Youjia Zheng

Zhijun Zeng, Yihang Zheng, Youjia Zheng et al.

Ultrasound Computed Tomography (USCT) provides a radiation-free option for high-resolution clinical imaging. Despite its potential, the computationally intensive Full Waveform Inversion (FWI) required for tissue property reconstruction limits its clinical utility. This paper introduces the Neural Born Series Operator (NBSO), a novel technique designed to speed up wave simulations, thereby facilitating a more efficient USCT image reconstruction process through an NBSO-based FWI pipeline. Thoroughly validated on comprehensive brain and breast datasets, simulated under experimental USCT conditions, the NBSO proves to be accurate and efficient in both forward simulation and image reconstruction. This advancement demonstrates the potential of neural operators in facilitating near real-time USCT reconstruction, making the clinical application of USCT increasingly viable and promising.

Zhijun Zeng, Youjia Zheng, Hao Hu et al.

Accurate and efficient simulation of wave equations is crucial in computational wave imaging applications, such as ultrasound computed tomography (USCT), which reconstructs tissue material properties from observed scattered waves. Traditional numerical solvers for wave equations are computationally intensive and often unstable, limiting their practical applications for quasi-real-time image reconstruction. Neural operators offer an innovative approach by accelerating PDE solving using neural networks; however, their effectiveness in realistic imaging is limited because existing datasets oversimplify real-world complexity. In this paper, we present OpenBreastUS, a large-scale wave equation dataset designed to bridge the gap between theoretical equations and practical imaging applications. OpenBreastUS includes 8,000 anatomically realistic human breast phantoms and over 16 million frequency-domain wave simulations using real USCT configurations. It enables a comprehensive benchmarking of popular neural operators for both forward simulation and inverse imaging tasks, allowing analysis of their performance, scalability, and generalization capabilities. By offering a realistic and extensive dataset, OpenBreastUS not only serves as a platform for developing innovative neural PDE solvers but also facilitates their deployment in real-world medical imaging problems. For the first time, we demonstrate efficient in vivo imaging of the human breast using neural operator solvers.

Youjia Zheng, Mohammad Zandsalimy, Shanu Sushmita

Large Language Models (LLMs) are increasingly vulnerable to a sophisticated form of adversarial prompting known as camouflaged jailbreaking. This method embeds malicious intent within seemingly benign language to evade existing safety mechanisms. Unlike overt attacks, these subtle prompts exploit contextual ambiguity and the flexible nature of language, posing significant challenges to current defense systems. This paper investigates the construction and impact of camouflaged jailbreak prompts, emphasizing their deceptive characteristics and the limitations of traditional keyword-based detection methods. We introduce a novel benchmark dataset, Camouflaged Jailbreak Prompts, containing 500 curated examples (400 harmful and 100 benign prompts) designed to rigorously stress-test LLM safety protocols. In addition, we propose a multi-faceted evaluation framework that measures harmfulness across seven dimensions: Safety Awareness, Technical Feasibility, Implementation Safeguards, Harmful Potential, Educational Value, Content Quality, and Compliance Score. Our findings reveal a stark contrast in LLM behavior: while models demonstrate high safety and content quality with benign inputs, they exhibit a significant decline in performance and safety when confronted with camouflaged jailbreak attempts. This disparity underscores a pervasive vulnerability, highlighting the urgent need for more nuanced and adaptive security strategies to ensure the responsible and robust deployment of LLMs in real-world applications.

Zhijun Zeng, Youjia Zheng, Chang Su et al.

Tissue mechanics--stiffness, density and impedance contrast--are broadly informative biomarkers across diseases, yet routine CT, MRI, and B-mode ultrasound rarely quantify them directly. While ultrasound tomography (UT) is intrinsically suited to in-vivo biomechanical assessment by capturing transmitted and reflected wavefields, efficient and accurate full-wave scattering models remain a bottleneck. Here, we introduce a generative neural physics framework that fuses generative models with physics-informed partial differential equation (PDE) solvers to produce rapid, high-fidelity 3D quantitative imaging of tissue mechanics. A compact neural surrogate for full-wave propagation is trained on limited cross-modality data, preserving physical accuracy while enabling efficient inversion. This enables, for the first time, accurate and efficient quantitative volumetric imaging of in vivo human breast and musculoskeletal tissues in under ten minutes, providing spatial maps of tissue mechanical properties not available from conventional reflection-mode or standard UT reconstructions. The resulting images reveal biomechanical features in bone, muscle, fat, and glandular tissues, maintaining structural resolution comparable to 3T MRI while providing substantially greater sensitivity to disease-related tissue mechanics.

Anjali Rawal, Hui Wang, Youjia Zheng et al.

Large language models (LLMs) have gained significant attention due to their ability to mimic human language. Identifying texts generated by LLMs is crucial for understanding their capabilities and mitigating potential consequences. This paper analyzes datasets of varying text lengths: small, medium, and large. We compare the performance of machine learning algorithms on four datasets: (1) small (tweets from Election, FIFA, and Game of Thrones), (2) medium (Wikipedia introductions and PubMed abstracts), and (3) large (OpenAI web text dataset). Our results indicate that LLMs with very large parameters (such as the XL-1542 variant of GPT2 with 1542 million parameters) were harder (74%) to detect using traditional machine learning methods. However, detecting texts of varying lengths from LLMs with smaller parameters (762 million or less) can be done with high accuracy (96% and above). We examine the characteristics of human and machine-generated texts across multiple dimensions, including linguistics, personality, sentiment, bias, and morality. Our findings indicate that machine-generated texts generally have higher readability and closely mimic human moral judgments but differ in personality traits. SVM and Voting Classifier (VC) models consistently achieve high performance across most datasets, while Decision Tree (DT) models show the lowest performance. Model performance drops when dealing with rephrased texts, particularly shorter texts like tweets. This study underscores the challenges and importance of detecting LLM-generated texts and suggests directions for future research to improve detection methods and understand the nuanced capabilities of LLMs.