LGSep 5, 2025
STL-based Optimization of Biomolecular Neural Networks for Regression and ControlEric Palanques-Tost, Hanna Krasowski, Murat Arcak et al.
Biomolecular Neural Networks (BNNs), artificial neural networks with biologically synthesizable architectures, achieve universal function approximation capabilities beyond simple biological circuits. However, training BNNs remains challenging due to the lack of target data. To address this, we propose leveraging Signal Temporal Logic (STL) specifications to define training objectives for BNNs. We build on the quantitative semantics of STL, enabling gradient-based optimization of the BNN weights, and introduce a learning algorithm that enables BNNs to perform regression and control tasks in biological systems. Specifically, we investigate two regression problems in which we train BNNs to act as reporters of dysregulated states, and a feedback control problem in which we train the BNN in closed-loop with a chronic disease model, learning to reduce inflammation while avoiding adverse responses to external infections. Our numerical experiments demonstrate that STL-based learning can solve the investigated regression and control tasks efficiently.
LGDec 20, 2021
Learning Spatio-Temporal Specifications for Dynamical SystemsSuhail Alsalehi, Erfan Aasi, Ron Weiss et al.
Learning dynamical systems properties from data provides important insights that help us understand such systems and mitigate undesired outcomes. In this work, we propose a framework for learning spatio-temporal (ST) properties as formal logic specifications from data. We introduce SVM-STL, an extension of Signal Signal Temporal Logic (STL), capable of specifying spatial and temporal properties of a wide range of dynamical systems that exhibit time-varying spatial patterns. Our framework utilizes machine learning techniques to learn SVM-STL specifications from system executions given by sequences of spatial patterns. We present methods to deal with both labeled and unlabeled data. In addition, given system requirements in the form of SVM-STL specifications, we provide an approach for parameter synthesis to find parameters that maximize the satisfaction of such specifications. Our learning framework and parameter synthesis approach are showcased in an example of a reaction-diffusion system.
SDOct 22, 2020
Parallel Tacotron: Non-Autoregressive and Controllable TTSIsaac Elias, Heiga Zen, Jonathan Shen et al.
Although neural end-to-end text-to-speech models can synthesize highly natural speech, there is still room for improvements to its efficiency and naturalness. This paper proposes a non-autoregressive neural text-to-speech model augmented with a variational autoencoder-based residual encoder. This model, called \emph{Parallel Tacotron}, is highly parallelizable during both training and inference, allowing efficient synthesis on modern parallel hardware. The use of the variational autoencoder relaxes the one-to-many mapping nature of the text-to-speech problem and improves naturalness. To further improve the naturalness, we use lightweight convolutions, which can efficiently capture local contexts, and introduce an iterative spectrogram loss inspired by iterative refinement. Experimental results show that Parallel Tacotron matches a strong autoregressive baseline in subjective evaluations with significantly decreased inference time.
IRJan 17, 2013
Affinity Weighted EmbeddingJason Weston, Ron Weiss, Hector Yee
Supervised (linear) embedding models like Wsabie and PSI have proven successful at ranking, recommendation and annotation tasks. However, despite being scalable to large datasets they do not take full advantage of the extra data due to their linear nature, and typically underfit. We propose a new class of models which aim to provide improved performance while retaining many of the benefits of the existing class of embedding models. Our new approach works by iteratively learning a linear embedding model where the next iteration's features and labels are reweighted as a function of the previous iteration. We describe several variants of the family, and give some initial results.
IRJun 18, 2012
Latent Collaborative RetrievalJason Weston, Chong Wang, Ron Weiss et al.
Retrieval tasks typically require a ranking of items given a query. Collaborative filtering tasks, on the other hand, learn to model user's preferences over items. In this paper we study the joint problem of recommending items to a user with respect to a given query, which is a surprisingly common task. This setup differs from the standard collaborative filtering one in that we are given a query x user x item tensor for training instead of the more traditional user x item matrix. Compared to document retrieval we do have a query, but we may or may not have content features (we will consider both cases) and we can also take account of the user's profile. We introduce a factorized model for this new task that optimizes the top-ranked items returned for the given query and user. We report empirical results where it outperforms several baselines.
LGJan 2, 2012
Scikit-learn: Machine Learning in PythonFabian Pedregosa, Gaël Varoquaux, Alexandre Gramfort et al.
Scikit-learn is a Python module integrating a wide range of state-of-the-art machine learning algorithms for medium-scale supervised and unsupervised problems. This package focuses on bringing machine learning to non-specialists using a general-purpose high-level language. Emphasis is put on ease of use, performance, documentation, and API consistency. It has minimal dependencies and is distributed under the simplified BSD license, encouraging its use in both academic and commercial settings. Source code, binaries, and documentation can be downloaded from http://scikit-learn.org.