real objects. The material's physical properties and the impact dynamics of the interaction are used to generate material-based sounds in real-time using physical modelling synthesis. In a user study with 24 participants, we compared our congruent material-based sounds to a generic sound effect, mirroring the current standard of non-context-aware sounds in AR applications. The results showed that material-based sounds led to significantly more realistic sonic interactions. Material-based sounds also enabled participants to distinguish visually similar materials with significantly greater accuracy and confidence. These findings show that context-aware, material-based sonic interactions in AR foster a stronger sense of realism and enhance our perception of real-world surroundings.

Fabian Deuser, Philipp Hausenblas, Hannah Schieber et al.

Contrastive learning is a representational learning paradigm in which a neural network maps data elements to feature vectors. It improves the feature space by forming lots with an anchor and examples that are either positive or negative based on class similarity. Hard negative examples, which are close to the anchor in the feature space but from a different class, improve learning performance. Finding such examples of high quality efficiently in large, high-dimensional datasets is computationally challenging. In this paper, we propose a GPU-friendly Locality-Sensitive Hashing (LSH) scheme that quantizes real-valued feature vectors into binary representations for approximate nearest neighbor search. We investigate its theoretical properties and evaluate it on several datasets from textual and visual domain. Our approach achieves comparable or better performance while requiring significantly less computation than existing hard negative mining strategies.

Daniel Roth, Marc Erich Latoschik

User embodiment is important for many virtual reality (VR) applications, for example, in the context of social interaction, therapy, training, or entertainment. However, there is no validated instrument to empirically measure the perception of embodiment, necessary to reliably evaluate this important quality of user experience (UX). To assess components of virtual embodiment in a valid, reliable, and consistent fashion, we develped a Virtual Embodiment Questionnaire (VEQ). We reviewed previous literature to identify applicable constructs and items, and performed a confirmatory factor analysis (CFA) on the data from three experiments (N = 196). Each experiment modified a distinct simulation property, namely, the level of immersion, the level of personalization, and the level of behavioral realism. The analysis confirmed three factors: (1) ownership of a virtual body, (2) agency over a virtual body, and (3) change in the perceived body schema. A fourth study (N = 22) further confirmed the reliability and validity of the scale and investigated the impacts of latency jitter of avatar movements presented in the simulation compared to linear latencies and a baseline. We present the final scale and further insights from the studies regarding related constructs.

Thomas Gerstner, Bastian Harrach, Daniel Roth

The Monte Carlo pathwise sensitivities approach is well established for smooth payoff functions. In this work, we present a new Monte Carlo algorithm that is able to calculate the pathwise sensitivities for discontinuous payoff functions. Our main tool is to combine the one-step survival idea of Glasserman and Staum with the stable differentiation approach of Alm, Harrach, Harrach and Keller. As an application we use the derived results for a two-dimensional calibration of a CoCo-Bond, which we model with different types of discretely monitored barrier options.