Elsi Kaiser

Woojae Jeong, Aditya Kommineni, Kleanthis Avramidis et al.

Depression and suicidality affect cognitive and emotional processes, yet objective, task-evoked neural readouts of mental health remain limited. We investigated the spatiotemporal dynamics of affective semantic processing using multivariate decoding of time-resolved, 64-channel electroencephalography (EEG). Participants (N=137) performed a sentence-evaluation task with emotionally salient, self-referential statements. We identified robust neural signatures of semantic processing, with peak decoding accuracy between 300-600 ms -- a window associated with rapid, stimulus-driven semantic evaluation and conflict monitoring. Relative to healthy controls, individuals with depression and suicidal ideation showed earlier onset, longer duration, and greater amplitude decoding responses, along with broader cross-temporal generalization and enhanced contributions from frontocentral and parietotemporal components. These findings suggest altered sensitivity and impaired disengagement from emotionally salient content in the clinical groups, advancing our understanding of the neurocognitive basis of mental health and establishing a compact and interpretable EEG-based index of semantic-evaluation dynamics with potential diagnostic relevance.

Hailin Hao, Elsi Kaiser

Speakers often have multiple ways to express the same meaning. The Uniform Information Density (UID) hypothesis suggests that speakers exploit this variability to maintain a consistent rate of information transmission during language production. Building on prior work linking UID to syntactic reduction, we revisit the finding that the optional complementizer $\textit{that}$ in English complement clauses is more likely to be omitted when the clause has low information density (i.e., more predictable). We advance this line of research by analyzing a large-scale, contemporary conversational corpus and using machine learning and neural language models to refine estimates of information density. Our results replicated the established relationship between information density and $\textit{that}$-mentioning. However, we found that previous measures of information density based on matrix verbs' subcategorization probability capture substantial idiosyncratic lexical variation. By contrast, estimates derived from contextual word embeddings account for additional variance in patterns of complementizer usage.

Kleanthis Avramidis, Woojae Jeong, Aditya Kommineni et al.

Identifying physiological and behavioral markers for mental health conditions is a longstanding challenge in psychiatry. Depression and suicidal ideation, in particular, lack objective biomarkers, with screening and diagnosis primarily relying on self-reports and clinical interviews. Here, we investigate eye tracking as a potential marker modality for screening purposes. Eye movements are directly modulated by neuronal networks and have been associated with attentional and mood-related patterns; however, their predictive value for depression and suicidality remains unclear. We recorded eye-tracking sequences from 126 young adults as they read and responded to affective sentences, and subsequently developed a deep learning framework to predict their clinical status. The proposed model included separate branches for trials of positive and negative sentiment, and used 2D time-series representations to account for both intra-trial and inter-trial variations. We were able to identify depression and suicidal ideation with an area under the receiver operating curve (AUC) of 0.793 (95% CI: 0.765-0.819) against healthy controls, and suicidality specifically with 0.826 AUC (95% CI: 0.797-0.852). The model also exhibited moderate, yet significant, accuracy in differentiating depressed from suicidal participants, with 0.609 AUC (95% CI 0.571-0.646). Discriminative patterns emerge more strongly when assessing the data relative to response generation than relative to the onset time of the final word of the sentences. The most pronounced effects were observed for negative-sentiment sentences, that are congruent to depressed and suicidal participants. Our findings highlight eye tracking as an objective tool for mental health assessment and underscore the modulatory impact of emotional stimuli on cognitive processes affecting oculomotor control.